CN104041488B - A kind of bisphenol AF is as the application of antibacterial agent and anti-biotic material - Google Patents
A kind of bisphenol AF is as the application of antibacterial agent and anti-biotic material Download PDFInfo
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- CN104041488B CN104041488B CN201410179016.3A CN201410179016A CN104041488B CN 104041488 B CN104041488 B CN 104041488B CN 201410179016 A CN201410179016 A CN 201410179016A CN 104041488 B CN104041488 B CN 104041488B
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- bisphenol
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- biotic material
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Abstract
The invention discloses a kind of bisphenol AF as the application of antibacterial agent and anti-biotic material, belong to antibacterial agent field.Described a kind of bisphenol AF is as the application of antibacterial agent, and described bisphenol AF is applicable to the antibacterial agent of gram-positive bacteria, and the structural formula of described bisphenol AF is:
Description
Technical field
The present invention relates to antibacterial agent field, particularly a kind of bisphenol AF is as the application of antibacterial agent and anti-biotic material.
Background technology
Anti-biotic material is the new function material that a class has sterilization, bacteriostasis property, is widely used.Its nucleus is antibacterial agent, and antibacterial agent is mainly divided into two large classes: inorganic antiseptic and organic antibacterial agent, by adding in common material by a small amount of antibacterial agent, make it to have anti-microbial property.
Anti-biotic material is mainly divided into inorganic antibacterial material and organic anti-bacterial material.Although inorganic antibacterial material activity is high, easy to change, cost is higher; And organic antibacterial agent is due to poor heat resistance, be unsuitable for being added into plastics, resin, these defects all limit the scope of application of anti-biotic material.
Bisphenol AF (Bisphenol AF, BPAF) is the crosslinking agent in a kind of fluorubber industry, fluorubber goods can be made to have better heat endurance, flame resistance and stability by adding bisphenol AF.Simultaneously, the important synthon of the high molecular polymers such as bisphenol AF or polyamide, Merlon and epoxy resin, various high molecular polymers containing bisphenol AF are widely used in high-temperature composite material, and extensive use in the every field such as electrochemistry and space technology science.
Summary of the invention
In order to solve the problem of prior art, embodiments provide a kind of bisphenol AF as the application of antibacterial agent and anti-biotic material.Described technical scheme is as follows:
On the one hand, embodiments provide the application of a kind of bisphenol AF as antibacterial agent, described bisphenol AF is applicable to the antibacterial agent of gram-positive bacteria, and the structural formula of described bisphenol AF is:
On the other hand, embodiments provide a kind of anti-biotic material, described anti-biotic material comprises one in plastics and resin and bisphenol AF, and the mass fraction of described bisphenol AF is 5%-20%.
Preferably, the mass fraction of described bisphenol AF is 10%-20%.
Particularly, described plastics are polypropylene, polyethylene or polystyrene.
Particularly, described resin is epoxy resin or phenolic resins.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: bisphenol AF provided by the invention significantly can suppress the growth of gram-positive bacteria, be 4-16 μ g/ml to the minimal inhibitory concentration of staphylococcus aureus, bacillus and streptomycete etc., the antibacterial effect of this bisphenol AF visible is good, it is good antibacterial agent, anti-biotic material provided by the invention comprises bisphenol AF, antibiotic rate can be made to reach more than 90% by adding bisphenol AF, making this anti-biotic material can play good inhibitory action to the growth of gram-positive bacteria.
Embodiment
For making the object, technical solutions and advantages of the present invention clearly, below embodiment of the present invention is described further in detail.
Embodiment one
Bisphenol AF is carried out minimal inhibitory concentration (Minimum Inhibition Concentration, MIC) test experiments, specific experiment step is as follows:
Inoculate a little bacterium in the conical flask that LB medium (Luria-Bertani medium) is housed from flat board, 37 DEG C of incubator overnight cultivate 12h-14h; Wherein, bacterium comprises: gram-positive bacteria and Gram-negative bacteria; The formula of LB medium is as follows: tryptone (Tryptone) 10g/L, yeast extract (Yeast extract) 5g/L, sodium chloride (NaCl) 10g/L.
Draw from conical flask the 2nd day morning bacterium liquid with 1% volume ratio transfer in the conical flask of LB medium that 5ml is housed, continue in 37 DEG C of shaking tables and cultivate 4h-5h, be 0.6 ~ 0.8 to OD600 (OD600 represents the light absorption value of this bacterium liquid at 600nm wavelength place), and record the concrete OD value (optical density, optical density) of bacterium liquid.
With LB medium, the bacterium liquid after cultivation is diluted 1000 times, make bacterial concentration be 10
5cFU/ml, draws the bacterium liquid after dilution, and adds in 96 orifice plates, every hole 150 μ l.
Compound concentration is the bisphenol AF solution of 128 μ g/ml, and draw in the 1st hole that this bisphenol AF solution of 150 μ l adds in 96 orifice plates, after mixing, sucking-off 150 μ l is in the 2nd hole, by that analogy.
After dropwising, 96 orifice plates are put into shaking table and cultivate 12h-14h through 37 DEG C.
Visually observe, do not become the minimal inhibitory concentration that the muddy minimum concentration corresponding to hole is this bacterium, specifically see table 1.
Table 1 is the minimal inhibitory concentration (MIC) of bisphenol AF to several bacterium
From table 1, bisphenol AF has good inhibition to gram-positive bacteria.
The bisphenol AF that the embodiment of the present invention provides significantly can suppress the growth of gram-positive bacteria, be 4-16 μ g/ml to the minimal inhibitory concentration of staphylococcus aureus, bacillus and streptomycete etc., the antibacterial effect of this bisphenol AF visible is good, is good antibacterial agent.
Embodiment two
According to the method used in National Standard of the People's Republic of China's " particular/special requirement of antibacterial, degerming, the purification function anti-biotic material of family expenses and similar applications electrical equipment ", bisphenol AF is made an addition in polypropylene plastics and epoxy resin respectively and carries out antibacterial test, wherein, the mass fraction of bisphenol AF can be 5%, 10% and 20%.
Result of the test show, the interpolation mass fraction in polypropylene plastics and epoxy resin be 5% the antibiotic rate of bisphenol AF to staphylococcus aureus all reach more than 90%.
Preferably, the interpolation mass fraction in polypropylene plastics and epoxy resin is that the antibiotic rate of bisphenol AF to staphylococcus aureus of 10-20% all reaches more than 99%.
Anti-biotic material provided by the invention comprises bisphenol AF, antibiotic rate can be made to reach more than 90%, making this anti-biotic material can play good inhibitory action to the growth of gram-positive bacteria by adding bisphenol AF.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. bisphenol AF is as an application for antibacterial agent, and described bisphenol AF is applicable to the antibacterial agent of gram-positive bacteria, and the structural formula of described bisphenol AF is:
2. an anti-biotic material, is characterized in that, described anti-biotic material comprises plastics and bisphenol AF or comprises resin and bisphenol AF, and the mass fraction of described bisphenol AF is 5%-20%.
3. anti-biotic material according to claim 2, is characterized in that, the mass fraction of described bisphenol AF is 10%-20%.
4. anti-biotic material according to claim 2, is characterized in that, described plastics are polypropylene, polyethylene or polystyrene.
5. anti-biotic material according to claim 2, is characterized in that, described resin is epoxy resin or phenolic resins.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410179016.3A CN104041488B (en) | 2014-04-29 | 2014-04-29 | A kind of bisphenol AF is as the application of antibacterial agent and anti-biotic material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410179016.3A CN104041488B (en) | 2014-04-29 | 2014-04-29 | A kind of bisphenol AF is as the application of antibacterial agent and anti-biotic material |
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| Publication Number | Publication Date |
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| CN104041488A CN104041488A (en) | 2014-09-17 |
| CN104041488B true CN104041488B (en) | 2015-11-04 |
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| CN201410179016.3A Active CN104041488B (en) | 2014-04-29 | 2014-04-29 | A kind of bisphenol AF is as the application of antibacterial agent and anti-biotic material |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107897181A (en) * | 2017-12-08 | 2018-04-13 | 江汉大学 | A kind of application of bisphenol-A and anti-biotic material |
| CN114073239A (en) * | 2020-08-17 | 2022-02-22 | 江苏大学 | Construction method and detection method of caenorhabditis elegans model polluted by hexafluorobisphenol AF |
Citations (3)
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| CN101199449A (en) * | 2007-11-20 | 2008-06-18 | 中国人民解放军第四军医大学 | Application of hyamine antibiont on dentistry antibacterial replacement material |
| CN101353545A (en) * | 2008-08-26 | 2009-01-28 | 苏州市明大高分子科技材料有限公司 | UV curing antibiotic coating and preparation thereof |
| US20090099331A1 (en) * | 2007-05-23 | 2009-04-16 | Stmicroelectronics S.R.L. | Synthesis and characterization of a novel proton exchange membrane (pem) for applications in fuel cells |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6419307A (en) * | 1987-07-14 | 1989-01-23 | Idemitsu Petrochemical Co | Light transmittable plastic fiber |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090099331A1 (en) * | 2007-05-23 | 2009-04-16 | Stmicroelectronics S.R.L. | Synthesis and characterization of a novel proton exchange membrane (pem) for applications in fuel cells |
| CN101199449A (en) * | 2007-11-20 | 2008-06-18 | 中国人民解放军第四军医大学 | Application of hyamine antibiont on dentistry antibacterial replacement material |
| CN101353545A (en) * | 2008-08-26 | 2009-01-28 | 苏州市明大高分子科技材料有限公司 | UV curing antibiotic coating and preparation thereof |
Non-Patent Citations (3)
| Title |
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| "AF821的化学合成、抗真菌活性及其对真菌细胞超微结构的影响";洪盈;《沈阳药学院学报》;19880301;第174-181页 * |
| "BPA与3种双酚类化合物的联合作用雌激素效应";张洪昌;《环境科学》;20090115;第260-265页 * |
| "双酚AF的合成和应用";晨光化工研究院二室;《塑料工业》;19771028;第4-8页 * |
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