CN103113276A - Dithiobiurea derivative and application thereof - Google Patents
Dithiobiurea derivative and application thereof Download PDFInfo
- Publication number
- CN103113276A CN103113276A CN2013100753317A CN201310075331A CN103113276A CN 103113276 A CN103113276 A CN 103113276A CN 2013100753317 A CN2013100753317 A CN 2013100753317A CN 201310075331 A CN201310075331 A CN 201310075331A CN 103113276 A CN103113276 A CN 103113276A
- Authority
- CN
- China
- Prior art keywords
- dithioureas
- derivative
- application
- dithiobiurea
- dithiobiurea derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a dithiobiurea derivative and an application thereof. The molecular structural formula of the bisthiobiurea derivative is shown in the description. The dithiobiurea derivative is applied to antibiosis and anion recognition. The dithiobiurea derivative provided by the invention has different antibacterial effects on erwinia herbicola, escherichia coli and staphylococcus aureus, and shows high sensitive recognition selectivity to part of anions.
Description
Technical field
The present invention relates to a kind of Dithioureas and in antibiotic and application Anion Recognition.
Background technology
Thiourea derivative in fields such as antibacterial, antitumor, catalysis, magnetic, optics, electrochemistry, nonlinear optics, chemical sensors, has been widely used, and therefore becomes the focus of current research.
Summary of the invention
The purpose of this invention is to provide a kind of Dithioureas and application.
The molecular structural formula of Dithioureas is:
Described Dithioureas is applied to antibiotic and Anion Recognition.
Dithioureas of the present invention is to the living bacillus of Ou Wenshi grass, subtilis, and intestinal bacteria and streptococcus aureus have antibacterial effect in various degree, and anionic part is shown highly sensitive identification selection.
Embodiment
Embodiment:
(1) molecular structural formula of Dithioureas is:
(2) Dithioureas is synthetic:
add 10 mmoles (1.35 grams in the round-bottomed flask of 100 milliliters, 1.2 milliliter) thiocarbanil and 10 milliliters of anhydrous methanols, stirred 20 minutes on magnetic stirring apparatus, add again with 10 mmoles (0.76 gram) thiocarbamide and 10 milliliters of mixing solutionss that anhydrous methanol is made, heating reflux reaction 3.5 hours, filter, and use respectively cold dehydrated alcohol, anhydrous methanol and anhydrous diethyl ether washing, be the dehydrated alcohol of 3:1 and the mixed solvent recrystallization of dimethyl sulfoxide (DMSO) (DMF) with volume ratio at last, obtain pale yellow crystals, be placed in vacuum drying oven 24 hours, namely make Dithioureas, output is 1.4 grams (productive rate is 66%).
(3) application of Dithioureas:
Antibiotic: in antibacterial experiment, find Dithioureas to the living bacillus of Ou Wenshi grass, subtilis, intestinal bacteria and streptococcus aureus have antibacterial effect in various degree.
Anion Recognition: when introduce Cl in dimethyl sulfoxide (DMSO) (DMSO) solution of Dithioureas
-, H
2PO
4 -During negatively charged ion, noticeable change has all occured in its solution colour and absorption spectrum, in view of Dithioureas reveals highly sensitive identification selection to these two kinds of anion forms, is used for making bore hole identification Cl
-, H
2PO
4 -Sensor.
The chemical reagent that uses in embodiment is analytical pure.
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310075331.7A CN103113276B (en) | 2013-03-11 | 2013-03-11 | Dithiobiurea derivative and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310075331.7A CN103113276B (en) | 2013-03-11 | 2013-03-11 | Dithiobiurea derivative and application thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103113276A true CN103113276A (en) | 2013-05-22 |
CN103113276B CN103113276B (en) | 2014-07-02 |
Family
ID=48411694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310075331.7A Expired - Fee Related CN103113276B (en) | 2013-03-11 | 2013-03-11 | Dithiobiurea derivative and application thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103113276B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104610119A (en) * | 2015-02-21 | 2015-05-13 | 桂林理工大学 | Bis-thiourea derivative and applications thereof |
CN111103249A (en) * | 2019-12-30 | 2020-05-05 | 南阳师范学院 | Bis-thiourea anion recognition receptor and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101982460A (en) * | 2010-09-16 | 2011-03-02 | 广西师范大学 | Dehydroabieticacyl thiourea derivatives, preparation method thereof and application |
WO2011066864A1 (en) * | 2009-12-03 | 2011-06-09 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method and compositions for inhibition of macrophage migration inhibitory factor (mif) |
-
2013
- 2013-03-11 CN CN201310075331.7A patent/CN103113276B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011066864A1 (en) * | 2009-12-03 | 2011-06-09 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method and compositions for inhibition of macrophage migration inhibitory factor (mif) |
CN101982460A (en) * | 2010-09-16 | 2011-03-02 | 广西师范大学 | Dehydroabieticacyl thiourea derivatives, preparation method thereof and application |
Non-Patent Citations (3)
Title |
---|
AI-FANG LI等: "Anion complexation and sensing using modified urea and thiourea-based", 《CHEMICAL SOCIETY REVIEWS》, vol. 39, no. 10, 31 October 2010 (2010-10-31), pages 3729 - 3745 * |
G. M. GOLZAR HOSSAIN 等: "Synthesis and characterization of N1-phenylhydrazine-1,2-bis(carbothioamide) and its evaluation for antimicrobial, antioxidant and brine shrimp lethality bioassay", 《ORGANIC CHEMISTRY INTERNATIONAL》, vol. 2012, 31 December 2012 (2012-12-31), pages 1 - 6 * |
吴芳英 等: "硫脲类阴离子受体的研究进展", 《化学进展》, vol. 16, no. 5, 30 September 2004 (2004-09-30), pages 776 - 784 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104610119A (en) * | 2015-02-21 | 2015-05-13 | 桂林理工大学 | Bis-thiourea derivative and applications thereof |
CN111103249A (en) * | 2019-12-30 | 2020-05-05 | 南阳师范学院 | Bis-thiourea anion recognition receptor and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN103113276B (en) | 2014-07-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103130695B (en) | Thiourea schiff base derivative and application thereof | |
Alaghaz et al. | Synthesis, spectroscopic identification, thermal, potentiometric and antibacterial activity studies of 4-amino-5-mercapto-S-triazole Schiff’s base complexes | |
Gowda et al. | Synthesis, antimicrobial, DNA-binding and photonuclease studies of Cobalt (III) and Nickel (II) Schiff base complexes | |
Chandra et al. | Syntheses, spectroscopic characterization, thermal study, molecular modeling, and biological evaluation of novel Schiff’s base benzil bis (5-amino-1, 3, 4-thiadiazole-2-thiol) with Ni (II), and Cu (II) metal complexes | |
Shebl et al. | Synthesis, spectroscopic studies, molecular modeling and antimicrobial activity of binuclear Co (II) and Cu (II) complexes of 4, 6-diacetylresorcinol | |
Shebl et al. | Structural diversity in binuclear complexes of alkaline earth metal ions with 4, 6-diacetylresorcinol | |
Jadhav et al. | Synthesis, spectral, thermal, potentiometric and antimicrobial studies of transition metal complexes of tridentate ligand | |
CN103113276B (en) | Dithiobiurea derivative and application thereof | |
Abdel Aziz et al. | Synthesis, spectral characterization, SEM, antimicrobial, antioxidative activity evaluation, DNA binding and DNA cleavage investigation of transition metal (II) complexes derived from a tetradentate Schiff base bearing thiophene moiety | |
CN103159655B (en) | Salicylic aldehyde thiourea derivative and application thereof | |
Nishat et al. | Synthesis, spectral characterization and biocidal activity of thermally stable polymeric Schiff base and its polymer metal complexes | |
CN103159654B (en) | Thiourea derivative and application | |
CN104557988B (en) | Nitrogen heterocyclic schiff bases silver complex and its preparation method and application | |
CN103145596B (en) | Double-phenyl thiourea derivative and application thereof | |
Kharadi et al. | In‐vitro antimicrobial, thermal and spectral studies of mixed ligand Cu (II) heterochelates of clioquinol and coumarin derivatives | |
Leela et al. | Synthesis, characterization, antimicrobial, DNA binding and cleavage studies of mixed ligand Cu (II), Co (II) complexes | |
Hassan et al. | Synthesis, characterization, speciation and biological studies on metal chelates of 1-benzoyl (1, 2, 4-triazol-3-yl) thiourea | |
CN103113275A (en) | Double-phenyl thiourea derivative and application thereof | |
CN103999872B (en) | Metal gel nano material of a kind of silver ion and preparation method thereof and application | |
CN103113310A (en) | Thiouracil derivative and application thereof | |
CN103724226A (en) | Concentrated hydrazine hydrate derivative of benzaldehyde and application of derivative | |
Jin et al. | Structure, luminescent and thermal properties of two novel lanthanide complexes with 3, 4-diethoxybenzoic acid and 5, 5′-dimethy-2, 2′-bipyridine | |
Čermáková et al. | Syntheses and magnetic properties of trinuclear trithiocyanurato-bridged manganese (II) complexes involving bidentate aromatic N-donor heterocycles | |
El-Ghamry et al. | Synthesis, structural, spectroscopic, biological and catalytic activity of Co (II), Ni (II) and Cu (II) complexes of benzilic hydrazide (BH) | |
CN105504089A (en) | P-nitrophenyl urea chitosan derivative and application |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140702 Termination date: 20210311 |