CN101537123A - Pharmaceutical composition for curing skin tinea and preparation method thereof - Google Patents
Pharmaceutical composition for curing skin tinea and preparation method thereof Download PDFInfo
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- CN101537123A CN101537123A CN 200810102437 CN200810102437A CN101537123A CN 101537123 A CN101537123 A CN 101537123A CN 200810102437 CN200810102437 CN 200810102437 CN 200810102437 A CN200810102437 A CN 200810102437A CN 101537123 A CN101537123 A CN 101537123A
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Abstract
The invention discloses a pharmaceutical composition for curing skin tinea and a preparation method thereof. The pharmaceutical composition is prepared by extracting the following effective components of a dozen of medical materials including siberian solomonseal rhizome, broom cypress fruit, epimedium, Indian bread, clove, cnidium fruit, wrinkled gianthyssop, toosendan fruit, kuhseng, dahurian angelica root, dictamnus albus, fistular onion stalk, anemarrhena rhizome, goldthread root, yellow-corktree bark, rhubarb, and the like. The pharmaceutical composition is used for curing various skin pruritus diseases of tinea manuum, tinea pedis, and the like.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of drug regimen that is used for the treatment of dermatophytosis and preparation method thereof.
Technical background
The tinea manuum and tinea pedis all are because the disease due to the fungal infection hand-foot skin.The tinea manuum is commonly called as " fungal infection of hand and foot ", and tinea pedis is commonly called as " beriberi ".Though cause that the fungal species of tinea manus and pedis is more, the overwhelming majority is due to the dermatophytosis.It is mainly propagated by hygienic article such as shared slippers, bath towels, and utilizing the crowd of public bathing equipment such as miner, athlete etc. is the group of people at high risk, can propagate within the family in addition.The tinea pedis sickness rate is higher than the tinea manuum, and usually is the source of infection of the tinea manuum.
The heavy winter in general summer of tinea pedis is light, the more person of sufficient antiperspirant, and also can take place winter.Erosion tends to secondary streptococcal infection and forms erysipelas between long-term finger of not healing, be the lower limb erysipelas commonly encountered diseases because of.
The tinea manuum often is secondary to tinea pedis, and many earlier since a hands, can be developed to both hands as not treating after the several years.Because hands is used for working, thus new infection usually caused after suffering from the tinea manuum, as cause tinea corporis, tinea cruris etc.
No matter be the tinea manuum or tinea pedis, as develop as one pleases, ungual infection can finally take place and form tinea unguium or be called tinea unguium in nearly all patient, and tinea unguium is more obstinate than tinea manus and pedis.
Tinea pedis is a kind of by fungus-caused infectiousness foot dermatosis.Its their early stage, pathogenic bacterium (as mycete, trichophyton etc.) are usually earlier invaded the skin between patient's toe, make that local skin vesicle occurs, peel or turns white, eliminating dampness by diuresis, and the affected part often very itches unbearably, so the patient tends to the hands affected part of scratching.This scratching usually can be damaged illing skin, causes that local skin splits, suppuration, pain, erosion, but also can make pathogenic bacterium spread other positions to sole, instep or even health, causes diseases such as the tinea manuum, tinea capitis, tinea unguium, tinea corporis, tinea cruris.Because tinea pedis is more common, and most tinea pedis patient severe complications can not occur yet, so people usually scorn to take even a glance to tinea pedis.But these tinea pedis patient may not know that tinea pedis such as untimely treatment can be brought out some acute inflammations, bring bigger misery to health, even life is threatened.Tinea pedis can cause following various acute inflammation.
1, acute lymphangitis just is easy to the secondary bacterial infection when symptoms such as dipping, erosion, vesicle or suppuration have appearred in the skin of patient's tinea pedis affected area, causes acute lymphangitis.To be pathogenic bacterium invade lymphatic vessel and the acute inflammation that causes from the skin of breakage to acute lymphangitis.This disease is mainly in medial leg.Symptoms such as that their early stage, tinea pedis affected area can occur is red, swollen, hot, pain.Subcutaneous lymphatic vessel can divide dark, shallow two-layer.Subcutaneous shallow-layer acute lymphangitis also is the red line rash, red lines can appear in the surface of patient's diseased region when this disease took place, and there is slight tenderness at the lines place, can develop from bottom to top during the lines expansion, and but rapid spread causes inguinal lymph nodes enlargement, tenderness to the groin place.The thick person of red line, explanation is in a bad way, and as untimely treatment, can cause that the lymph node of getting involved suppurates, diabrosis.If ceased the subcutaneous deep acute lymphangitis, then the surface of diseased region red line can not occur, may have only bar shaped to touch a tender spot and distinguish.In addition, the acute lymphangitis patient also usually can be with symptoms such as in various degree fear of cold, heating, inappetence, malaises.
2, this disease of acute cellulitis generally occurs in the affected area of tinea pedis.Because the skin of affected area is more loose, so inflammation very easily causes acute diffuse suppurative inflammation to diffusion all around, also can feed through under the fascia sometimes, or even deep muscle tissue.That patient's illing skin generally all has is significantly red, swollen, hot, the pain symptom, and the skin lesion place is kermesinus, unclear with the boundary of surrounding tissue.When diseased region is more shallow, when local organization was relatively loose, the swelling meeting of diseased region obviously but pain is lighter; Darker when diseased region, when local organization was dense, the swelling of diseased region was then not obvious and pain is very violent.This type of patient is usually with fear of cold, heating, symptom such as weak.If this patient fails to be treated timely, this inflammation can increase the weight of rapidly, can cause local suppurate or the local hemorrhage necrosis occurring, even can cause septicemia and jeopardize patient's life.
3, erysipelas: as the tinea pedis patient infection during beta hemolytic streptococcus, this pathogenic bacterium just very the skin of The book of Changes tinea pedis affected area invade medium-sized or tiny lymphatic vessel, cause skin and netted vasculolymphatic acute inflammation, just erysipelas.The morbidity of this disease is more hurried, many insteps in patient's tinea pedis one side, shank place occur red and swollen, scorching hot and the erythra of pain are arranged during beginning, erythra begins to harden then, is formed with the patch of burning sensation, and spreads the speckle that becomes large stretch of scarlet towards periphery rapidly.These specklees and normal skin boundary clear fade by it, and tenderness are arranged.The vesicle or the bulla of serosity or purulent secretion also can appear containing in the patient who has at the erythra place.In addition, this patient is also usually with symptoms such as hyperpyrexia, fear of cold, headache, joint aches, general malaises.This disease is treated completely as can not get, and tends to fall ill repeatedly, and the lymphatic vessel of illing skin blocks if long-term morbidity then can make, lymph fluid is retarded by silt, and causes this place's pachyderma chap, even the secondary elephatiasis.
Above-mentioned these skin acute inflammations, though also can fall ill separately, those have tinea pedis, fail often easier these diseases of secondary of patient of treatment in time again.So getting tinea pedis will treat energetically.When particularly having caused complication, more can not adopt a casual attitude by tinea pedis.
The present invention is to be a kind of Chinese medicine composition that is used for the treatment of skin pruritus such as the tinea manuum, tinea pedis clinically that develop in conjunction with present herbal pharmaceutical technology on the basis with the Traditional Chinese medical theory.
Summary of the invention:
One of purpose of the present invention provides a kind of drug regimen that is used for the treatment of dermatophytosis.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Rhizoma Polygonati 100-200 part Fructus Kochiae 100-200 part Herba Epimedii 100-200 part
Rhizoma Smilacis Glabrae 100-200 part Flos Caryophylli 100-200 part Fructus Cnidii 100-200 part
Herba Pogostemonis 80-160 part Fructus Toosendan 80-160 part Radix Sophorae Flavescentis 80-160 part
The very light blue 80-160 part of Radix Angelicae Dahuricae 80-160 part shaggy-fruited dittany 80-160 part
Rhizoma Anemarrhenae 30-60 part Rhizoma Coptidis 100-200 part Cortex Phellodendri 100-200 part
Radix Et Rhizoma Rhei 100-200 part sodium benzoate 2-5 part
The active component that preferred following raw materials according is made, curative effect is better:
150 parts of 150 parts of Herba Epimedii of 150 parts of Fructus Kochiae of Rhizoma Polygonati
150 parts of 150 parts of Fructus Cnidiis of 150 portions of Flos Caryophyllis of Rhizoma Smilacis Glabrae
100 parts of 100 parts of Radix Sophorae Flavescentiss of 100 parts of Fructus Toosendans of Herba Pogostemonis
Very light blue 100 parts of 100 parts of shaggy-fruited dittany 80-160 of Radix Angelicae Dahuricae part
120 parts of 120 portions of Cortex Phellodendris of 50 portions of Rhizoma Coptidis of the Rhizoma Anemarrhenae
3 parts of 120 parts of sodium benzoate of Radix Et Rhizoma Rhei
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Sophorae Flavescentis, Herba Epimedii, Cortex Phellodendri, Fructus Toosendan add the airtight dipping secondary of 60% ethanol, 24 hours for the first time, 12 hours for the second time, filter merging filtrate;
(2) Rhizoma Polygonati, the Fructus Kochiae, Rhizoma Smilacis Glabrae, Flos Caryophylli, Fructus Cnidii, Herba Pogostemonis, the Radix Angelicae Dahuricae, shaggy-fruited dittany, very light blue, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Radix Et Rhizoma Rhei decoct with water three times, and 2 hours for the first time, each 1 hour later on, filter, merging filtrate concentrates, add Alumen while hot, stir and make dissolving;
(3) above-mentioned two solution are merged, add the 10mol/L sodium hydroxide solution and regulate pH value to 5.0, left standstill 24 hours, filter, filtrate adds sodium benzoate, stirs and makes dissolving, adds water to ormal weight, filters, promptly.
By the following examples technical scheme of the present invention is described further.
Embodiment 1:
1. write out a prescription
150 parts of 150 parts of Herba Epimedii of 150 parts of Fructus Kochiae of Rhizoma Polygonati
150 parts of 150 parts of Fructus Cnidiis of 150 portions of Flos Caryophyllis of Rhizoma Smilacis Glabrae
100 parts of 100 parts of Radix Sophorae Flavescentiss of 100 parts of Fructus Toosendans of Herba Pogostemonis
Very light blue 100 parts of 100 parts of shaggy-fruited dittany 80-160 of Radix Angelicae Dahuricae part
120 parts of 120 portions of Cortex Phellodendris of 50 portions of Rhizoma Coptidis of the Rhizoma Anemarrhenae
3 parts of 120 parts of sodium benzoate of Radix Et Rhizoma Rhei
2. preparation technology
(1) Radix Sophorae Flavescentis, Herba Epimedii, Cortex Phellodendri, Fructus Toosendan add the airtight dipping secondary of 60% ethanol, 24 hours for the first time, 12 hours for the second time, filter merging filtrate;
(2) Rhizoma Polygonati, the Fructus Kochiae, Rhizoma Smilacis Glabrae, Flos Caryophylli, Fructus Cnidii, Herba Pogostemonis, the Radix Angelicae Dahuricae, shaggy-fruited dittany, very light blue, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Radix Et Rhizoma Rhei decoct with water three times, and 2 hours for the first time, each 1 hour later on, filter, merging filtrate concentrates, add Alumen while hot, stir and make dissolving;
(3) above-mentioned two solution are merged, add the 10mol/L sodium hydroxide solution and regulate pH value to 5.0, left standstill 24 hours, filter, filtrate adds sodium benzoate, stirs and makes dissolving, adds water to ormal weight, filters, promptly.
Claims (5)
1, a kind of drug regimen that is used for the treatment of dermatophytosis is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Rhizoma Polygonati 100-200 part Fructus Kochiae 100-200 part Herba Epimedii 100-200 part
Rhizoma Smilacis Glabrae 100-200 part Flos Caryophylli 100-200 part Fructus Cnidii 100-200 part
Herba Pogostemonis 80-160 part Fructus Toosendan 80-160 part Radix Sophorae Flavescentis 80-160 part
The very light blue 80-160 part of Radix Angelicae Dahuricae 80-160 part shaggy-fruited dittany 80-160 part
Rhizoma Anemarrhenae 30-60 part Rhizoma Coptidis 100-200 part Cortex Phellodendri 100-200 part
Radix Et Rhizoma Rhei 100-200 part sodium benzoate 2-5 part
2, a kind of drug regimen that is used for the treatment of dermatophytosis according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
150 parts of 150 parts of Herba Epimedii of 150 parts of Fructus Kochiae of Rhizoma Polygonati
150 parts of 150 parts of Fructus Cnidiis of 150 portions of Flos Caryophyllis of Rhizoma Smilacis Glabrae
100 parts of 100 parts of Radix Sophorae Flavescentiss of 100 parts of Fructus Toosendans of Herba Pogostemonis
Very light blue 100 parts of 100 parts of shaggy-fruited dittany 80-160 of Radix Angelicae Dahuricae part
120 parts of 120 portions of Cortex Phellodendris of 50 portions of Rhizoma Coptidis of the Rhizoma Anemarrhenae
3 parts of 120 parts of sodium benzoate of Radix Et Rhizoma Rhei
3, according to the described a kind of drug regimen that is used for the treatment of dermatophytosis of claim 1-2, it is characterized in that adopting following method to make:
(1) Radix Sophorae Flavescentis, Herba Epimedii, Cortex Phellodendri, Fructus Toosendan add the airtight dipping secondary of 60% ethanol, 24 hours for the first time, 12 hours for the second time, filter merging filtrate;
(2) Rhizoma Polygonati, the Fructus Kochiae, Rhizoma Smilacis Glabrae, Flos Caryophylli, Fructus Cnidii, Herba Pogostemonis, the Radix Angelicae Dahuricae, shaggy-fruited dittany, very light blue, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Radix Et Rhizoma Rhei decoct with water three times, and 2 hours for the first time, each 1 hour later on, filter, merging filtrate concentrates, add Alumen while hot, stir and make dissolving;
(3) above-mentioned two solution are merged, add the 10mol/L sodium hydroxide solution and regulate pH value to 5.0, left standstill 24 hours, filter, filtrate adds sodium benzoate, stirs and makes dissolving, adds water to ormal weight, filters, promptly.
4, according to any one described a kind of drug regimen that is used for the treatment of dermatophytosis among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of drug regimen that is used for the treatment of dermatophytosis of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810102437 CN101537123A (en) | 2008-03-21 | 2008-03-21 | Pharmaceutical composition for curing skin tinea and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810102437 CN101537123A (en) | 2008-03-21 | 2008-03-21 | Pharmaceutical composition for curing skin tinea and preparation method thereof |
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| CN 200810102437 Pending CN101537123A (en) | 2008-03-21 | 2008-03-21 | Pharmaceutical composition for curing skin tinea and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953930A (en) * | 2010-10-25 | 2011-01-26 | 李文波 | Externally-applied traditional Chinese medicine for treating tinea capitis |
| CN103845701A (en) * | 2012-12-04 | 2014-06-11 | 天津大学 | External compound tincture for treating dermatophytosis |
| CN103893484A (en) * | 2014-03-30 | 2014-07-02 | 王秋莉 | Traditional Chinese medicine composition for treating pruritus cutanea after hematodialysis |
| CN105079619A (en) * | 2015-08-18 | 2015-11-25 | 阳颖娟 | Ointment for treating skin itch and preparation method thereof |
-
2008
- 2008-03-21 CN CN 200810102437 patent/CN101537123A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953930A (en) * | 2010-10-25 | 2011-01-26 | 李文波 | Externally-applied traditional Chinese medicine for treating tinea capitis |
| CN101953930B (en) * | 2010-10-25 | 2012-08-29 | 姜秀芹 | Externally-applied traditional Chinese medicine for treating tinea capitis |
| CN103845701A (en) * | 2012-12-04 | 2014-06-11 | 天津大学 | External compound tincture for treating dermatophytosis |
| CN103845701B (en) * | 2012-12-04 | 2016-06-08 | 天津大学 | The externally used compound tincture for the treatment of beriberi |
| CN103893484A (en) * | 2014-03-30 | 2014-07-02 | 王秋莉 | Traditional Chinese medicine composition for treating pruritus cutanea after hematodialysis |
| CN105079619A (en) * | 2015-08-18 | 2015-11-25 | 阳颖娟 | Ointment for treating skin itch and preparation method thereof |
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Open date: 20090923 |