CN103783545B - A kind of preparation method of three marrow powder - Google Patents
A kind of preparation method of three marrow powder Download PDFInfo
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- CN103783545B CN103783545B CN201410034397.6A CN201410034397A CN103783545B CN 103783545 B CN103783545 B CN 103783545B CN 201410034397 A CN201410034397 A CN 201410034397A CN 103783545 B CN103783545 B CN 103783545B
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
- A23L13/20—Meat products; Meat meal; Preparation or treatment thereof from offal, e.g. rinds, skins, marrow, tripes, feet, ears or snouts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
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- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of preparation method of three marrow powder, first the brains of animal, marrow, spinal cord are extracted the effective ingredients such as composite phospholipid wherein by abstraction technique, then adopt hypothermic lyophilization technology above-mentioned effective ingredient to be made three marrow extract powders; Two, animal skeleton is extracted the effective ingredients such as its bone collagen polypeptide through biological enzymolysis, then through the method for high-pressure fog, the effective ingredients such as above-mentioned bone collagen polypeptide are prepared into bone extracts of animals powder; Three, the animal skeleton after enzymolysis after super-dry, then makes the full osteotrophy powder of animal by superfine communication technique; Four, three marrow extract powders, bone extracts of animals powder, animal full osteotrophy powder are aided with again the three marrow functional food that the collocation of plant derived foods science is prepared into various series after mixing according to a certain percentage.The three marrow powder produced economical and effectively can improve the physiological function of human body, can improve immunity and improve bone density and reduce bone to run off.
Description
Technical field
The present invention relates to a kind of preparation method of animal marrow powder, specifically a kind of preparation method of three marrow powder, belongs to functional food technical field.
Background technology
Modern medicine study shows, brains are nervous centralis command systems of human body, controls all physiological activities and the metabolic function of each organ-tissue.It not only commands the thinking of people, language, action, also control the immunologic function of human body self, is described as " headquarter "; Spinal cord is the nerve conduction system of human body, and all actions, the walking of people will lean on spinoneural conduction just can complete.If spinal cord interrupts, lower limb will be paralysed; The cord cell of people reduces, and just there will be slow in action, the phenomenons such as waist leg is ineffective, are described as " signal corps "; Marrow is the hematopoiesis wanted of body weight for humans and immune organ, ceaselessly manufactures various haemocyte and immunocyte its a moment, resists the invasion and attack of bacterium and virus, is described as " combat troop " that defendance is healthy.Both Each performs its own functions, cooperatively interacts again, indispensable for brains, spinal cord, marrow this " three marrows ".In China's Traditional Chinese medical theory, just there is the viewpoint of " marrow goes disease god smooth all over the body from being good for, blood loses Naokong to the empty essence of marrow from exhausting " from ancient times.Mend " mending marrow with the marrow " history in theoretical existing more than 3,000 year of human body marrow with animal marrow, record according to Compendium of Material Medica: " animal marrow (brains, spinal cord, marrow), property is sweet, enters kidney channel, has effect that marrow is supported in tonifying yin." proposition of king of medicine SUN Si miao: " marrow can be mended marrow, strengthen the bone, and promotes longevity." " Chinese medicinal herbal " record: " with animal three marrow, brains, marrow can be mended, beneficial consumptive disease, control neurasthenia, migraine and general headache and old man dizzy.”
Along with development that is biomedical and Life Engineering technology, more and more deep to the research of brains, spinal cord, marrow both at home and abroad, and be applied to clinical treatment.Such as: U.S., moral, Ying Deng state medical circle extract cerebrin, gangliosides, nerve growth factor from ox brain, be used for the treatment of craniocerebral injury, senile dementia, insomnia, the disease such as forgetful, the progress of making a breakthrough property, and gratifying effect is obtained in Anti-endotoxin activity is old, but learning to read and write based on Traditional Chinese doctors ', the active principle composition of comprehensive extraction animal three marrow is prepared into three marrow functional food aspects, yet there are no this report at present both at home and abroad.
Summary of the invention
For above-mentioned prior art Problems existing, the invention provides a kind of preparation method of three marrow powder, the active principle composition effectively extracting animal three marrow is prepared into three marrow functional food.
To achieve these goals, the technical solution used in the present invention is: a kind of preparation method of three marrow powder, comprises the following steps:
Three marrow extract powder preparations: the brains of animal, marrow, spinal cord are extracted composite phospholipid effective ingredient wherein by fluid extraction technology, then adopt hypothermic lyophilization technology that above-mentioned effective ingredient is made three marrow extract powders;
Prepared by bone extracts of animals powder: animal skeleton is extracted effective ingredient through biological enzymolysis, then through the method for high-pressure fog, above-mentioned effective ingredient is prepared into bone extracts of animals powder;
The full osteotrophy powder preparation of animal: the animal skeleton after enzymolysis after super-dry, then makes the full osteotrophy powder of animal by superfine communication technique;
Finally by three marrow extract powders, bone extracts of animals powder, the full osteotrophy powder mixing of animal.
Wherein, three marrow extract powder, preparation method thereof concrete steps are:
(1) get fresh brains, marrow and spinal cord are by rinsed with deionized water except crude removal, and clean, freezing rear chopping is for subsequent use;
(2) get brains, three marrows that marrow and spinal cord mix in 2:1:2 ratio are placed in extractor, are separated metabolism of lipid and cholesterol wherein, obtain phosphatide crude product;
(3) phosphatide crude product is added in benzinum in proportion carry out separating and extracting, then filter, after the filtrate heating water bath after filtration, namely obtain phosphatide;
(4) phosphatide is put into cool chamber,-1 to-3 DEG C is cooled to fully charge again from room temperature, then continue to be refrigerated to-17 to-19 DEG C, then vacuum drying is carried out, in vacuum drying chamber, pressure is less than 30Pa, temperature of heating plate is 28-31 DEG C, drying time 18-22 hour, the phosphatide powder made is three marrow extract powder.
The concrete steps preparing bone extracts of animals powder comprise:
(1) get fresh animal shin bone, spine, with deionized water high pressure washing except crude removal, and smash with broken bone machine;
(2) getting the Animal Bone after fragmentation, join in autoclaving tank, is 0.2-0.3Mpa boiling after 1-2 hour at pressure, by the fat in oil water separator removing Animal Bone;
(3) the Animal Bone mixture after degreasing is added trypsase in enzymatic vessel and carry out biological enzymolysis;
(4) be 95 DEG C in temperature, under time 10min condition, carry out going out enzyme;
(5) product after enzyme that goes out carries out spraying dry, makes bone extracts of animals powder.
The concrete steps of the full osteotrophy powder of preparation animal are:
(1) the spinal joints head that enzymolysis and extraction of learning from else's experience is crossed, then through poach twice, each amount of water is 6 times of bone amount; Remove not well-done residual meat and greasy, discard water cooking liquid;
(2) back cavity bone is boiled in water intaking, and drying, pulverizing make the full osteotrophy powder of animal.
The concrete steps being mixed with finished product are:
(1) learn from else's experience handle well three marrow extract powders, bone extracts of animals powder, the full osteotrophy powder of animal and bean powder, whole milk powder, combination vitamin, fully mix in three-dimensional mixer after weighing;
(2) material mixed more than, is sieved by stainless steel vibratory sieve, and rust steel vibrating screen mesh size is 40 orders.
Described " animal " refers to ox, buffalo, yak, pig or sheep.
The invention has the beneficial effects as follows: the present invention adopts fresh animal brains, marrow, spinal cord, spinal joints by overcritical and biological extractive technique, effectively phosphatide, bone collagen polypeptide, spinal joints powder are combined, that makes is aly rich in the mineral matter such as calcium, phosphorus, can improve immunity and improve bone density and reduce bone to run off.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1:
Three marrow extract powder preparations
1, get fresh ox brains 100Kg, marrow 50Kg and spinal cord 100Kg, by rinsed with deionized water except crude removal, clean residual water, freezing rear chopping is for subsequent use.
2, three marrows mixed are placed in supercritical extract tank, pass into supercritical CO 2 after sealing, operating temperature 45 degree, pressure 15MPa, is separated wherein metabolism of lipid and cholesterol, and extract is three marrow extract crude product 125Kg.
3, in 125Kg tri-marrow extract crude product, add 375Kg benzinum and carry out separating and extracting 5h, then filter, namely the filtrate after filtration obtain three marrow extract powder 85Kg after 30 DEG C of Water Under bath heating 8h.
4, three marrow extract powder 80Kg are put into cool chamber,-2 DEG C are cooled to very to fully charge from room temperature in 30min, (about 4h), then continue to be refrigerated to-18 DEG C, then at vacuum drying chamber inner drying, wherein in vacuum drying chamber, pressure is less than 30Pa, temperature of heating plate is 30 DEG C, 20 hours drying times, make three marrow extract powder 80Kg, moisture is less than 1%.
Two, bone extracts of animals powder preparation
1, get fresh ox shin bone 500Kg, spine 300Kg, with deionized water high pressure washing except crude removal, and smash ox bone with broken bone machine.
2, getting the ox bone after fragmentation, join in autoclaving tank, is 0.2Mpa boiling after 1 hour at pressure, by the fat in oil water separator removing extract.
3, the ox bone mixture after degreasing is added trypsase in 0.5% ratio in enzymatic vessel and enter biological enzymolysis 5 hours under temperature is 48 DEG C of conditions.
4, be 95 DEG C in temperature, under time 10min condition, carry out going out enzyme.
5, the product after enzyme that goes out is 140 DEG C at EAT, and temperature of outgoing air is carry out spraying dry under the condition of 70 DEG C, makes bone extracts of animals powder.
Three, the full osteotrophy powder preparation of animal:
The spinal joints head 200Kg that enzymolysis and extraction of learning from else's experience is crossed, then through poach twice, each amount of water is bone amount 1000Kg.Remove not well-done residual meat and greasy, discard water cooking liquid.
Ossa tibiale posterius head is boiled in water intaking, and drying, pulverizing make the full osteotrophy powder of animal.
Four, finished product packing
Learn from else's experience handle well three marrow extract powder 80Kg, bone extracts of animals powder 80Kg, bone extracts of animals powder 20Kg and bean powder 50Kg, whole milk powder 5Kg, combine vitamin 0.025Kg, fully mix in three-dimensional mixer after weighing.
The material more than mixed, is sieved by stainless steel vibratory sieve, requires whole mistake 40 eye mesh screen.Material after sieve, carries out packing by automatic packaging machine aluminium foil bag, single bag of net weight 30g.
After testing: product calcium content: 2300mg/100g, protein content: 18g/100g, three marrow extractive content: 50g/100g.
Embodiment 2:
One, three marrow extract powder preparations
1, get fresh ox brains 100Kg, marrow 50Kg and spinal cord 100Kg, by rinsed with deionized water except crude removal, clean residual water, freezing rear chopping is for subsequent use.
2, three marrows mixed are placed in supercritical extract tank, pass into supercritical CO 2 after sealing, operating temperature 55 degree, pressure 25MPa, is separated wherein metabolism of lipid and cholesterol, and extract is three marrow extract crude product 125Kg.
3,125Kg tri-marrow extract crude product adds 500Kg benzinum and carries out separating and extracting 6h, then filters, and namely the filtrate after filtration obtain three marrow extract powder 85Kg after 40 DEG C of Water Unders bath heating 7h.
4, three marrow extract powder are put into cool chamber,-2 DEG C are cooled to very to fully charge from room temperature in 30min, (about 4h), then continue to be refrigerated to-18 DEG C, in vacuum drying chamber, vacuum pressure is less than 30Pa, and temperature of heating plate is 30 DEG C, 20 hours drying times, make three marrow extract powder 80Kg, moisture is less than 1%.
Two, bone extracts of animals powder preparation
1, get fresh ox shin bone 500Kg, spine 300Kg, with deionized water high pressure washing except crude removal, and smash ox bone with broken bone machine.
2, getting the ox bone after fragmentation, join in autoclaving tank, is 0.3Mpa boiling after 1.5 hours at pressure, by the fat in oil water separator removing extract.
3, the ox bone mixture after degreasing is added trypsase in 1.0 % ratios in enzymatic vessel and enter biological enzymolysis 6 hours under temperature is 49 DEG C of conditions.
4, be 95 DEG C in temperature, under time 10min condition, carry out going out enzyme.
5, the product after enzyme that goes out is 160 DEG C at EAT, and temperature of outgoing air is carry out spraying dry under the condition of 80 DEG C, makes bone extracts of animals powder.
Three, the full osteotrophy powder preparation of animal:
The spinal joints head 200Kg that enzymolysis and extraction of learning from else's experience is crossed, then through poach twice, each amount of water is bone amount 1000Kg.Remove not well-done residual meat and greasy, discard water cooking liquid.
Ossa tibiale posterius, shin bone are boiled in water intaking, and drying, pulverizing make the full osteotrophy powder of animal.
Four, finished product packing
Learn from else's experience handle well three marrow extract powder 80Kg, bone extracts of animals powder powder 80Kg, animal full osteotrophy powder 20Kg and bean powder 10Kg, whole milk powder 5Kg, combine vitamin 0.025Kg, fully mix in three-dimensional mixer after weighing.
The material more than mixed, is sieved by stainless steel vibratory sieve, requires whole mistake 40 eye mesh screen.Material after sieve, carries out packing by automatic packaging machine aluminium foil bag, single bag of net weight 30g.
After testing: product calcium content: 2250mg/100g, protein content: 19g/100g, three marrow extractive content: 52g/100g.
The three marrow powder 200g chosen in embodiment 1 carry out clinical testing as product:
Research object selection measures through bmd of proximal femur the postmenopausal women that (considering that the more interference of the elderly's lumbar vertebrae hyperosteogeny is evaluated) is diagnosed as bone amount minimizing or osteoporotic 55 ~ 75 years old in Beijing Jishuitan Hospital, survey, general health check-up and corresponding laboratory examination is carried out by special messenger, get rid of secondary osteoporosis and take and affect Bone m etabolism medicine person, as hyperthyroidism, diabetes, liver-kidney diseases, the person etc. that takes glucocorticoid, be divided into three marrow powder group S and Caltrate D positive controls C at random.Complete data person S group is 36 examples, C group is 30 examples, mean age is respectively (65.3 ± 3.36) year and (64.9 ± 5.98) year, mean bone density is respectively 0.5389 ± 0.0672 and 0.5589 ± 0.576, through inspection, two groups of ages and the equal no difference of science of statistics of bone density (P>0.05).Research object is voluntary participation, and signs Informed Consent Form.According to the Ministry of Public Health " health food inspection and assessment technical specification " (version in 2003) and " human feeding trial code ", develop programs with reference to the requirement of U.S. FDA to osteoporosis research.S group takes 2 bag of two or three marrow powder for each person every day, point 2 clothes.C group takes Caltrate D 1.5 for each person every day, point 3 clothes.Two groups for each person every day supplementing calcium element content be 900mg, take 6 months continuously.Research object viewing duration must not take the medicine affecting Bone m etabolism, diet structure and life style constant.
Indexs measure and method:
BMD measures: adopt the XR.36 type dual intensity x line borne densitometers that Nodand company of the U.S. produces, and measures neck of femur, greater trochanter and Ward ' s trigonum, machine long-term Quality Control accuracy (CV) <1%.Adopt WHO Criteria of Osteoporosis b1, bone amount reduces: 2.5<T<1.0; Osteoporosis: T≤2.5.
Other detect: urinary hydroxyproline ultra-violet and visible spectrophotometer toluene-sodium-sulfonchloramide detection method, blood sugar glucose oxidase method, and routine blood test is with instrumental method (XT.1800i).Survey and general health check-up: comprise height, body weight, blood pressure, eyesight, age of meuopause, day activity, eating habit, father and mother and my medical history, situation etc. of taking medicine.
The change of bone symptom is observed: project is pain in back and loin, arthralgia, crouching play obstacle, tetany etc.
Syndrome Scale, nothing:
Nearly 1-2 months without uncomfortable sensation; Light: can to do not feel like oneself; In: significant discomfort, but can stand; Heavy: discomfort is difficult to stand.
Statistical procedures:
Compare and more all adopt between group the t inspection of front and back difference mean in bone density group; The change of bone symptom adopts the Chi-square Test of difference between front and back classification constituent ratio.P<0.05 judges that difference has conspicuousness, and P<0.01 is that difference has pole conspicuousness.
Ordinary circumstance:
Without major reaction event and the case of therefore withdrawing in test.Few patients slightly foretells fire (mouth, nose congestion and swelling pain etc.) after taking three marrow powder, taking Caltrate D has abdominal distension, constipation, drinks more water many can solution through eating vegetables and fruits.
Femoral neck bone mineral density situation of change:
After two groups of tests, near end of thighbone three position and mean bone density have increases (except C group neck of femur) in various degree,
But all there is not significant difference in each position of C group.S group is except neck of femur, and difference all has conspicuousness or pole conspicuousness, in table 1.
Ratio shared by near end of thighbone mean bone density rising number after experiment, S group is 75%, C group is 57%, and through inspection, t=1.58, P>0.05, not yet occur notable difference.
Bone symptom situation of change:
With lumbago, arthralgia that osteoporosis is the most common, squat down obstacle and tetany statistics, two groups all have improvement in various degree, but C group does not all occur significant difference.S group, except squatting down except obstacle, all has statistically significant or pole marked change, in table 2, table 3.
S group urine and blood index situation urinary hydroxyproline, creatinine (HOP, Cr), in S group detection 31 people, before examination, average is (35.64 ± 14.31) mg/g, is (31.23 ± 12.23) mg/g after examination, average 4.41 m/g, 12.4% that decline, no significant difference (t=1.36, P>O.05) before and after test.Hemoglobin, before test, average is (133.94 ± 8.46) g, L, and (135.65 ± 8.09) g/L after test, rise 1.71 g/L, and difference has conspicuousness (t=1.95, P<0.05).
Platelet count, before experiment, 205 × 109/L, 211 × 109/L after test, through statistical test no significant difference (P>0.05), but mean platelet volume increases to 9.45fl by 7.12fl, increase 2.42fl, increase by 34.0%, t=11.47, P<0.001, difference has pole conspicuousness.Blood pressure, blood fat, blood sugar, red in blood count, change equal not statistically significant (or in normal range (NR) fluctuation) before and after lymph corpuscle relative value.In S group eye test 30 people, by 60 eyes statistics, eyesight does not become 15 eyes (accounting for 25%), and visual impairment 2 eyes (accounting for 3%), eyesight improves 43 eyes (accounting for 72%).Through Chi-square Test, z2=3.024, P>0.05, show that change there is no significant.Calcium be control osteoporotic basic medication, but about the report of its anti-bone loss effect very not consistent.The H1 such as Aloia finds to have replenished the calcium long-term advantageous effect, but Dawson-Hughes does not find this effect, and finds that women that only dietary calcium intake is low plays advantageous effect to neck of femur after supplementing calcium.This test Caltrate D group is except neck of femur average minimizing 0.40%, greater trochanter Ward ' s triangle and mean bone density increase (though not yet occurring significant difference) all to some extent, also reflects this uncertainty, perhaps be similar to the old day for human beings calcium intake in Beijing area relatively high (Beijing 510.5 mg, the whole nation is 388.8 mg per capita) and above report.S group 4 position bone density all increases, and do not occur that silicon is shown except property except neck of femur only increases 0.31%, all the other 3 positions all increase considerably, and mean bone density increases by 1.61%, P<0.0025, and difference has pole conspicuousness.This post menopausal 55 ~ 75 years old annual bone amount of women on average decline 0.5-2.5% background under, seem very outstanding.In bone symptom, C group is efficient from 35% (lumbago) to 67% (tetany), and display seemingly has certain improvement, but not yet occurs significant difference.S group is efficient all has conspicuousness or pole conspicuousness from 60% (arthralgia) to 75% (tetany) difference, takes a turn for the better obvious.
Claims (1)
1. a preparation method for three marrow powder, is characterized in that comprising:
One, three marrow extract powder preparations
1, get fresh ox brains 100Kg, marrow 50Kg and spinal cord 100Kg, by rinsed with deionized water except crude removal, clean residual water, freezing rear chopping is for subsequent use,
2, three marrows mixed are placed in supercritical extract tank, pass into supercritical CO 2 after sealing, operating temperature 45 degree, pressure 15MPa, is separated wherein metabolism of lipid and cholesterol, and extract is three marrow extract crude product 125Kg,
3, in 125Kg tri-marrow extract crude product, add 375Kg benzinum and carry out separating and extracting 5h, then filter, namely the filtrate after filtration obtain three marrow extract powder 85kg after 30 DEG C of Water Under bath heating 8h,
4, three marrow extract powder 80Kg are put into cool chamber,-2 DEG C are cooled to until fully charge from room temperature in 30min, then continue to be refrigerated to-18 DEG C, then at vacuum drying chamber inner drying, wherein in vacuum drying chamber, pressure is less than 30Pa, and temperature of heating plate is 30 DEG C, 20 hours drying times, make three marrow extract powder 80Kg, moisture is less than 1%;
Two, bone extracts of animals powder preparation
1, get fresh ox shin bone 500Kg, spine 300Kg, with deionized water high pressure washing except crude removal, and smash ox bone with broken bone machine,
2, getting the ox bone after fragmentation, join in autoclaving tank, is 0.2Mpa boiling after 1 hour at pressure, by the fat in oil water separator removing extract,
3, the ox bone mixture after degreasing is added trypsase in 0.5% ratio in enzymatic vessel and enter biological enzymolysis 5 hours under temperature is 48 DEG C of conditions,
4, be 95 DEG C in temperature, under time 10min condition, carry out going out enzyme,
5, the product after enzyme that goes out is 140 DEG C at EAT, and temperature of outgoing air is carry out high-pressure spray-drying under the condition of 70 DEG C, makes bone extracts of animals powder;
Three, the full osteotrophy powder preparation of animal:
The spinal joints head 200Kg that enzymolysis and extraction of learning from else's experience is crossed, then through poach twice, each amount of water is 1000Kg, removes not well-done residual meat and greasy, discards water cooking liquid,
Back cavity bone is boiled in water intaking, and drying, ultramicro grinding make the full osteotrophy powder of animal;
Four, finished product packing:
Learn from else's experience handle well three marrow extract powder 80Kg, bone extracts of animals powder 80Kg, animal full osteotrophy powder 20Kg and bean powder 50Kg, whole milk powder 5Kg, combine vitamin 0.025Kg, fully mix in three-dimensional mixer after weighing,
The material more than mixed, is sieved by stainless steel vibratory sieve, requires whole mistake 40 eye mesh screen, and after sieve, material carries out packing by automatic packaging machine aluminium foil bag, single bag of net weight 30g.
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| CN107397219A (en) * | 2017-05-22 | 2017-11-28 | 青海高原红绿色保健制品有限公司 | A kind of marrow polypeptide powder of yak three and preparation method thereof |
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| CN108477507A (en) * | 2018-03-13 | 2018-09-04 | 江苏诺普乐生物科技有限公司 | A kind of natural no added three marrow meal replacement powders and preparation method thereof |
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| CN108991399A (en) * | 2018-08-01 | 2018-12-14 | 郑悦彤 | A kind of preparation method of ox marrow powder |
| CN109123442A (en) * | 2018-08-01 | 2019-01-04 | 郑悦彤 | A kind of preparation method of ox marrow piece |
| CN108949880B (en) * | 2018-08-03 | 2021-07-20 | 吉林大学 | Preparation method and application of bovine spinal peptide |
| CN115039811A (en) * | 2022-06-28 | 2022-09-13 | 陕西真创髓养医食研究有限公司 | Ternary medulla peptide with good absorption effect and production method thereof |
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Effective date of registration: 20160127 Address after: 221006 No. 9, Changxin Road, Third Industrial Park, Xuzhou hi tech Industrial Development Zone, Jiangsu, China Patentee after: JIANGSU NUOPULE BIOTECHNOLOGY CO., LTD. Address before: 221000, Bai village, Qingshan springs town, Jiawang District, Jiangsu, Xuzhou Patentee before: XUZHOU SANSUI BIOTECHNOLOGY CO., LTD. |
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Inventor after: Wu Shuxun Inventor before: Zhao Baomin |