CN103819367A - Diethylin salicylaldehyde semicarbazone and application thereof - Google Patents
Diethylin salicylaldehyde semicarbazone and application thereof Download PDFInfo
- Publication number
- CN103819367A CN103819367A CN201410057766.3A CN201410057766A CN103819367A CN 103819367 A CN103819367 A CN 103819367A CN 201410057766 A CN201410057766 A CN 201410057766A CN 103819367 A CN103819367 A CN 103819367A
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- China
- Prior art keywords
- diethylin
- urea
- amino
- application
- salicylidene
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses diethylin salicylaldehyde semicarbazone and an application thereof. A structural formula of diethylin salicylaldehyde semicarbazone is shown in the description. The diethylin salicylaldehyde semicarbazone is used for antibiosis. The diethylin salicylaldehyde semicarbazone has different degrees of anti-bacterial effects for erwinia herbicola, escherichia coli and staphylococcus aureus.
Description
Technical field
The present invention relates to a kind of diethylin salicylidene Urea,amino-and the application in antibacterial field.
Background technology
Thiosemicarbazone derivatives belongs to the special western Buddhist alkali of a class, and it contains R
1-C=N-NH-CS-NH-R
2group.In group, nitrogen-atoms, sulphur atom contain lone-pair electron, can form coordination structure of all shapes and colors with transition metal.In addition, the character such as biology that (thiosemicarbazone) compound has, catalysis, anti-oxidant, fluorescence, inhibition, makes it to have broad application prospects in fields such as pharmacy, biology, chemical industry, functional materials, technical analysis.
Summary of the invention
The object of this invention is to provide a kind of diethylin salicylidene Urea,amino-and application.
Diethylin salicylidene Urea,amino-molecular structural formula be:
Described diethylin salicylidene Urea,amino-is applied to antibacterial.
Diethylin salicylidene Urea,amino-of the present invention has antibacterial effect in various degree to the raw bacillus of Ou Wenshi grass, intestinal bacteria and streptococcus aureus.
Embodiment
embodiment:
(1) diethylin salicylidene Urea,amino-molecular structural formula be:
(2) diethylin salicylidene Urea,amino-preparation method:
Get 5 mmole 4-diethylin salicylic aldehydes (0.9662 gram) and be placed in 100 milliliters of there-necked flasks also with 30 milliliters of anhydrous alcohol solutions, separately take 5 mmole Urea,amino-(0.3753 gram) and be dissolved in 20 ml distilled waters, warming-in-water to 80 ℃, the latter is slowly splashed into the former, add again 1.5 milliliters of Glacial acetic acid, continue back flow reaction 4 hours, after leaving standstill, add distilled water extraction, there is pistac precipitation, suction filtration, and with the each washing of dehydrated alcohol and distilled water three times, be placed in the dry diethylin salicylidene Urea,amino-that makes of vacuum drying oven, MS-ESI:m/z 272.9 [M+Na]
+, Calcd. Mr:250.30.
(3) diethylin salicylidene Urea,amino-application:
By antibacterial experiment, find that the diethylin salicylidene Urea,amino-of the present embodiment has antibacterial effect in various degree to the raw bacillus of Ou Wenshi grass, intestinal bacteria and streptococcus aureus, table 1 is antibacterial experiment data.
Table 1 antibacterial experiment data (antibacterial circle diameter, mm)
Antibacterial circle diameter has weak anti-microbial activity at 7 ~ 8mm, has medium tenacity anti-microbial activity at 9 ~ 13mm, has stronger anti-microbial activity at 14 ~ 25mm.Can find out from upper table data, the dimethylaminobenzaldehyde thiourea derivative of the present embodiment is medium to the antibacterial effect of the raw bacillus of Ou Wenshi grass, intestinal bacteria and streptococcus aureus.
The chemical reagent using in embodiment is analytical pure.
Claims (2)
1. a diethylin salicylidene Urea,amino-, it is characterized in that this diethylin salicylidene Urea,amino-molecular structural formula be:
。
According to claim 1 diethylin salicylidene Urea,amino-application, it is characterized in that described diethylin salicylidene Urea,amino-is applied to antibacterial.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410057766.3A CN103819367A (en) | 2014-02-20 | 2014-02-20 | Diethylin salicylaldehyde semicarbazone and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410057766.3A CN103819367A (en) | 2014-02-20 | 2014-02-20 | Diethylin salicylaldehyde semicarbazone and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103819367A true CN103819367A (en) | 2014-05-28 |
Family
ID=50754704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410057766.3A Pending CN103819367A (en) | 2014-02-20 | 2014-02-20 | Diethylin salicylaldehyde semicarbazone and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103819367A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107337950A (en) * | 2017-07-21 | 2017-11-10 | 南京信息工程大学 | Fluorescent paint and preparation method thereof made of bigcatkin willow aldehydes schiff bases |
-
2014
- 2014-02-20 CN CN201410057766.3A patent/CN103819367A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 冯舒航 等: "光致变色4-二乙胺基水杨醛缩对碘苯胺席夫碱的固相合成及其发光性能", 《功能材料》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107337950A (en) * | 2017-07-21 | 2017-11-10 | 南京信息工程大学 | Fluorescent paint and preparation method thereof made of bigcatkin willow aldehydes schiff bases |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140528 |