CN103709083A - Benzaldehyde thiosemicarbazone derivative and application - Google Patents
Benzaldehyde thiosemicarbazone derivative and application Download PDFInfo
- Publication number
- CN103709083A CN103709083A CN201410024602.0A CN201410024602A CN103709083A CN 103709083 A CN103709083 A CN 103709083A CN 201410024602 A CN201410024602 A CN 201410024602A CN 103709083 A CN103709083 A CN 103709083A
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- Prior art keywords
- thiosemicarbazone derivative
- benzaldehyde thiosemicarbazone
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- benzaldehyde
- derivative
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- 0 CC(C=NNC(N)=S)=C*(*C=NNC(N)=S)=IC Chemical compound CC(C=NNC(N)=S)=C*(*C=NNC(N)=S)=IC 0.000 description 1
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a benzaldehyde thiosemicarbazone derivative and an application. The structural formula of the benzaldehyde thiosemicarbazone derivative is as shown in the specification. The benzaldehyde thiosemicarbazone derivative is applied to antibiosis and has the antibiosis effect of different degrees on Erwinia herbicola, escherichia coli and staphylococcus aureus.
Description
Technical field
The present invention relates to a kind of benzaldehyde thiosemicarbazone derivative and the application on antibacterial thereof.
Background technology
Thiocarbamide and Schiff base derivatives, in fields such as antibacterial, antitumor, catalysis, magnetic, optics, electrochemistry, nonlinear optics and chemical sensors, have been widely used, and therefore becomes the focus of current research.
Summary of the invention
The object of this invention is to provide a kind of benzaldehyde thiosemicarbazone derivative and application thereof.
The structural formula of benzaldehyde thiosemicarbazone derivative is:
Described benzaldehyde thiosemicarbazone derivative be applied in antibacterial on.
Benzaldehyde thiosemicarbazone derivative of the present invention is to the raw bacillus of Ou Wenshi grass, and intestinal bacteria and streptococcus aureus have antibacterial effect in various degree.
Embodiment
embodiment:
(1) structural formula of benzaldehyde thiosemicarbazone derivative is:
(2) preparation method of benzaldehyde thiosemicarbazone derivative is:
25mL is dissolved with to 0.1823g(2mmol) ethanol solution of thiosemicarbazide is placed in the 250mL three-necked bottle that reflux condensate device is housed, and in 80 ℃ of thermostat water baths magnetic agitation; Dropwise drip 9mL and be dissolved with 0.1341g(1mmol) ethanol solution of m-terephthal aldehyde; Drip 1mL Glacial acetic acid; Continue to reflux 5 hours, have milky white precipitate to separate out; Filtration obtains white solid and is benzaldehyde thiosemicarbazone derivative.
(3) application of benzaldehyde thiosemicarbazone derivative:
Antibacterial: in antibacterial experiment, the benzaldehyde thiosemicarbazone derivative that discovery the present embodiment makes is to the raw bacillus of Ou Wenshi grass, and intestinal bacteria and streptococcus aureus have antibacterial effect in various degree.Table 1 is antibacterial experiment data.
Table 1. antibacterial experiment result/inhibition zone (mm)
| Concentration (mg/mL) | Intestinal bacteria | Streptococcus aureus | Erwinia herbicola |
| 0.25 | 6.44 | 0.28 | 4.88 |
| 0.50 | 5.16 | 2.84 | 8.12 |
| 1.00 | 2.74 | 5.66 | 6.56 |
| 1.50 | 9.28 | 6.04 | 13.04 |
| 2.00 | 13.84 | 14.68 | 17.76 |
(note: compound has weak anti-microbial activity at 7 ~ 8mm; 9 ~ 13mm has medium tenacity anti-microbial activity; 14 ~ 25mm has stronger anti-microbial activity.)
The chemical reagent using in embodiment is analytical pure.
Claims (2)
1. a benzaldehyde thiosemicarbazone derivative, is characterized in that benzaldehyde thiosemicarbazone derivative molecular structural formula is:
。
2. the application of benzaldehyde thiosemicarbazone derivative according to claim 1, it is characterized in that described benzaldehyde thiosemicarbazone derivative be applied in antibacterial on.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410024602.0A CN103709083A (en) | 2014-01-20 | 2014-01-20 | Benzaldehyde thiosemicarbazone derivative and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410024602.0A CN103709083A (en) | 2014-01-20 | 2014-01-20 | Benzaldehyde thiosemicarbazone derivative and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103709083A true CN103709083A (en) | 2014-04-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410024602.0A Pending CN103709083A (en) | 2014-01-20 | 2014-01-20 | Benzaldehyde thiosemicarbazone derivative and application |
Country Status (1)
| Country | Link |
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| CN (1) | CN103709083A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106818767A (en) * | 2017-02-28 | 2017-06-13 | 山东农业大学 | A kind of composition pesticide and its preparation and application |
-
2014
- 2014-01-20 CN CN201410024602.0A patent/CN103709083A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| 刘春萍，等: "邻苯二甲醛双缩氨基硫脲Schiff碱及其银配合物的合成与表征", 《广州化工》 * |
| 张韬: "缩氨基硫脲的合成及其性能研究", 《绍兴文理学院学报》 * |
| 江元汝，等: "一种新型双Schiff碱及其配合物的合成", 《西安建筑科技大学学报（自然科学版）》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106818767A (en) * | 2017-02-28 | 2017-06-13 | 山东农业大学 | A kind of composition pesticide and its preparation and application |
| CN106818767B (en) * | 2017-02-28 | 2019-11-22 | 山东农业大学 | A kind of composition pesticide and its preparation and application |
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| PB01 | Publication | ||
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| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140409 |