CN103781798B - 内皮糖蛋白多肽及其用途 - Google Patents

内皮糖蛋白多肽及其用途 Download PDF

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Publication number
CN103781798B
CN103781798B CN201280030070.0A CN201280030070A CN103781798B CN 103781798 B CN103781798 B CN 103781798B CN 201280030070 A CN201280030070 A CN 201280030070A CN 103781798 B CN103781798 B CN 103781798B
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CN
China
Prior art keywords
endoglin
amino acid
fusion protein
polypeptide
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201280030070.0A
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English (en)
Chinese (zh)
Other versions
CN103781798A (zh
Inventor
阿斯亚·格林贝格
罗斯莱因·卡斯顿盖
埃里克·维尔纳
拉温德拉·库玛
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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Priority to CN201810139884.7A priority Critical patent/CN108178789B/zh
Priority to CN201810139885.1A priority patent/CN108341863A/zh
Publication of CN103781798A publication Critical patent/CN103781798A/zh
Application granted granted Critical
Publication of CN103781798B publication Critical patent/CN103781798B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201280030070.0A 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途 Expired - Fee Related CN103781798B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201810139884.7A CN108178789B (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途
CN201810139885.1A CN108341863A (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477585P 2011-04-20 2011-04-20
US61/477,585 2011-04-20
PCT/US2012/034295 WO2012145539A1 (en) 2011-04-20 2012-04-19 Endoglin polypeptides and uses thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201810139885.1A Division CN108341863A (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途
CN201810139884.7A Division CN108178789B (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途

Publications (2)

Publication Number Publication Date
CN103781798A CN103781798A (zh) 2014-05-07
CN103781798B true CN103781798B (zh) 2018-03-13

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CN201280030070.0A Expired - Fee Related CN103781798B (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途
CN201810139885.1A Pending CN108341863A (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途
CN201810139884.7A Expired - Fee Related CN108178789B (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途

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CN201810139885.1A Pending CN108341863A (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途
CN201810139884.7A Expired - Fee Related CN108178789B (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途

Country Status (8)

Country Link
US (3) US9932386B2 (OSRAM)
EP (2) EP2699590B8 (OSRAM)
JP (3) JP6250533B2 (OSRAM)
CN (3) CN103781798B (OSRAM)
AU (4) AU2012245439B2 (OSRAM)
CA (1) CA2833747C (OSRAM)
DK (1) DK2699590T3 (OSRAM)
WO (1) WO2012145539A1 (OSRAM)

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JP2018070625A (ja) 2018-05-10
JP7097930B2 (ja) 2022-07-08
US20210300991A1 (en) 2021-09-30
EP2699590B8 (en) 2019-04-17
DK2699590T3 (en) 2019-05-06
AU2020244456A1 (en) 2020-10-29
AU2017201711B2 (en) 2019-04-18
CN108178789B (zh) 2021-11-02
CN108341863A (zh) 2018-07-31
EP3549952A1 (en) 2019-10-09
AU2017201711A1 (en) 2017-04-13
WO2012145539A1 (en) 2012-10-26
AU2012245439B2 (en) 2017-04-06
AU2019204979B2 (en) 2020-07-16
JP2014513951A (ja) 2014-06-19
CA2833747A1 (en) 2012-10-26
US20150307588A1 (en) 2015-10-29
US20180258156A1 (en) 2018-09-13
JP2020202844A (ja) 2020-12-24
JP6803315B2 (ja) 2020-12-23
AU2019204979A1 (en) 2019-08-01
US9932386B2 (en) 2018-04-03
AU2012245439A1 (en) 2013-11-28
CN108178789A (zh) 2018-06-19
CA2833747C (en) 2022-10-18
EP2699590A1 (en) 2014-02-26
CN103781798A (zh) 2014-05-07
US10981972B2 (en) 2021-04-20
JP6250533B2 (ja) 2017-12-20
EP2699590B1 (en) 2019-02-20

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