CN103841825B - 从微生物生物质中获取含脂质组合物的方法 - Google Patents

从微生物生物质中获取含脂质组合物的方法 Download PDF

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Publication number
CN103841825B
CN103841825B CN201280007938.5A CN201280007938A CN103841825B CN 103841825 B CN103841825 B CN 103841825B CN 201280007938 A CN201280007938 A CN 201280007938A CN 103841825 B CN103841825 B CN 103841825B
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CN
China
Prior art keywords
oil
biomass
acid
extraction
yeast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280007938.5A
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English (en)
Chinese (zh)
Other versions
CN103841825A (zh
Inventor
M.阿维高斯蒂
T.A.贝尔
R.E.博克拉斯
O.W.古特斯彻
K.W.胡特臣森
S-C.梁
R.D.奥尔兰迪
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EIDP Inc
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EI Du Pont de Nemours and Co
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Publication of CN103841825A publication Critical patent/CN103841825A/zh
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Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C11B1/104—Production of fats or fatty oils from raw materials by extracting using super critical gases or vapours
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/20—Shaping or working-up of animal feeding-stuffs by moulding, e.g. making cakes or briquettes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/25—Shaping or working-up of animal feeding-stuffs by extrusion
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Animal Husbandry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Sustainable Development (AREA)
  • Fats And Perfumes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Edible Oils And Fats (AREA)
CN201280007938.5A 2011-02-11 2012-02-10 从微生物生物质中获取含脂质组合物的方法 Expired - Fee Related CN103841825B (zh)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US201161441854P 2011-02-11 2011-02-11
US201161441836P 2011-02-11 2011-02-11
US201161441842P 2011-02-11 2011-02-11
US201161441849P 2011-02-11 2011-02-11
US61/441836 2011-02-11
US61/441,842 2011-02-11
US61/441842 2011-02-11
US61/441854 2011-02-11
US61/441849 2011-02-11
US61/441,836 2011-02-11
US61/441,854 2011-02-11
US61/441,849 2011-02-11
US201161487019P 2011-05-17 2011-05-17
US61/487019 2011-05-17
US61/487,019 2011-05-17
PCT/US2012/024662 WO2012109545A2 (en) 2011-02-11 2012-02-10 Method for obtaining a lipid-containing composition from microbial biomass

Publications (2)

Publication Number Publication Date
CN103841825A CN103841825A (zh) 2014-06-04
CN103841825B true CN103841825B (zh) 2017-03-22

Family

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Family Applications (1)

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CN201280007938.5A Expired - Fee Related CN103841825B (zh) 2011-02-11 2012-02-10 从微生物生物质中获取含脂质组合物的方法

Country Status (6)

Country Link
US (2) US8999663B2 (https=)
EP (1) EP2672833A4 (https=)
JP (1) JP6061866B2 (https=)
CN (1) CN103841825B (https=)
CA (2) CA3026436A1 (https=)
WO (1) WO2012109545A2 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011133610A1 (en) * 2010-04-22 2011-10-27 E. I. Du Pont De Nemours And Company Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass
US20140323569A1 (en) * 2011-07-21 2014-10-30 Krishna Raman Microbial oils enriched in polyunsaturated fatty acids
AU2013371074B2 (en) 2012-12-24 2018-07-26 Qualitas Health Inc. Eicosapentaenoic acid (EPA) formulations
PL3077489T3 (pl) 2013-12-04 2021-11-08 Nippon Suisan Kaisha, Ltd. Olej drobnoustrojowy zawierający kwas dihomo-gamma-linolenowy i biomasa drobnoustrojowa zawierająca kwas dihomo-gamma-linolenowy
CL2013003813A1 (es) * 2013-12-31 2014-06-06 Univ Pontificia Catolica Chile Procedimiento para la obtención de carotenoides (en particular astaxantina) a partir de un sustrato de microalgas en polvo, el que se comprime para formar pellets, los cuales son sometidos a extracción por dioxido de carbono (co2) supercrítico.
CN106795452A (zh) 2014-09-17 2017-05-31 日本水产株式会社 含有二十碳五烯酸烷基酯的组合物及其制造方法
US11464244B2 (en) 2014-10-02 2022-10-11 Evonik Operations Gmbh Feedstuff of high abrasion resistance and good stability in water, containing PUFAs
WO2016050552A1 (de) 2014-10-02 2016-04-07 Evonik Degussa Gmbh Verfahren zur herstellung einer pufas enthaltenden biomasse mit hoher zellstabilität
ES2900848T5 (en) 2014-10-02 2025-09-25 Evonik Operations Gmbh Method for preparing an animal feed
US10619175B2 (en) * 2014-10-02 2020-04-14 Evonik Operations Gmbh Process for producing a PUFA-containing feedstuff by extruding a PUFA-containing biomass
WO2016065231A1 (en) * 2014-10-24 2016-04-28 Trustees Of Dartmouth College Aquaculture feed formulation and aquaculture product produced with the same
JP2018502593A (ja) * 2015-01-26 2018-02-01 ロケット フレールＲｏｑｕｅｔｔｅ Ｆｒｅｒｅｓ 脂質に富む粉砕された微細藻類の粉末を調製するための方法
US20180187121A1 (en) * 2015-06-15 2018-07-05 White Dog Labs, Inc. Method for producing one or more oil-soluble bioproducts
CN106434777B (zh) * 2015-08-05 2020-01-14 嘉必优生物技术（武汉）股份有限公司 一种微生物来源的磷脂型多不饱和脂肪酸油脂
CN104962589B (zh) * 2015-08-05 2019-02-26 嘉必优生物技术（武汉）股份有限公司 一种富含磷脂型多不饱和脂肪酸的微生物油脂及制备方法
CN107778337B (zh) * 2016-08-26 2020-12-08 国投生物科技投资有限公司 超临界二氧化碳萃取螺旋藻中糖脂的方法
CA3094044C (en) * 2018-03-16 2023-07-18 Ricoh Company, Ltd. Method of producing extract and extraction residue of biological material, extract, and extraction residue
CN113574045A (zh) * 2019-03-14 2021-10-29 帝斯曼知识产权资产管理有限公司 从微生物细胞组合物中获得脂质的方法
FI131688B1 (en) * 2019-06-12 2025-09-17 Aurotec Gmbh Thin-film treatment apparatus
FR3103355B1 (fr) 2019-11-26 2024-05-31 Polaris Composition d’huile de micro-organismes enrichie en acides gras polyinsaturés
AU2021220796A1 (en) * 2020-02-10 2022-09-29 C16 Biosciences, Inc. Microbially produced palm oil substitutes
CN111822716A (zh) * 2020-07-21 2020-10-27 泉州华大超硬工具科技有限公司 一种新型工艺串珠的制备方法
JP7653446B2 (ja) * 2020-10-02 2025-03-28 日本たばこ産業株式会社 たばこシート
WO2022104046A1 (en) * 2020-11-12 2022-05-19 C16 Biosciences, Inc. Edible microbial oil
WO2022104063A2 (en) * 2020-11-12 2022-05-19 C16 Biosciences, Inc. Personal care compositions comprising microbially produced oil
CN118434429A (zh) * 2021-10-17 2024-08-02 利库德有限公司 含八氢番茄红素的油树脂和组合物
TWI901501B (zh) * 2025-01-09 2025-10-11 昭輝實業股份有限公司 利用模擬移動床(smb)從藻油萃取並分離高濃度dha及epa的製程方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011521A1 (en) * 1988-05-27 1989-11-30 Staroil Limited Process for preparing polyunsaturated fatty acids
WO2010010364A2 (en) * 2008-07-24 2010-01-28 Pharma Marine As Process for the purification of oils

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675132A (en) 1985-03-28 1987-06-23 The United States Of America As Represented By The Secretary Of Commerce Polyunsaturated fatty acids from fish oils
IT1205043B (it) 1987-05-28 1989-03-10 Innova Di Ridolfi Flora & C S Procedimento per l'estrazione di esteri di acidi grassi poliinsaturi da olii di pesce e composizioni farmaceutiche e dietetiche contenenti detti esteri
JPH0611793B2 (ja) * 1989-08-17 1994-02-16 旭化成工業株式会社 微粒化セルロース系素材の懸濁液及びその製造方法
EP0442184A1 (en) 1990-02-15 1991-08-21 Campbell Soup Company Production of low cholesterol animal fat by short path distillation
US20050027004A1 (en) * 1993-06-09 2005-02-03 Martek Biosciences Corporation Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions
ZA964248B (en) 1995-06-23 1997-11-27 Du Pont Uniform mixtures of pesticidal granules.
JP4545235B2 (ja) * 1996-03-28 2010-09-15 ディーエスエム アイピー アセッツ ビー．ブイ． 顆粒状微生物バイオマスの製造法とそのバイオマスからの貴重化合物の単離法
CN1217029A (zh) * 1996-03-28 1999-05-19 吉斯特-布罗卡迪斯股份有限公司 从用巴氏法灭菌的生物量中制备含有微生物多不饱和脂肪酸的油的方法
US6255505B1 (en) 1996-03-28 2001-07-03 Gist-Brocades, B.V. Microbial polyunsaturated fatty acid containing oil from pasteurised biomass
EP0904339B2 (en) 1996-05-15 2006-09-20 DSM IP Assets B.V. Sterol extraction with a polar solvent to give low sterol microbial oil
US5786188A (en) * 1996-06-05 1998-07-28 The United States Of America As Represented By The Secretary Of Agriculture Fungal inoculum preparation
AU725220B2 (en) 1997-03-14 2000-10-05 E.I. Du Pont De Nemours And Company Apparatus for breaking and separating particles
TW533235B (en) 1997-06-11 2003-05-21 Idemitsu Petrochemical Co Method for extracting fat-soluble components from microbial cells
SE0001386L (sv) 2000-04-13 2001-10-14 Net Insight Ab Method and apparatus for data transfer between circuit switched and packet switched environments
EP1178118A1 (en) * 2000-08-02 2002-02-06 Dsm N.V. Isolation of microbial oils
WO2003049832A1 (en) 2001-12-12 2003-06-19 Martek Biosciences Boulder Corp. Extraction and winterization of lipids from oilseed and microbial sources
EA013051B1 (ru) * 2002-06-19 2010-02-26 ДСМ Ай Пи ЭССЕТС Б.В. Масло из микробных клеток, композиция, содержащая масло, и способ получения масла
FI116627B (fi) * 2002-11-01 2006-01-13 Danisco Menetelmä triglyseridien rasvahappoketjukoostumuksen säätelemiseksi sekä niiden käyttö
US8313911B2 (en) 2003-05-07 2012-11-20 E I Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US7238482B2 (en) 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US7550286B2 (en) 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
DK1893731T3 (da) 2005-06-23 2012-07-16 Dsm Ip Assets Bv Fremgangsmåde til opnåelse af lipid fra celler
MY139389A (en) 2005-07-20 2009-09-30 Malaysian Palm Oil Board Mpob Production of edible oil with high diglyceride content
US7977498B2 (en) * 2005-08-26 2011-07-12 Ocean Nutrition Canada Limited Reduction of sterols and other compounds from oils
AU2006316610B2 (en) 2005-11-23 2012-06-14 E. I. Du Pont De Nemours And Company Delta-9 elongases and their use in making polyunsaturated fatty acids
US7695950B2 (en) 2006-05-17 2010-04-13 E. I. Du Pont De Nemours And Company Δ5 desaturase and its use in making polyunsaturated fatty acids
US7678560B2 (en) 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
CA2663807C (en) 2006-10-30 2018-05-01 E.I. Du Pont De Nemours And Company .delta.17 desaturase and its use in making polyunsaturated fatty acids
DK2129777T3 (en) 2007-04-03 2016-01-25 Du Pont MULTIZYMER AND USE THEREOF FOR THE PRODUCTION OF polyunsaturated fatty acids
US8957280B2 (en) 2007-05-03 2015-02-17 E. I. Du Pont De Nemours And Company Delta-5 desaturases and their use in making polyunsaturated fatty acids
CN101939434B (zh) * 2007-05-24 2015-03-25 纳幕尔杜邦公司 用于在大豆中提高种子贮藏油脂的生成和改变脂肪酸谱的来自解脂耶氏酵母的dgat基因
EP2172558B1 (en) * 2007-07-30 2017-07-19 Nippon Suisan Kaisha, Ltd. Method for production of epa-enriched oil and dha-enriched oil
US20090117253A1 (en) 2007-10-03 2009-05-07 E. I. Du Pont De Nemours And Company Peroxisome biogenesis factor protein (pex) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms
US20090155447A1 (en) * 2007-12-12 2009-06-18 Solae, Llc Protein extrudates comprising omega-3 fatty acids
US20100170144A1 (en) * 2008-04-09 2010-07-08 Solazyme, Inc. Hydroprocessing Microalgal Oils
AU2009293160B2 (en) 2008-09-19 2013-11-21 E. I. Du Pont De Nemours And Company Mutant delta5 desaturases and their use in making polyunsaturated fatty acids
JP5731982B2 (ja) * 2008-10-14 2015-06-10 ソラザイム, インコーポレイテッドSolazyme Inc 微細藻類バイオマスの食物組成物
AU2009335903B2 (en) 2008-12-18 2016-04-14 E. I. Du Pont De Nemours And Company Reducing byproduction of malonates in a fermentation process
US8399226B2 (en) * 2009-06-16 2013-03-19 E I Du Pont De Nemours And Company High eicosapentaenoic acid oils from improved optimized strains of Yarrowia lipolytica
EP2519332B1 (en) 2009-12-30 2014-03-05 BASF Pharma (Callanish) Limited Simulated moving bed chromatographic separation process for the purification of polyunsaturated fatty acids
WO2011133610A1 (en) 2010-04-22 2011-10-27 E. I. Du Pont De Nemours And Company Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass
US9040730B2 (en) * 2011-02-11 2015-05-26 E I Du Pont De Nemours And Company Purification of triglyceride oil from microbial sources using short path distillation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011521A1 (en) * 1988-05-27 1989-11-30 Staroil Limited Process for preparing polyunsaturated fatty acids
WO2010010364A2 (en) * 2008-07-24 2010-01-28 Pharma Marine As Process for the purification of oils

Also Published As

Publication number Publication date
US20150218484A1 (en) 2015-08-06
JP2014510165A (ja) 2014-04-24
US20130046105A1 (en) 2013-02-21
EP2672833A4 (en) 2015-06-10
CA3026436A1 (en) 2012-08-16
CN103841825A (zh) 2014-06-04
WO2012109545A3 (en) 2014-02-20
CA2825039A1 (en) 2012-08-16
JP6061866B2 (ja) 2017-01-18
AU2012214266A1 (en) 2013-07-25
WO2012109545A2 (en) 2012-08-16
CA2825039C (en) 2020-04-28
US8999663B2 (en) 2015-04-07
EP2672833A2 (en) 2013-12-18

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