CN103819376A - Dichloro salicylaldehyde thiourea derivative and application thereof - Google Patents
Dichloro salicylaldehyde thiourea derivative and application thereof Download PDFInfo
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- CN103819376A CN103819376A CN201410057769.7A CN201410057769A CN103819376A CN 103819376 A CN103819376 A CN 103819376A CN 201410057769 A CN201410057769 A CN 201410057769A CN 103819376 A CN103819376 A CN 103819376A
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- Prior art keywords
- thiourea derivative
- salicylaldehyde
- dichloro
- application
- dichloro salicylaldehyde
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a dichloro salicylaldehyde thiourea derivative and an application thereof. A structural formula of the dichloro salicylaldehyde thiourea derivative is shown as the description. The dichloro salicylaldehyde thiourea derivative is used for antibiosis. The dichloro salicylaldehyde thiourea derivative has different degrees of anti-bacterial effects for erwinia herbicola, escherichia coli and staphylococcus aureus.
Description
Technical field
The present invention relates to a kind of dichloro-salicylaldehyde's thiourea derivative and the application at antibiosis thereof.
Background technology
Thiosemicarbazone derivatives belongs to the special western Buddhist alkali of a class, and it contains R
1-C=N-NH-CS-NH-R
2group.In group, nitrogen-atoms, sulphur atom contain lone-pair electron, can form coordination structure of all shapes and colors with transition metal.In addition, the character such as biology that (thiosemicarbazone) compound has, catalysis, anti-oxidant, fluorescence, inhibition, makes it to have broad application prospects in fields such as pharmacy, biology, chemical industry, functional materials, technical analysis.
Summary of the invention
The object of this invention is to provide a kind of dichloro-salicylaldehyde's thiourea derivative and application thereof.
The molecular structural formula of dichloro-salicylaldehyde's thiourea derivative is:
Described dichloro-salicylaldehyde's thiourea derivative is applied to antibacterial.
Dichloro-salicylaldehyde's thiourea derivative of the present invention has antibacterial effect in various degree to the raw bacillus of Ou Wenshi grass, intestinal bacteria and streptococcus aureus.
Embodiment
embodiment:
(1) molecular structural formula of dichloro-salicylaldehyde's thiourea derivative is:
(2) preparation method of dichloro-salicylaldehyde's thiourea derivative is:
A. take thiocarbanil and O-Phenylene Diamine according to mol ratio 1:1, at 20 ℃, reaction generates intermediate
n-(2-amino) phenyl-
n-phenylthiourea, suction filtration is also used washing with alcohol three times, makes white solid after vacuum-drying.
B. get the white solid dissolve with ethanol of 80 milliliters that 5 mmoles (1.2165 grams) step a makes in the there-necked flask of 250 milliliters, get again 3 of 5 mmoles (0.9551 gram), 5-dichloro-salicylaldehyde with the dissolve with ethanol of 20 milliliters in beaker, when warming-in-water to 60 ℃, the latter is slowly splashed in above-mentioned there-necked flask, soon just there is salmon precipitation, continue back flow reaction 3 hours, cool overnight, there is orange red needle-like crystal to separate out, suction filtration is also used washing with alcohol three times, after vacuum-drying, make dichloro-salicylaldehyde's thiourea derivative, MS-ESI:m/z 413.8 (MH
-), Calcd. Mr:416.32.
(3) application of dichloro-salicylaldehyde's thiourea derivative:
By antibacterial experiment, find that dichloro-salicylaldehyde's thiourea derivative of the present embodiment has antibacterial effect in various degree to the raw bacillus of Ou Wenshi grass, intestinal bacteria and streptococcus aureus, table 1 is antibacterial experiment data.
Table 1 antibacterial experiment data (antibacterial circle diameter, mm)
Antibacterial circle diameter has weak anti-microbial activity at 7 ~ 8mm, has medium tenacity anti-microbial activity at 9 ~ 13mm, has stronger anti-microbial activity at 14 ~ 25mm.Can find out from upper table data, dichloro-salicylaldehyde's thiourea derivative of the present embodiment is medium on the weak side to the antibacterial effect of the raw bacillus of Ou Wenshi grass, intestinal bacteria and streptococcus aureus.
The chemical reagent using in embodiment is analytical pure.
Claims (2)
1. dichloro-salicylaldehyde's thiourea derivative, is characterized in that the molecular structural formula of this dichloro-salicylaldehyde's thiourea derivative is:
2. the application of dichloro-salicylaldehyde's thiourea derivative according to claim 1, is characterized in that described dichloro-salicylaldehyde's thiourea derivative is applied to antibacterial.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410057769.7A CN103819376A (en) | 2014-02-20 | 2014-02-20 | Dichloro salicylaldehyde thiourea derivative and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410057769.7A CN103819376A (en) | 2014-02-20 | 2014-02-20 | Dichloro salicylaldehyde thiourea derivative and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103819376A true CN103819376A (en) | 2014-05-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410057769.7A Pending CN103819376A (en) | 2014-02-20 | 2014-02-20 | Dichloro salicylaldehyde thiourea derivative and application thereof |
Country Status (1)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104592075A (en) * | 2014-12-28 | 2015-05-06 | 桂林理工大学 | Dichlorosalicylaldehyde thiourea derivative and application thereof |
| CN104610117A (en) * | 2015-02-21 | 2015-05-13 | 桂林理工大学 | Bis-phenylthiourea and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4268640A (en) * | 1978-11-22 | 1981-05-19 | Osaka Soda Co. Ltd. | Curable composition of halogen-containing polymer |
| EP2251687A1 (en) * | 2009-05-11 | 2010-11-17 | The Provost Fellows And Scholars Of The College Of The Holy and Undivided Trinity Of Queen Elizabeth Near Dublin | Colorimetric anion sensor element |
| CN103130695A (en) * | 2013-03-24 | 2013-06-05 | 桂林理工大学 | Thiourea schiff base derivative and application thereof |
-
2014
- 2014-02-20 CN CN201410057769.7A patent/CN103819376A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4268640A (en) * | 1978-11-22 | 1981-05-19 | Osaka Soda Co. Ltd. | Curable composition of halogen-containing polymer |
| EP2251687A1 (en) * | 2009-05-11 | 2010-11-17 | The Provost Fellows And Scholars Of The College Of The Holy and Undivided Trinity Of Queen Elizabeth Near Dublin | Colorimetric anion sensor element |
| CN103130695A (en) * | 2013-03-24 | 2013-06-05 | 桂林理工大学 | Thiourea schiff base derivative and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104592075A (en) * | 2014-12-28 | 2015-05-06 | 桂林理工大学 | Dichlorosalicylaldehyde thiourea derivative and application thereof |
| CN104610117A (en) * | 2015-02-21 | 2015-05-13 | 桂林理工大学 | Bis-phenylthiourea and application thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20140528 |