CN103845701B - The externally used compound tincture for the treatment of beriberi - Google Patents
The externally used compound tincture for the treatment of beriberi Download PDFInfo
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- CN103845701B CN103845701B CN201210513068.0A CN201210513068A CN103845701B CN 103845701 B CN103845701 B CN 103845701B CN 201210513068 A CN201210513068 A CN 201210513068A CN 103845701 B CN103845701 B CN 103845701B
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Abstract
The present invention discloses a kind of externally used compound tincture treating beriberi, it is characterized in that making with following raw material by weight percentage: the antifungal drug 0%��4% suppressing ergosterol synthesis, suppress the antifungal drug 0%��5% of squalene epoxidase, Whitfield's ointment 5%��15%, phenylformic acid 5%��12%, laurocapram 1%��3%, glycerine 1%��5%, sealwort extracting solution 2%��5%, ginger extract 2%��5%, Radix Sophorae Flavescentis extractive liquid 1%��5%, cloves extracting solution 1%��6%, rhizoma extracting liquid 1%��6%, shaddock ped extracting solution 3%��10%, surplus is medical alcohol. The tincture of the present invention, has synergy between its each component, it is possible to Mutiple Targets kills fungi, powerful efficient, thoroughly kills fungi in Low doses. Having curative effect fast, effective, recurrence rate is low, it may also be useful to feature easily. Curative ratio reaches 100%. This compound tincture use safety.
Description
Technical field
The present invention relates to a kind of topical drug, particularly relate to a kind of externally used compound tincture treating beriberi.
Background technology
Beriberi also claims " tinea pedis ", is a kind of common fungi infestation dermatoses, is medically called tinea pedis. Somebody lumps " beriberi " and " vitamin B1 deficiency " together, this be in fact not to. In fact, the beriberi that we say at ordinary times is not the vitamin B1 deficiency on general strict medical. The English of real beriberi is beriberi, causes because lacking VITAMIN. VITMAIN B1, other name is thiamines (thiamine), is extensively present in the cereal such as rice bran, wheat bran, and in yeast, content is higher. It has relation with the carbohydrate metabolism of human body, if lacked, pyruvic acid accumulates, and there will be polyneuritis, the symptom such as amyotrophy and edema of lower limbs, is referred to as vitamin B1 deficiency on clinical.
Tinea pedis is commonly called as tinea pedis and beriberi in life, and people only know that tinea pedis does not but know tinea pedis mostly. In fact tinea pedis is a kind of tetter, and the source of its title is relevant with the British army stationed in Hongkong. After the first time Opium War (1840-1842) in 1840��1842 years is suffered a defeat, in Sino-British " Treaty of Nanjing ", Hong Kong is ceded to Britain by the Qing Dynasty, and hereafter, annual Dou You British troops comes port and performs defence task. Owing to Britain soldier custom is in the gentle Europe life of annual weather, comes Hong Kong of humid, add the rich air-locked army boots of long-term dress, cause a lot of soldier to suffer from a kind of tetter, pin has been grown many bubbles, some decortication, some red and swollen suppuration, very itches unbearably. But owing to Europe doctor have never been seen this kind of disease, so being just summed up as a kind of prevailing disease in Hong Kong, and called after HongKongFoot, translation comes to be exactly tinea pedis. Afterwards, along with the development of Western medicine in China expands, early stage translation title " tinea pedis " also just instead of " tinea pedis ", becomes the most general title.
Owing to fungi easily multiplies in the environment that humidity is warm, such as, when, under the state that skin remains on humid, sole, just the most easily multiplies fungi, breed in a large number when fungi and invade cortex inside, just can bring out tinea pedis always. The reason of sole humidity has a lot, such as: sweaty feet; Swim or after a bath pin has not thoroughly been dried afterwards; Often dress seal very tight air-locked shoes such as boots; The environment being in sweltering heat or humidity is medium. Cause the common fungi adularescent candidiasis of beriberi, trichophyton and alpha fungus etc., be distributed widely in nature, easily grow in warm, moist environment, breeding. Beriberi is higher at China's sickness rate, though not being serious disease, but can affect the mood of people, life and work, if treated not in time, it is possible to infect to other position, as caused the tinea manuum and onychomycosis etc., sometimes being scratched because itching, secondary bacteriological infection, causes more serious complication. Medically beriberi is divided into three types: rotten to the corn type, blister type, scales of skin that peel off keratinization type. Common infection site is between toe, and symptom shows as local itch, skin bubbles, peels off or chap, the subcutis swelling that skin injury also can cause exposing and infection. Owing to tinea pedis occurs the most easily in damp and hot environment, so the shoes that duty changes clothes footwear socks, to change sweep gas good, noticing that the Personal hygiene etc. in public place is all conducive to preventing tinea pedis.
At present, the medicine that domestic market is treated beriberi is a lot, mostly is chemical synthetic drug. But there is the length course for the treatment of in the medicine wherein having, take effect slow, unsatisfactory curative effect and the problem such as cannot effect a radical cure.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, it is provided that a kind of courses of pharmaceuticals is short, instant effect, curative effect are good and the externally used compound tincture for the treatment of beriberi that is that substantially can effect a radical cure.
The technical scheme of the present invention is summarized as follows:
A kind of externally used compound tincture treating beriberi, make with following raw material by weight percentage: the antifungal drug 0%��4% suppressing ergosterol synthesis, suppress the antifungal drug 0%��5% of squalene epoxidase, Whitfield's ointment 5%��15%, phenylformic acid 5%��12%, laurocapram 1%��3%, glycerine 1%��5%, sealwort extracting solution 2%��5%, ginger extract 2%��5%, Radix Sophorae Flavescentis extractive liquid 1%��5%, cloves extracting solution 1%��6%, rhizoma extracting liquid 1%��6%, shaddock ped extracting solution 3%��10%, surplus is medical alcohol.
Preferably the antifungal drug of described suppression ergosterol synthesis is 1%��2%, and the antifungal drug of described suppression squalene epoxidase is 1%��2%, and described Whitfield's ointment is 10%, described phenylformic acid is 7%, described laurocapram is 2%, and described glycerine is 3%, and described sealwort extracting solution is 2.5%, described ginger extract is 3%, described Radix Sophorae Flavescentis extractive liquid is 2%, and described cloves extracting solution is 3%, and described rhizoma extracting liquid is 3%, described shaddock ped extracting solution is 5%, and surplus is medical alcohol.
The preferred miconazole nitrate of antifungal drug, econazole nitrate, KETOKONAZOL, itraconazole and the clotrimazole at least one that described suppression ergosterol synthesizes.
The preferred butenafine hydrochloride of antifungal drug of described suppression squalene epoxidase, Terbinafine Hcl and tolnaftate at least one.
The externally used compound tincture of the treatment beriberi of the present invention, has synergy between its each component, it is possible to Mutiple Targets kills fungi, powerful efficient, thoroughly kills fungi in Low doses. Having curative effect fast, effective, recurrence rate is low, it may also be useful to feature easily. Medication 1��2 course for the treatment of (7-15 days), can fully recover, and curative ratio reaches 100%. This compound tincture use safety, has no side effect.
Embodiment
The source of each extracting solution: the raw material of Chinese medicine extract of the present invention is commercialization.
Sealwort extracting solution: fresh root of Rhizoma Polygonati block is cleaned to dry and pulverized to constant weight, crosses 20,60,100 order sieves respectively, and times distilled water 80 DEG C extracts twice to add 15, each 2 hours, united extraction liquid, filters, and extracting solution concentrates to 1/2nd, obtains sealwort extracting solution.
Ginger extract: old ginger washes, smashs to pieces to pasty state, times volumetric concentration that adds 1 be 95% aqueous ethanolic solution soak 6 hours, centrifugal, get supernatant concentration to three/bis-, obtain ginger extract.
Radix Sophorae Flavescentis extractive liquid: kuh-seng pulverizing medicinal materials becomes coarse particles, by the aqueous ethanolic solution refluxing extraction 3 times that volumetric concentration is 70%, the quality of aqueous ethanolic solution is respectively 10 times, 8 times, 6 times of kuh-seng medicinal material, extraction time is respectively 1.5 hours, 1 hour, 1 hour, united extraction liquid, filtering, extracting solution concentrates to 1/3rd, obtains Radix Sophorae Flavescentis extractive liquid.
Cloves extracting solution: cloves pulverizing medicinal materials, times 95% alcohol reflux that adds 10 2 hours, filters, concentrates to 1/5th, obtain cloves extracting solution.
Rhizoma extracting liquid: coptis pulverizing medicinal materials, times volumetric concentration that adds 10 is the aqueous ethanolic solution refluxing extraction twice of 75%, each 2 hours, and united extraction liquid filters, and extracting solution concentrates to 1/4th, obtains rhizoma extracting liquid.
Shaddock ped extracting solution: shaddock ped is pulverized, the aqueous ethanolic solution refluxing extraction twice taking 20 times, 10 times volumetric concentrations as 60%, each 1.5 hours, united extraction liquid, filtered, and extracting solution concentrates to 1/5th, obtains shaddock ped extracting solution.
Embodiment 1
Treat an externally used compound tincture for beriberi, make by following method:
By Whitfield's ointment 150g, phenylformic acid 70g, laurocapram 10g, glycerine 20g, sealwort extracting solution 20g, ginger extract 20g, Radix Sophorae Flavescentis extractive liquid 15g, cloves extracting solution 20g, rhizoma extracting liquid 30g, shaddock ped extracting solution 50g, is added in container, adds medical alcohol 595g, and stirred at ambient temperature dissolves obtained.
Embodiment 2
Treat an externally used compound tincture for beriberi, make by following method:
By econazole nitrate 30g, Whitfield's ointment 70g, phenylformic acid 50g, laurocapram 10g, glycerine 20g, sealwort extracting solution 20g, ginger extract 20g, Radix Sophorae Flavescentis extractive liquid 50g, cloves extracting solution 10g, rhizoma extracting liquid 10g, shaddock ped extracting solution 30g, being added in container, add medical alcohol 680g, stirred at ambient temperature dissolves obtained.
Embodiment 3
Treat an externally used compound tincture for beriberi, make by following method:
By Terbinafine Hcl 20g, Whitfield's ointment 70g, phenylformic acid 50g, laurocapram 10g, glycerine 30g, sealwort extracting solution 25g, ginger extract 20g, Radix Sophorae Flavescentis extractive liquid 15g, cloves extracting solution 60g, rhizoma extracting liquid 10g, shaddock ped extracting solution 30g, adding medical alcohol 660g, stirred at ambient temperature dissolves obtained.
Embodiment 4
Treat an externally used compound tincture for beriberi, make by following method:
By miconazole nitrate 20g, Terbinafine Hcl 15g, Whitfield's ointment 70g, phenylformic acid 50g, laurocapram 10g, glycerine 10g, sealwort extracting solution 20g, ginger extract 50g, Radix Sophorae Flavescentis extractive liquid 10g, cloves extracting solution 10g, rhizoma extracting liquid 10g, shaddock ped extracting solution 30g, adds medical alcohol 695g, and stirred at ambient temperature dissolves obtained.
Embodiment 5
Treat an externally used compound tincture for beriberi, make by following method:
By econazole nitrate 20g, tolnaftate 20g, Whitfield's ointment 80g, phenylformic acid 50g, laurocapram 10g, glycerine 20g, sealwort extracting solution 25g, ginger extract 20g, Radix Sophorae Flavescentis extractive liquid 15g, cloves extracting solution 10g, rhizoma extracting liquid 60g, shaddock ped extracting solution 30g is added in container, adds medical alcohol 640g, and stirred at ambient temperature dissolves obtained.
Embodiment 6
Treat an externally used compound tincture for beriberi, make by following method:
By itraconazole 20g, Whitfield's ointment 100g, phenylformic acid 50g, laurocapram 10g, glycerine 20g, sealwort extracting solution 20g, ginger extract 30g, Radix Sophorae Flavescentis extractive liquid 10g, cloves extracting solution 10g, rhizoma extracting liquid 20g, shaddock ped extracting solution 100g is added in container, adding medical alcohol 610g, stirred at ambient temperature dissolves obtained.
Embodiment 7
Treat an externally used compound tincture for beriberi, make by following method:
By econazole nitrate 20g, butenafine hydrochloride 10g, Whitfield's ointment 70g, phenylformic acid 60g, laurocapram 20g, glycerine 20g, sealwort extracting solution 25g, ginger extract 25g, Radix Sophorae Flavescentis extractive liquid 10g, cloves extracting solution 10g, rhizoma extracting liquid 15g, shaddock ped extracting solution 30g is added in container, adds medical alcohol 685g, and stirred at ambient temperature dissolves obtained.
Embodiment 8
Treat an externally used compound tincture for beriberi, make by following method:
By KETOKONAZOL 30g, butenafine hydrochloride 15g, Whitfield's ointment 60g, phenylformic acid 50g, laurocapram 30g, glycerine 20g, sealwort extracting solution 25g, ginger extract 30g, Radix Sophorae Flavescentis extractive liquid 10g, cloves extracting solution 10g, rhizoma extracting liquid 10g, shaddock ped extracting solution 30g is added in container, adds medical alcohol 680g, and stirred at ambient temperature dissolves obtained.
Embodiment 9
Treat an externally used compound tincture for beriberi, make by following method:
By butenafine hydrochloride 50g, Whitfield's ointment 50g, phenylformic acid 120g, laurocapram 15g, glycerine 20g, sealwort extracting solution 20g, ginger extract 25g, Radix Sophorae Flavescentis extractive liquid 15g, cloves extracting solution 30g, rhizoma extracting liquid 10g, shaddock ped extracting solution 30g is added in container, adding medical alcohol 615g, stirred at ambient temperature dissolves obtained.
Embodiment 10
Treat an externally used compound tincture for beriberi, make by following method:
By miconazole nitrate 20g, butenafine hydrochloride 15g, Whitfield's ointment 100g, phenylformic acid 50g, laurocapram 10g, glycerine 50g, sealwort extracting solution 20g, ginger extract 20g, Radix Sophorae Flavescentis extractive liquid 10g, cloves extracting solution 10g, rhizoma extracting liquid 15g, shaddock ped extracting solution 35g is added in container, adds medical alcohol 645g, and stirred at ambient temperature dissolves obtained.
Embodiment 11
Treat an externally used compound tincture for beriberi, make by following method:
By clotrimazole 40g, Whitfield's ointment 90g, phenylformic acid 70g, laurocapram 10g, glycerine 20g, sealwort extracting solution 25g, ginger extract 20g, Radix Sophorae Flavescentis extractive liquid 20g, cloves extracting solution 15g, rhizoma extracting liquid 20g, shaddock ped extracting solution 50g is added in container, adding medical alcohol 620g, stirred at ambient temperature dissolves obtained.
Embodiment 12
Treat an externally used compound tincture for beriberi, make by following method:
By itraconazole 10g, butenafine hydrochloride 20g, Whitfield's ointment 60g, phenylformic acid 50g, laurocapram 10g, glycerine 20g, sealwort extracting solution 50g, ginger extract 20g, Radix Sophorae Flavescentis extractive liquid 15g, cloves extracting solution 10g, rhizoma extracting liquid 12g, shaddock ped extracting solution 35g is added in container, adds medical alcohol 688g, and stirred at ambient temperature dissolves obtained.
Embodiment 13
Treat an externally used compound tincture for beriberi, make by following method:
By miconazole nitrate 10g, butenafine hydrochloride 20g, Whitfield's ointment 100g, phenylformic acid 70g, laurocapram 20g, glycerine 30g, sealwort extracting solution 25g, ginger extract 30g, Radix Sophorae Flavescentis extractive liquid 20g, cloves extracting solution 30g, rhizoma extracting liquid 30g, shaddock ped extracting solution 50g is added in container, adds medical alcohol 565g, and stirred at ambient temperature dissolves obtained.
Embodiment 14
Treat an externally used compound tincture for beriberi, make by following method:
By miconazole nitrate 20g, Terbinafine Hcl 10g, Whitfield's ointment 100g, phenylformic acid 70g, laurocapram 20g, glycerine 30g, sealwort extracting solution 25g, ginger extract 30g, Radix Sophorae Flavescentis extractive liquid 20g, cloves extracting solution 30g, rhizoma extracting liquid 30g, shaddock ped extracting solution 50g is added in container, adds medical alcohol 565g, and stirred at ambient temperature dissolves obtained.
Effect experimental:
Select 15��70 years old age, 1500 ringworm of the foot patients, have mild infection or severe infections (slight patient's symptom: sole and heel portion, dry decortication, itches; Severe patient symptom: get blister between toe, bottom sole, fester, decortication, very itches), it is divided into 15 groups at random, often organize 100 people, 1 control group is the antifungal drug of commercially available common suppression ergosterol synthesis, and 14 experimental group, are respectively the externally used compound tincture of the treatment beriberi of embodiment 1-14, the tincture obliterating of control group and the present invention is in cleaning the affected part after drying, every day 2 times. Treatment result is in table 1, and tracing observation, substantially without recurrence. Patient generally reflects after using that the externally used compound tincture sterilizing and itch-relieving ability of the treatment beriberi of the present invention is strong, it may also be useful to convenient, effect relaxes, and has no side effect, without recurrence phenomenon after more. This tincture instant effect, the course for the treatment of is short, and slight patient takes effect for 2��3 days, within 5��7 days, can fully recover; Severe patient takes effect for 4��5 days, recovery from illness in 10��15 days.
Table 1
Note: control group is the antifungal drug of commercially available common suppression ergosterol synthesis.
The present invention treats the using method of the externally used compound tincture of beriberi: external application; By pin clean dry after, by the tincture obliterating of the present invention in or be sprayed on affected part, every day 1��2 time. Note: alcohol and described medicine allergy sufferers are forbidden; Lactating women are cautious use of.
Claims (4)
1. treat the externally used compound tincture of beriberi for one kind, it is characterized in that making with following raw material by weight percentage: the antifungal drug 0%��4% suppressing ergosterol synthesis, suppress the antifungal drug 0%��5% of squalene epoxidase, Whitfield's ointment 5%��15%, phenylformic acid 5%��12%, laurocapram 1%��3%, glycerine 1%��5%, sealwort extracting solution 2%��5%, ginger extract 2%��5%, Radix Sophorae Flavescentis extractive liquid 1%��5%, cloves extracting solution 1%��6%, rhizoma extracting liquid 1%��6%, shaddock ped extracting solution 3%��10%, surplus is medical alcohol.
2. a kind of externally used compound tincture treating beriberi according to claim 1, it is characterized in that the antifungal drug that described suppression ergosterol synthesizes is 1%��2%, the antifungal drug of described suppression squalene epoxidase is 1%��2%, described Whitfield's ointment is 10%, described phenylformic acid is 7%, described laurocapram is 2%, described glycerine is 3%, described sealwort extracting solution is 2.5%, described ginger extract is 3%, described Radix Sophorae Flavescentis extractive liquid is 2%, described cloves extracting solution is 3%, described rhizoma extracting liquid is 3%, described shaddock ped extracting solution is 5%, surplus is medical alcohol.
3. a kind of externally used compound tincture treating beriberi according to claim 1 and 2, it is characterised in that the antifungal drug of described suppression ergosterol synthesis is miconazole nitrate, econazole nitrate, KETOKONAZOL, itraconazole and clotrimazole at least one.
4. a kind of externally used compound tincture treating beriberi according to claim 1 and 2, it is characterised in that the antifungal drug of described suppression squalene epoxidase is butenafine hydrochloride, Terbinafine Hcl and tolnaftate at least one.
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| CN105311542A (en) * | 2015-11-26 | 2016-02-10 | 青岛海之源智能技术有限公司 | Terbinafine hydrochloride compound composition and preparation method and application |
| CN105362504A (en) * | 2015-11-26 | 2016-03-02 | 青岛海之源智能技术有限公司 | Terbinafine hydrochloride compound tincture and preparation method and application |
| CN110251555A (en) * | 2019-07-23 | 2019-09-20 | 燕奇锋 | A kind of tinea pedis preparation and preparation method thereof |
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| CN101518608A (en) * | 2009-03-30 | 2009-09-02 | 四川农业大学 | Anti-candidiasis albrican cream and preparation method thereof |
| CN101537123A (en) * | 2008-03-21 | 2009-09-23 | 北京中泰天和科技有限公司 | Pharmaceutical composition for curing skin tinea and preparation method thereof |
| CN102772764A (en) * | 2012-07-19 | 2012-11-14 | 张吉玲 | Nursing traditional Chinese medicine disinfectant and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537123A (en) * | 2008-03-21 | 2009-09-23 | 北京中泰天和科技有限公司 | Pharmaceutical composition for curing skin tinea and preparation method thereof |
| CN101518608A (en) * | 2009-03-30 | 2009-09-02 | 四川农业大学 | Anti-candidiasis albrican cream and preparation method thereof |
| CN102772764A (en) * | 2012-07-19 | 2012-11-14 | 张吉玲 | Nursing traditional Chinese medicine disinfectant and preparation method |
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