TWI809148B - Composition comprising eutectic mixture of boscalid and a strobilurin fungicide, preparing method thereof, and combating or controlling fungi method - Google Patents

Abstract

The present invention relates to a eutectic mixture of boscalid and strobilurin fungicide. Agrochemical compositions comprising a eutectic mixture of boscalid and a strobilurin fungicide and a method of controlling phytopathogenic fungi using said compositions are also provided.

Description

Compositions comprising eutectic mixtures of bakleyl and strobilurin fungicides, Its preparation procedure and method for combating or controlling fungi

The present invention relates to a composition comprising a eutectic mixture of boscalid and strobilurin fungicides. The present invention further relates to a process for formulating a composition comprising a eutectic mixture of bacrine and strobilurin fungicides, and to a method of using such compositions for controlling phytopathogenic fungi.

Bakret is a family of fungicides known as succinate dehydrogenase inhibitors. It is a fungicide that has translaminar and acropetal migration within plant leaves, providing preventive and in some cases curative action. It inhibits spore germination, germination tube elongation, and also effectively inhibits all other stages of fungal development. Baccarat series are used to control Alternaria blight, Botrytis, Powdery mildew, Purple blotch, Rust, Leaf spot, Target spot, Gray module, and Stem rot.

In order to broaden the spectrum of activity and enhance the effectiveness of fungicidal control, succinate dehydrogenase inhibitors, such as bacilli, are often combined with other classes of fungicidally active ingredients. One of the important class of fungicides is quinone exo-inhibitors (Q _o I).

Strobilurins are Q _o I inhibitory fungicides and inhibit fungal respiration by binding to the cytochrome bc ₁ complex at the Q _o I site in mitochondrial respiration. These fungicides work by inhibiting the ability of fungi to perform normal respiration. These strobilurin dual chemicals have very specific target sites or mode-of-action (MOA). The strobilurins are known to control fungi such as: Erysiphe graminis on temperate cereals, Puccinia spp., Leptosphaeria nodorum, wheat Septoria tritici and Pyrenophora teres, Pyricularia oryzae and Rhizoctonia solani on rice; Plasmopara viticola on grape vines and Uncinula necator; Sphaerotheca fuliginea and Pseudoperonospora cubensis on Cucurbitaceae; Phytophthora infestans and Alternaria solani on tomato; Mycosphaerella arachidis, Rhizoctonia solani and Sclerotium rolfsii on peanuts; Monilinia spp on peaches .) and Cladosporium carpophilum; Pythium spp. and Rhizoctonia solani on turf; Mycosphaerella spp. on bananas; Cladosporium caryigenum; Elsinoe fawcettii, Colletotrichum spp. and Guignardia citricarpa on citrus; Anthrax stinger on coffee Colletotrichum spp. and Hemileia vastatrix.

Given that improvements in the effective control of phytopathogenic fungi can be expected by combining succinate dehydrogenase inhibitors with strobilurin fungicides, there is a need to explore and develop stable compositions of active ingredients from these groups.

Notably, becryl undergoes irrepressible morphological changes when in contact with water or solvents. It was further observed that technically specific, tedious and expensive procedures are often required to produce commercially formulations of bacillit as produced commercially and for the intended application. Stability issues can also arise with such formulations when stored for extended periods of time.

Therefore, there is a need to develop stable compositions of bcclidin together with strobilurin fungicides to eliminate the disadvantages of known formulations.

Surprisingly, the inventors of the present invention have found that it is possible to prepare compositions comprising eutectic mixtures of bacrine and strobilurin fungicides which do not undergo any morphological changes, are stable and are very suitable for controlling phytopathogens Anticipated applications for sexual fungi.

Purpose of the present invention:

It is an object of the present invention to provide a composition comprising a eutectic mixture of bacrine and strobilurin fungicides.

Another object of the present invention is to provide a composition comprising a eutectic mixture of bakleyl and yatormin.

Another object of the present invention is to provide a composition comprising a eutectic mixture of bakleyl and fluoxastrobin.

Yet another object of the present invention is to provide a procedure for the preparation of eutectic mixtures of bacrine and strobilurin fungicides.

Another object of the present invention is to provide a procedure for the preparation of fungicidal compositions comprising eutectic mixtures of bacrine and strobilurin fungicides.

A eutectic mixture comprising buclide and strobilurin fungicides.

The present invention provides an agricultural chemical composition comprising a eutectic mixture of bacrine and strobilurin fungicides.

The present invention provides an agrochemical composition comprising a eutectic mixture of buccalidine and a strobilurin fungicide, wherein the composition comprises between 10 and 90% by weight of buccalidine and between 90 and 10 % between strobilurin fungicides.

A eutectic mixture comprising bakleyl and yatormin.

The present invention further provides an agricultural chemical composition, which comprises a eutectic mixture of becryl and yatomin.

The present invention further provides an agricultural chemical composition comprising a eutectic mixture of becryl and yatormine, wherein the composition comprises between 10 and 90% by weight of becryl and between 90 and 10% of Tomin.

A eutectic mixture of becryl and yatormin, wherein the eutectic mixture is characterized by a DSC onset temperature of 100±3°C and an endothermic peak of 103.5±3°C.

The present invention further provides an agrochemical composition comprising a eutectic mixture of bectilide and yatormin, wherein the eutectic mixture is characterized by a DSC onset temperature of 100±3°C and an endothermic peak of 103.5±3°C.

A eutectic mixture comprising bakleyl and fluoxastrobin.

The present invention further provides an agricultural chemical composition, which comprises a eutectic mixture of bakleyl and fluoxastrobin.

The present invention further provides an agrochemical composition comprising a eutectic mixture of buccolidine and fluoxastrobin, wherein the composition comprises between 10 and 90% by weight of bucrine and between 90 and 10% fluoxastrobin.

A eutectic mixture of bakleyl and fluoxastrobin, wherein the eutectic mixture is characterized in that DSC has an onset temperature of 92±3°C and an endothermic peak of 97±3°C.

The present invention further provides an agrochemical composition comprising a eutectic mixture of bakleyl and fluoxastrobin, wherein the eutectic mixture is characterized in that DSC has an onset temperature of 92±3°C and an endotherm of 97±3°C peak.

A eutectic mixture of bakleyl and fluoxastrobin, wherein the eutectic mixture is characterized in that DSC has an onset temperature of 100±3°C and an endothermic peak of 107±3°C.

The present invention further provides an agrochemical composition comprising a eutectic mixture of bakleyl and fluoxastrobin, wherein the eutectic mixture is characterized in that DSC has an onset temperature of 100±3°C and an endotherm of 107±3°C peak.

The present invention relates to a process for formulating an agrochemical composition comprising a eutectic mixture of bacrine and strobilurin fungicides.

Further, it relates to a process for preparing a eutectic mixture of bacrine and strobilurin fungicides.

The present invention further provides a method of controlling phytopathogenic fungi, the method comprising applying to plants or their habitat, plant seeds or soil a fungicidally effective amount of a eutectic mixture comprising buccalide and strobilurin fungicides composition.

The present invention can be understood by referring to the following figures: Figure 1: DSC thermogram of Bekley.

Figure 2: DSC thermogram of yatormin.

Figure 3: DSC thermograms of Bakleyl and Yatomin, the ratio of which is 60:40.

Figure 4: The phase diagram of the eutectic mixture of bekleyl and yatormin.

Figure 5: DSC thermogram of Example 2.

Fig. 6: DSC thermogram of Example 3.

Fig. 7: DSC thermogram of Example 8.

Figure 8: DSC thermogram of Example 2 after storage for 9 months.

Figure 9: DSC thermogram of fluoxastrobin.

Fig. 10: The DSC thermogram of the mixture of bakleyl and fluoxastrobin at a ratio of 30:70 (Example 9).

Fig. 11: The DSC thermogram of the mixture of bakleyl and fluoxastrobin at a ratio of 25:75 (Example 10).

The inventors of the present invention have surprisingly found that it is possible to successfully prepare eutectic mixtures of bacrine and strobilurin compounds which are stable and very suitable for their intended use in the control of phytopathogenic fungi.

Furthermore, the inventors of the present invention have observed that compositions comprising eutectic mixtures of bakleyl and strobilurin compounds do not suffer from uncontrolled morphological changes in the preparation of such compositions, and further noted These compositions remain stable during long-term storage.

With regard to the present invention, Bakret refers to 2-chloro-N-(4'-chlorobiphenyl-2-yl)nicotinamide, its salts and derivatives and polymorphs. Throughout the specification, the term "boscalid" includes the known polymorphic forms of the molecule, ie, the anhydrate I, anhydrate II and hydrate forms of boscalid.

The term "eutectic mixture" is defined as a mixture of two or more components which do not normally interact to form new compounds, but which, in certain proportions, inhibit the crystallization process of each other, resulting in A system with a lower melting point of either of the components. Plot the onset melting temperature of the eutectic mixture (using Differential Scanning Calorimetry - DSC thermogram) and the difference % transition of the two components The phase diagram of the quantitative components, illustrating the melting mode of the composition according to the invention. The point at which all components in a mixture are in equilibrium is called the eutectic point.

The term eutectic mixture is also understood to include mixtures according to the invention of the ratio of the two components in which the melting point is reduced to a minimum. However, it shall also include other ratios having a melting point higher than that of the eutectic mixture, although lower than that of the individual components, at which at least a portion of the active ingredients mixed are at the eutectic point.

In one embodiment, the present invention provides a eutectic mixture comprising bacrine and a strobilurin fungicide.

In one embodiment, the present invention provides an agrochemical composition comprising a eutectic mixture of bacrine and a strobilurin fungicide.

In one embodiment of the present invention, there is provided an agrochemical composition comprising a eutectic mixture of bacrine and strobilurin fungicides; and at least one agrochemically acceptable excipient, wherein the The formation of eutectic mixtures inhibits the crystallization process of the buclide and strobilurin fungicides.

In one embodiment, the composition comprises Bacrine in a form selected from the group comprising: Bacrine Anhydrate Modified I, Bacclelide Anhydrate Modified II, and Bacrine Hydrate Form.

In one embodiment, the composition according to the invention comprises a strobilurin fungicide selected from the group comprising: azoxystrobin, pyraclostrobin, trifluroxystrobin, pyridine Picoxystrobin, fluoxastrobin, mandestrobin, pyribencarb, coumoxystrobin, enoxastrobin , flufenoxystrobin, pyraoxystrobin, pyramethstrobin, triclopyricarb, dimoxystrobin, fenaminstrobin, phenoxy Metominostrobin, orysastrobin, and Kresoxim-methyl.

In a preferred embodiment, the composition according to the present invention comprises a fungicide selected from the following group, which includes: ytropamine, becclomin, trifluramine, fluoxastrobin and picoxystrobin.

In one embodiment of the present invention, the composition comprises 10 to 90% by weight of buccalidine and 90 to 10% of strobilurin fungicide.

In one embodiment of the present invention, the composition comprises 50 to 80% by weight of buccalidine and about 50 to 20% of strobilurin fungicide.

In one embodiment of the present invention, the composition comprises, by weight of the active ingredient, between 50 and 80% of the buccalidine and between 50 and 20% of the strobilurin fungicide.

In one embodiment, the present invention provides a eutectic mixture of bakleyl and yatormin.

In one embodiment, the present invention provides a eutectic mixture comprising bakleyl and yatormine, the molar ratio of which is 1.5:1.

In one embodiment of the present invention, there is provided an agrochemical composition comprising a eutectic mixture of bakleyl and yatormin.

In one embodiment of the present invention, the composition comprises 10 to 90% of bacilli and 90 to 10% of atropamine by weight.

In some embodiments of the present invention, the composition comprises between 50 and 80% by weight of bacilli and between 50 and 20% of atropamine.

In some embodiments of the present invention, the composition comprises, by weight of the active ingredient, between 50 and 80% of bacilli and between 50 and 20% of atropamine.

In one embodiment, the present invention provides a eutectic mixture comprising, by weight of the active ingredient, about 60% of bacilli and about 40% of atropamine.

In one embodiment, the composition comprises, by weight of the active ingredient, about 60% bacilli and about 40% atropamine.

In one embodiment, the composition comprises bacclelid and yatormin at a molar ratio of 1:9 to 9:1.

In one embodiment, the composition comprises bacclelid and yatormin at a molar ratio of 1:5 to 5:1.

In one embodiment, the composition includes bacrine and yatormin in a molar ratio of 1:3 to 3:1.

In a preferred embodiment, the composition comprises bacrine and yatormin at a molar ratio of 1.5:1.

In one embodiment, the present invention provides a eutectic mixture comprising bakleyl and yatormine, the molar ratio of which is 1.5:1.

In one embodiment, a composition comprising a eutectic mixture of bakleyl and tropamine is characterized by a DSC onset temperature of 100±3°C and an endothermic peak of 103°C±3°C.

In one embodiment, the present invention provides a eutectic mixture comprising bakleyl and tropamine, characterized in that DSC has an onset temperature of 100±3°C and an endothermic peak of 103°C±3°C.

In one embodiment, a composition comprising a eutectic mixture of bakleyl and tropamine is characterized by a DSC onset temperature of 100±3°C and an endothermic peak between 103°C and 106°C.

In one embodiment, the present invention provides a eutectic mixture comprising bakleyl and tropamine, characterized in that DSC has an onset temperature of 100±3°C and an endothermic peak between 103°C and 106°C.

In a preferred embodiment, the composition comprising the eutectic mixture of bacletide and tropamine is characterized by a DSC onset temperature of 100±3°C and an endothermic peak of 103.5°C.

In one embodiment, the present invention provides a eutectic mixture comprising bakleyl and tropamine, characterized in that DSC has an onset temperature of 100±3°C and an endothermic peak of 103.5°C.

In one embodiment, the present invention provides a eutectic mixture of bacilli and fluoxastrobin.

In one embodiment of the present invention, there is provided an agrochemical composition comprising a eutectic mixture of bakleyl and fluoxastrobin.

In one embodiment of the present invention, the composition comprises 10 to 90% by weight of buclide and 90 to 10% of fluoxastrobin.

In some embodiments of the present invention, the composition comprises between 50 and 80% by weight of bacilli and between 50 and 20% of fluoxastrobin.

In certain embodiments of the present invention, the composition comprises, by weight of the active ingredient, between 50 and 80% of buccalidine and between 50 and 20% of fluoxastrobin.

In one embodiment, the present invention provides a eutectic mixture comprising, by weight of the active ingredient, about 60% bacilli and about 40% fluoxastrobin.

In one embodiment, the composition comprises, by weight of the active ingredient, about 60% bacilli and about 40% fluoxastrobin.

In one embodiment, the composition comprises bakleyl and fluoxastrobin in a molar ratio of 1:9 to 9:1.

In one embodiment, the composition comprises bakleyl and fluoxastrobin in a molar ratio of 1:5 to 5:1.

In one embodiment, the composition includes bakleyl and fluoxastrobin in a molar ratio of 1:3 to 3:1.

In one embodiment, the composition comprises bakleyl and fluoxastrobin at a molar ratio of 1.5:1.

In one embodiment, the present invention provides a eutectic mixture comprising bakleyl and fluoxastrobin, the molar ratio of which is 1:3.

In one embodiment, a composition comprising a eutectic mixture of bakleyl and fluoxastrobin is characterized by a DSC onset temperature of 92±3°C and an endothermic peak of 97±3°C.

In one embodiment, the present invention provides a eutectic mixture comprising bakleyl and fluoxastrobin, characterized in that DSC has an onset temperature of 100±3°C and an endothermic peak of 107°C±3°C.

In a preferred embodiment, the composition comprising the eutectic mixture of bakleyl and fluoxastrobin is characterized by a DSC onset temperature of 92±3°C and an endothermic peak of 97 to 100°C.

In a preferred embodiment, the composition comprising the eutectic mixture of bakleyl and fluoxastrobin is characterized by DSC having an endothermic peak with an onset temperature of 107 to 109°C at 100±3°C.

In one embodiment, the present invention provides a process for preparing a eutectic mixture of bacrine and strobilurin fungicides.

In one embodiment, the present invention provides a process for preparing a eutectic mixture of buccalidine and a strobilurin fungicide, the process comprising subjecting the buccalidine and strobilurin fungicide to solution crystallization, Dry milling, solvent drop milling techniques, or spray drying techniques.

In one embodiment, the present invention provides a process for preparing a eutectic mixture of buccalidine and strobilurin, the process comprising the following steps: a. preparing buccalidine and strobilurin in one or more solvents a concentrated solution of the strobilurin fungicide; b. optionally evaporating the solvent; and c. trituration or precipitation with an anti-solvent to obtain a eutectic mixture.

In one embodiment, the present invention provides a process for preparing a eutectic mixture of buccalidine and strobilurin, the process comprising the following steps: a. preparing buccalidine and strobilurin in one or more solvents A concentrated solution of the strobilurin fungicide; b. evaporation of the solvent to induce crystallization to obtain a eutectic mixture.

In one embodiment, the solvent of step a) is selected from aliphatic alcohols, ketones, esters, ethers, polar protic solvents, polar aprotic solvents, halogenated solvents, aliphatic hydrocarbons, or aromatic hydrocarbons.

In one embodiment of the present invention, the anti-solvent can be aliphatic hydrocarbon or aromatic hydrocarbon.

In one embodiment of step (b), the solvent is partially evaporated.

In one embodiment of step (b), the solvent is completely evaporated.

In one embodiment of the present invention, the anti-solvent in step c) is selected from aliphatic or aromatic hydrocarbon solvents.

In one embodiment, the present invention provides a process for preparing a eutectic mixture of buccalidine and strobilurin fungicides, the process comprising the following steps: a. b. optionally blending a solvent into the blend; and c. grinding or crushing or milling the blend to obtain the eutectic mixture.

In one embodiment, the temperature at which step (a), step (b) or step (c) of the process is carried out is not limited.

In another embodiment, step (a), step (b) or step (c) of the procedure is carried out at a temperature below the melting point of the buccalide and strobilurin fungicides.

The present invention further provides a procedure for the preparation of a composition comprising a eutectic mixture of bacilli and strobilurin fungicides.

In one embodiment, there is provided a process for preparing a composition comprising a eutectic mixture of bacrine and strobilurin fungicides, the process comprising adding or not adding an agrochemically acceptable excipient A eutectic mixture of the buccalidine and strobilurin fungicides is prepared in the case of a fungicide, and the mixture is further processed into a suitable form.

In one embodiment, a process is provided for preparing a granular composition comprising a eutectic mixture of bacrine and a strobilurin fungicide.

In one embodiment of the present invention, a granular composition comprising a eutectic mixture of bacrine and strobilurin fungicides is prepared by a procedure comprising the following steps: (a) preparing bacrine and strobilurin fungicides A eutectic mixture of strobilurin fungicides, optionally with agrochemically acceptable excipients; (b) optionally adding one or more other agrochemicals; (c) optionally grinding and pulverizing; and (d) granulating the mixture to obtain a granular composition.

In one embodiment of the present invention, a granular composition comprising a eutectic mixture of bacrine and strobilurin fungicides is prepared by a procedure comprising the following steps: (a) preparing bacrine and strobilurin fungicides A eutectic mixture of a strobilurin fungicide having at least one agrochemically acceptable excipient; (b) optionally with the addition of one or more other agrochemicals; (c) ground and comminuted; and ( d) Granulating the mixture to obtain a granular composition.

The step of granulating the mixture is not particularly limited. Suitable granulation procedures are the customary procedures described in granulation technology, such as spray drying, fluid bed granulation, agglomeration, pan granulation, and especially extrusion granulation.

In one embodiment of the present invention, a granular composition comprising a eutectic mixture of bacrine and strobilurin fungicides is prepared by a procedure comprising: (a) mixing bacrine and strobilurin fungicides mixing the strobilurin fungicide with at least one facilitating chemically acceptable excipient; (b) grinding and pulverizing; and (c) granulating the mixture to obtain a granular composition.

In one embodiment, the mixing of step (a) includes grinding.

In one embodiment of the present invention, the eutectic mixture is prepared by grinding bakleyl with a strobilurin fungicide.

In one embodiment, the eutectic mixture is prepared by co-milling bacrine with a strobilurin fungicide.

In one embodiment, the eutectic mixture is prepared by melting the bacilli and strobilurin fungicides together.

In one embodiment, the eutectic mixture is prepared by crystallizing the buccalidine and strobilurin fungicides from one or more suitable solvents.

In one embodiment, suitable solvents for the preparation of eutectic mixtures of bucaria and strobilurin fungicides are selected from alcohols, esters, ethers, ketones, aldehydes, halogenated hydrocarbons, aromatic hydrocarbons, aliphatic Hydrocarbons, amides, and water or mixtures thereof.

In one embodiment, the eutectic mixture is prepared by granulating a mixture of bacilli and strobilurin fungicides.

In one embodiment, the granulation procedure is not particularly limited, and can be performed by spray drying, fluidized bed granulation, agglomeration, pan granulation, and extrusion granulation.

In one embodiment, the eutectic mixture is prepared by granulating a mixture of bacilli and a strobilurin fungicide, wherein the strobilurin fungicide is selected from the group consisting of: strobilurin , bacmin, trifluramine, trifluoxystrobin, picoxystrobin, fluoxastrobin, methoxyacetamidostrobin, pyribencarb, syringstrobin, cylostrobin, fluoxin Micarid, pyraclostrobin, pyraclostrobin, cloxastrobin, kysastrobin, fentil-stazobine, fenoxystrobin, orysastrobin, or cloxastrobin.

In one embodiment, the eutectic mixture is prepared by granulating a mixture of becryl and yatormin.

The fungicidal composition according to the present invention may further comprise other agrochemically suitable excipients, such as auxiliary adjuvants/surfactants, such as wetting agent diffusing agents, penetration aids, dispersants, carriers, sticking agents (sticking agent) and binders, inert ingredients, pH modifiers, suspending agents, spray droplet modifiers, pigments, antioxidants, UV protectants, compatibilizing agents, defoamers, sequestering agents ), neutralizers, corrosion inhibitors, dyes, odorants, fertilizers, micronutrients, emollients, lubricants, and the like.

Agrochemical compositions comprising eutectic mixtures of buclide and strobilurin fungicides can be prepared as dispersible granules, wettable powders, dry flowables, emulsions, dispersions, suspension concentrates Encapsulation of polymeric materials, oil dispersions, emulsifiable concentrates, microemulsions, flowable concentrates, or suspo-emulsions.

The composition according to the present invention may further comprise one or more other active ingredients. Other active ingredients may be fungicides, insecticides or herbicides.

In one embodiment, the additional active ingredient is a fungicide. In this embodiment, the composition of the present invention includes a third fungicide.

In one embodiment, the additional fungicide may be a combination of two or more additional fungicides. In this embodiment, the composition of the present invention includes a third and a fourth fungicide.

In one embodiment, the composition of the present invention comprises a third and a fourth fungicide selected from the group consisting of multisite contact fungicides, conazole fungicides and succinate dehydrogenase inhibitors .

In one embodiment, the third fungicide may be a multi-point contact fungicide.

In one embodiment, the multi-point contact fungicide may be selected from the group consisting of: (i) copper fungicide selected from copper oxychloride, copper sulfate, hydroxide Copper and tribasic copper sulfate (Bordeaux mixture); (ii) elemental sulfur; (iii) dithicarbamic ester fungicides selected from amobam, thiram ( asomate), azithiram oxide, carbamorph, cufraneb, cuprobam, disulfiram, ferbam, smeide ( Metam), nabam, tecoram, thiram, urbacide, ziram, dazomet, etem, generation Sen ring (milneb), mancopper (mancopper), zinc manganese Naipu (mancozeb), manganese Naipu (maneb), metiram, polycarbamate, methyl zinc Naipu (propineb) and zinc Naipu (zineb); (iv) Phthalimide fungicides, selected from folpet, captan and captafol; (v) chlorothalonil; (vi) sulfamide fungicides from dichlorofluanid) and tolylfluanid; (vii) guanidine fungicides selected from dodine, guazantine and iminoctaadine; (viii) anilazine; (ix) dithianon; and (x) combinations thereof.

In one embodiment, the third fungicide is mancozeb.

In one embodiment, the dosage of the third fungicide zinc manganese Naipu on the field is 0.5kg/ha to 5.0kg/ha.

In one embodiment, the dosage of the third fungicide zinc manganese Naipu on the field is 1.0kg/ha to 3.0kg/ha.

In one embodiment, the multi-site fungicide is tetrachloroisobenzene.

咪唑、撲克拉、撲克拉-錳、賽福座、阿扎康唑、比多農、溴克座、環克座、苄氯三唑醇、待克利、戴尼唑、達克利、依普座、乙環唑、芬克座、三氟苯唑、氟喹唑、護矽得、護汰芬、呋菌唑、呋醚唑、菲克利、易胺座、種菌唑、滅特座、邁克尼、平克座、普克利、丙硫菌 唑、奎因克座、矽氟唑、得克利、四克利、三泰芬、三泰隆、滅菌唑、單克素、稻瘋酯及單克素-P。 In one embodiment, the third fungicide may be an azole fungicide selected from the group consisting of: campanola, clotrimazole, examidate,

Imidazole, Pokra, Pokra-Manganese, Saifuzuo, Azaconazole, Bidronon, Bromogram, Cyclogram, Benzylclotriazole, Taikeli, Danizole, Dacley, Ipzu , Etoconazole, Funkza, Triflubenazole, Fluquinazole, Husilide, Hutifen, Fuconazole, Fufeconazole, Fickley, Yiminzuo, Buconazole, Metezuo, McNee , Pink, Pukley, Prothioconazole, Quinque, Silfluazole, Decley, Four Keli, San Taifen, San Tyrone, Fenconazole, Monograms, Padrazil and Monograms- p.

In one embodiment, the third fungicide may be a second succinate dehydrogenase inhibitor selected from the group consisting of: benodanil, flutolanil, mepronin ( mepronil), fluopyram, fenfuram, carboxin, oxycarboxin, thifluzamide, bixafen, fluoride Fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, and sedaxane.

咪唑(oxpoconazole)、撲克拉(prochloraz)、撲克拉-錳(prochloraz-manganese)、賽福座(triflumizole)、阿扎康唑(azaconazole)、比多農(bitertanol)、溴克座(bromuconazole)、環克座(cyproconazo1e)、苄氯三唑醇(diclobutrazol)、待克利(difenoconazole)、戴尼唑(diniconazole)、達克利(diniconazole-M)、依普座(epoxiconazole)、乙環唑(etaconazole)、芬克座(fenbuconazole)、三氟苯唑(fluotrimazole)、氟喹唑(fluquinconazole)、護矽得(flusilazole)、護汰芬(flutriafol)、呋菌唑(furconazole)、呋醚唑(furconazole-cis)、菲克利(hexaconazole)、易胺座(imibenconazole)、種菌唑(ipconazole)、滅特座(metconazole)、邁克尼(myclobutanil)、平克座(pencoconazole)、普克利(propiconazole)、丙硫菌唑(prothioconazole)、奎因克座(quinconazole)、矽氟唑(simeconazole)、得克利(tebuconazole)、四克利(tetraconazole)、三泰芬(triadimefon)、三泰隆(triadimenol)、滅菌唑(triticonazole)、單克素(uniconazole)、稻瘋酯(perfurazoate)及單克素-P(uniconazole-P)。 In one embodiment, the third fungicide is a multi-point contact fungicide, and the fourth fungicide may be an azole fungicide selected from the group consisting of climbazole, clarithromycin Clotrimazole, imazalil,

Imidazole (oxpoconazole), pokla (prochloraz), pokla-manganese (prochloraz-manganese), triflumizole, azaconazole, bitertanol, bromuconazole, Cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole , fenbuconazole, fluotrimazole, fluquinconazole, flusilazole, flutriafol, furconazole, furconazole- cis), hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, pencoconazole, propiconazole, propylthio Prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole ), uniconazole, perfurazoate and uniconazole-P.

咪唑、撲克拉、撲克拉-錳、賽福座、阿扎康唑、比多農、溴克座、環克座、苄氯三唑醇、待克利、戴尼唑、達克利、依普座、乙環唑、芬克座、三氟苯唑、氟喹唑、護矽得、護汰芬、呋菌唑、呋醚唑、菲克利、易胺座、種菌唑、滅特座、邁克尼、平克座、普克利、丙硫菌唑、奎因克座、矽氟唑、得克利、四克利、三泰芬、三泰隆、滅菌唑、單克素、稻瘋酯及單克素-P。 In one embodiment, the third fungicide may be an azole fungicide selected from the group consisting of: campanola, clotrimazole, examidate,

Imidazole, Pokra, Pokra-Manganese, Saifuzuo, Azaconazole, Bidronon, Bromogram, Cyclogram, Benzylclotriazole, Taikeli, Danizole, Dacley, Ipzu , Etoconazole, Funkza, Triflubenazole, Fluquinazole, Husilide, Hutifen, Fuconazole, Fufeconazole, Fickley, Yiminzuo, Buconazole, Metezuo, McNee , Pink, Pukley, Prothioconazole, Quinque, Silfluazole, Decley, Four Keli, San Taifen, San Tyrone, Fenconazole, Monograms, Padrazil and Monograms- p.

In one embodiment, the third fungicide can be a multi-point contact fungicide, and the fourth fungicide can be a second succinate dehydrogenase inhibitor selected from the group consisting of: Rupifen, fuduonin, methpronin, fluopyram, forfamide, wilting, xibaoxin, seflumet, bixafen, flufenpyramide, furabi, pyrazole Naprofen, penflufen, penthiopyrad, and cycloflufen.

In one embodiment, the third fungicide may be mancozeb and the fourth fungicide may be a second succinate dehydrogenase inhibitor selected from the group consisting of: Maiguanin, fuduonin, methpronin, fluopyram, forfamide, wilting, xibaoxin, seflumet, bixafen, flufenpyramide, furabi, pyrimidine pyraclostrobin, flufenadin, penthiopyrad, and cycloflufen.

In one embodiment, the third fungicide may be zinc manganese, and the fourth fungicide may be fluopyram.

In one embodiment, the third fungicide can be zinc manganese Naipur, and the fourth fungicide can be salfluramide.

In one embodiment, the third fungicide can be Zinc manganese Naipur, and the fourth fungicide can be bixafen.

In one embodiment, the third fungicide may be zinc manganese Naipur, and the fourth fungicide may be flucloxam.

In one embodiment, the third fungicide can be Naipur, and the fourth fungicide can be Pyrazonium.

In one embodiment, the third fungicide can be Zinc manganese Naipur, and the fourth fungicide can be penthiopyrad.

In one embodiment, the third fungicide may be Zinc manganese Naipur, and the fourth fungicide may be Cyclofen.

In one embodiment, the third fungicide is a multi-point contact fungicide, and the fourth fungicide is an azole fungicide selected from the group consisting of prothioconazole, declel, cyclomethicone, and The general seat, the special seat and the Dekley.

In one embodiment, the third fungicide can be zinc manganese, and the fourth fungicide can be prothioconazole.

In one embodiment, the third fungicide can be ZnMn Naipur, and the fourth fungicide can be Declair.

In one embodiment, the third fungicide can be zinc manganese Naipur, and the fourth fungicide can be cyclomethicone.

In one embodiment, the third fungicide can be ZnMn Naipur, and the fourth fungicide can be Ipza.

In one embodiment, the third fungicide can be ZnMn Naipur, and the fourth fungicide can be ZnMn.

Compositions according to the present invention may be prepared as pre-mixes, or by tank mixing with other actives, or alternatively may be sold as part of a kit containing bacrine and globulina Eutectic mixtures of strobilurin fungicides, together with other ingredients, may be mixed prior to spraying or in one part as pre-mixed kits containing eutectic mixtures of strobilurin and strobilurin fungicides, and In another part are other active substances or suitable agrochemical excipients.

Compositions of the present invention comprising eutectic mixtures of buccalide and strobilurin fungicides are suitable for combating or controlling fungi.

The present invention provides a method of controlling phytopathogenic fungi, the method comprising applying to plants or their habitat, plant seeds or soil a fungicidally effective amount of a eutectic mixture of buccalide and strobilurin fungicides. Composition.

Accordingly, there is provided a method of combating or controlling fungi, the method comprising applying to a plant or its habitat, plant seeds or soil a fungicidally effective amount of a composition comprising a eutectic mixture of buccalide and strobilurin fungicides things.

In one embodiment, there is provided a method of combating or controlling fungi, the method comprising applying to a plant or its habitat, plant seeds or soil a fungicidally effective amount of a fungicide comprising buclide and strobilurin. Compositions of molten mixtures, wherein the strobilurin fungicide is selected from the group consisting of ytropamine, bectilamine, trifluramine, azflustrobin, picoxystrobin, fluoxastrobin, methoxyethyl Aminostrobin, pyribencarb, syringstrobin, erythoxystrobin, fludiostrobin, pyraclostrobin, pyraclostrobin, cloxastrobin, krasstrobin, fenamistazobine, benzene Oxystrobin, orysastrobin, or cloxin.

In one embodiment, there is provided a method of combating or controlling fungi, the method comprising applying to a plant or its habitat, plant seeds or soil a fungicidally effective amount of a composition comprising a eutectic mixture of bakleyl and yatormine.

In one embodiment, there is provided a method of combating or controlling fungi, the method comprising applying to a plant or its habitat, a plant seed or soil a fungicidally effective amount of a composition comprising a eutectic mixture of bakleyl and fluoxastrobin things.

The following is a preferred embodiment of the present invention, which is illustrative and non-limiting: A eutectic mixture comprising bacilli and strobilurin fungicides.

An agricultural chemical composition comprising a eutectic mixture of bacrine and strobilurin fungicides.

An agrochemical composition comprising a eutectic mixture of buccalidine and a strobilurin fungicide, wherein the composition comprises between 10 and 90% by weight of buccalidine and between 90 and 10% strobilurin fungicides.

A eutectic mixture comprising bakleyl and yatormin.

An agricultural chemical composition, which comprises a eutectic mixture of becryl and yatomin.

An agrochemical composition comprising a eutectic mixture of becrylide and yatormin, wherein the composition comprises 10 to 90% of becryl and 90 to 10% of yatormin by weight.

A eutectic mixture of becryl and yatormin, wherein the eutectic mixture is characterized by a DSC onset temperature of 100±3°C and an endothermic peak of 103.5±3°C.

A composition comprising a eutectic mixture of bacletide and yatormin, wherein the eutectic mixture is characterized by a DSC onset temperature of 100±3°C and an endothermic peak of 103.5±3°C.

A eutectic mixture comprising bakleyl and fluoxastrobin.

An agricultural chemical composition, which comprises a eutectic mixture of bakleyl and fluoxastrobin.

An agricultural chemical composition comprising a eutectic mixture of bucaria and fluoxastrobin, wherein the composition comprises between 10 and 90% by weight of bucaria and between 90 and 10% of fluoxastrobin ester.

A eutectic mixture of bakleyl and fluoxastrobin, wherein the eutectic mixture is characterized in that DSC has an onset temperature of 92±3°C and an endothermic peak of 97±3°C.

A composition comprising a eutectic mixture of bakleyl and fluoxastrobin, wherein the eutectic mixture is characterized by a DSC onset temperature of 92±3°C and an endothermic peak of 97±3°C.

A eutectic mixture of bakleyl and fluoxastrobin, wherein the eutectic mixture is characterized by a DSC onset temperature of 100±3°C and an endothermic peak of 107±3°C.

A composition comprising a eutectic mixture of bakleyl and fluoxastrobin, wherein the eutectic mixture is characterized by a DSC onset temperature of 100±3°C and an endothermic peak of 107±3°C.

A process for formulating an agrochemical composition comprising a eutectic mixture of bacrine and strobilurin fungicides.

A process for the preparation of a eutectic mixture of a strobilurin fungicide and a buccalide comprising co-processing the buccalidine and a strobilurin fungicide in a predetermined ratio.

A method of controlling phytopathogenic fungi comprising applying to a plant or its habitat, plant seeds or soil a fungicidally effective amount of a composition comprising a eutectic mixture of buccalide and strobilurin fungicides.

A eutectic mixture comprising buclide and strobilurin fungicides.

An agricultural chemical composition comprising a eutectic mixture of bacrine and strobilurin fungicides.

An agrochemical composition comprising a eutectic mixture of buccalidine and a strobilurin fungicide; and at least one agrochemically acceptable excipient, wherein formation of the eutectic mixture inhibits buccalidine and strobilurin fungicides; Crystallization procedure for the strobilurin fungicide.

A composition comprising, by weight, between 10 and 90% buccalidine and between 90 and 10% strobilurin fungicides, wherein at least a portion of the fungicide mixture is a eutectic mixture form.

A composition comprising, by weight, between 50 and 80% buccalidine and between 50 and 20% strobilurin fungicides, wherein at least a portion of the fungicide mixture is a eutectic mixture form.

A composition comprising, by weight of the active ingredient, between 50 and 80% bacrine and between 50 and 20% strobilurin fungicides, wherein at least a portion of the fungicide mixture is co- form of molten mixture.

A eutectic mixture of becryl and yatormin.

An agricultural chemical composition, which comprises a eutectic mixture of becryl and yatomin.

A composition comprising between 10 and 90% by weight of becryl and between 90 and 10% of atropamine, wherein at least a portion of the fungicide mixture is in the form of a eutectic mixture.

A composition comprising between 50 and 80% by weight of becryl and between 50 and 20% of atropamine, wherein at least a portion of the fungicide mixture is in the form of a eutectic mixture.

A composition comprising, by weight of active ingredient, between 50 and 80% of bacilli and between 50 and 20% of atropamine, wherein at least a portion of the fungicide mixture is in the form of a eutectic mixture.

A eutectic mixture comprising, by weight of active ingredient, about 60% becryl and about 40% atropamine.

A composition comprising, by weight of active ingredient, about 60% becryl and about 40% atropamine, wherein the fungicide mixture is in the form of a eutectic mixture.

A eutectic mixture comprising, by weight of active ingredients, about 37.5% becryl and about 25% atropamine.

A composition comprising, by weight of active ingredient, about 37.5% bacilli and about 25% atropamine, wherein the fungicide mixture is in the form of a eutectic mixture.

A composition comprising bacilli and yatormin in a molar ratio of 1:9 to 9:1, wherein at least a part of the fungicide mixture is in the form of a eutectic mixture.

A composition, which comprises bacilli and yatormine, the molar ratio of which is 1:5 to 5:1, wherein at least a part of the fungicide mixture is in the form of eutectic mixture.

A composition comprising bacilli and yatormin in a molar ratio of 1:3 to 3:1, wherein at least a part of the fungicide mixture is in the form of a eutectic mixture.

A composition comprising bacilli and yatormin at a molar ratio of 1.5:1, wherein the fungicide mixture is in the form of a eutectic mixture.

A eutectic mixture, which contains bakleyl and yatormin, with a molar ratio of 1.5:1.

A composition comprising a eutectic mixture of bakleyl and tropamine is characterized in that DSC has an onset temperature of 100±3°C and an endothermic peak of 103±3°C.

A eutectic mixture comprising bakleyl and tropamine is characterized by a DSC onset temperature of 100±3°C and an endothermic peak of 103±3°C.

A composition comprising a eutectic mixture of bakleyl and yatormin is characterized by a DSC onset temperature of 100±3°C and an endothermic peak between 102°C and 106°C.

A eutectic mixture comprising bakleyl and tropamine is characterized by a DSC onset temperature of 100±3°C and an endothermic peak between 102°C and 106°C.

A composition comprising a eutectic mixture of bacletide and tropamine is characterized by a DSC onset temperature of 100.07°C and an endothermic peak of 103.5°C.

A eutectic mixture comprising bakleyl and tropamine is characterized by a DSC onset temperature of 100.07°C and an endothermic peak of 103.5°C.

A eutectic mixture comprising bakleyl and yatormin is characterized by having a DSC thermogram as shown in FIG. 3 .

A composition comprising bacryl and yatormin is characterized by having a DSC thermogram as shown in FIG. 3 .

A eutectic mixture comprising bakleyl and yatormin is characterized by having a phase diagram as shown in FIG. 4 .

A composition comprising bekleyl and yatormin is characterized by having a phase diagram as shown in FIG. 4 .

A eutectic mixture of bacilli and fluoxastrobin.

An agricultural chemical composition, which comprises a eutectic mixture of bakleyl and fluoxastrobin.

A composition comprising between 10 and 90% by weight of becryl and between 90 and 10% of fluoxastrobin, wherein at least a portion of the fungicide mixture is in the form of a eutectic mixture.

A composition comprising between 50 and 80% by weight of becryl and between 20 and 50% of fluoxastrobin, wherein at least a portion of the fungicide mixture is in the form of a eutectic mixture.

A composition comprising between 20 and 50% by weight of becryl and between 50 and 80% of fluoxastrobin, wherein at least a portion of the fungicide mixture is in the form of a eutectic mixture.

A composition comprising, by weight of active ingredient, between 50 and 80% of buccolidine and between 50 and 20% of fluoxastrobin, wherein at least a portion of the fungicide mixture is in the form of a eutectic mixture .

A composition comprising, by weight of active ingredient, between 20 and 50% of baccolidine and between 50 and 80% of fluoxastrobin, wherein at least a portion of the fungicide mixture is in the form of a eutectic mixture .

A eutectic mixture comprising, by weight of the active ingredient, about 25% bekret and about 75% fluoxastrobin.

A composition comprising, by weight of active ingredient, about 25% baccolidine and about 75% fluoxastrobin, wherein the fungicide mixture is in the form of a eutectic mixture.

A eutectic mixture comprising, by weight of the active ingredient, about 50% bacilli and about 50% fluoxastrobin.

A composition comprising, by weight of the active ingredient, about 50% buccolidine and about 50% fluoxastrobin, wherein at least a portion of the fungicide mixture is in the form of a eutectic mixture.

A eutectic mixture comprising, by weight of the active ingredient, about 60% bekret and about 40% fluoxastrobin.

A composition comprising, by weight of active ingredient, about 60% baccolidine and about 40% fluoxastrobin, wherein at least a portion of the fungicide mixture is in the form of a eutectic mixture.

A eutectic mixture comprising, by weight of active ingredient, about 75% bucret and about 25% fluoxastrobin.

A composition comprising, by weight of active ingredient, about 75% baccolidine and about 25% fluoxastrobin, wherein at least a portion of the fungicide mixture is in the form of a eutectic mixture.

A composition comprising buclide and fluoxastrobin in a molar ratio of 1:9 to 9:1, wherein at least a part of the fungicide mixture is in the form of a eutectic mixture.

A composition comprising buclide and fluoxastrobin in a molar ratio of 1:5 to 5:1, wherein at least a part of the fungicide mixture is in the form of a eutectic mixture.

A composition comprising buclide and fluoxastrobin in a molar ratio of 1:3 to 3:1, wherein at least a part of the fungicide mixture is in the form of a eutectic mixture.

A composition comprising buclide and fluoxastrobin in a molar ratio of 1.5:1, wherein at least a part of the fungicide mixture is in the form of a eutectic mixture.

A eutectic mixture comprising buclide and fluoxastrobin in a molar ratio of 1:3.

A composition comprising a eutectic mixture of bakleyl and fluoxastrobin is characterized in that DSC has an onset temperature of 92±3°C and an endothermic peak of 97±3°C.

A eutectic mixture comprising bakleyl and fluoxastrobin is characterized by a DSC onset temperature of 92±3°C and an endothermic peak of 97±3°C.

A composition comprising a eutectic mixture of bakleyl and fluoxastrobin is characterized by a DSC onset temperature of 92±3°C and an endothermic peak between 94°C and 100°C.

A composition comprising a eutectic mixture of bakleyl and fluoxastrobin is characterized by a DSC onset temperature of 92±3°C and an endothermic peak between 97 and 99°C.

A composition comprising a eutectic mixture of bakleyl and fluoxastrobin is characterized by a DSC onset temperature of 100±3°C and an endothermic peak between 104°C and 110°C.

A composition comprising a eutectic mixture of bakleyl and fluoxastrobin is characterized in that DSC has an onset temperature of 100±3°C and an endothermic peak of 107°C to 108°C.

A eutectic mixture comprising bakleyl and fluoxastrobin is characterized by having a DSC thermogram as shown in FIG. 10 and FIG. 11 .

A composition comprising bakleyl and fluoxastrobin is characterized by having a DSC thermogram as shown in Fig. 10 and Fig. 11 .

A eutectic mixture comprising bacrine, a strobilurin fungicide and a third fungicide.

A eutectic mixture comprising bacrine, a strobilurin fungicide, at least one third fungicide, and at least one fourth fungicide.

An agricultural chemical composition comprising a eutectic mixture of bacrine and strobilurin fungicides, and a third fungicide.

An agricultural chemical composition comprising a eutectic mixture of bacrine and strobilurin fungicides, at least one third fungicide, and at least one fourth fungicide.

The invention will now be described with reference to the following specific examples. It should be noted that the following examples illustrate rather than limit the invention, and that those skilled in the art will be able to design many alternative embodiments without departing from the scope of the invention.

Example 1: The eutectic mixture of Bacryl and Atropamine according to the present invention was prepared as follows:

Grind bekrell and yatormin at different ratios as shown in Table 1 in an agate mortar and grind the mixture thoroughly. The resulting mixture was analyzed by DSC.

Method for detecting eutectic mixture:

Eutectic mixtures were detected by recording DSC.

The endothermic peak of Bekleyl was recorded between 144 and 148°C (onset temperature of 144.71, △H=83.65J/g) [Figure 1]. The endothermic peak of ytropamine was recorded between 112 and 118°C (onset temperature of 114.34.2°C, △H=86.19J/g) [Figure 2]. DSC was performed on mixtures of various ratios of bectilide:yatormin. The results showed that the ratio of Becglide:Atropamine was 60:40, and the eutectic mixture formed showed a single endothermic peak (eutectic point) at 103.5°C (Fig. 3). In all other ratios, two different endotherms were observed, one from the melting of the eutectic mixture and the other from the melting of the excess components, which are depicted in the phase diagram (Fig. 4).

Example 2 : A composition comprising a eutectic mixture of Bacrine (anhydrous modified I) and atropamine according to the present invention, which has been prepared as follows:

Weigh the bekrell and yatomin, grind in an agate mortar, and grind the mixture thoroughly. The mixture was then ground in an Air jet mill with the listed ingredients to obtain the desired particle size. Add water to this powdered mixture to prepare the dough. Pellets were prepared by placing the dough in a granulator. Dry the granules using a drier, then sieve. Particles were analyzed by DSC. The DSC endothermic peak was observed at: 104.5°C. (Figure 5).

Example 3 : A composition comprising a eutectic mixture of Bacrine (anhydrous modification II) and atropamine according to the present invention, which has been prepared as follows:

The Bacryl and Yatropin were weighed, and then ground together with the listed ingredients in an air jet mill to obtain the desired particle size, and the composition was prepared according to the procedure in Example 2. Particles were analyzed by DSC. The DSC endothermic peak was observed at the following conditions: 105.89°C. (Figure 6).

Details of various inventive compositions according to the present invention are given in Table 4, which comprise eutectic mixtures of bakleyl and atropamine. The composition was prepared according to the procedure of Example 2.

Different formulations were prepared using different ratios of bacilli and yatormin. Details of the weight ratios of the various components are listed in Table 4 below:

Stability of formulations according to the invention

The storage stability of the bakleyl-yatropin composition prepared according to the present invention was tested according to the BIS specification. Samples were kept at room temperature (27±2°C) to ensure real-time stability of the formulation. The inventors have observed that the composition prepared according to the present invention is stable and the morphology of the composition has not been observed Variety. The DSC of Example 2, after storage for 9 months, showed an endothermic peak corresponding to the eutectic mixture at 105.3°C (Fig. 8), demonstrating the stability of the composition.

Example 4: The eutectic mixture of bacilli and fluoxastrobin according to the present invention was prepared as follows (dry grinding method):

Grind bacilli and fluoxastrobin in different ratios as shown in Table 5 in an agate mortar and grind the mixture thoroughly. The resulting mixture was analyzed by DSC.

Method for detecting eutectic mixture:

Eutectic mixtures were detected by recording DSC.

The endothermic peak of Bekleyl was recorded between 144 and 148°C (onset temperature of 144.71, △H=83.65J/g) [Figure 1]. The endothermic peak of fluoxastrobin was recorded between 104 and 114°C (onset temperature of 105.82°C, △H=72.04J/g) [Figure 9]. DSC was performed on mixtures of various ratios of bacilli:fluoxastrobin. The results showed that the ratio of Bakleyl: fluoxastrobin was 30:70, and the eutectic mixture formed showed a single endothermic peak (eutectic point) at 97.7°C (Fig. 10).

Example 5: According to the eutectic mixture of bakleyl and fluoxastrobin of the present invention is prepared as follows (solvent evaporation method):

Stir beclay (1.005g, 1.02 mol) and fluoxastrobin (4.029g, 3.0 mol) in acetone (20ml) until dissolved at 50 to 55°C, and keep the solution at this temperature for 15min . The solvent was partially evaporated and the concentrated solution was set aside for 18 hours to promote crystallization. The crystalline solid was dried under vacuum to obtain 4.9 g of eutectic mixture (Bekrell:fluoxastrobin:25:75). Crystals were analyzed by DSC. The DSC endothermic peak was observed at: 107.5°C. (Fig. 11).

Example 6 : A composition comprising a eutectic mixture of Bacrine (anhydrous modification II) and fluoxastrobin according to the present invention, which has been prepared as follows:

Take out the buccalide and fluoxastrobin, and prepare the composition according to the procedure in Example 2.

Details of various compositions of the invention according to the invention are given in Table 7, which comprise eutectic mixtures of bakret and fluoxastrobin. The composition was prepared according to the procedure of Example 2.

Different formulations were prepared using different ratios of bacilli and fluoxastrobin. Details of the weight ratios of the various components are listed in Table 7 below:

Field trial research:

Solution: use the composition of the eutectic mixture of bakleyl and yatormine prepared according to the present invention as a fungicide to carry out a field test. These compositions are optionally mixed with other tank mixing aids and applied to tomatoes (early blight), peppers (powdery mildew), onions (fusarium wilt), and grapes (powdery mildew) at an application rate of 500 to 600 kg/ha. ). The dosage of the commercially known formulation of Becmin 12.8%+Beccleline 25.2% WG-Visma is 600ml/h. The dosage of Atropin 250 SC-Amistar is 562.5ml/h in a commercially known formulation. The observations at 10 days and 14 days after treatment are summarized in the table below, demonstrating the biological efficacy of the composition.

Field Trials: Fungal Control Studies in Tomatoes (Early Blight), Peppers (Powdery Mildew), Onions (Fusarium Wilt), and Grapes (Powdery Mildew).

Tests of formulations containing eutectic mixtures of bacrylide and yatoramine (Example 2), and market samples of becclemine + bacrylide WG (VISMA) and yatoramine (AMISTAR) at various doses for tomato, pepper , onion, and grape fungus control. Fungi include Phytophthora solani on tomato, Leveillula taurica on pepper, Stemphylium vesicarium on onion, and Leveillula taurica on grape.

From the above results it has been observed that the formulation comprising the eutectic mixture of Buccolid and Itropamine prepared according to Example 2 showed good fungal control at a lower application rate of 400 kg/ha. already Note that, at any given application rate, compared to VISMA (12.8% bacclemine + 25.2% WG, commercial sample) and AMISTAR (yatropamine 250 SC, commercial sample), the combination of Bacryl and The formulation of the eutectic mixture of yatormin showed high bioefficacy and high consistency. More specifically, it has been observed that formulations comprising eutectic mixtures of buclide and yatormin, at a lower application rate of 500.0 kg/ha, were more effective than VISMA at an application rate of 600 kg/ha and at an application rate of 562.5 kg/ha. ha's AMISTAR showed better biological efficacy. Therefore, it was concluded that formulations comprising eutectic mixtures of bacrine and yatormin could be effectively used at lower doses as Fungicide with better biological efficacy.

Claims (12)

A eutectic mixture of 50-80% boscalid and 50-20% strobilurin fungicide selected from the group comprising: Azoxystrobin, picoxystrobin, trifloxystrobin and fluoxastrobin, wherein the eutectic mixture has An endothermic peak. An agricultural chemical composition comprising a eutectic mixture of 50-80% buccalidine and 50-20% strobilurin fungicide selected from the group comprising: Azoxystrobin, picoxystrobin, trifloxystrobin and fluoxastrobin, wherein the eutectic mixture is at 103.5±3°C, 97±3°C or 107±3°C Has an endothermic peak. A process for the preparation of a eutectic mixture of 50-80% buccalidine and 50-20% strobilurin fungicide, the process comprising subjecting the buccalide and strobilurin fungicide to solution crystallization, dry Milling, solvent drop milling technique, or spray drying technique, wherein the eutectic mixture has an endothermic peak at 103.5±3°C, 97±3°C or 107±3°C. A procedure as claimed in claim 3, wherein the procedure comprises: a. preparing a concentrated solution of buccalidine and strobilurin fungicides in one or more solvents; b. optionally evaporating the solvent , the solvent is selected from aliphatic alcohols, ketones, esters, ethers, polar protic solvents, polar aprotic solvents, halogenated solvents, aliphatic hydrocarbons or aromatic hydrocarbons; and c. Trituration or precipitation with an antisolvent to obtain A eutectic mixture wherein the anti-solvent is selected from aliphatic or aromatic hydrocarbon solvents. Such as applying for the procedure of item 3 of the patent scope, wherein the procedure includes: a. blending bakleyl with strobilurin fungicide; b. Optionally blending into the blend a solvent selected from aliphatic alcohols, ketones, esters, ethers, polar protic solvents, polar aprotic solvents, halogenated solvents, aliphatic hydrocarbons or aromatic and c. grinding or crushing or milling the blend to obtain the eutectic mixture. A eutectic mixture of 50-80% becryl and 50-20% tropamine, which has an endothermic peak at 103.5±3°C. An agrochemical composition comprising a eutectic mixture of becrylide and yatormin, wherein the composition comprises 50-80% by weight of becrylide and 50-20% of yatormin, and Wherein the eutectic mixture has an endothermic peak at 103.5±3°C. A eutectic mixture of 50-80% beclay and 50-20% fluoxastrobin, which has an endothermic peak at 97±3°C. An agricultural chemical composition comprising a eutectic mixture of buccalidine and fluoxastrobin, wherein the composition comprises between 50-80% by weight of a buccalidine and between 50-20% of fluoropyrim Strostrobin, and wherein the eutectic mixture has an endothermic peak at 97±3°C. A process for formulating an agrochemical composition comprising a eutectic mixture of 50-80% buccalidine and 50-20% strobilurin fungicide comprising the addition or absence of agrochemically acceptable Preparation of eutectic mixture of bacrine and strobilurin fungicides with excipients, and further processing of the mixture into a suitable form, wherein the eutectic mixture is at 103.5±3°C, 97±3 °C or 107±3°C has an endothermic peak. Such as the procedure of item 10 of the scope of the patent application, wherein the agricultural chemical composition is formulated into a granular composition. A method of combating or controlling fungi, the method comprising contacting the fungi or their genetic loci with a fungicidally effective amount of a composition comprising 50-80% buccalidine and 50-20% strobilurin fungicidal A eutectic mixture of a strobilurin fungicide selected from the group comprising: atropamine, pyridoxine Strostrobin, triflurin and fluoxastrobin, wherein the eutectic mixture has an endothermic peak at 103.5±3°C, 97±3°C or 107±3°C.