CN103724226A - Concentrated hydrazine hydrate derivative of benzaldehyde and application of derivative - Google Patents
Concentrated hydrazine hydrate derivative of benzaldehyde and application of derivative Download PDFInfo
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- CN103724226A CN103724226A CN201410024615.8A CN201410024615A CN103724226A CN 103724226 A CN103724226 A CN 103724226A CN 201410024615 A CN201410024615 A CN 201410024615A CN 103724226 A CN103724226 A CN 103724226A
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- Prior art keywords
- derivative
- benzaldehyde
- hydrazine hydrate
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- phenyl aldehyde
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a concentrated hydrazine hydrate derivative of benzaldehyde and an application of the derivative. The structural formula of the concentrated hydrazine hydrate derivative of benzaldehyde is (img file='2014100246158100004dest_path_image001. TIF' wi='448' he='72' /). The concentrated hydrazine hydrate derivative of benzaldehyde is applied to antibacterial field. The concentrated hydrazine hydrate derivative of benzaldehyde has the antibacterial effects on Erwinia herbicola, escherichia coli and staphylococcus aureus in different degrees.
Description
Technical field
The present invention relates to a kind of phenyl aldehyde shrinks and closes hydrazine derivative and the application on antibacterial thereof.
Background technology
Schiff base derivatives, in fields such as antibacterial, antitumor, catalysis, magnetic, optics, electrochemistry, nonlinear optics and chemical sensors, has been widely used, and therefore becomes the focus of current research.
Summary of the invention
The object of this invention is to provide a kind of phenyl aldehyde shrink and close hydrazine derivative and application thereof.
The structural formula that hydrazine derivative is closed in phenyl aldehyde shrink is:
Described phenyl aldehyde shrink close hydrazine derivative be applied in antibacterial on.
Phenyl aldehyde of the present invention shrinks and closes hydrazine derivative to the raw bacillus of Ou Wenshi grass, and intestinal bacteria and streptococcus aureus have antibacterial effect in various degree.
Embodiment
embodiment:
(1) the phenyl aldehyde structural formula close hydrazine derivative that shrinks is:
(2) the phenyl aldehyde preparation method close hydrazine derivative of shrinking is:
25mL is dissolved with to 1.4919g(10mmol) ethanol solution of paradimethy laminobenzaldehyde is placed in the 50mL three-necked flask that reflux condensate device is housed, and in 20 ℃ of thermostat water baths magnetic agitation; Dropwise dripping 10mL, to be dissolved with 0.2425mL (5mmol) density be the ethanol solution of 1.032g/mL hydrazine hydrate again; Reflux 4 hours, visible yellow color Precipitation; With obtaining yellow solid after rotatory evaporator evaporation, be phenyl aldehyde and shrink and close hydrazine derivative.
(3) application that phenyl aldehyde shrinks and closes hydrazine derivative:
Antibacterial: in antibacterial experiment, the phenyl aldehyde that discovery the present embodiment makes shrinks and closes hydrazine derivative to the raw bacillus of Ou Wenshi grass, and intestinal bacteria and streptococcus aureus have antibacterial effect in various degree.Table 1 is antibacterial experiment data.
Table 1. bacteriostatic experiment result/antibacterial circle diameter (mm)
| Concentration (mg/mL) | Intestinal bacteria | Streptococcus aureus | The raw bacillus of Ou Wenshi grass |
| 0.25 | 7.56 | 6.46 | 7.76 |
| 0.5 | 7.8 | 7.16 | 7.84 |
| 1 | 8.54 | 8.3 | 8.12 |
| 1.5 | 9.56 | 8.42 | 8.02 |
| 2 | 9.88 | 8.58 | 9.04 |
(note: the bacteriostatic activity of title complex has weak bacteriostatic activity at 7 ~ 8mm; 9 ~ 13mm has medium tenacity bacteriostatic activity; 14 ~ 25mm has stronger bacteriostatic activity.）
The chemical reagent using in embodiment is analytical pure.
Claims (2)
1. phenyl aldehyde shrinks and closes a hydrazine derivative, it is characterized in that molecular structural formula is:
。
2. the application that phenyl aldehyde according to claim 1 shrinks and closes hydrazine derivative, it is characterized in that described phenyl aldehyde shrink close hydrazine derivative be applied in antibacterial on.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410024615.8A CN103724226A (en) | 2014-01-20 | 2014-01-20 | Concentrated hydrazine hydrate derivative of benzaldehyde and application of derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410024615.8A CN103724226A (en) | 2014-01-20 | 2014-01-20 | Concentrated hydrazine hydrate derivative of benzaldehyde and application of derivative |
Publications (1)
| Publication Number | Publication Date |
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| CN103724226A true CN103724226A (en) | 2014-04-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410024615.8A Pending CN103724226A (en) | 2014-01-20 | 2014-01-20 | Concentrated hydrazine hydrate derivative of benzaldehyde and application of derivative |
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| CN (1) | CN103724226A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104183873A (en) * | 2014-09-07 | 2014-12-03 | 桂林理工大学 | Electrolyte containing Bi-(p-(N,N,N-dodecyl dimethylamino ammonium bromide) benzaldehyde) hydrazine and preparation method of electrolyte |
| CN104241709A (en) * | 2014-09-07 | 2014-12-24 | 桂林理工大学 | Electrolyte containing bis-(p-N,N,N-tetradecyl dimethylamino ammonium bromide) benzaldehyde) hydrazine and preparation method of electrolyte containing bis-(p-N,N,N-tetradecyl dimethylamino ammonium bromide) benzaldehyde) hydrazine |
| CN106380423A (en) * | 2016-08-25 | 2017-02-08 | 中国科学院上海微系统与信息技术研究所 | Compound capable of detecting organophosphate neurotoxic agent stimulants and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103086919A (en) * | 2013-01-24 | 2013-05-08 | 桂林理工大学 | In-situ synthesis method for 4-(diethylamino)-salicylaldehyde hydrazine hydrate bis-schiff base |
-
2014
- 2014-01-20 CN CN201410024615.8A patent/CN103724226A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103086919A (en) * | 2013-01-24 | 2013-05-08 | 桂林理工大学 | In-situ synthesis method for 4-(diethylamino)-salicylaldehyde hydrazine hydrate bis-schiff base |
Non-Patent Citations (2)
| Title |
|---|
| 孙宏 等: "对二甲氨基苯甲醛分光光度法测定水中肼", 《环境科学》 * |
| 王坤 等: "双对二甲氨基苯甲醛缩连氮的合成及其对金属离子的识别", 《内蒙古石油化工》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104183873A (en) * | 2014-09-07 | 2014-12-03 | 桂林理工大学 | Electrolyte containing Bi-(p-(N,N,N-dodecyl dimethylamino ammonium bromide) benzaldehyde) hydrazine and preparation method of electrolyte |
| CN104241709A (en) * | 2014-09-07 | 2014-12-24 | 桂林理工大学 | Electrolyte containing bis-(p-N,N,N-tetradecyl dimethylamino ammonium bromide) benzaldehyde) hydrazine and preparation method of electrolyte containing bis-(p-N,N,N-tetradecyl dimethylamino ammonium bromide) benzaldehyde) hydrazine |
| CN104183873B (en) * | 2014-09-07 | 2017-01-11 | 桂林理工大学 | Electrolyte containing Bi-(p-(N,N,N-dodecyl dimethylamino ammonium bromide) benzaldehyde) hydrazine and preparation method of electrolyte |
| CN106380423A (en) * | 2016-08-25 | 2017-02-08 | 中国科学院上海微系统与信息技术研究所 | Compound capable of detecting organophosphate neurotoxic agent stimulants and application thereof |
| CN106380423B (en) * | 2016-08-25 | 2018-03-30 | 中国科学院上海微系统与信息技术研究所 | The compound of the detectable organophosphate nerve agents analogies of one kind and its application |
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Application publication date: 20140416 |