CN103113276B - Dithiobiurea derivative and application thereof - Google Patents

Dithiobiurea derivative and application thereof Download PDF

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Publication number
CN103113276B
CN103113276B CN201310075331.7A CN201310075331A CN103113276B CN 103113276 B CN103113276 B CN 103113276B CN 201310075331 A CN201310075331 A CN 201310075331A CN 103113276 B CN103113276 B CN 103113276B
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China
Prior art keywords
dithioureas
derivative
application
dithiobiurea
recognition
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CN103113276A (en
Inventor
丁国华
江道勇
高蕊
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Guilin University of Technology
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Guilin University of Technology
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention discloses a dithiobiurea derivative and an application thereof. The molecular structural formula of the bisthiobiurea derivative is shown in the description. The dithiobiurea derivative is applied to antibiosis and anion recognition. The dithiobiurea derivative provided by the invention has different antibacterial effects on erwinia herbicola, escherichia coli and staphylococcus aureus, and shows high sensitive recognition selectivity to part of anions.

Description

A kind of Dithioureas and application
Technical field
The present invention relates to a kind of Dithioureas and in antibacterial and application Anion Recognition.
Background technology
Thiourea derivative, in fields such as antibacterial, antitumor, catalysis, magnetic, optics, electrochemistry, nonlinear optics, chemical sensors, has been widely used, and therefore becomes the focus of current research.
Summary of the invention
The object of this invention is to provide a kind of Dithioureas and application.
The molecular structural formula of Dithioureas is:
Figure 117483DEST_PATH_IMAGE001
。
Described Dithioureas is applied to antibacterial and Anion Recognition.
Dithioureas of the present invention is to the raw bacillus of Ou Wenshi grass, subtilis, and intestinal bacteria and streptococcus aureus have antibacterial effect in various degree, and anionic part is shown to highly sensitive identification selection.
Embodiment
embodiment:
(1) molecular structural formula of Dithioureas is:
Figure 446833DEST_PATH_IMAGE001
。
(2) Dithioureas is synthetic:
In the round-bottomed flask of 100 milliliters, add (1.35 grams of 10 mmoles, 1.2 milliliters) thiocarbanil and 10 milliliters of anhydrous methanols, on magnetic stirring apparatus, stir 20 minutes, add again with 10 mmoles (0.76 gram) thiocarbamide and 10 milliliters of mixing solutionss that anhydrous methanol is made, heating reflux reaction 3.5 hours, filter, and use respectively cold dehydrated alcohol, anhydrous methanol and anhydrous diethyl ether washing, the mixed solvent recrystallization of the dehydrated alcohol that is finally 3:1 by volume ratio and dimethyl sulfoxide (DMSO) (DMF), obtain pale yellow crystals, be placed in vacuum drying oven 24 hours, make Dithioureas, output is 1.4 grams (productive rate is 66%).
(3) application of Dithioureas:
Antibacterial: in antibacterial experiment, find that Dithioureas is to the raw bacillus of Ou Wenshi grass, subtilis, intestinal bacteria and streptococcus aureus have antibacterial effect in various degree.
Anion Recognition: when introducing Cl in the dimethyl sulfoxide (DMSO) to Dithioureas (DMSO) solution -, H 2pO 4 -when negatively charged ion, all there is noticeable change in its solution colour and absorption spectrum, in view of Dithioureas reveals highly sensitive identification selection to these two kinds of anion forms, for making bore hole identification Cl -, H 2pO 4 -sensor.
The chemical reagent using in embodiment is analytical pure.

Claims (1)

1. Dithioureas, in an application for Anion Recognition, is characterized in that described Dithioureas molecular structural formula is:
；
Described Dithioureas is applied to Cl -and H 2pO 4 -these two kinds of Anion Recognition.
CN201310075331.7A 2013-03-11 2013-03-11 Dithiobiurea derivative and application thereof Expired - Fee Related CN103113276B (en)

Priority Applications (1)

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CN103113276B true CN103113276B (en) 2014-07-02

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104610119A (en) * 2015-02-21 2015-05-13 桂林理工大学 Bis-thiourea derivative and applications thereof
CN111103249A (en) * 2019-12-30 2020-05-05 南阳师范学院 Bis-thiourea anion recognition receptor and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101982460A (en) * 2010-09-16 2011-03-02 广西师范大学 Dehydroabieticacyl thiourea derivatives, preparation method thereof and application
WO2011066864A1 (en) * 2009-12-03 2011-06-09 Ecole Polytechnique Federale De Lausanne (Epfl) Method and compositions for inhibition of macrophage migration inhibitory factor (mif)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011066864A1 (en) * 2009-12-03 2011-06-09 Ecole Polytechnique Federale De Lausanne (Epfl) Method and compositions for inhibition of macrophage migration inhibitory factor (mif)
CN101982460A (en) * 2010-09-16 2011-03-02 广西师范大学 Dehydroabieticacyl thiourea derivatives, preparation method thereof and application

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Ai-Fang Li等.Anion complexation and sensing using modified urea and thiourea-based.《Chemical Society Reviews》.2010,第39卷(第10期),3729-3745.
Anion complexation and sensing using modified urea and thiourea-based;Ai-Fang Li等;《Chemical Society Reviews》;20101031;第39卷(第10期);第3729-3745页 *
G. M. Golzar Hossain 等.Synthesis and characterization of N1-phenylhydrazine-1,2-bis(carbothioamide) and its evaluation for antimicrobial, antioxidant and brine shrimp lethality bioassay.《Organic Chemistry International》.2012,第2012卷1-6.
Synthesis and characterization of N1-phenylhydrazine-1,2-bis(carbothioamide) and its evaluation for antimicrobial, antioxidant and brine shrimp lethality bioassay;G. M. Golzar Hossain 等;《Organic Chemistry International》;20121231;第2012卷;第2页 *
吴芳英 等.硫脲类阴离子受体的研究进展.《化学进展》.2004,第16卷(第5期),776-784.
硫脲类阴离子受体的研究进展;吴芳英 等;《化学进展》;20040930;第16卷(第5期);第776-784页 *

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