CN103159654B - Thiourea derivative and application - Google Patents

Thiourea derivative and application Download PDF

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Publication number
CN103159654B
CN103159654B CN201310104368.8A CN201310104368A CN103159654B CN 103159654 B CN103159654 B CN 103159654B CN 201310104368 A CN201310104368 A CN 201310104368A CN 103159654 B CN103159654 B CN 103159654B
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China
Prior art keywords
thiourea derivative
urea derivatives
application
thiocarbamide urea
thiocarbamide
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Expired - Fee Related
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CN201310104368.8A
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Chinese (zh)
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CN103159654A (en
Inventor
丁国华
江道勇
高蕊
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Guilin University of Technology
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Guilin University of Technology
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention discloses a thiourea derivative and application. The structural formula of the thiourea derivative is shown in the specification. The thiourea derivative is applied to bacteria resistance and anion recognition, has different degrees of antibacterial effects on bacillus subtilis, erwinia herbicola, escherichia coli and staphylococcus aureus and shows high-sensitivity recognition selectivity on part of negative ions.

Description

A kind of thiocarbamide urea derivatives and application
Technical field
The present invention relates to a kind of thiocarbamide urea derivatives and the application in antibacterial and Anion Recognition thereof.
Background technology
Thiourea derivative, in fields such as antibacterial, antitumor, catalysis, magnetic, optics, electrochemistry, nonlinear optics and chemical sensors, has been widely used, and therefore becomes the focus of current research.
Summary of the invention
The object of this invention is to provide a kind of thiocarbamide urea derivatives and application thereof.
The structural formula of thiocarbamide urea derivatives is:
?。
Described thiocarbamide urea derivatives is applied in antibacterial and Anion Recognition.
Thiocarbamide urea derivatives of the present invention is to subtilis, the raw bacillus of Ou Wenshi grass, and subtilis, intestinal bacteria and streptococcus aureus have antibacterial effect in various degree, and anionic part is shown to highly sensitive identification selection.
Embodiment
embodiment:
(1) structural formula of thiocarbamide urea derivatives is:
?。
(2) preparation method of thiocarbamide urea derivatives is:
In the round-bottomed flask of 100 milliliters, add (1.2 milliliters of 10 mmoles, 1.35 grams) thiocarbanil and 20 milliliters of anhydrous methanols, on magnetic stirring apparatus, stir 20 minutes, add again with 10 mmoles (0.75 gram) Urea,amino-and 25 milliliters of solution that anhydrous methanol makes, heating reflux reaction 3.5 hours, filter and use respectively cold dehydrated alcohol, anhydrous methanol and anhydrous diethyl ether respectively wash 3 times, the dehydrated alcohol that is finally 3:1 by volume ratio and dimethyl sulfoxide (DMSO) (DMF) mixed solvent recrystallization, obtain pale yellow crystals, be placed in vacuum drying oven 24 hours, make thiocarbamide urea derivatives, output is 1.5 grams (productive rate is 71%).
(3) application of thiocarbamide urea derivatives:
Antibacterial: in antibacterial experiment, the thiocarbamide urea derivatives that the present embodiment makes is to subtilis, the raw bacillus of Ou Wenshi grass, subtilis, intestinal bacteria and streptococcus aureus have antibacterial effect in various degree.
Anion Recognition: the thiocarbamide urea derivatives that the present embodiment is made is dissolved in dimethyl sulfoxide (DMSO) (DMSO) and makes solution, then to introduce in the solution making F-, Cl-, H 2pO 4-negatively charged ion, all there is noticeable change in solution colour and absorption spectrum, in view of thiocarbamide urea derivatives reveals highly sensitive identification selection to these three kinds of anion forms, for make bore hole identification F-, Cl-, H 2pO 4-sensor.
The chemical reagent using in embodiment is analytical pure.

Claims (1)

1. an application for thiocarbamide urea derivatives, the molecular structural formula of this thiocarbamide urea derivatives is:
；
It is characterized in that described thiocarbamide urea derivatives is applied to antibacterial and Anion Recognition.
CN201310104368.8A 2013-03-28 2013-03-28 Thiourea derivative and application Expired - Fee Related CN103159654B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310104368.8A CN103159654B (en) 2013-03-28 2013-03-28 Thiourea derivative and application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310104368.8A CN103159654B (en) 2013-03-28 2013-03-28 Thiourea derivative and application

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CN103159654A CN103159654A (en) 2013-06-19
CN103159654B true CN103159654B (en) 2014-12-03

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104610118A (en) * 2015-02-21 2015-05-13 桂林理工大学 Phenylthiourea derivative and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3109859A (en) * 1960-10-21 1963-11-05 Monsanto Canada Ltd Disubstituted guanidines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3109859A (en) * 1960-10-21 1963-11-05 Monsanto Canada Ltd Disubstituted guanidines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A. Dutta Ahmed等.N-thiocarbamoyl-N’-carbamoyl hydrazine derivativesand their metal complexes.《J.inorg.nucl.Chem.》.1966,第28卷第1633页配体1. *
C.K Bradsher等.some 4-substituted thiourazoles.《Notes》.1958,第23卷第618页及第619页表1最后一个化合物. *
N-thiocarbamoyl-N’-carbamoyl hydrazine derivativesand their metal complexes;A. Dutta Ahmed等;《J.inorg.nucl.Chem.》;19661231;第28卷;第1633页配体1 *
some 4-substituted thiourazoles;C.K Bradsher等;《Notes》;19580430;第23卷;第618页及第619页表1最后一个化合物 *

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