CN103830504A - 一种治疗中晚期肝癌的中药水丸制剂 - Google Patents
一种治疗中晚期肝癌的中药水丸制剂 Download PDFInfo
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Abstract
本发明涉及中医成药。尤其是一种治疗中晚期肝癌的中药水丸制剂。本发明采用如下中药组方配伍：人参、黄芪、灵芝、龙葵、猪苓、女贞子、白芷、白花蛇舌草、半枝莲、茯苓、蚤休、蟾蜍、壁虎、枸杞、白术、鳖甲、水红花子、鹿角胶、全蝎共十九味中药。使用本发明对症治疗，可提高疗效，改善生活质量，延长生存期，本发明可起到保护肝细胞，减轻化疗毒副作用，提高免疫功能，抑杀癌瘤细胞作用。
Description
技术领域：本发明涉及中医成药，一种治疗中晚期肝癌的中药水丸制剂。
背景技术：肝癌起病隐匿，不易早期发现，一经有了自觉症状，病程已是中晚期，往往失去了治疗时机。同时，肝癌的病因病机复杂，病程进展快，极具侵袭性，明确诊断时已出现转移，很难治疗。
发明内容：对于那些术后复发，再切除再复发，以复发与转移的预防等问题，对于那些不能接受手术治疗，介入治疗或放化疗的中晚期肝癌患者，以及术后体质的恢复，放化疗后毒副反应的治疗等问题，西医则显得束手无策，这时中医的对症治疗则有极大优势。因此，本发明采用如下中药组方配伍(以下简称“龙鳖灵芝丸”)：人参、黄芪、灵芝、龙葵、猪苓、女贞子、白芷、白花蛇舌草、半枝莲、茯苓、蚤休、蟾蜍、壁虎、枸杞、白术、鳖甲、水红花子、鹿角胶、全蝎共十九味中药。本方中人参、黄芪、灵芝、枸杞提高机体抗病能力，提高机体免疫功能来防治肿瘤，本发明以免疫治疗为主要手段，枸杞、猪苓所含多糖能诱导LKA细胞活性，能使巨噬细胞NK生成增加。女贞子、龙葵不但能抗肿瘤，而且治疗白细胞减少症。白花蛇舌草、半枝莲、蚤休清热解毒，抗癌抑癌，现代药理证实其尚有调整免疫功能。灵芝益气强状，养心安神，主治虚劳赢弱，并有促进T淋巴细胞生成作用，同时也能促进巨噬细胞生成作用，鳖甲坚阴散结，消癥化积，蜈蚣、全蝎熄风镇痉，攻毒散结，通络止痛，其走窜之力最速，内而脏腑外而经络。凡气血凝聚之处皆能开之，性有微毒，而转善解毒。凡一切疮疡诸毒皆能消之。蟾蜍、壁虎拔毒散肿，破癥结，利水湿，化痰凝，消癌肿。全方共奏扶正祛邪，抗癌消瘤之功。
单纯化疗对肝癌疗效很差，尤其对于有肝硬变背景的中晚期肝癌患者，对化疗耐受量小，疗效难以提高。在化疗时联合使用本发明龙鳖灵芝丸对症治疗。可提高疗效，改善生活质量。延长生存期，本发明可起到保护肝细胞，减轻化疗毒副反应，提高免疫功能，协助抑杀癌瘤细胞的作用。
具体实施方式：本发明为一种动物药与中草药制备剂，下列十九味中药材按重量比组成：蟾蜍6g、壁虎6g、蜈蚣6g、全蝎6g、鳖甲15g、鹿角胶10g、人参20g、黄芪40g、灵芝30g、枸杞20g、猪苓20g、女贞子30g、白花蛇舌草30g、蚤休20g、龙葵30g、半枝莲15g、白术30g、茯苓20g、水红花子15g。
制备方法与使用：蟾蜍、壁虎、蜈蚣、全蝎、鳖甲、鹿角胶晒干或烘干后碾碎成粉末。人参、黄芪、灵芝、枸杞、猪苓、女贞子、白花蛇舌草、蚤休、龙葵、半枝莲、白术、茯苓、水红花子共入锅用水煮熬2小时，滤取药汁与动物类药粉搅拌均匀后蜥蜴干或烘干。第2次，第3次各加水煮熬1小时，分别滤取药汁与药粉搅拌均匀后晒干或烘干。
将经过3次药汁搅拌均匀晒干或烘干后的药粉进一步研细过100目筛，水泛为丸，如绿豆大，晒干或烘干即制备成“龙鳖灵芝丸”。
成人每服3克，日服3次，温开水送下，小儿老年体弱者酌减。
本实施例适用于中晚期肝癌治疗。
典型病例：
赵某某，男，75岁。该患者因右肋不适隐痛胀痛，时而频作。于2000年10月经某大医院做彩超检查，示肝内占位性病变，又经CT扫描诊断为肝癌，后因尿少双下肢浮肿，邀余诊治。
初诊，右肋下胀痛，疲乏无力，食欲不振，嗳气，下肢微肿，尿少，腹胀，脉弦细，苔薄黄，肝右肋下约3cm质硬。中医辩证：气滞血瘀，夹湿毒内蕴。
治法：疏肝理气，活血化瘀，佐以利湿清毒。
方药：1、投以“龙鳖灵芝丸”3克/次，3次/日。
2、辅以“紫胡12克，白芍20克，红花15克，桃仁20克，莪术15克，薏苡仁20克，茯苓皮20克，丹参20克，厚卜20克”以上方煎剂服用，日二次，早晚分服，每日一剂。
以上方为主加减服用半年多，病情稳定，双下肢浮肿消失，且尿量正常，三年后随访该老人仍健在。
孙某某，男，50岁，于2000年8月感觉腹胀，右肋下痛疼，伴食少，消瘦，日渐加重，在民间服用偏方治疗一年未效，于2002年6月来诊，所持某医院B超示肝右叶肝癌声像，肝核素扫描示肝右叶占位。HBSAg阳性，AFP阳性。查体见：腹胀，右肋下及腰背部痛疼2周，伴食少纳呆，倦怠嗜卧，头晕目眩，舌质淡红，舌苔薄白，脉弦细，右肋下肝大5cm，剑下4cm质硬，综上，中医辩证：正虚邪盛，邪毒乘虚而入，致肝脏功能失调，气滞血瘀，痰结湿聚、阻塞经络，不通则痛，瘀久则成积块。辩证：肝郁脾虚型。治法：养血舒肝，益气健脾，消肿散结。方药：(1)当归15克，白芍20克，柴胡15克，白术20克，干姜15克，大枣7枚，三棱15克，文术15克，薄荷10克，甘草10克，日一剂，早晚分服。(2)龙鳖灵芝丸3克/次，3次/日。
以上方剂连服120剂，症状明显好转，肝右肋下1cm，剑下7.3cm，右肋下及腰背部痛疼减轻。随访存活5年后辞世，带瘤生存5年。
伍某，男，40岁，于2005年11月在某医院诊为肝癌，行肝局部切除加静脉化疗。病理诊断为肝梁状细胞癌，II期伴肝硬化，手术后右肋隐痛，胃纳不佳，时有腹胀，舌苔厚腻，脉弦细。中医辩证：脾虚湿盛，湿浊困脾。治法：益气健脾，清热利湿。方药：(1)党参20克，佛手20克，八月扎20克，白术30克，茯苓20克，陈皮15克，枳壳10克，苦参20克，薏苡仁20克，厚卜20克，土茯苓30克，仙鹤草15克，败酱草20克，田基黄15克，莪术15克，日一剂，早晚分服。(2)龙鳖灵芝丸3克/次，3次/日。
该患长期间歇服药，至今已存活5年，2010年经CT、B超复查，未见肝癌复发。
曲某某，男，48岁，患者因右上腹部肿块伴刺痛。于2000年12月到当地市立医院同位素扫描发现肝内占位病变，即转来就诊，查体：上腹部隆起，肝上界右锁骨中线第6肋间，肋下13.5cm，剑下6cm，质硬，肝表面触诊结节状，舌红绛，苔黄花剥，脉弦数，AFP阴性，谷氨酰转肽酶224u超声波示肝区可见丛状波，诊断为原发性肝癌。中医辩症：肝瘀脾虚。治法：健脾理气，化瘀软坚。方药：(1)龙鳖灵芝丸内服，3克/次，3次/日。(2)丹参15克、苏木15克、牡蛎15克、鼠妇15克、茯苓15克、香附20克、柴胡15克、陈皮15克、穿山甲10克，桃仁10克，沉香末3克(冲服)上方日一剂，早晚分服。治疗二月后，肝区刺痛消失，肝脏无增大。遂只服龙鳖灵芝丸，以固后效。翠年后，经某医院复查，肿块大小基本无变化。因病人一般情况良好，患者本人及家属认为不是肝癌，遂停止服药，同年年底，终因旧病复发病情恶化不幸辞世。
本发明“龙鳖灵芝丸”通过26例中晚期肝癌患者对症加减服用，有效者24例，总有效率93％，远期随访26例患者生存一年以内者6例，占23％，1至3年的10例，占38％，3至5年以上的8例，占30％。
Claims (1)
1.本发明一种治疗中晚期肝癌的中药水丸制剂。其特征在于组方配伍和各中药重量：蟾蜍6g、壁虎6g、蜈蚣6g、全蝎6g、鳖甲15g、鹿角胶10g、人参20g、黄芪40g、灵芝30g、枸杞20g、猪苓20g、女贞子30g、白花蛇舌草30g、蚤休20g、龙葵30g、半枝莲15g、白术30g、茯苓20g、水红花子15g。
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