CN103783515B - A kind of Radix Angelicae Sinensis Chinese yam dispersible tablet and preparation method - Google Patents
A kind of Radix Angelicae Sinensis Chinese yam dispersible tablet and preparation method Download PDFInfo
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- 235000002722 Dioscorea batatas Nutrition 0.000 title claims abstract description 37
- 235000006536 Dioscorea esculenta Nutrition 0.000 title claims abstract description 37
- 240000001811 Dioscorea oppositifolia Species 0.000 title claims abstract description 37
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 title claims abstract description 37
- 239000007919 dispersible tablet Substances 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 34
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 24
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 22
- 239000008213 purified water Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 17
- 244000293323 Cosmos caudatus Species 0.000 claims abstract description 17
- 235000005956 Cosmos caudatus Nutrition 0.000 claims abstract description 17
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 17
- DKKCQDROTDCQOR-UHFFFAOYSA-L Ferrous lactate Chemical compound [Fe+2].CC(O)C([O-])=O.CC(O)C([O-])=O DKKCQDROTDCQOR-UHFFFAOYSA-L 0.000 claims abstract description 17
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 17
- 229930195725 Mannitol Natural products 0.000 claims abstract description 17
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 17
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229920002472 Starch Polymers 0.000 claims abstract description 17
- 239000004376 Sucralose Substances 0.000 claims abstract description 17
- 241000222355 Trametes versicolor Species 0.000 claims abstract description 17
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 17
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 17
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 17
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 17
- 239000004225 ferrous lactate Substances 0.000 claims abstract description 17
- 229940037907 ferrous lactate Drugs 0.000 claims abstract description 17
- 235000013925 ferrous lactate Nutrition 0.000 claims abstract description 17
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 17
- 239000000594 mannitol Substances 0.000 claims abstract description 17
- 235000010355 mannitol Nutrition 0.000 claims abstract description 17
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 17
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 17
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 17
- 239000000741 silica gel Substances 0.000 claims abstract description 17
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 17
- 239000011734 sodium Substances 0.000 claims abstract description 17
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 17
- 239000008107 starch Substances 0.000 claims abstract description 17
- 235000019698 starch Nutrition 0.000 claims abstract description 17
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 17
- 235000019408 sucralose Nutrition 0.000 claims abstract description 17
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 12
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 12
- 229940046009 vitamin E Drugs 0.000 claims abstract description 12
- 239000011709 vitamin E Substances 0.000 claims abstract description 12
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 11
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 11
- 239000011718 vitamin C Substances 0.000 claims abstract description 11
- 239000004615 ingredient Substances 0.000 claims abstract description 7
- 239000008187 granular material Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 12
- 238000001238 wet grinding Methods 0.000 claims description 11
- 238000010298 pulverizing process Methods 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000007654 immersion Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000000084 colloidal system Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 abstract description 4
- 210000000481 breast Anatomy 0.000 abstract description 4
- 230000037006 agalactosis Effects 0.000 abstract description 3
- 230000037182 bone density Effects 0.000 abstract description 3
- 230000007812 deficiency Effects 0.000 abstract description 3
- 208000036654 deficiency anemia Diseases 0.000 abstract description 3
- 238000010792 warming Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 238000000227 grinding Methods 0.000 description 5
- 208000019395 Lactation disease Diseases 0.000 description 4
- 206010042576 Suppressed lactation Diseases 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical group C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of Radix Angelicae Sinensis Chinese yam dispersible tablet, comprise following parts by weight ingredient: Rhizoma Dioscoreae 200-400 part, Radix Angelicae Sinensis 80-120 part, microcrystalline Cellulose 40-60 part, Coriolus Versicolor P.E. 0.12-0.32 part, Margarita powder 0.35-0.75 part, ferrous lactate 0.003-0.007 part, vitamin C? 1-2 part, vitamin E? 0.003-0.007 part, mannitol 100-170 part, sucralose 10-15 part, micropowder silica gel 10-50 part, carboxymethyl cellulose 3-5 part, carboxymethyl starch sodium 55-80 part, magnesium stearate 4-6 part, Purified Water q. s.The present invention has tonify deficiency warming middle-JIAO, enriches blood to increase breast, increase bone density, improve the effects such as nutritional anemia, is applicable to agalactosis in puerperal, for recovering aid.
Description
Technical field
The invention belongs to nutritional health food field, be specially a kind of Radix Angelicae Sinensis Chinese yam dispersible tablet and preparation method.
Background technology
Puerperal hypogalactia, disease sees lack of lactation after delivery, or galactopoiesis is not enough, measures rare less.For the agalactosis in puerperal that insufficiency of vital energy and blood causes.Disease sees puerperal hypogalactia or hypogalactia, and breast is not swollen, not bitterly, or occasionally has a small amount of milk to flow out, pale complexion, dizziness and tinnitus, shortness of breath and palpitation, and lochia amount is few.Puerperal hypogalactia is all that food supply mode among the people does and improves, and the dietary product being applicable to long-term edible auxiliary treatment is little.Therefore the dietary product researching and developing a kind of safe adjunct therapy is very with practical value.
Summary of the invention
For above-mentioned situation, technical problem solved by the invention is to provide a kind of tonify deficiency warming middle-JIAO, and the preparation method increasing breast, increase bone density, improve the Radix Angelicae Sinensis Chinese yam dispersible tablet of nutritional anemia of enriching blood, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of Radix Angelicae Sinensis Chinese yam dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 200-400 part, Radix Angelicae Sinensis 80-120 part, microcrystalline Cellulose 40-60 part, Coriolus Versicolor P.E. 0.12-0.32 part, Margarita powder 0.35-0.75 part, ferrous lactate 0.003-0.007 part, vitamin C 1-2 part, vitamin E 0.003-0.007 part, mannitol 100-170 part, sucralose 10-15 part, micropowder silica gel 10-50 part, carboxymethyl cellulose 3-5 part, carboxymethyl starch sodium 55-80 part, magnesium stearate 4-6 part, Purified Water q. s.
As preferably, described a kind of Radix Angelicae Sinensis Chinese yam dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 300 parts, Radix Angelicae Sinensis 100 parts, microcrystalline Cellulose 50 parts, Coriolus Versicolor P.E. 0.22 part, Margarita powder 0.55 part, ferrous lactate 0.005 part, vitamin C 1.5 parts, vitamin E 0.005 part, 135 parts, mannitol, sucralose 12.5 parts, micropowder silica gel 30 parts, carboxymethyl cellulose 4 parts, carboxymethyl starch sodium 67.5 parts, magnesium stearate 5 parts, Purified Water q. s.
A preparation method for Radix Angelicae Sinensis Chinese yam dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam clean, shred after add the purified water of Rhizoma Dioscoreae times of weight 2-4 times amount, break into homogenate, cross and filter crude fibre, collect filtrate, then filtrate is carried out high temperature sterilize within the scope of 105-120 DEG C, sterilizing time is 8-12s, obtained Chinese yam pulp, for subsequent use;
(2) get raw material Radix Angelicae Sinensis to clean, add Radix Angelicae Sinensis times of weight 8-10 times amount purified water and soak 30-40min, filter after the Radix Angelicae Sinensis heating extraction 30-60min after immersion, obtain Radix Angelicae Sinensis extracting solution for subsequent use, medicinal residues colloidal grinding wears into 400-500 order Radix Angelicae Sinensis wet-milling, for subsequent use;
(3) get microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) the Radix Angelicae Sinensis wet-milling that Radix Angelicae Sinensis extracting solution Chinese yam pulp obtained for step (1), step (2) obtained, step (2) obtain is uniformly mixed, in mixture, add carboxymethyl cellulose, microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium after pulverizing in vitamin C, vitamin E and above-mentioned steps stir, blender rotating speed is 10-20r/min, time is 10-20min, obtains mixture for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 1-5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Radix Angelicae Sinensis Chinese yam dispersible tablet.
Get in described step (1) fresh Chinese yam clean, shred after add the purified water of Rhizoma Dioscoreae times of weight 4 times amount, break into homogenate, cross and filter crude fibre, collect filtrate, then high temperature sterilize when filtrate being carried out 105 DEG C, sterilizing time is 12s, obtained Chinese yam pulp.
Get raw material Radix Angelicae Sinensis in described step (2) to clean, add Radix Angelicae Sinensis times of weight 10 times amount purified water and soak 40min, filter after the Radix Angelicae Sinensis heating extraction 60min after immersion, obtain Radix Angelicae Sinensis extracting solution for subsequent use, medicinal residues colloidal grinding wears into 500 order Radix Angelicae Sinensis wet-millings.
In sum, beneficial effect of the present invention:
The present invention has tonify deficiency warming middle-JIAO, enriches blood to increase breast, increase bone density, improve the effects such as nutritional anemia, is applicable to agalactosis in puerperal, for recovering aid.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
A kind of Radix Angelicae Sinensis Chinese yam dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 200 parts, Radix Angelicae Sinensis 80 parts, microcrystalline Cellulose 40 parts, Coriolus Versicolor P.E. 0.12 part, Margarita powder 0.35 part, ferrous lactate 0.003 part, vitamin C 1 part, vitamin E 0.003 part, 100 parts, mannitol, sucralose 10 parts, micropowder silica gel 10 parts, carboxymethyl cellulose 3 parts, carboxymethyl starch sodium 55 parts, magnesium stearate 4 parts, Purified Water q. s.
A preparation method for Radix Angelicae Sinensis Chinese yam dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam clean, shred after add the purified water of Rhizoma Dioscoreae times of weight 2-4 times amount, break into homogenate, cross and filter crude fibre, collect filtrate, then filtrate is carried out high temperature sterilize within the scope of 105-120 DEG C, sterilizing time is 8-12s, obtained Chinese yam pulp, for subsequent use;
(2) get raw material Radix Angelicae Sinensis to clean, add Radix Angelicae Sinensis times of weight 8-10 times amount purified water and soak 30-40min, filter after the Radix Angelicae Sinensis heating extraction 30-60min after immersion, obtain Radix Angelicae Sinensis extracting solution for subsequent use, medicinal residues colloidal grinding wears into 400-500 order Radix Angelicae Sinensis wet-milling, for subsequent use;
(3) get microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) the Radix Angelicae Sinensis wet-milling that Radix Angelicae Sinensis extracting solution Chinese yam pulp obtained for step (1), step (2) obtained, step (2) obtain is uniformly mixed, in mixture, add carboxymethyl cellulose, microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium after pulverizing in vitamin C, vitamin E and above-mentioned steps stir, blender rotating speed is 10-20r/min, time is 10-20min, obtains mixture for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 1-5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Radix Angelicae Sinensis Chinese yam dispersible tablet.
Embodiment 2
A kind of Radix Angelicae Sinensis Chinese yam dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 300 parts, Radix Angelicae Sinensis 100 parts, microcrystalline Cellulose 50 parts, Coriolus Versicolor P.E. 0.22 part, Margarita powder 0.55 part, ferrous lactate 0.005 part, vitamin C 1.5 parts, vitamin E 0.005 part, 135 parts, mannitol, sucralose 12.5 parts, micropowder silica gel 30 parts, carboxymethyl cellulose 4 parts, carboxymethyl starch sodium 67.5 parts, magnesium stearate 5 parts, Purified Water q. s.
A preparation method for Radix Angelicae Sinensis Chinese yam dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam clean, shred after add the purified water of Rhizoma Dioscoreae times of weight 2-4 times amount, break into homogenate, cross and filter crude fibre, collect filtrate, then filtrate is carried out high temperature sterilize within the scope of 105-120 DEG C, sterilizing time is 8-12s, obtained Chinese yam pulp, for subsequent use;
(2) get raw material Radix Angelicae Sinensis to clean, add Radix Angelicae Sinensis times of weight 8-10 times amount purified water and soak 30-40min, filter after the Radix Angelicae Sinensis heating extraction 30-60min after immersion, obtain Radix Angelicae Sinensis extracting solution for subsequent use, medicinal residues colloidal grinding wears into 400-500 order Radix Angelicae Sinensis wet-milling, for subsequent use;
(3) get microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) the Radix Angelicae Sinensis wet-milling that Radix Angelicae Sinensis extracting solution Chinese yam pulp obtained for step (1), step (2) obtained, step (2) obtain is uniformly mixed, in mixture, add carboxymethyl cellulose, microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium after pulverizing in vitamin C, vitamin E and above-mentioned steps stir, blender rotating speed is 10-20r/min, time is 10-20min, obtains mixture for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 1-5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Radix Angelicae Sinensis Chinese yam dispersible tablet.
Embodiment 3
A kind of Radix Angelicae Sinensis Chinese yam dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 400 parts, Radix Angelicae Sinensis 120 parts, microcrystalline Cellulose 60 parts, Coriolus Versicolor P.E. 0.32 part, Margarita powder 0.75 part, ferrous lactate 0.007 part, Catergen part, vitamin E 0.007 part, 170 parts, mannitol, sucralose 15 parts, micropowder silica gel 50 parts, carboxymethyl cellulose 5 parts, carboxymethyl starch sodium 80 parts, magnesium stearate 6 parts, Purified Water q. s.
A preparation method for Radix Angelicae Sinensis Chinese yam dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam clean, shred after add the purified water of Rhizoma Dioscoreae times of weight 2-4 times amount, break into homogenate, cross and filter crude fibre, collect filtrate, then filtrate is carried out high temperature sterilize within the scope of 105-120 DEG C, sterilizing time is 8-12s, obtained Chinese yam pulp, for subsequent use;
(2) get raw material Radix Angelicae Sinensis to clean, add Radix Angelicae Sinensis times of weight 8-10 times amount purified water and soak 30-40min, filter after the Radix Angelicae Sinensis heating extraction 30-60min after immersion, obtain Radix Angelicae Sinensis extracting solution for subsequent use, medicinal residues colloidal grinding wears into 400-500 order Radix Angelicae Sinensis wet-milling, for subsequent use;
(3) get microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) the Radix Angelicae Sinensis wet-milling that Radix Angelicae Sinensis extracting solution Chinese yam pulp obtained for step (1), step (2) obtained, step (2) obtain is uniformly mixed, in mixture, add carboxymethyl cellulose, microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium after pulverizing in vitamin C, vitamin E and above-mentioned steps stir, blender rotating speed is 10-20r/min, time is 10-20min, obtains mixture for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 1-5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Radix Angelicae Sinensis Chinese yam dispersible tablet.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (1)
1. a Radix Angelicae Sinensis Chinese yam dispersible tablet, is characterized in that: be made up of following parts by weight ingredient: Rhizoma Dioscoreae 300 parts, Radix Angelicae Sinensis 100 parts, microcrystalline Cellulose 50 parts, Coriolus Versicolor P.E. 0.22 part, Margarita powder 0.55 part, ferrous lactate 0.005 part, vitamin C 1.5 parts, vitamin E 0.005 part, 135 parts, mannitol, sucralose 12.5 parts, micropowder silica gel 30 parts, carboxymethyl cellulose 4 parts, carboxymethyl starch sodium 67.5 parts, magnesium stearate 5 parts, Purified Water q. s; Its preparation method is:
(1) get fresh Chinese yam clean, shred after add the purified water of Rhizoma Dioscoreae weight 2-4 times amount, break into homogenate, cross and filter crude fibre, collect filtrate, then filtrate is carried out high temperature sterilize within the scope of 105-120 DEG C, sterilizing time is 8-12s, obtained Chinese yam pulp, for subsequent use;
(2) get raw material Radix Angelicae Sinensis to clean, add Radix Angelicae Sinensis weight 8-10 times amount purified water and soak 30-40min, filter after the Radix Angelicae Sinensis heating extraction 30-60min after immersion, obtain Radix Angelicae Sinensis extracting solution for subsequent use, 400-500 order Radix Angelicae Sinensis wet-milling worn into by medicinal residues colloid mill, for subsequent use;
(3) get microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) the Radix Angelicae Sinensis wet-milling that Radix Angelicae Sinensis extracting solution Chinese yam pulp obtained for step (1), step (2) obtained, step (2) obtain is uniformly mixed, in mixture, add carboxymethyl cellulose, microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium after pulverizing in vitamin C, vitamin E and step (3) stir, blender rotating speed is 10-20r/min, time is 10-20min, obtains mixture for subsequent use;
(5) mixture that step (4) is obtained is made granule, granule is dried 1-5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Radix Angelicae Sinensis Chinese yam dispersible tablet.
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|---|---|---|---|---|
| EP1481211B1 (en) * | 2001-11-29 | 2009-04-22 | J. Rettenmaier & Söhne GmbH + Co. KG | Process for co-spray drying liquid herbal extracts with dry silicified mcc |
| CN102113669A (en) * | 2009-12-30 | 2011-07-06 | 徐德连 | Green health-care noodles for puerpera lactation promotion |
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