CN103787913A - Salicylaldehyde anil derivative and application thereof - Google Patents
Salicylaldehyde anil derivative and application thereof Download PDFInfo
- Publication number
- CN103787913A CN103787913A CN201410057765.9A CN201410057765A CN103787913A CN 103787913 A CN103787913 A CN 103787913A CN 201410057765 A CN201410057765 A CN 201410057765A CN 103787913 A CN103787913 A CN 103787913A
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- CN
- China
- Prior art keywords
- salicylaldehyde
- anils
- salicylidene
- application
- anil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention discloses a salicylaldehyde anil derivative and application thereof. The molecular structural formula of the salicylaldehyde anil derivative is as shown in the specification, and the salicylaldehyde anil derivative is applied to anti-bacteria. The salicylaldehyde anil derivative disclosed by the invention achieves different degrees of anti-bacteria effect on Erwinia grass chrysanthemi, colibacillus and staphylococcus aureus.
Description
Technical field
The present invention relates to a kind of salicylidene anils and the application in antibacterial field thereof.
Background technology
Thiosemicarbazone derivatives belongs to the special western Buddhist alkali of a class, and it contains R
1-C=N-NH-CS-NH-R
2group.In group, nitrogen-atoms, sulphur atom contain lone-pair electron, can form coordination structure of all shapes and colors with transition metal.In addition, the character such as biology that (thiosemicarbazone) compound has, catalysis, anti-oxidant, fluorescence, inhibition, makes it to have broad application prospects in fields such as pharmacy, biology, chemical industry, functional materials, technical analysis.
Summary of the invention
The object of this invention is to provide a kind of salicylidene anils and application thereof.
The molecular structural formula of salicylidene anils is:
。
Described salicylidene anils is applied to antibacterial.
Salicylidene anils of the present invention has antibacterial effect in various degree to the raw bacillus of Ou Wenshi grass, intestinal bacteria and streptococcus aureus.
Embodiment
embodiment:
(1) molecular structural formula of salicylidene anils is:
(2) preparation method of salicylidene anils is:
Get 10 mmole salicylic aldehydes (1.1 milliliters) and be placed in 100 milliliters of there-necked flasks also with 20 milliliters of anhydrous alcohol solutions, separately taking 10 mmole 3-carboxyl aniline (1.3714 grams) is dissolved in 35 milliliters of dehydrated alcohols, cryosel is bathed control temperature, at 5 ~ 8 ℃, the latter is slowly splashed into the former, there is in the near future a large amount of faint yellow precipitations, continue reaction 1 hour, suction filtration after leaving standstill, and with absolute ethanol washing three times, be placed in the dry salicylidene anils, MS-ESI:m/z 240.1 (MH of making of silica gel drier
-); Calcd. Mr:241.24.
(3) application of salicylidene anils:
By antibacterial experiment, find that the salicylidene anils of the present embodiment has antibacterial effect in various degree to the raw bacillus of Ou Wenshi grass, intestinal bacteria and streptococcus aureus, table 1 is antibacterial experiment data.
Table 1 antibacterial experiment data (antibacterial circle diameter, mm)
Antibacterial circle diameter has weak anti-microbial activity at 7 ~ 8mm, has medium tenacity anti-microbial activity at 9 ~ 13mm, has stronger anti-microbial activity at 14 ~ 25mm.Can find out from upper table data, the salicylidene anils of the present embodiment is medium on the weak side to the antibacterial effect of the raw bacillus of Ou Wenshi grass, intestinal bacteria and streptococcus aureus.
The chemical reagent using in embodiment is analytical pure.
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201410057765.9A CN103787913A (en) | 2014-02-20 | 2014-02-20 | Salicylaldehyde anil derivative and application thereof |
Applications Claiming Priority (1)
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---|---|---|---|
CN201410057765.9A CN103787913A (en) | 2014-02-20 | 2014-02-20 | Salicylaldehyde anil derivative and application thereof |
Publications (1)
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CN103787913A true CN103787913A (en) | 2014-05-14 |
Family
ID=50664028
Family Applications (1)
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CN201410057765.9A Pending CN103787913A (en) | 2014-02-20 | 2014-02-20 | Salicylaldehyde anil derivative and application thereof |
Country Status (1)
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CN (1) | CN103787913A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111971271A (en) * | 2018-01-09 | 2020-11-20 | 香港理工大学 | Compound with antibacterial activity |
-
2014
- 2014-02-20 CN CN201410057765.9A patent/CN103787913A/en active Pending
Non-Patent Citations (2)
Title |
---|
李光华 等: "一种新的有机光致变色及热致变色化合物间氨基苯甲酸缩3,5二氯水杨醛希夫碱", 《发光学报》 * |
殷德飞 等: "含席夫碱基的螺吡喃双功能光致变色材料的合成及性质", 《高等学校化学学报》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111971271A (en) * | 2018-01-09 | 2020-11-20 | 香港理工大学 | Compound with antibacterial activity |
JP2021510143A (en) * | 2018-01-09 | 2021-04-15 | ザ ホンコン ポリテクニック ユニバーシティ | Compound with antibacterial activity |
EP3737664A4 (en) * | 2018-01-09 | 2021-12-01 | The Hong Kong Polytechnic University | Compounds with antimicrobial activity |
US11479529B2 (en) | 2018-01-09 | 2022-10-25 | The Hong Kong Polytechnic University | Compounds with antimicrobial activity |
CN111971271B (en) * | 2018-01-09 | 2023-10-10 | 香港理工大学 | Compound with antibacterial activity |
JP7450887B2 (en) | 2018-01-09 | 2024-03-18 | ザ ホンコン ポリテクニック ユニバーシティ | Compounds with antibacterial activity |
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Application publication date: 20140514 |