CN103704707B - A kind of Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet and preparation method - Google Patents

A kind of Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet and preparation method Download PDF

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CN103704707B
CN103704707B CN201310748520.6A CN201310748520A CN103704707B CN 103704707 B CN103704707 B CN 103704707B CN 201310748520 A CN201310748520 A CN 201310748520A CN 103704707 B CN103704707 B CN 103704707B
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陈慧婷
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Anhui Tongque Erqiao Biotechnology Co ltd
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    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A23L29/30Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
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    • A61K36/906Zingiberaceae (Ginger family)
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Abstract

The invention discloses a kind of Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet, comprise following parts by weight ingredient: Rhizoma Dioscoreae 200-400 part, Rhizoma Zingiberis Recens 100-200 part, Radix Angelicae Sinensis 100-200 part, microcrystalline Cellulose 40-60 part, Coriolus Versicolor P.E. 0.12-0.32 part, Margarita powder 0.35-0.75 part, ferrous lactate 0.003-0.007 part, vitamin C? 1-2 part, vitamin E? 0.003-0.007 part, mannitol 100-170 part, sucralose 10-15 part, micropowder silica gel 10-50 part, carboxymethyl cellulose 3-5 part, carboxymethyl starch sodium 55-80 part, magnesium stearate 4-6 part.The present invention has temperature compensation QI and blood, increases bone density, increases immunity, improves the effects such as nutritional anemia.Be applicable to postpartum anemia, state of an illness the lighter, pale complexion, dizziness, eye conjunctiva color is light; State of an illness severe one, shallow complexion, edema, malaise, cardiopalmus, stomach poor appetite move back, short of breath etc., for recovering aid.

Description

A kind of Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet and preparation method
Technical field
The invention belongs to nutritional health food field, be specially a kind of Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet and preparation method.
Background technology
Blood trouble during owing to producing, functional activities of the body fluid is de-with blood, women is at physical weakness in puerperal, susceptible is caught a cold by exopathogen such as wind, cold, wets, cause cough, fever, headache, general malaise, or occur puerperal reposition of the womb slowly, the common clinical disease such as haemophilia, postpartum anemia, if not in addition science, treat in time, nurse one's health, not only can affect the growth promoter of baby, also will have a strong impact on the physical and mental health in women's puerperal.The traditional Chinese medical science is thought, postpartum women Massive Bleeding, impairment of body fluid exhaustion of blood, blood-stasis internal-depression, disorder of QI movement, and vigour is impaired, and the turbid liquid of remaining blood to the greatest extent, does not easily occur various diseases.Women's puerperal disease is commonly encountered diseases and the frequently-occurring disease of gynecological, is that harm body of women is healthy, even life-threatening important diseases.Although also have Chinese Traditional Medicines or the formula of a lot of postpartum women disease at present, although treatment prescribed preparation is a lot, be all occur with the form of medicine, the dietary product being applicable to long-term edible auxiliary treatment is little.Therefore the dietary product researching and developing a kind of safe adjunct therapy is very with practical value.
Summary of the invention
For above-mentioned situation, the preparation method that technical problem solved by the invention is to provide a kind of temperature compensation QI and blood, increases bone density, increases immunity, improves the Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet of nutritional anemia, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 200-400 part, Rhizoma Zingiberis Recens 100-200 part, Radix Angelicae Sinensis 100-200 part, microcrystalline Cellulose 40-60 part, Coriolus Versicolor P.E. 0.12-0.32 part, Margarita powder 0.35-0.75 part, ferrous lactate 0.003-0.007 part, vitamin C 1-2 part, vitamin E 0.003-0.007 part, mannitol 100-170 part, sucralose 10-15 part, micropowder silica gel 10-50 part, carboxymethyl cellulose 3-5 part, carboxymethyl starch sodium 55-80 part, magnesium stearate 4-6 part.
As preferably, described a kind of Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 300 parts, 150 parts, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis 150 parts, microcrystalline Cellulose 50 parts, Coriolus Versicolor P.E. 0.22 part, Margarita powder 0.55 part, ferrous lactate 0.005 part, vitamin C 1.5 parts, vitamin E 0.005 part, 135 parts, mannitol, sucralose 12.5 parts, micropowder silica gel 30 parts, carboxymethyl cellulose 4 parts, carboxymethyl starch sodium 67.5 parts, magnesium stearate 5 parts.
A preparation method for Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam and clean peeling, the vitamin C that Rhizoma Dioscoreae after peeling adds 0.2% carries out color fixative, Rhizoma Dioscoreae after color fixative boils 10-15min within the scope of 80-90 DEG C, pull an oar after adding the water of Rhizoma Dioscoreae quality times 6-10 times amount, slurry granularity is 300-400 order, temperature controls within the scope of 40-45 DEG C, 200-250 mesh screen is used after making beating, impurity is discharged, again the serosity after filtration is carried out high temperature instantaneous sterilization, temperature controls as within the scope of 100-130 DEG C, and the time is 5-10s, obtain Chinese yam pulp, for subsequent use;
(2) get raw material Rhizoma Zingiberis Recens, Radix Angelicae Sinensis is cleaned, coarse powder is broken into 30 orders, is uniformly mixed, add the water of above-mentioned raw materials gross mass times 8-12 times amount, reflux, extract, 2-3 time, temperature is within the scope of 40-95 DEG C, extraction time is 30-60min/ time, merge extractive liquid, filters, by extracting solution concentrating under reduced pressure, extracting solution after concentrated is dried within the scope of 45-60 DEG C, make powder, obtain Rhizoma Zingiberis Recens Radix Angelicae Sinensis and extract mixture, for subsequent use;
(3) get microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) the Rhizoma Zingiberis Recens Radix Angelicae Sinensis that Chinese yam pulp obtained for step (1), step (2) obtain is extracted mixture to be uniformly mixed, in mixture, add carboxymethyl cellulose, microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium after pulverizing in vitamin C, vitamin E and above-mentioned steps stir, blender rotating speed is 10-20r/min, time is 10-20min, obtains mixture for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 1-5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet.
Get fresh Chinese yam in described step (1) and clean peeling, the vitamin C that Rhizoma Dioscoreae after peeling adds 0.2% carries out color fixative, Rhizoma Dioscoreae after color fixative boils 15min at 80 DEG C, and pull an oar after adding the water of Rhizoma Dioscoreae quality times 10 times amount, slurry granularity is 300 orders, it is under 45 DEG C of conditions that temperature controls, use 200 mesh screen after making beating, impurity is discharged, then the serosity after filtering is carried out high temperature instantaneous sterilization, temperature control is 105 DEG C of condition lower times is 6s, obtains Chinese yam pulp.
Get raw material Rhizoma Zingiberis Recens in described step (2), Radix Angelicae Sinensis is cleaned, coarse powder is broken into 30 orders, is uniformly mixed, and adds the water of above-mentioned raw materials gross mass times 9 times amount, reflux, extract, 3 times, temperature is 75 DEG C of condition lower extraction times is 30min/ time, merge extractive liquid, filters, by extracting solution concentrating under reduced pressure, extracting solution after concentrated is dried within the scope of 60 DEG C, makes powder, obtain Rhizoma Zingiberis Recens Radix Angelicae Sinensis and extract mixture.
In sum, beneficial effect of the present invention:
The present invention has temperature compensation QI and blood, increases bone density, increases immunity, improves the effects such as nutritional anemia.Be applicable to postpartum anemia, state of an illness the lighter, pale complexion, dizziness, eye conjunctiva color is light; State of an illness severe one, shallow complexion, edema, malaise, cardiopalmus, stomach poor appetite move back, short of breath etc., for recovering aid.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
A kind of Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 200 parts, Rhizoma Zingiberis Recens 100-200 part, Radix Angelicae Sinensis 100 parts, microcrystalline Cellulose 40 parts, Coriolus Versicolor P.E. 0.12 part, Margarita powder 0.35 part, ferrous lactate 0.003 part, vitamin C 1 part, vitamin E 0.003 part, 100 parts, mannitol, sucralose 10 parts, micropowder silica gel 10 parts, carboxymethyl cellulose 3 parts, carboxymethyl starch sodium 55 parts, magnesium stearate 4 parts.
A preparation method for Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam and clean peeling, the vitamin C that Rhizoma Dioscoreae after peeling adds 0.2% carries out color fixative, Rhizoma Dioscoreae after color fixative boils 10-15min within the scope of 80-90 DEG C, pull an oar after adding the water of Rhizoma Dioscoreae quality times 6-10 times amount, slurry granularity is 300-400 order, temperature controls within the scope of 40-45 DEG C, 200-250 mesh screen is used after making beating, impurity is discharged, again the serosity after filtration is carried out high temperature instantaneous sterilization, temperature controls as within the scope of 100-130 DEG C, and the time is 5-10s, obtain Chinese yam pulp, for subsequent use;
(2) get raw material Rhizoma Zingiberis Recens, Radix Angelicae Sinensis is cleaned, coarse powder is broken into 30 orders, is uniformly mixed, add the water of above-mentioned raw materials gross mass times 8-12 times amount, reflux, extract, 2-3 time, temperature is within the scope of 40-95 DEG C, extraction time is 30-60min/ time, merge extractive liquid, filters, by extracting solution concentrating under reduced pressure, extracting solution after concentrated is dried within the scope of 45-60 DEG C, make powder, obtain Rhizoma Zingiberis Recens Radix Angelicae Sinensis and extract mixture, for subsequent use;
(3) get microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) the Rhizoma Zingiberis Recens Radix Angelicae Sinensis that Chinese yam pulp obtained for step (1), step (2) obtain is extracted mixture to be uniformly mixed, in mixture, add carboxymethyl cellulose, microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium after pulverizing in vitamin C, vitamin E and above-mentioned steps stir, blender rotating speed is 10-20r/min, time is 10-20min, obtains mixture for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 1-5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet.
Embodiment 2
A kind of Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 300 parts, 150 parts, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis 150 parts, microcrystalline Cellulose 50 parts, Coriolus Versicolor P.E. 0.22 part, Margarita powder 0.55 part, ferrous lactate 0.005 part, vitamin C 1.5 parts, vitamin E 0.005 part, 135 parts, mannitol, sucralose 12.5 parts, micropowder silica gel 30 parts, carboxymethyl cellulose 4 parts, carboxymethyl starch sodium 67.5 parts, magnesium stearate 5 parts.
A preparation method for Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam and clean peeling, the vitamin C that Rhizoma Dioscoreae after peeling adds 0.2% carries out color fixative, Rhizoma Dioscoreae after color fixative boils 10-15min within the scope of 80-90 DEG C, pull an oar after adding the water of Rhizoma Dioscoreae quality times 6-10 times amount, slurry granularity is 300-400 order, temperature controls within the scope of 40-45 DEG C, 200-250 mesh screen is used after making beating, impurity is discharged, again the serosity after filtration is carried out high temperature instantaneous sterilization, temperature controls as within the scope of 100-130 DEG C, and the time is 5-10s, obtain Chinese yam pulp, for subsequent use;
(2) get raw material Rhizoma Zingiberis Recens, Radix Angelicae Sinensis is cleaned, coarse powder is broken into 30 orders, is uniformly mixed, add the water of above-mentioned raw materials gross mass times 8-12 times amount, reflux, extract, 2-3 time, temperature is within the scope of 40-95 DEG C, extraction time is 30-60min/ time, merge extractive liquid, filters, by extracting solution concentrating under reduced pressure, extracting solution after concentrated is dried within the scope of 45-60 DEG C, make powder, obtain Rhizoma Zingiberis Recens Radix Angelicae Sinensis and extract mixture, for subsequent use;
(3) get microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) the Rhizoma Zingiberis Recens Radix Angelicae Sinensis that Chinese yam pulp obtained for step (1), step (2) obtain is extracted mixture to be uniformly mixed, in mixture, add carboxymethyl cellulose, microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium after pulverizing in vitamin C, vitamin E and above-mentioned steps stir, blender rotating speed is 10-20r/min, time is 10-20min, obtains mixture for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 1-5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet.
Embodiment 3
A kind of Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 400 parts, 200 parts, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis 200 parts, microcrystalline Cellulose 60 parts, Coriolus Versicolor P.E. 0.32 part, Margarita powder 0.75 part, ferrous lactate 0.007 part, Catergen part, vitamin E 0.007 part, 170 parts, mannitol, sucralose 15 parts, micropowder silica gel 50 parts, carboxymethyl cellulose 5 parts, carboxymethyl starch sodium 80 parts, magnesium stearate 6 parts.
A preparation method for Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam and clean peeling, the vitamin C that Rhizoma Dioscoreae after peeling adds 0.2% carries out color fixative, Rhizoma Dioscoreae after color fixative boils 10-15min within the scope of 80-90 DEG C, pull an oar after adding the water of Rhizoma Dioscoreae quality times 6-10 times amount, slurry granularity is 300-400 order, temperature controls within the scope of 40-45 DEG C, 200-250 mesh screen is used after making beating, impurity is discharged, again the serosity after filtration is carried out high temperature instantaneous sterilization, temperature controls as within the scope of 100-130 DEG C, and the time is 5-10s, obtain Chinese yam pulp, for subsequent use;
(2) get raw material Rhizoma Zingiberis Recens, Radix Angelicae Sinensis is cleaned, coarse powder is broken into 30 orders, is uniformly mixed, add the water of above-mentioned raw materials gross mass times 8-12 times amount, reflux, extract, 2-3 time, temperature is within the scope of 40-95 DEG C, extraction time is 30-60min/ time, merge extractive liquid, filters, by extracting solution concentrating under reduced pressure, extracting solution after concentrated is dried within the scope of 45-60 DEG C, make powder, obtain Rhizoma Zingiberis Recens Radix Angelicae Sinensis and extract mixture, for subsequent use;
(3) get microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) the Rhizoma Zingiberis Recens Radix Angelicae Sinensis that Chinese yam pulp obtained for step (1), step (2) obtain is extracted mixture to be uniformly mixed, in mixture, add carboxymethyl cellulose, microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium after pulverizing in vitamin C, vitamin E and above-mentioned steps stir, blender rotating speed is 10-20r/min, time is 10-20min, obtains mixture for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 1-5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.

Claims (1)

1. a Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet, is characterized in that: be made up of following parts by weight ingredient: Rhizoma Dioscoreae 300 parts, 150 parts, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis 150 parts, microcrystalline Cellulose 50 parts, Coriolus Versicolor P.E. 0.22 part, Margarita powder 0.55 part, ferrous lactate 0.005 part, vitamin C 1.5 parts, vitamin E 0.005 part, 135 parts, mannitol, sucralose 12.5 parts, micropowder silica gel 30 parts, carboxymethyl cellulose 4 parts, carboxymethyl starch sodium 67.5 parts, magnesium stearate 5 parts; Its preparation method is:
(1) get fresh Chinese yam and clean peeling, the vitamin C that Rhizoma Dioscoreae after peeling adds 0.2% carries out color fixative, and the Rhizoma Dioscoreae after color fixative boils 15min at 80 DEG C, pulls an oar after adding the water of Rhizoma Dioscoreae quality doubly 10 times amount, slurry granularity is 300 orders, it is under 45 DEG C of conditions that temperature controls, and uses 200 mesh screen after making beating, and impurity is discharged, again the serosity after filtration is carried out high temperature instantaneous sterilization, temperature control is 105 DEG C of condition lower times is 6s, obtains Chinese yam pulp, for subsequent use;
(2) get raw material Rhizoma Zingiberis Recens, Radix Angelicae Sinensis is cleaned, coarse powder is broken into 30 orders, is uniformly mixed, add the water of above-mentioned raw materials gross mass times 9 times amount, reflux, extract, 3 times, temperature is 75 DEG C of condition lower extraction times is 30min/ time, merge extractive liquid, filter, by extracting solution concentrating under reduced pressure, the extracting solution after concentrated is dried within the scope of 60 DEG C, makes powder, obtain Rhizoma Zingiberis Recens Radix Angelicae Sinensis and extract mixture, for subsequent use;
(3) get microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) the Rhizoma Zingiberis Recens Radix Angelicae Sinensis that Chinese yam pulp obtained for step (1), step (2) obtain is extracted mixture to be uniformly mixed, in mixture, add carboxymethyl cellulose, microcrystalline Cellulose, Coriolus Versicolor P.E., Margarita powder, ferrous lactate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium after pulverizing in vitamin C, vitamin E and above-mentioned steps stir, blender rotating speed is 10-20r/min, time is 10-20min, obtains mixture for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 1-5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Rhizoma Zingiberis Recens Radix Angelicae Sinensis dispersible tablet.
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