CN103768086B - 寡核苷酸螯合物的用途 - Google Patents

寡核苷酸螯合物的用途 Download PDF

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Publication number
CN103768086B
CN103768086B CN201410046103.1A CN201410046103A CN103768086B CN 103768086 B CN103768086 B CN 103768086B CN 201410046103 A CN201410046103 A CN 201410046103A CN 103768086 B CN103768086 B CN 103768086B
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oligonucleotide
chelate
experimenter
rep
kinds
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Chinese (zh)
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CN103768086A (zh
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安德鲁·瓦利恩特
米歇尔·巴齐内
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Replicor Inc
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Replicor Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/04Chelating agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
CN201410046103.1A 2010-08-20 2011-08-18 寡核苷酸螯合物的用途 Active CN103768086B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37525710P 2010-08-20 2010-08-20
US61/375,257 2010-08-20
CN201180035946.6A CN103052405B (zh) 2010-08-20 2011-08-18 寡核苷酸螯合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201180035946.6A Division CN103052405B (zh) 2010-08-20 2011-08-18 寡核苷酸螯合物

Publications (2)

Publication Number Publication Date
CN103768086A CN103768086A (zh) 2014-05-07
CN103768086B true CN103768086B (zh) 2015-10-14

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ID=45594559

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410046103.1A Active CN103768086B (zh) 2010-08-20 2011-08-18 寡核苷酸螯合物的用途
CN201180035946.6A Active CN103052405B (zh) 2010-08-20 2011-08-18 寡核苷酸螯合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201180035946.6A Active CN103052405B (zh) 2010-08-20 2011-08-18 寡核苷酸螯合物

Country Status (35)

Country Link
US (2) US8513211B2 (https=)
EP (1) EP2605794B1 (https=)
JP (1) JP5775581B2 (https=)
KR (3) KR101606495B1 (https=)
CN (2) CN103768086B (https=)
AU (1) AU2011291401B2 (https=)
BR (1) BR112013003875B1 (https=)
CA (2) CA2806616C (https=)
CL (1) CL2013000445A1 (https=)
CO (1) CO6670525A2 (https=)
CR (1) CR20130069A (https=)
CU (1) CU20130022A7 (https=)
CY (1) CY1118207T1 (https=)
DK (1) DK2605794T3 (https=)
DO (1) DOP2013000041A (https=)
EA (1) EA026660B1 (https=)
EC (1) ECSP13012449A (https=)
ES (1) ES2598556T3 (https=)
GT (1) GT201300040A (https=)
HR (1) HRP20161333T1 (https=)
HU (1) HUE029521T2 (https=)
IL (1) IL224237A (https=)
LT (1) LT2605794T (https=)
MX (1) MX340294B (https=)
MY (1) MY160961A (https=)
NZ (1) NZ606364A (https=)
PH (1) PH12013500192B1 (https=)
PL (1) PL2605794T3 (https=)
PT (1) PT2605794T (https=)
RS (1) RS55245B1 (https=)
SG (1) SG187165A1 (https=)
SI (1) SI2605794T1 (https=)
SM (1) SMT201600370B (https=)
WO (1) WO2012021985A1 (https=)
ZA (1) ZA201300497B (https=)

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AU2007282224B2 (en) 2006-08-11 2013-08-29 Vico Therapeutics B.V. Methods and means for treating DNA repeat instability associated genetic disorders
CA2723672C (en) 2007-05-11 2019-09-03 Adynxx, Inc. Gene expression and pain
AU2008317566B2 (en) 2007-10-26 2014-05-01 Academisch Ziekenhuis Leiden Means and methods for counteracting muscle disorders
EP2119783A1 (en) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
CN112251436A (zh) 2012-01-27 2021-01-22 比奥马林技术公司 治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
SMT201700339T1 (it) 2012-04-23 2017-09-07 Biomarin Tech Bv Oligonucleotidi di modulazione dell'rna con caratteristiche migliorate per il trattamento dei disturbi neuromuscolari
EP3511022A1 (en) * 2012-05-10 2019-07-17 Adynxx, Inc. Formulations for the delivery of active ingredients
MY168778A (en) * 2012-05-18 2018-12-04 Replicor Inc Oligonucleotide chelate complex-polypeptide compositions and methods
AR091065A1 (es) * 2012-05-18 2014-12-30 Replicor Inc Una formulacion farmaceutica que comprende un quelato de oligonucleotidos antiviral para el tratamiento de una infeccion antiviral
EP2870246B1 (en) 2012-07-03 2019-09-11 BioMarin Technologies B.V. Oligonucleotide for the treatment of muscular dystrophy patients
AU2013308045B2 (en) * 2012-08-30 2018-10-04 Replicor Inc. Methods for the treatment of hepatitis B and hepatitis D infections
HRP20231400T1 (hr) 2014-07-10 2024-02-16 Replicor Inc. Kelirani fosforotioirani polimeri nukleinskih kiselina, namijenjeni upotrebi u kombinaciji s inhibitorom hbv polimeraze u liječenju infekcija virusima hepatitisa b i hepatitisa d
JP6705807B2 (ja) 2014-08-15 2020-06-03 エーダイニクス インコーポレイテッド 疼痛を治療するためのオリゴヌクレオチドデコイ
WO2016030863A1 (en) 2014-08-29 2016-03-03 Glaxosmithkline Intellectual Property Development Limited Compounds and methods for treating viral infections
AU2016250576C1 (en) * 2015-04-23 2021-05-06 Geron Corporation Methods of polynucleotide preparation using multivalent cation salt compositions
US11166976B2 (en) 2018-11-08 2021-11-09 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods
PE20211783A1 (es) * 2018-11-08 2021-09-08 Aligos Therapeutics Inc Polimeros oligonucleotidos que inhiben el transporte de antigenos y metodos
WO2021198958A1 (en) 2020-04-01 2021-10-07 Janssen Biopharma, Inc. Nucleic acid polymers
WO2022109129A1 (en) * 2020-11-20 2022-05-27 Aligos Therapeutics, Inc. Conjugates of s-antigen transport inhibiting oligonucleotide polymers having enhanced liver targeting
TW202245809A (zh) 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
WO2022152869A1 (en) 2021-01-15 2022-07-21 Janssen Sciences Ireland Unlimited Company Use of oligonucleotides for individuals with hepatic impairment
EP4367241A1 (en) 2021-07-09 2024-05-15 GlaxoSmithKline Intellectual Property (No.3) Limited Use of oligonucleotides for individuals with renal impairment
EP4728073A1 (en) * 2023-06-16 2026-04-22 Ractigen Therapeutics Oligonucleotide formulation

Citations (2)

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Publication number Priority date Publication date Assignee Title
US6011143A (en) * 1997-09-12 2000-01-04 Canon Kabushiki Kaisha Artificial nucleic acids and a method of making
US20070105116A1 (en) * 2003-09-02 2007-05-10 Japan Science And Technology Agency Metal complex type nucleic acid

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JP2001514873A (ja) * 1997-08-20 2001-09-18 ソーマジェニックス インコーポレイテッド 結合特性が改善されたアンチセンスおよびアンチジーン治療薬並びにそれらの使用方法
US6653467B1 (en) * 2000-04-26 2003-11-25 Jcr Pharmaceutical Co., Ltd. Medicament for treatment of Duchenne muscular dystrophy
JP4836366B2 (ja) * 2000-08-25 2011-12-14 雅文 松尾 デュシェンヌ型筋ジストロフィー治療剤
WO2005026188A1 (ja) 2003-09-08 2005-03-24 Japan Science And Technology Agency 金属錯体型核酸
JP2009500020A (ja) * 2005-07-01 2009-01-08 バイオヴェリス コーポレイション 核酸を検出、増幅および/また単離するための組成物および方法
WO2009065181A1 (en) * 2007-11-21 2009-05-28 Apollo Life Sciences Limited Nanostructures suitable for delivery of agents

Patent Citations (2)

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US6011143A (en) * 1997-09-12 2000-01-04 Canon Kabushiki Kaisha Artificial nucleic acids and a method of making
US20070105116A1 (en) * 2003-09-02 2007-05-10 Japan Science And Technology Agency Metal complex type nucleic acid

Non-Patent Citations (3)

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Title
Influence of divalent cations on the conformation of phosphorothioate oligodeoxynucleotides: a circular dichroism study;Siddhesh D. Patil and David G. Rhodes;《Nucleic Acids Research》;20001231;第28卷(第12期);第2439-2445页 *
反义寡核苷酸的体内研究;Akhtar S. et al.;《Foreign Medical Sciences Section on Pharmacy》;19971231;第24卷(第6期);第327-330页 *
反义寡核苷酸研究进展;陈星云;《国外医学分子生物学分册》;20001231;第22卷(第4期);第236-240页 *

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NZ606364A (en) 2014-12-24
DOP2013000041A (es) 2017-12-15
WO2012021985A1 (en) 2012-02-23
EP2605794A1 (en) 2013-06-26
PL2605794T3 (pl) 2017-01-31
SG187165A1 (en) 2013-02-28
HK1198123A1 (en) 2015-03-13
HUE029521T2 (en) 2017-03-28
CN103768086A (zh) 2014-05-07
AU2011291401A1 (en) 2013-01-10
JP2013536195A (ja) 2013-09-19
CA2806616C (en) 2015-08-11
PH12013500192B1 (en) 2018-11-23
CA2855690C (en) 2015-08-25
US8513211B2 (en) 2013-08-20
IL224237A (en) 2015-09-24
BR112013003875A2 (en) 2018-03-13
MY160961A (en) 2017-03-31
HRP20161333T1 (hr) 2016-12-02
AU2011291401B2 (en) 2014-11-27
US8716259B2 (en) 2014-05-06
CR20130069A (es) 2013-09-20
MX2013001668A (es) 2013-07-22
CY1118207T1 (el) 2017-06-28
ES2598556T3 (es) 2017-01-27
ECSP13012449A (es) 2013-04-30
KR20150039873A (ko) 2015-04-13
PT2605794T (pt) 2016-10-25
RS55245B1 (sr) 2017-02-28
MX340294B (es) 2016-07-04
US20130296410A1 (en) 2013-11-07
US20120046348A1 (en) 2012-02-23
KR101606495B1 (ko) 2016-03-28
EA201300259A1 (ru) 2013-12-30
CN103052405A (zh) 2013-04-17
HK1184058A1 (zh) 2014-01-17
CO6670525A2 (es) 2013-05-15
KR20150082685A (ko) 2015-07-15
SMT201600370B (it) 2016-11-10
EP2605794B1 (en) 2016-07-20
CA2855690A1 (en) 2012-02-23
EP2605794A4 (en) 2014-07-02
EA026660B1 (ru) 2017-05-31
ZA201300497B (en) 2013-09-25
CU20130022A7 (es) 2013-04-19
DK2605794T3 (en) 2016-10-24
BR112013003875B1 (pt) 2021-10-05
GT201300040A (es) 2014-09-02
CA2806616A1 (en) 2012-02-23
JP5775581B2 (ja) 2015-09-09
PH12013500192A1 (https=) 2013-03-11
CN103052405B (zh) 2015-11-25
LT2605794T (lt) 2016-10-25
KR20130099067A (ko) 2013-09-05
SI2605794T1 (sl) 2017-01-31
CL2013000445A1 (es) 2013-11-22

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