CN101700317A - Preparation capable of improving fundus and retina microcirculation lesion and restoring ocular and retina microcirculation lesion and damage and method for preparing same - Google Patents
Preparation capable of improving fundus and retina microcirculation lesion and restoring ocular and retina microcirculation lesion and damage and method for preparing same Download PDFInfo
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- CN101700317A CN101700317A CN200910272758A CN200910272758A CN101700317A CN 101700317 A CN101700317 A CN 101700317A CN 200910272758 A CN200910272758 A CN 200910272758A CN 200910272758 A CN200910272758 A CN 200910272758A CN 101700317 A CN101700317 A CN 101700317A
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Abstract
The invention relates to preparation capable of improving fundus and retina microcirculation lesion and restoring ocular and retina microcirculation lesion and damage and a method for preparing the same. The preparation comprises mother-of-pearl, privet, rhizoma atractylodis, chrysanthemum, poria, cassia seeds, mulberry, Chinese wolfberry fruit, zinc gluconate, taurine and the like. The method for preparing the preparation comprises the following steps: decocting the qualified privet, the qualified rhizoma atractylodis and the qualified chrysanthemum in water, filtering to obtain decoction, cooling and concentrating the decoction into clear paste, and decompressing and drying the clear paste in vacuum to obtain dry extractive A; decocting the qualified mother-of-pearl in alkaline water, rising the decocted mother-of-pearl in clear water, scraping the black peel of the mother-of-pearl, calcining the mother-of-pearl crisp on an iron wire gauze, and pulverizing and sieving the mother-of-pearl by a sieve of 100 mesh to obtain extractive B; mixing the zinc gluconate and the taurine, pulverizing and sieving the zinc gluconate and the taurine by the sieve of 100 mesh to obtain powder C; and mixing the dry extractive A, the extractive B and the powder C to obtain the preparation. Clinically tested by the Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology, the preparation has the efficacy of improving the fundus and retina microcirculation lesion and restoring the ocular and retina microcirculation lesion and damage.
Description
Technical field
The present invention relates to a kind of preparation that can improve optical fundus and retinal microcirculation pathological changes and repairing lesion and damnification of eye and preparation method thereof.
Background technology
Being used to improve asthenopic medicine now has a lot, as " a kind of eye health-care edible capsule and preparation method " (Chinese patent application number 99114543), constituted by Fructus Benincasae powder, Flos Chrysanthemi powder, Pericarpium Citri tangerinae powder, Thallus Laminariae (Thallus Eckloniae) powder, embryo nelumbinis powder or Radix Ginseng powder, its preparation method be raw material through pre-freeze, lyophilization, pulverize, sieve, make powdery respectively, thereafter mix and mix thoroughly, dress capsule packing.As " a kind of control eyestrain and compound preparation hypersensitive of being mainly used in " (Chinese patent application number 200610045770); be to be main medicine, be equipped with suitable adjuvant therapy medicaments such as Mentholum, hyaluronate sodium, glycerol etc. and pharmaceutic adjuvant such as compositions such as antiseptic, buffer agent with those four kinds of medicines such as quick of taurine, vitamin B6, maleic acid phenalgin.
Concha Margaritifera compatibility Fructus Lycii, Fructus Ligustri Lucidi Concha Margaritifera liver heat removing and eyesight improving; Fructus Lycii, Fructus Ligustri Lucidi nourishing the liver and kidney and make eye bright. three's compatibility, the effect that tonifying liver, kidney tonifying are arranged, makes eye bright is with diseases such as the poor vision of the what treatment hepatic and renal YIN deficiency, blurring of vision. to improving retina good effect is arranged.
Summary of the invention
The objective of the invention is at above-mentioned present situation, aim to provide and a kind ofly can improve vision, regulate the eye microcirculation, promote preparation of vision restoration and preparation method thereof.
The implementation of the object of the invention is, a kind of preparation that can improve optical fundus and retinal microcirculation pathological changes and repairing lesion and damnification of eye is made up of following components by weight proportion:
Concha Margaritifera 1-3 Fructus Ligustri Lucidi 5-10
Rhizoma Atractylodis 5-10 Flos Chrysanthemi 10-20
Poria 5-10 Semen Cassiae 5-10
Fructus Mori 5-10 Fructus Lycii 5-10
Zinc gluconate 1-2 taurine 7-15
A kind of preparation method that can improve the preparation of optical fundus and retinal microcirculation pathological changes and repairing lesion and damnification of eye, concrete steps are as follows:
1) be that 5-10 Fructus Ligustri Lucidi, 5-10 Rhizoma Atractylodis, 10-20 Flos Chrysanthemi, 5-10 Poria, 5-10 Semen Cassiae, Fructus Mori 5-10, Fructus Lycii 5-10 are concocted and put into the Chinese medicine extraction jar after qualified with weight ratio, add its weight 6-8 water doubly, heating decocted 2 hours, filter, filtering residue adds 4-6 water doubly again, heating decocted 2 hours, filtered
2) merge twice decoction liquor, left standstill 24 hours, filter and remove residue,
3) filtrate is cooled to 4 ℃, and being concentrated into relative density is 1.25 ± 0.05, and the medicine juice amount is the clear paste of the 1/3-1/4 of former amount of filtrate,
4) with clear paste, the vacuum decompression drying gets dry extract A,
5) getting weight ratio is the 1-3 Concha Margaritifera, concocts to put into aqueous alkali after qualified and boil, and puts into clear water then and embathes, and takes out, and scrapes off top casting skin with pocket knife, is placed on the wire gauze and calcines, and stirs at any time, in order to avoid burn, burns to crisp back and pulverizes, cross 100 mesh sieves and get extract B,
6) weight ratio 1-2 zinc gluconate, 7-15 taurine are mixed pulverizing, cross 100 mesh sieves and get powder C,
7) dry extract A and extract B, powder C mix homogeneously are got preparation.
This preparation energy alleviating asthenopia; microcirculation improvement; protection eye blood capillary health; alleviate intraocular pressure; nutrition second nerve is removed noxious substance in the retina, suppresses to eliminate the eye paathogenic factor; safeguard the prevention eye health, all effective to cataract, glaucoma, trachoma, epiphora induced by wind, excessive tear disease, vitreous opacity, retinopathy, dacryocystisis, corneal nebula, stasis of blood naked eyes, conjunctivitis, presbyopia, myopia, amblyopia and diabetes complicated with ophthalmopathy person etc.Preparation method is simple.
The specific embodiment
This preparation is formulated by Concha Margaritifera, Fructus Ligustri Lucidi, Rhizoma Atractylodis, Flos Chrysanthemi, Poria, Semen Cassiae, Fructus Mori, Fructus Lycii, zinc gluconate, taurine etc.The Chinese medicine function of Concha Margaritifera: liver YANG hyperactivity suppressing, liver heat removing and eyesight improving.Be used for deficiecny of liver-YIN, the headache due to the excessive rising of liver-YANG, dizzy, tinnitus, agitation, cards such as insomnia.Concha Margaritifera has the suppressing the hyperactive liver and subsiding YANG effect close with Concha Haliotidis.Normal and the Radix Paeoniae Alba, the Radix Rehmanniae, Dens Draconis are equal to usefulness, return Tibetan soup as first and second.Be used for diseases such as deficiency of the liver conjunctival congestion photophobia.Merit with liver heat removing and eyesight improving.Control the conjunctival congestion photophobia, can be equal to usefulness with Flos Chrysanthemi, Herba Senecionis Scandentis, Semen Plantaginis.The poor vision that is used for the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.Can the tonifying liver kidney yin control poor vision, often join Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Lycii is equal to usefulness, controls early whitening of beard and hair, often joins Herba Ecliptae, and Fructus Mori are equal to usefulness, control fever due to yin deficiency, often join Cortex Lycii, and Radix Rehmanniae is equal to usefulness.Be used for nyctalopia, eyes dusk puckery, wet resistance taste, distension and fullness in the abdomen, damp-warm diseases and damp invasion of lower energizer, the foot swelling and pain in knee, flaccidity is soft unable. normal and Cortex Magnoliae Officinalis, compatibilities such as Pericarpium Citri Reticulatae are used.The work that Flos Chrysanthemi has refreshment eyesight improving to reduce internal heat can also make all right clearing away heart-fire detoxification of the transference cure of eyestrain.Taurine is a kind of special aminoacid, is the requisite a kind of nutrient of human body, and the marvellous effect of balance health is arranged.Except eyes, taurine also has important effect to other organ.Semen Cassiae can help irritability, beneficial smart water; The accent end is coated with, the detumescence poison, and the Xie temple are controlled headache, paste the brain heart again and end epistaxis; Make pillow and win Semen sojae atricolor, control wind syndrome of head, make eye bright.
Concha Margaritifera compatibility Fructus Lycii, Fructus Ligustri Lucidi Concha Margaritifera liver heat removing and eyesight improving; Fructus Lycii, Fructus Ligustri Lucidi nourishing the liver and kidney and make eye bright. three's compatibility, the effect that tonifying liver, kidney tonifying are arranged, makes eye bright is with diseases such as the poor vision of the what treatment hepatic and renal YIN deficiency, blurring of vision. to improving retina good effect is arranged.
Enumerate the specific embodiment of the invention below:
Example; get the 5g Fructus Ligustri Lucidi; the 5g Rhizoma Atractylodis; the 10g Flos Chrysanthemi; the 5g Poria; the 5g Semen Cassiae; Fructus Mori 5g; put into the Chinese medicine extraction jar after the process of preparing Chinese medicine of 5g Fructus Lycii is qualified, add the water of 6 times of its weight, heating decocted 2 hours; filter, filtering residue adds 4 times water again, and heating decocted 2 hours; filter; merge decoction liquor twice, left standstill filter and remove residue 24 hours; filtrate is cooled to 4 ℃; being concentrated into relative density is 1.25, and the medicine juice amount is 1/3 a clear paste of former amount of filtrate, with clear paste; the vacuum decompression drying; dry extract A, get the 1g Concha Margaritifera, concoct and put into aqueous alkali after qualified and boil; putting into clear water then embathes; take out, scrape off top casting skin, be placed on the wire gauze again and calcine with pocket knife; at any time stir; in order to avoid burn, burn to crisp back and pulverize, cross 100 mesh sieves and get extract B; get the 1g zinc gluconate; the 7g taurine mixes to be pulverized; cross 100 mesh sieves and get powder C, with dry extract A and extract B; powder C mix homogeneously adds the capsular auxiliary agent of system, gets capsule preparations by the capsular technology of preparation.
Example 2, get 6g Fructus Ligustri Lucidi, 6g Rhizoma Atractylodis, 12g Flos Chrysanthemi, 6g Poria, 6g Semen Cassiae, 6g Fructus Mori, 6g Fructus Lycii, 1.5g Concha Margaritifera, 1.5g zinc gluconate, 8g taurine.
Example 3, with example 1, different is to get 7g Fructus Ligustri Lucidi, 7g Rhizoma Atractylodis, 15g Flos Chrysanthemi, 5g Poria, 7g Semen Cassiae, 7g Fructus Mori, 7g Fructus Lycii, 2g Concha Margaritifera, 2g zinc gluconate, 10g taurine.
Example 4, with example 1; different is; get 8g Fructus Ligustri Lucidi, 8g Rhizoma Atractylodis, 18g Flos Chrysanthemi, 8g Poria, 8g Semen Cassiae, 8g Fructus Mori, 8g Fructus Lycii and put into the Chinese medicine extraction jar; the water heating that adds 7 times of its weight decocted 2 hours, filtered, and filtering residue adds 5 times water heating again and decocted 2 hours; cross liquid and be cooled to 4 ℃; being concentrated into relative density is 1.25, and the medicine juice amount is 1/4 a clear paste of former amount of filtrate, gets 2.5g Concha Margaritifera, 2.5g zinc gluconate, 12g taurine.
Example 5, with example 1; different is; get 10g Fructus Ligustri Lucidi, 10g Rhizoma Atractylodis, 20g Flos Chrysanthemi, 10g Poria, 10g Semen Cassiae, 10g Fructus Mori, 10g Fructus Lycii and put into the Chinese medicine extraction jar; the water heating that adds 6 times of its weight decocted 2 hours; filter, filtering residue adds 5 times water again, and filtrate cooling concentration to relative density is 1.30; the medicine juice amount is 1/3 a clear paste of former amount of filtrate, gets 3g Concha Margaritifera, 3g zinc gluconate, 15g taurine.
Liyuan Hospital Attached to Tongji Medical College, Huazhong Science and Technol selects the age in old people's 40 examples between 40-70 year, oral capsule preparations, every day 2 times, each one, 36 day one-period.
Formulate efficacy assessment standard with reference to " new Chinese medicine clinical research guideline " that health ministry was issued in 2002, its symptom efficacy result sees the following form:
As can be seen from the table, this preparation improves visual deterioration and blind disease, degeneration of macula, retinitis pigmentosa, glaucoma, cataract, vitreous opacity, nyctalopia, muscae volitantes, optical fundus blood vessel sclerosis, hypertrophy etc. to the patient, item symptoms such as various oculopathy such as hypermetropia, myopia are obviously improved, and illustrate that this preparation has to the present invention relates to have the effect of improving optical fundus and retinal microcirculation pathological changes and repairing lesion and damnification of eye.
Claims (2)
1. preparation that can improve optical fundus and retinal microcirculation pathological changes and repairing lesion and damnification of eye is characterized in that being made up of following components by weight proportion:
Concha Margaritifera 1-3 Fructus Ligustri Lucidi 5-10
Rhizoma Atractylodis 5-10 Flos Chrysanthemi 10-20
Poria 5-10 Semen Cassiae 5-10
Fructus Mori 5-10 Fructus Lycii 5-10
Zinc gluconate 1-2 taurine 7-15.
2. the described a kind of preparation method that can improve the preparation of optical fundus and retinal microcirculation pathological changes and repairing lesion and damnification of eye of claim 1 is characterized in that concrete steps are as follows:
1) be that 5-10 Fructus Ligustri Lucidi, 5-10 Rhizoma Atractylodis, 10-20 Flos Chrysanthemi, 5-10 Poria, 5-10 Semen Cassiae, Fructus Mori 5-10, Fructus Lycii 5-10 are concocted and put into the Chinese medicine extraction jar after qualified with weight ratio, add its weight 6-8 water doubly, heating decocted 2 hours, filter, filtering residue adds 4-6 water doubly again, heating decocted 2 hours, filtered
2) merge twice decoction liquor, left standstill 24 hours, filter and remove residue,
3) filtrate is cooled to 4 ℃, and being concentrated into relative density is 1.25 ± 0.05, and the medicine juice amount is the clear paste of the 1/3-1/4 of former amount of filtrate,
4) with clear paste, the vacuum decompression drying gets dry extract A,
5) getting weight ratio is the 1-3 Concha Margaritifera, concocts to put into aqueous alkali after qualified and boil, and puts into clear water then and embathes, and takes out, and scrapes off top casting skin with pocket knife, is placed on the wire gauze and calcines, and stirs at any time, in order to avoid burn, burns to crisp back and pulverizes, cross 100 mesh sieves and get extract B,
6) weight ratio 1-2 zinc gluconate, 7-15 taurine are mixed pulverizing, cross 100 mesh sieves and get powder C,
7) dry extract A and extract B, powder C mix homogeneously are got preparation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910272758XA CN101700317B (en) | 2009-11-16 | 2009-11-16 | Preparation capable of improving fundus and retina microcirculation lesion and restoring ocular and retina microcirculation lesion and damage, and method for preparing same |
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| CN200910272758XA CN101700317B (en) | 2009-11-16 | 2009-11-16 | Preparation capable of improving fundus and retina microcirculation lesion and restoring ocular and retina microcirculation lesion and damage, and method for preparing same |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991111A (en) * | 2010-10-12 | 2011-03-30 | 烟台大洋制药有限公司 | Drug or heal-care food capable of alleviating visual fatigue |
| CN102755561A (en) * | 2012-02-18 | 2012-10-31 | 李国� | Health care product used for diabetic fundus hemorrhage |
| CN102973907A (en) * | 2011-09-07 | 2013-03-20 | 菏泽普恩药业有限公司 | Compound preparation of traditional Chinese medicine and Western medicine for duck spleen necrosis control |
| CN103251927A (en) * | 2013-04-11 | 2013-08-21 | 深圳市百汇生物技术有限公司 | Composition containing bilberry extract |
| CN104491403A (en) * | 2014-12-08 | 2015-04-08 | 四川金堂海纳生物医药技术研究所 | Medicine for treating central retinochoroiditis and preparation method |
| CN104721348A (en) * | 2015-04-07 | 2015-06-24 | 孟祥波 | Traditional Chinese medicine decoction for treating acute dacryocystitis and preparation method thereof |
| CN104740086A (en) * | 2015-04-21 | 2015-07-01 | 青岛辰达生物科技有限公司 | Traditional Chinese medicine composition for treating myopia complicated primary open-angle glaucoma |
| CN105535258A (en) * | 2015-12-24 | 2016-05-04 | 兰州古驰生物科技有限公司 | Traditional Chinese medicine health-care preparation for regulating asthenopia |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100428944C (en) * | 2005-03-31 | 2008-10-29 | 扬子江药业集团有限公司 | Compound traditional Chinese medicine for improving eyesight and its prepn. method |
| CN100364593C (en) * | 2006-02-20 | 2008-01-30 | 王信锁 | Oral liquid for promoting eyesight and protecting eye |
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2009
- 2009-11-16 CN CN200910272758XA patent/CN101700317B/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991111A (en) * | 2010-10-12 | 2011-03-30 | 烟台大洋制药有限公司 | Drug or heal-care food capable of alleviating visual fatigue |
| CN101991111B (en) * | 2010-10-12 | 2013-07-31 | 烟台大洋制药有限公司 | Drug or heal-care food capable of alleviating visual fatigue |
| CN102973907A (en) * | 2011-09-07 | 2013-03-20 | 菏泽普恩药业有限公司 | Compound preparation of traditional Chinese medicine and Western medicine for duck spleen necrosis control |
| CN102755561A (en) * | 2012-02-18 | 2012-10-31 | 李国� | Health care product used for diabetic fundus hemorrhage |
| CN102755561B (en) * | 2012-02-18 | 2013-11-20 | 李国� | Health care product used for diabetic fundus hemorrhage |
| CN103251927A (en) * | 2013-04-11 | 2013-08-21 | 深圳市百汇生物技术有限公司 | Composition containing bilberry extract |
| CN104491403A (en) * | 2014-12-08 | 2015-04-08 | 四川金堂海纳生物医药技术研究所 | Medicine for treating central retinochoroiditis and preparation method |
| CN104721348A (en) * | 2015-04-07 | 2015-06-24 | 孟祥波 | Traditional Chinese medicine decoction for treating acute dacryocystitis and preparation method thereof |
| CN104740086A (en) * | 2015-04-21 | 2015-07-01 | 青岛辰达生物科技有限公司 | Traditional Chinese medicine composition for treating myopia complicated primary open-angle glaucoma |
| CN105535258A (en) * | 2015-12-24 | 2016-05-04 | 兰州古驰生物科技有限公司 | Traditional Chinese medicine health-care preparation for regulating asthenopia |
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| CN101700317B (en) | 2012-02-01 |
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