CN107372835A - A kind of bone density that increases promotes the health nutrient of bone health to chew milk piece and preparation method thereof - Google Patents
A kind of bone density that increases promotes the health nutrient of bone health to chew milk piece and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/18—Milk in dried and compressed or semi-solid form
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
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- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The present invention discloses increase bone density and promotes the health nutrient of bone health to chew milk piece and preparation method thereof, and ultra-fine enzymolysis bone meal 26 parts by weight of the milk piece main component by deer shin bone or sheep shin bone are chewed in the nutrition；The parts by weight of wolfberry fruit powder 13, the parts by weight of whole milk powder 26 composition.It, with matrimony vine nourishing kidney yin, with the two effect of milk powder increase and adjustable flavor taste, plays strengthening the bones and muscles, the effect of contraction of dispelling pain altogether with ossein deer (sheep) bone warming and invigorating kidney Yang.Its preparation method collection micronized, enzymolysis, the high-new process technology of big medicine food of chewable tablets three is all over the body; and flavouring agent is done with milk powder; the bioavilability of functional component in product can not only be significantly improved; also there is the peculiar flavour of nutrition healthy food, to old age, gastrointestinal function is poor, long-term use of person is particularly suitable.
Description
Technical field
The present invention relates to a kind of health food and preparation method thereof technology, and in particular to one kind increase bone density promotes bone to be good for
The health nutrient of health chews milk piece and preparation method thereof.
Background technology
Osteoporosis is a kind of general metabolism skeletal diseases.It is characterized in that bone amount is reduced and bone tissue micro-structural is damaged,
Easily fractured so as to cause bone fragility to increase.At present, osteoporosis is with as having a strong impact on the global society of human health
Meeting common problem, but the cause and onset of disease mechanism sick to this is not yet fully apparent from, and lack special effective treatment method.Sclerotin
It is loose to betide different sexes and any age, but it is more common in mid-aged population.The epidemiology survey of 2006 shows, I
State there are about 69,440,000 people for more than 50 years old and suffer from osteoporosis in crowd, about 200,000,000 1 million peoples have Low BMD.
Bone amount reduction, osteoporosis, osteoporotic fracture are three disease course stages of osteoporosis.Osteoporosis
Property fracture be osteoporosis maximum harm, there is high disability rate, high mortality, high medical expense and family social burden
" three high " feature.The danger that osteoporosis fracture occurs in all one's life for women is 40%, and all one's life osteoporosis occurs for male
The danger of disease property fracture is 13%.
Bone density (BMD) measures, and is current diagnosis osteoporosis, prediction osteoporotic fracture risk, monitoring nature disease
Journey and the optimal quantitative criterion for evaluating therapeutic effect of drug intervention.Bone density value is less than with the agnate normal adult peak bone mass of sex not
It is normal for bone density during 1 standard deviation of foot；When bone density value reduces by 1~2.5 standard deviation for bone amount lowly (reduction)；Bone density
Value reduction degree is equal to or more than during 2.5 standard deviations be osteoporosis.
Modern medicine emphasizes that osteoporosis can prevent controlling, and prevents more more real and important than treating.To there is bone
The loose hazards of matter and the low person of bone amount, the target of preventing and treating are to prevent or delay it to develop into osteoporosis；To osteoporosis
The target of disease person preventing and treating is to avoid it from fracturing.
Preventing and treating the complete measure of osteoporosis includes five aspects：I.e.：Life style is adjusted, prevents from falling, bone health base
This replenishers, pharmaceutical intervention, athletic rehabilitation.The purpose is to：Improve the clinical symptoms such as ostalgia, improve bone density, improve bone mass,
Reduce fracture.
It is to prevent and treat the key link of osteoporosis to improve bone density.And it is used as the basic replenishers calcium of currently used bone health
And vitamin D, formed from bone in terms of required nutritional ingredient, for promoting bone health, then obvious deficiency be present.
The content of the invention
Present invention collection traditional Chinese medical science advantageous feature：The present invention is theoretical according to Chinese medicine experience, with ossein deer (sheep) bone warming and invigorating kidney Yang,
With matrimony vine nourishing kidney yin, with the two effect of milk powder increase and adjustable flavor taste, strengthening the bones and muscles is played altogether, the effect of contraction of dispelling pain.This hair
Bright methods described collection micronized, enzymolysis, the high-new process technology of big medicine food of chewable tablets three are the whole body, and do flavor with milk powder
Agent, the bioavilability of functional component in product, the also peculiar flavour with nutrition healthy food can be not only significantly improved,
To old age, gastrointestinal function is poor, long-term use of person is particularly suitable.
First, the present invention discloses a kind of chewing milk flake products for the healthcare function that there is increase bone density to promote bone health,
Its main component by deer shin bone or sheep shin bone ultra-fine enzymolysis bone meal 2-6 parts by weight；Wolfberry fruit powder 1-3 parts by weight, whole milk powder 2-6
Parts by weight form.
In addition, invention additionally discloses the preparation method of chewing milk piece described above, it comprises the following steps,
(1) prepared by ultra-fine enzymolysis bone meal：
1. scalding deodorization：By fresh deer shin bone or sheep shin bone, 2-5 times is added to measure water, 100 DEG C, 15-30 minutes/time, scalding 2-3
Secondary, clear water rinses；
2. boiling：Take the material of step 1. to add 2-5 times to measure water, airtight heating, pressure 0.1Mpa, 2-4 hour, take extraction
Liquid stand at low temperature, except degreasing；
3. grind：Fresh bone after step 2. boiling is crushed to below 0.5-1cm, is crushed to 300-500 mesh, high pressure
Homogeneous, bone oar is made；
4. digest：3. pulp that step obtains merges mixing, neutral proteinase/papain/tryptose with cooking liquor
Enzyme or its complex enzyme are digested；
5. it is spray-dried：Enzymolysis bone oar is adjusted to 60 DEG C of proportion 1.05-1.15, spray drying；
(2) prepared by wolfberry fruit powder：Matrimony vine water extracts 2-3 times, 60-90 DEG C of temperature；
(3) milk piece is chewed to prepare：The ultra-fine enzymolysis bone meal 2-6 parts by weight for taking step 1 to obtain；The wolfberry fruit powder that step 2 obtains
1-3 parts by weight, the mixing of whole milk powder 2-6 parts by weight, the maltitol or dextrin of 1-3 parts by weight are added, is mixed, granulation；Dry,
Whole grain；Tabletting.
In preferable technical scheme, for the preparation method of chewing milk piece described above, wherein described enzymolysis bar
Part is：55-80 DEG C, pH5.0-8.0,4-6 hour of temperature；Enzyme deactivation：60-80 DEG C, 30-60 minutes；
In preferable technical scheme, for the preparation method of chewing milk piece described above, wherein described matrimony vine water
Extracting method is：For the first time plus 8-10 times of water is measured, and for the second time plus 6-8 times of water is measured, 60-90 DEG C of temperature；Each extraction time 60-90 points
Clock；Merge extract solution, concentrate, spray drying.
In preferable technical scheme, for the preparation method of chewing milk piece described above, wherein described granulation side
Method is that softwood, the granulation of 12-14 mesh sieves is made with the ethanol of 60-70% concentration.
In preferable technical scheme, for the preparation method of chewing milk piece described above, wherein described drying, whole
Grain, the actual conditions of tabletting is as follows, dries：50-70 DEG C of temperature, hour time 4-6, moisture control below 8-12%；14-16 mesh
Whole grain is sieved, 0.5-1% silica/magnesium stearate is added and is well mixed；Tabletting：Finished product sheet hardness：3-4Kgf/mm2, piece weight：
1.0-2.0g/ piece.
The present invention intends the angle from full nutrients for bones, according to traditional Chinese medicine food therapy theory and experience, to increase bone density, promotes
Bone health, prevent and treat osteoporosis, there is provided a kind of safe and reliable health functional food convenient to take.
Beneficial effect
1. using the technique such as ball milling, high-pressure homogeneous, fresh bone is processed into superfine powder, to make it have good dissolubility,
Add the percent hydrolysis of bone collagen and the conversion ratio of bone calcium；
2. in the bone meal processing of routine, enzymolysis process is added, macromolecular bone collagen is hydrolyzed to micromolecule polypeptide
And amino acid, calcium phosphate enzymolysis is solubility calcium, promotes calcium to form chelating calcium with amino acid and small-molecular peptides chelant, can substantially carry
The absorption rate of high bone collagen and calcium.
3. modern pharmaceutical chewable tablets process technology is introduced health products manufacture field, there is product in good taste, can be with nozzle
Chew or, composition dissolution is rapid, absorb soon, bioavilability is high, steady quality, is convenient for carrying, is more suitable for designed for old people.
Full nutrients for bones advantage：Modern forward position theory of medicine of the invention based on bone aging and nutrients for bones, with reference to the traditional Chinese medical science
Shen controls bone and kidney deficiency marrow subtract the empty physiology interpretation of the cause, onset and process of an illness of bone, by the screening and assessment of the dietary therapy of Chinese medicine prescription to the successive dynasties, establish with bone
Powder warming and invigorating kidney Yang, kidney yin is nourished with matrimony vine, the two effect is aided in milk powder and also serves as the scientific formula of flavor conditioning agent.From efficient
Absorb and be easy to the angle taken, be that the modern of the present invention is protected using micronized, enzymolysis and the process technology high-new greatly of chewable tablets three
The Integration ofTechnology advantageous feature of health food.The present invention is osteoporosis, bone amount is low and its High risk group provides one kind newly
There is full nutrients for bones composition characteristic, have preferably increase bone density, promote the health nutrient of bone health to act on.Its milk
Flavor and the chewable product form for sucking clothes, are more suitable for designed for old people.
Brief description of the drawings
The process route chart of Fig. 1 present invention.
Embodiment
Following nonlimiting examples can make one of ordinary skill in the art be more fully understood the present invention, but not with
Any mode limits the present invention.
Embodiment 1
The present invention relates to a kind of there is increase bone density to promote the healthcare function of bone health to chew the product formula of milk piece
And preparation method thereof.The product is applied to osteoporosis, bone amount reduces and its High risk group.
1. prepared by ultra-fine enzymolysis bone meal：
1. scalding is except stench：By fresh deer shin bone, add 3 times of amount water, 100 DEG C, 15 minutes/time, scalding 2 times, clear water rinses 3
It is secondary.
2. boiling：Take material to be put into extractor and add 2 times of amount water, airtight heating, pressure 0.1Mpa, 2 hours, take extraction
Liquid stand at low temperature, grease is pumped, it is standby.
3. grind：Fresh bone after boiling is crushed to below 1cm, grinds (corase grind：70 mesh, fine grinding：300
Mesh), it is high-pressure homogeneous, bone oar is made.
4. digest：Pulp merges mixing, neutral protease enzymolysis with cooking liquor.Enzymatic hydrolysis condition：5 hours time, temperature 55
DEG C, pH7.0.Enzyme deactivation：80 DEG C, 30 minutes.Also papain/trypsase/complex enzyme zymohydrolysis can be used, its hydrolysis result is with
Property protease is without big difference.
5. it is spray-dried:Enzymolysis bone oar is adjusted to proportion 1.1 (60 DEG C), spray drying.
2. prepared by wolfberry fruit powder：Matrimony vine water extracts 2 times, 90 DEG C of temperature.For the first time plus 10 times of water is measured, second plus 6 times of amounts of water,
Each 60 minutes extraction times.Merge extract solution, concentrate, spray drying.
3. chew milk piece to prepare：
By ultra-fine 4 parts of enzymolysis bone deer shin bone；2 parts of wolfberry fruit powder, the ratio that 4 parts of whole milk powder weighs bone meal, wolfberry fruit powder, milk
Powder, add appropriate amount of auxiliary materials, be well mixed, softwood, the granulation of 14 mesh sieves is made with 60% ethanol.Dry：Temperature 60 C, 4 hours time,
Moisture control less than 10%.Whole grain：14 mesh sieve whole grains, add 1% silica and be well mixed.Tabletting：Finished product sheet hardness：3-
4Kgf/mm2, piece weight：1.0g/ piece.Each 2-4 pieces, it is daily 2-3 times.To dosage range like this, can be selected according to patient profiles edible
Time and dosage.
4. the fresh deer shin bone of the ultra-fine enzymolysis bone meal in above-mentioned steps 1 is changed to sheep shin bone, and according to 1~3 the step of system
It is standby to chew milk piece.
Embodiment 2
Deer/lamb bone meal, wolfberry fruit powder and its research of compatibility function of resisting osteoporosis
Purpose：Observe the effect of the anti-osteoporosis such as deer bone.
Model：Vitamin A acid causes mouse osteoporosis model.
Animal：SPF level kunming mices, male, body weight：25±2g.
Medicine：Vitamin A acid (Ai Li can)：10mg/ pieces, Shandong Liang Fu pharmaceutical Co. Ltds, lot number：150302..
Deer bone powder, lamb bone meal, wolfberry fruit powder are provided by Yao Xuantang Traditional Chinese healths research institute of Daliang City.
Test method：
If normal, model, lamb bone meal, deer bone powder, wolfberry fruit powder, sheep bone wolfberry fruit powder, totally 7 groups, every group 8 of deer bone wolfberry fruit powder.
Model control group gavage gives vitamin A acid 90mg/kg/d, 1 time a day.Each Germicidal efficacy group gives lamb bone meal etc. respectively；It is normal right
Isometric physiological saline is given according to group.2 times a day.Totally 15 days.Administration terminates next day, and solution takes right lateral thigh bone, surveys dry weight, ash
Weight.As a result 1. be see the table below
Lamb bone meal of table 1. etc. causes the protective effect of mouse osteoporosis to vitamin A acid
Note：*, compared with normal group, P<0.01；##, compared with model group, P<0.01；#, compared with model group, P<
0.05.
From the data analysis of above-mentioned table 1, it can be deduced that clear and definite conclusion：Though deer, sheep, wolfberry fruit powder cause mouse sclerotin to vitamin A acid
It is loose to have certain protective role or trend but best with compound compatibility effect.
Embodiment 3, eating effect of the present invention：Increasing action of the ossein to middle-aged and old bone densities
1. general information：Observe number of cases 32.Man 8, female 24.Age is 55-80 year.In 32, bone amount low 16
Example, bone density value -2.5<T≤- 1 is between；Osteoporosis 16, bone density T≤- 2.5.
2. tester：Ultrasonic bone density type analyzer.MQD-700. Jinan Ming Quan medical science and technologies Co., Ltd
3. detection position：At distal radius 1/3rd.
4. observation index：Bone density T values.
5. observation procedure：0 month：It is edible first 1 day；3 months：Eat 3 months next day；6 months：Eat 6 months next day；Each inspection
Survey 1 time.
6. eating method：Ossein：1g/ pieces.The dosage of first 3 months is 4 pieces/times, and 2 times/day, the dosage of latter 3 months is 3
Piece/times, 2 times/day.
7. observation unit：Traditional chinese medical science clinic of Yao Xuantang Traditional Chinese healths research institute of Daliang City.
8. observe result：Edible ossein 3 months, the bone density value full recovery of the low person of bone amount is normal, osteoporosis person
Close to normally.Edible ossein 6 months, bone amount is low and the bone density value full recovery of osteoporosis person is normal.The results detailed in：Table
2nd, table 3, table 4.
9. conclusion：The present invention promotes the effect of bone health with bone density is significantly increased.
Influence of the ossein of table 2. to middle-aged and old bone densities
The influence of the ossein of table 3. middle-aged and old bone densities low to bone amount
Influence of the ossein of table 4. to osteoporosis the elderly's bone density
Embodiment 4, typical case：
1st, Zhang Guoxian, female, 60 years old.Right fracture of tibia is postoperative, lumbago, and after Changes in weather, right leg is uncomfortable, Bone mineral density
T values are -2.3.Edible ossein 3 months, dosage are 4 pieces/times, 2 times/day.Pain disappears, and right leg sense of discomfort in Changes in weather disappears
Lose, leg is strong, has much energy.Bone mineral density T values are -0.5, recover normal.
2nd, Yang Shunfang, female, 79 years old.Lumbago, lower limb are heavy, diabetic history, and Bone mineral density T values are -3.6.Edible bone
Element 6 months, the dosage of first 3 months is 4 pieces/times, and 2 times/day, the dosage of latter 3 months is 3 pieces/times, 2 times/day.Eat 3 months waists
Backache disappears, and leg is strong, upper downstairs not in difficulty.Bone mineral density T values are -1.5 after edible 6 months, in good condition, are not had
There are the symptoms such as pain is powerless.
3rd, Li Yongchang, man, 68 years old.Lumbago, skelagia is powerless, and upper difficulty downstairs, Bone mineral density T values are -3.0.It is edible
Ossein 6 months, preceding 3 months dosages are 4 pieces/times, 2 times/day；Individual month dosage is 3 pieces/times, 2 times/day afterwards.Eat 3 months backs
Pain disappears, and skelagia disappears, effectively, upper no longer difficult downstairs.3 months Bone mineral density T values are that bone density inspection in -0.1,6 months is T
Value -0.1, recover normal.
Claims (6)
- A kind of 1. chewing milk piece for the healthcare function that there is increase bone density to promote bone health, it is characterised in that：Main component by The ultra-fine enzymolysis bone meal 2-6 parts by weight of deer shin bone or sheep shin bone；Wolfberry fruit powder 1-3 parts by weight, whole milk powder 2-6 parts by weight composition.
- 2. the preparation method of milk piece is chewed as claimed in claim 1, it is characterised in that：Comprise the following steps,(1) prepared by ultra-fine enzymolysis bone meal：1. scalding deodorization：By fresh deer shin bone or sheep shin bone, 2-5 times is added to measure water, 100 DEG C, 15-30 minutes/time, scalding 2-3 times, clearly Water rinses；2. boiling：Take the material of step 1. to add 2-5 times to measure water, airtight heating, pressure 0.1Mpa, 2-4 hour, take extract solution low Temperature is stood, except degreasing；3. grind：It is high-pressure homogeneous by the pulverizing fresh bone after step 2. boiling to 300-500 mesh, bone oar is made；4. digest：3. pulp that step obtains merges mixing with cooking liquor, neutral proteinase/papain/trypsase or Its complex enzyme is digested；5. it is spray-dried：Enzymolysis bone oar is adjusted to 60 DEG C of proportion 1.05-1.15, spray drying；(2) prepared by wolfberry fruit powder：Matrimony vine water extracts 2-3 times, 60-90 DEG C of temperature；(3) milk piece is chewed to prepare：The ultra-fine enzymolysis bone meal 2-6 parts by weight for taking step (1) to obtain；The wolfberry fruit powder that step (2) obtains 1-3 parts by weight, the mixing of whole milk powder 2-6 parts by weight, the maltitol or dextrin of 1-3 parts by weight are added, is mixed, granulation；Dry, Whole grain；Tabletting.
- 3. the preparation method according to claim 2 for chewing milk piece, it is characterised in that：The enzymatic hydrolysis condition is：Temperature 55- 80 DEG C, pH5.0-8.0,4-6 hours；Enzyme deactivation：60-80 DEG C, 30-60 minutes.
- 4. the preparation method according to claim 2 for chewing milk piece, it is characterised in that：The matrimony vine water extraction is taken as the first time 8-10 times of water is added to measure, for the second time plus 6-8 times of water is measured, 60-90 DEG C of temperature；Each extraction time 60-90 minutes；Merge extract solution, it is dense Contracting, spray drying.
- 5. the preparation method according to claim 2 for chewing milk piece, it is characterised in that：The granulation is dense with 60-70% Softwood, the granulation of 12-14 mesh sieves is made in the ethanol of degree.
- 6. the preparation method according to claim 2 for chewing milk piece, it is characterised in that：The drying, whole grain, the tool of tabletting Concrete conditions in the establishment of a specific crime is as follows, dries：50-70 DEG C of temperature, hour time 4-6, moisture control below 8-12%；14-16 mesh sieve whole grains, add 0.5-1% silica/magnesium stearate is well mixed；Tabletting：Finished product sheet hardness：3-4Kgf/mm2, piece weight：1.0-2.0g/ piece.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109601626A (en) * | 2019-01-18 | 2019-04-12 | 宁夏阿色羔农业科技有限公司 | A kind of fructus lycii milk tablet and preparation method thereof |
| CN109645135A (en) * | 2019-01-21 | 2019-04-19 | 西北师范大学 | A kind of preparation method of fructus lycii donkey milk piece |
| CN111213723A (en) * | 2018-11-27 | 2020-06-02 | 内蒙古伊利实业集团股份有限公司 | Composition for enhancing bone strengthening effect of dairy products |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109645135A (en) * | 2019-01-21 | 2019-04-19 | 西北师范大学 | A kind of preparation method of fructus lycii donkey milk piece |
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