CN101637258A - Health food used for improving immunity - Google Patents
Health food used for improving immunity Download PDFInfo
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- CN101637258A CN101637258A CN200910091300A CN200910091300A CN101637258A CN 101637258 A CN101637258 A CN 101637258A CN 200910091300 A CN200910091300 A CN 200910091300A CN 200910091300 A CN200910091300 A CN 200910091300A CN 101637258 A CN101637258 A CN 101637258A
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Abstract
The invention discloses a health food which is used for improving immunity, mainly comprising the following materials according to parts by weight: 2-6 parts of ginseng extractive, 3-9 parts of barbary wolfberry fruit extractive, 0.5-1.5 parts of prepared radix polygoni multiflori extractive and 90-270 parts of silkie extractive liquid. The oral liquid dosage form prepared by the invention has notable efficiency and high bioavailability, and is easy to eat and convenient to take; the compliance is good after allocating taste, thus the health food is suitable for taking. As a health food of traditional Chinese medicine for improving immunity, the product provided by the invention has natural raw materials, is safe to eat and is a health food with extensive physiologicalaction, comprehensivenutrition and good taste.
Description
Technical field
The present invention relates to a kind of health food that is used to strengthen immunity.
Background technology
Modern society, sub-health state is very general, the various diseases reason be hypoimmunity at all.In the past, we always blamed the reason of falling ill to those bacteriums, virus singlely, and bacterium and virus can only cause disease on the person lower for the resistance in fact.Reality is that our everyone health all is subjected to many threats easily, comprise air pollution, food pollution, environmental pollution, operating pressure, economic pressures, improper diet or the like seem the unimportant but utmost point and be unfavorable for healthy factor, all can cause hypoimmunity.In recent years, owing to causing crowd's quantity of hypoimmunity, many reasons constantly increase, therefore, improve immunity and also become the topic that everybody often talks about, become the focus of growing interest, exploitation is that health care foods just has vast social effect to strengthen immunity, and has huge market potential.
At present, circulate on the domestic market through SFDA approval be that the health food of major function is more to strengthen immunity, it is also varied to fill a prescription.Approved be that the health food of major function mainly contains to strengthen immunity: extra large trump bovine colostrum, magnificent woods board bee glue soft capsule, solemn and just and board is solemn and just and wine, Hang Jian board dendrobium candidum tea, the sun are given birth to board genseng health unit of section powder, day source hall board bee glue capsule, storage health board ganoderma spove powder electuary, ancient cooking vessel board rose soft capsule, king of breaststroke's board Oviductus ranae soft capsules etc. forever.But how with single raw material prescription, do not possess the compatibility principle of the traditional Chinese medical science, can't reach the effect that strengthens immunity from the theory of traditional Chinese medical science aspect.
Summary of the invention
The purpose of this invention is to provide a kind of health food that is used to strengthen immunity.
For achieving the above object, technical scheme of the present invention provides a kind of health food that is used to strengthen immunity, and it is mainly made by the material of following parts by weight:
Ginseng extract: 2-6 part; Fructus lycii P.E: 3-9 part; Radix Polygoni Multiflori Preparata extract: 0.5-1.5 part; Black-bone chicken extract: 90-270 part.
Above-mentioned health food, it is preferably mainly made by the material of following parts by weight:
Ginseng extract: 4 parts; Fructus lycii P.E: 6 parts; Radix Polygoni Multiflori Preparata extract: 1 part; Black-bone chicken extract: 180 parts.
Above-mentioned health food, it can also contain one or more the auxiliary material that is selected from honey, sucrose, glucose, maltose, xylitol, the potassium sorbate.
Above-mentioned health food, wherein said ginseng extract are commercially available common convenience goods, and it preferably contains the qualified products of total saponin(e 〉=10.0% weight concentration.
Above-mentioned health food, wherein said Fructus lycii P.E are commercially available common convenience goods, and it preferably contains the qualified products of thick polysaccharide 〉=30.0% weight concentration.
Above-mentioned health food, wherein said Radix Polygoni Multiflori Preparata extract are commercially available common convenience goods, and it preferably contains the qualified products of anthraquinone 〉=0.1% weight concentration.
Above-mentioned health food, wherein said black-bone chicken extract are commercially available common convenience goods, its be blackbone Chicken or Os Gallus Domesticus carry through water or alcohol extracting after the extract that obtains, it preferably contains the qualified products of protein 〉=0.2% weight concentration.
Above-mentioned health food, a kind of commonly used, production process is simple and easy and the form of taking that is easy to carry about with one is a drink form, can called after genseng black chicken oral liquid.Its every 100mL product contains total saponin(e 200mg, thick polysaccharide 800mg.
The preparation method of described genseng black chicken oral liquid may further comprise the steps: after described four kinds of materials are sieved, mix, heat then and keeps boiling 20-40 minute, stirring is simultaneously fully dissolved various raw materials, sieve then filtrate; Then honey is joined in the filtrate, stir, add potassium sorbate again, fully stir and make dissolving, mix, be settled to capacity with purified water, refrigeration is left standstill then, refilter filtrate; The can of gained filtrate gets finished product after sterilization, packing to container.
Various extracts that relate among the present invention or extract be Chinese medicine material through water carry or alcohol extracting after product, they are extensive use on market all, the preparation of various extracts is existing technology, the product that obtains is difference to some extent on material concentration just, and its various products all can practice in the present invention.
The prescription of health food provided by the invention comes from Chinese traditional traditional Chinese medical science prescription, the extract of selecting black-bone chicken for use is a primary raw material, add high-quality Chinese medical extract-Radix Polygoni Multiflori Preparata extract, ginseng extract, Fructus lycii P.E commonly used, to realize strengthening body immunity comprehensively, strengthen the effect of body resistance against diseases.The rules of treatment low to immunity of organisms according to traditional traditional Chinese medicine from transferring tonifying liver, kidney, are grown the compatibility relationship prescription that spleen is supported lung, and black-bone chicken is nourishing liver and kidney in the side, blood-enrich; The yang-energy of prepared fleece flower root tonifying liver, the cloudy gas of beneficial spleen.Prepared fleece flower root and black-bone chicken mutually 5 can reach and nourish blood, strong kidney, enriching yin benefit liver, mend the effect that essence is added marrow.Fruit of Chinese wolfberry kidney tonifying moistening lung, production of sperm benefit gas; Genseng reinforces vital energy, reinforces the spleen to benefit the lung, promoting production of body fluid and inducing sedation of the mind.Four medicines phase 5 is transferred tonifying liver, kidney, and grow spleen and support lung, strengthening vital QI to eliminate pathogenic factors, thus reach enhancing immunity, the function of disease-prevention health.
Genseng black chicken oral liquid provided by the invention incorporates modern crafts and makes oral liquid formulation, and effect is remarkable, edible safety, and the bioavilability height, taking convenience, this product is through the taste allotment, and compliance is good, preferably taking.Prescription all meets the requirement of Ricipe for health care food from the consumption of effective compatibility and safety, this prescription is safe and effective.Therefore, as the Chinese medicine and health food that strengthens immunity, raw material is natural, edible safety, be a kind of physiological action extensively, the health food of comprehensive nutrition, good mouthfeel, the market space is huge, has certain comprehensive advantage.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: the genseng black chicken oral liquid
Component: ginseng extract 200g, Fructus lycii P.E 300g, Radix Polygoni Multiflori Preparata extract 50g, black-bone chicken extract 9000g, honey 1000g, potassium sorbate 10g, purified water.
Preparation:
1, preliminary treatment, dosing
The black-bone chicken extract (is asked commerce and trade Co., Ltd available from Beijing phoenix gift essence, protein 〉=0.2%), ginseng extract is (available from Jilin Hongjiu Biotech Co., Ltd., total saponin(e 〉=10.0%), Radix Polygoni Multiflori Preparata extract is (available from the careless industry and trade in Xuancheng City hundred Co., Ltd, anthraquinone 〉=0.1%), Fructus lycii P.E is (available from the careless industry and trade in Xuancheng City hundred Co., Ltd, thick polysaccharide 〉=30.0%) go external packing, inner packing enters clean area by the logistics buffer channel.Add in the preparing tank after above four kinds of raw materials are crossed 80 mesh sieves respectively, 30min is boiled in heating, stirs simultaneously each raw material is fully dissolved, and crosses 200 mesh sieves while hot, filtrate 1.Honey is joined in the filtrate 1, stir, add the potassium sorbate of formula ratio, fully stir and make dissolving, mix, be settled to capacity 10000mL with purified water (meet " two ones of Chinese pharmacopoeia versions in 2000).Get mixed liquor 1.24h is left standstill in refrigeration, filters with flame filter press, gets filtrate 2.
2, embedding: filtrate 2 is placed in the clean stainless steel receiver of cleaning and sterilization, and in the plastic bottle easy to break that meets hygienic requirements, adjusting the loading amount specification is that 10mL/ props up with plastic bottle bottle placer easy to break can.
3, afterwards through sterilization, lamp inspection, packing, product inspection, obtain qualified products.
Embodiment 2:
Except that amounts of components and embodiment 1 were different, all the other were with embodiment 1:
Component: ginseng extract 100g, Fructus lycii P.E 450g, Radix Polygoni Multiflori Preparata extract 25g, black-bone chicken extract 13500g, honey 1474g, potassium sorbate 14.74g, purified water.
Embodiment 3:
Except that amounts of components and embodiment 1 were different, all the other were with embodiment 1:
Component: ginseng extract 300g, Fructus lycii P.E 150g, Radix Polygoni Multiflori Preparata extract 75g, black-bone chicken extract 4500g, honey 526g, potassium sorbate 5.26g, purified water.
The test example:
Below data by experiment illustrate effect of the present invention.
Toxicological test:
Test objective: whether the check product has toxicity.
Test material:
The genseng black chicken oral liquid that sample: embodiment 1 provides, human body oral liquid recommended amounts are 20mL every day, become body weight for humans to press 60kg and calculate, and amount to dosage 0.33mL/kgbw.Getting 5 times of concentrates experimentizes.
Animal used as test: cleaning level Kunming mouse, SD rat and feed.
Experimental situation condition: temperature 22-24 ℃, humidity 52-58%.
Test method:
By acute toxicity test in mice (get 5 times of concentrates of genseng black chicken oral liquid and irritate stomach to the disposable per os of mouse) so that the filling body of stomach of 0.2mL/10gbw is long-pending, (five dosage are established in test to Salmonella reversion test, be respectively 5000 μ g/ wares, 1000 μ g/ wares, 200 μ g/ wares, 40 μ g/ wares, 8 μ g/ wares, establish simultaneously from beaming back change, solvent control and the contrast of positive mutagens), the PCEMNR micronucleus test is (with the positive contrast of the endoxan of 40mg/kgbw dosage, the negative contrast of distilled water, 3 dosage of test group are respectively 10.0mL/kgbw, 5.0mL/kgbw, 2.5mL/kgbw, get 5 times of concentrate 50.0mL of genseng black chicken oral liquid, 25.0mL, 12.5mL adding distil water is to 100mL, the test solution that is subjected to that is made into corresponding dosage is given mouse stomach), the mouse sperm deformity test is (with the positive contrast of the endoxan of 40mg/kgbw dosage, the negative contrast of distilled water, 3 dosage of test group are respectively 10.0mL/kgbw, 5.0mL/kgbw, 2.5mL/kgbw, get 5 times of concentrate 50.0mL of genseng black chicken oral liquid, 25.0mL, 12.5mL adding distil water is to 100mL, the test solution that is subjected to that is made into corresponding dosage is given mouse stomach), feeding trial (was got 5 times of concentrate 16.5mL of genseng black chicken oral liquid in 30 days, 33mL, the 66mL adding distil water is settled to 100mL, control group gives equal-volume distilled water, irritate stomach every day once, continuous 30 days) carry out toxicology test evaluation.
Result of the test:
1 acute oral toxicity test result:
The maximal tolerance dose (MTD) of female, male Kunming mouse belongs to nontoxic level all greater than 20.0mL/kgbw.
2. three genetic toxicity test results:
The result is all negative for three genetic toxicity tests (Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity test).
3,30 days feeding trial results:
Genseng black chicken oral liquid with 8.25mL/kgbw, 16.5mL/kgbw, 33.0mL/kgbw dosage (be equivalent to human body RD 25,50,100 times) is given rat oral gavage 30 days, experimental session, animal growth is good, each dosage group body weight, weightening finish, food utilization, routine blood test index, blood biochemistry index, organ weights and internal organs/body weight ratio and control group compare, there was no significant difference (P＞0.05).Gross anatomy is not seen the abnormal change relevant with sample with tissue pathology checking.
Function test:
Test objective: the health care test material whether the check product has this enhancing immunity:
The genseng black chicken oral liquid that sample: embodiment 1 provides, pitchy liquid, 10mL/ props up, and cool place, ventilation, the preservation of dry place are put in sealing.
Experimental animal: 200 of cleaning level Kunming kind female mices, body weight is 18-22g.
Experimental situation condition: barrier system.Temperature 22-24 ℃, humidity 52-58%.
Dosage is selected and sample treatment: establish the basic, normal, high dosage of genseng black chicken oral liquid and be respectively 1.67mL/kgbw, 3.33mL/kgbw, 10.00mL/kgbw (be equivalent to respectively human body RD 5,10,30 times).When basic, normal, high dosage is subjected to the test solution preparation, get 16.7mL, 33.3mL, 100mL genseng black chicken oral liquid adding distil water respectively to 200mL, control group gives isopyknic distilled water, give animal subject respectively and irritate stomach, irritate stomach every day once, irritate the long-pending 0.2mL/10gbw of being of body of stomach, continuous 30 days.
Key instrument and reagent: animal platform chessboard, assay balance, clean bench, CO2gas incubator, autoclave, filter, centrifuge, 722 spectrophotometers, constant water bath box, ELIASA, microscope etc.
Test method: the determination experiment that mouse lymphocyte transformation experiment, antibody-producting cell detection, the mensuration of HD50 value, the mouse carbon of inducing by internal organs/weight ratio pH-value determination pH, delayed allergy, ConA is cleaned up experiment, the rich and powerful macrophage phagocytic chicken red blood cell experiment of little tree, NK cytoactive carries out assessment of function.
Result of the test:
Per os gives the genseng black chicken oral liquid 30 days of mouse 1.67mL/kgbw, 3.33mL/kgbw, 10.00mL/kgbw dosage, 3.33mL/kgbw, 10.00mL/kgbw dosage can strengthen the mouse delayed allergy, improve the antibody-producting cell number of mouse, 10.00mL/kgbw dosage can improve the ability that mouse monokaryon-macrophage carbon is cleaned up, and compares P＜0.05 or P＜0.01 with control group.Weight of mice, spleen/body weight ratio, thymus gland/body weight ratio, lymphocyte transformation ability, serum HD50 value, the ability of macrophage phagocytic chicken red blood cell, NK cytoactive there is not obvious influence (P＞0.05).Under this experiment condition, point out this sample to have the function that strengthens immunity.
Concrete experimental result data sees the following form:
Table 1 genseng black chicken oral liquid is to the influence of mouse delayed allergy (DTH)
As shown in Table 1, per os gives the genseng black chicken oral liquid 30 days of mouse various dose, and middle and high dosage group swelling degree of the paw is apparently higher than control group, and difference has conspicuousness (P＜0.05 or P＜0.01).
Table 2 genseng black chicken oral liquid is to the influence of mouse antibodies cellulation number
As shown in Table 2, per os gives the genseng black chicken oral liquid 30 days of mouse various dose, and middle and high dosage group antibody-producting cell number is apparently higher than control group, and difference has conspicuousness (P＜0.05 or P＜0.01).
Table 3 genseng black chicken oral liquid is to influence that mouse monokaryon-macrophage carbon is cleaned up
As shown in Table 3, per os gives the genseng black chicken oral liquid 30 days of mouse various dose, and high dose group mouse phagocytic index is significantly higher than control group, and difference has conspicuousness (P＜0.05).
As can be seen from the above embodiments, the embodiment of the invention is that primary raw material develops by selecting black-bone chicken, the fruit of Chinese wolfberry, genseng and prepared fleece flower root for use.The compatibility of whole prescription is the rules of treatment low to immunity of organisms according to traditional traditional Chinese medicine, from transferring tonifying liver, kidney, grows the compatibility relationship prescription that spleen is supported lung, and black-bone chicken is nourishing liver and kidney in the side, blood-enrich; The yang-energy of prepared fleece flower root tonifying liver, the cloudy gas of beneficial spleen.Prepared fleece flower root and black-bone chicken mutually 5 nourishes blood, strong kidney, enriching yin benefit liver, mends the effect that essence is added marrow.Fruit of Chinese wolfberry kidney tonifying moistening lung, production of sperm benefit gas; Genseng reinforces vital energy, reinforces the spleen to benefit the lung, promoting production of body fluid and inducing sedation of the mind.Many medicines phases 5, adjusting and reinforcing liver and kidney is grown spleen and is supported lung, benefiting qi and nourishing blood, beneficial essence is added marrow, Yin-nourishing and Yang-supporting, strengthening vital QI to eliminate pathogenic factors, thus reach enhancing immunity, prophylactic health care.This product research achievement is better than existing similar functional food, suits to take for a long time.
The above only is a preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1, a kind of health food that is used to strengthen immunity is characterized in that, it is mainly made by the material of following parts by weight:
Ginseng extract: 2-6 part; Fructus lycii P.E: 3-9 part; Radix Polygoni Multiflori Preparata extract: 0.5-1.5 part; Black-bone chicken extract: 90-270 part.
2, health food as claimed in claim 1 is characterized in that, it is mainly made by the material of following parts by weight:
Ginseng extract: 4 parts; Fructus lycii P.E: 6 parts; Radix Polygoni Multiflori Preparata extract: 1 part; Black-bone chicken extract: 180 parts.
3, health food as claimed in claim 1 or 2 is characterized in that, it also contains one or more the auxiliary material that is selected from honey, sucrose, glucose, maltose, xylitol, the potassium sorbate.
4, as each described health food of claim 1-3, it is characterized in that, contain total saponin(e 〉=10.0% weight concentration in the described ginseng extract.
5, as each described health food of claim 1-4, it is characterized in that, contain thick polysaccharide 〉=30.0% weight concentration in the described Fructus lycii P.E.
6, as each described health food of claim 1-5, it is characterized in that, contain anthraquinone 〉=0.1% weight concentration in the described Radix Polygoni Multiflori Preparata extract.
7, as each described health food of claim 1-6, it is characterized in that, contain protein 〉=0.2% weight concentration in the described black-bone chicken extract.
8, health food as claimed in claim 7 is characterized in that, described health food is the genseng black chicken oral liquid.
9, health food as claimed in claim 8 is characterized in that, the every 100mL product of described oral liquid contains total saponin(e 200mg, thick polysaccharide 800mg.
10, the preparation method of claim 8 or 9 described health foods is characterized in that, may further comprise the steps: after described four kinds of materials are sieved, mix, heat then and keep boiling 20-40 minute, stir simultaneously various raw materials are fully dissolved, sieve then filtrate; Then honey is joined in the filtrate, stir, add potassium sorbate again, fully stir and make dissolving, mix, be settled to capacity with purified water, refrigeration is left standstill then, refilter filtrate; The can of gained filtrate gets finished product after sterilization, packing to container.
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| CN2009100913004A CN101637258B (en) | 2009-08-17 | 2009-08-17 | Health food used for improving immunity |
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| CN101637258B CN101637258B (en) | 2012-05-23 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727760A (en) * | 2012-06-24 | 2012-10-17 | 宁波市鄞州奥胜生物科技有限公司 | Health product for enhancing physical strength |
| CN107822140A (en) * | 2017-12-09 | 2018-03-23 | 李宇星 | A kind of ginseng functional beverage |
| CN108112862A (en) * | 2017-12-19 | 2018-06-05 | 徐义才 | A kind of natural animal-plant nutritional ingredient composition and preparation method thereof |
| CN109674058A (en) * | 2019-02-28 | 2019-04-26 | 江西普正制药有限公司 | A kind of Cortex Eucommiae Gallus domesticlus brisson preparation and preparation method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057583A (en) * | 1990-06-27 | 1992-01-08 | 张洪昌 | A kind of method for making of kidney-tonifying and yang-strengthening oral solution |
| CN1056067C (en) * | 1994-08-05 | 2000-09-06 | 丛玉俭 | Wuji (black-bone chicken) tonic liquid |
| CN1054047C (en) * | 1994-10-26 | 2000-07-05 | 李发荣 | Nutritive black-bone chicken wolfberry fruit wine for nourishing blood |
| CN1185321A (en) * | 1996-12-19 | 1998-06-24 | 刘升 | A tonic with effects in nourishing liver, invigorating kidney, and regulating yin and yang, and its preparation method |
| CN1302796C (en) * | 2004-07-26 | 2007-03-07 | 凌沛学 | Traditional Chinese medicament for treating woman subhealthy faligue syndrome and its preparation method |
-
2009
- 2009-08-17 CN CN2009100913004A patent/CN101637258B/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727760A (en) * | 2012-06-24 | 2012-10-17 | 宁波市鄞州奥胜生物科技有限公司 | Health product for enhancing physical strength |
| CN102727760B (en) * | 2012-06-24 | 2014-06-25 | 宁波市鄞州奥胜生物科技有限公司 | Health product for enhancing physical strength |
| CN107822140A (en) * | 2017-12-09 | 2018-03-23 | 李宇星 | A kind of ginseng functional beverage |
| CN108112862A (en) * | 2017-12-19 | 2018-06-05 | 徐义才 | A kind of natural animal-plant nutritional ingredient composition and preparation method thereof |
| CN109674058A (en) * | 2019-02-28 | 2019-04-26 | 江西普正制药有限公司 | A kind of Cortex Eucommiae Gallus domesticlus brisson preparation and preparation method thereof |
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| CN101637258B (en) | 2012-05-23 |
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