AU2011291401B2 - Oligonucleotide chelate complexes - Google Patents

Oligonucleotide chelate complexes Download PDF

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Publication number
AU2011291401B2
AU2011291401B2 AU2011291401A AU2011291401A AU2011291401B2 AU 2011291401 B2 AU2011291401 B2 AU 2011291401B2 AU 2011291401 A AU2011291401 A AU 2011291401A AU 2011291401 A AU2011291401 A AU 2011291401A AU 2011291401 B2 AU2011291401 B2 AU 2011291401B2
Authority
AU
Australia
Prior art keywords
oligonucleotide
chelate complex
rep
chelate
divalent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011291401A
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English (en)
Other versions
AU2011291401A1 (en
Inventor
Michel Bazinet
Andrew Vaillant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Replicor Inc
Original Assignee
Replicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45594559&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2011291401(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Replicor Inc filed Critical Replicor Inc
Publication of AU2011291401A1 publication Critical patent/AU2011291401A1/en
Application granted granted Critical
Publication of AU2011291401B2 publication Critical patent/AU2011291401B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
AU2011291401A 2010-08-20 2011-08-18 Oligonucleotide chelate complexes Ceased AU2011291401B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37525710P 2010-08-20 2010-08-20
US61/375,257 2010-08-20
PCT/CA2011/000956 WO2012021985A1 (en) 2010-08-20 2011-08-18 Oligonucleotide chelate complexes

Publications (2)

Publication Number Publication Date
AU2011291401A1 AU2011291401A1 (en) 2013-01-10
AU2011291401B2 true AU2011291401B2 (en) 2014-11-27

Family

ID=45594559

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011291401A Ceased AU2011291401B2 (en) 2010-08-20 2011-08-18 Oligonucleotide chelate complexes

Country Status (35)

Country Link
US (2) US8513211B2 (https=)
EP (1) EP2605794B1 (https=)
JP (1) JP5775581B2 (https=)
KR (3) KR101606495B1 (https=)
CN (2) CN103768086B (https=)
AU (1) AU2011291401B2 (https=)
BR (1) BR112013003875B1 (https=)
CA (2) CA2806616C (https=)
CL (1) CL2013000445A1 (https=)
CO (1) CO6670525A2 (https=)
CR (1) CR20130069A (https=)
CU (1) CU20130022A7 (https=)
CY (1) CY1118207T1 (https=)
DK (1) DK2605794T3 (https=)
DO (1) DOP2013000041A (https=)
EA (1) EA026660B1 (https=)
EC (1) ECSP13012449A (https=)
ES (1) ES2598556T3 (https=)
GT (1) GT201300040A (https=)
HR (1) HRP20161333T1 (https=)
HU (1) HUE029521T2 (https=)
IL (1) IL224237A (https=)
LT (1) LT2605794T (https=)
MX (1) MX340294B (https=)
MY (1) MY160961A (https=)
NZ (1) NZ606364A (https=)
PH (1) PH12013500192B1 (https=)
PL (1) PL2605794T3 (https=)
PT (1) PT2605794T (https=)
RS (1) RS55245B1 (https=)
SG (1) SG187165A1 (https=)
SI (1) SI2605794T1 (https=)
SM (1) SMT201600370B (https=)
WO (1) WO2012021985A1 (https=)
ZA (1) ZA201300497B (https=)

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AU2007282224B2 (en) 2006-08-11 2013-08-29 Vico Therapeutics B.V. Methods and means for treating DNA repeat instability associated genetic disorders
CA2723672C (en) 2007-05-11 2019-09-03 Adynxx, Inc. Gene expression and pain
AU2008317566B2 (en) 2007-10-26 2014-05-01 Academisch Ziekenhuis Leiden Means and methods for counteracting muscle disorders
EP2119783A1 (en) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
CN112251436A (zh) 2012-01-27 2021-01-22 比奥马林技术公司 治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
SMT201700339T1 (it) 2012-04-23 2017-09-07 Biomarin Tech Bv Oligonucleotidi di modulazione dell'rna con caratteristiche migliorate per il trattamento dei disturbi neuromuscolari
EP3511022A1 (en) * 2012-05-10 2019-07-17 Adynxx, Inc. Formulations for the delivery of active ingredients
MY168778A (en) * 2012-05-18 2018-12-04 Replicor Inc Oligonucleotide chelate complex-polypeptide compositions and methods
AR091065A1 (es) * 2012-05-18 2014-12-30 Replicor Inc Una formulacion farmaceutica que comprende un quelato de oligonucleotidos antiviral para el tratamiento de una infeccion antiviral
EP2870246B1 (en) 2012-07-03 2019-09-11 BioMarin Technologies B.V. Oligonucleotide for the treatment of muscular dystrophy patients
AU2013308045B2 (en) * 2012-08-30 2018-10-04 Replicor Inc. Methods for the treatment of hepatitis B and hepatitis D infections
HRP20231400T1 (hr) 2014-07-10 2024-02-16 Replicor Inc. Kelirani fosforotioirani polimeri nukleinskih kiselina, namijenjeni upotrebi u kombinaciji s inhibitorom hbv polimeraze u liječenju infekcija virusima hepatitisa b i hepatitisa d
JP6705807B2 (ja) 2014-08-15 2020-06-03 エーダイニクス インコーポレイテッド 疼痛を治療するためのオリゴヌクレオチドデコイ
WO2016030863A1 (en) 2014-08-29 2016-03-03 Glaxosmithkline Intellectual Property Development Limited Compounds and methods for treating viral infections
AU2016250576C1 (en) * 2015-04-23 2021-05-06 Geron Corporation Methods of polynucleotide preparation using multivalent cation salt compositions
US11166976B2 (en) 2018-11-08 2021-11-09 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods
PE20211783A1 (es) * 2018-11-08 2021-09-08 Aligos Therapeutics Inc Polimeros oligonucleotidos que inhiben el transporte de antigenos y metodos
WO2021198958A1 (en) 2020-04-01 2021-10-07 Janssen Biopharma, Inc. Nucleic acid polymers
WO2022109129A1 (en) * 2020-11-20 2022-05-27 Aligos Therapeutics, Inc. Conjugates of s-antigen transport inhibiting oligonucleotide polymers having enhanced liver targeting
TW202245809A (zh) 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
WO2022152869A1 (en) 2021-01-15 2022-07-21 Janssen Sciences Ireland Unlimited Company Use of oligonucleotides for individuals with hepatic impairment
EP4367241A1 (en) 2021-07-09 2024-05-15 GlaxoSmithKline Intellectual Property (No.3) Limited Use of oligonucleotides for individuals with renal impairment
EP4728073A1 (en) * 2023-06-16 2026-04-22 Ractigen Therapeutics Oligonucleotide formulation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011143A (en) * 1997-09-12 2000-01-04 Canon Kabushiki Kaisha Artificial nucleic acids and a method of making

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001514873A (ja) * 1997-08-20 2001-09-18 ソーマジェニックス インコーポレイテッド 結合特性が改善されたアンチセンスおよびアンチジーン治療薬並びにそれらの使用方法
US6653467B1 (en) * 2000-04-26 2003-11-25 Jcr Pharmaceutical Co., Ltd. Medicament for treatment of Duchenne muscular dystrophy
JP4836366B2 (ja) * 2000-08-25 2011-12-14 雅文 松尾 デュシェンヌ型筋ジストロフィー治療剤
US20070105116A1 (en) 2003-09-02 2007-05-10 Japan Science And Technology Agency Metal complex type nucleic acid
WO2005026188A1 (ja) 2003-09-08 2005-03-24 Japan Science And Technology Agency 金属錯体型核酸
JP2009500020A (ja) * 2005-07-01 2009-01-08 バイオヴェリス コーポレイション 核酸を検出、増幅および／また単離するための組成物および方法
WO2009065181A1 (en) * 2007-11-21 2009-05-28 Apollo Life Sciences Limited Nanostructures suitable for delivery of agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011143A (en) * 1997-09-12 2000-01-04 Canon Kabushiki Kaisha Artificial nucleic acids and a method of making

Also Published As

Publication number Publication date
NZ606364A (en) 2014-12-24
DOP2013000041A (es) 2017-12-15
WO2012021985A1 (en) 2012-02-23
EP2605794A1 (en) 2013-06-26
PL2605794T3 (pl) 2017-01-31
SG187165A1 (en) 2013-02-28
HK1198123A1 (en) 2015-03-13
HUE029521T2 (en) 2017-03-28
CN103768086A (zh) 2014-05-07
CN103768086B (zh) 2015-10-14
AU2011291401A1 (en) 2013-01-10
JP2013536195A (ja) 2013-09-19
CA2806616C (en) 2015-08-11
PH12013500192B1 (en) 2018-11-23
CA2855690C (en) 2015-08-25
US8513211B2 (en) 2013-08-20
IL224237A (en) 2015-09-24
BR112013003875A2 (en) 2018-03-13
MY160961A (en) 2017-03-31
HRP20161333T1 (hr) 2016-12-02
US8716259B2 (en) 2014-05-06
CR20130069A (es) 2013-09-20
MX2013001668A (es) 2013-07-22
CY1118207T1 (el) 2017-06-28
ES2598556T3 (es) 2017-01-27
ECSP13012449A (es) 2013-04-30
KR20150039873A (ko) 2015-04-13
PT2605794T (pt) 2016-10-25
RS55245B1 (sr) 2017-02-28
MX340294B (es) 2016-07-04
US20130296410A1 (en) 2013-11-07
US20120046348A1 (en) 2012-02-23
KR101606495B1 (ko) 2016-03-28
EA201300259A1 (ru) 2013-12-30
CN103052405A (zh) 2013-04-17
HK1184058A1 (zh) 2014-01-17
CO6670525A2 (es) 2013-05-15
KR20150082685A (ko) 2015-07-15
SMT201600370B (it) 2016-11-10
EP2605794B1 (en) 2016-07-20
CA2855690A1 (en) 2012-02-23
EP2605794A4 (en) 2014-07-02
EA026660B1 (ru) 2017-05-31
ZA201300497B (en) 2013-09-25
CU20130022A7 (es) 2013-04-19
DK2605794T3 (en) 2016-10-24
BR112013003875B1 (pt) 2021-10-05
GT201300040A (es) 2014-09-02
CA2806616A1 (en) 2012-02-23
JP5775581B2 (ja) 2015-09-09
PH12013500192A1 (https=) 2013-03-11
CN103052405B (zh) 2015-11-25
LT2605794T (lt) 2016-10-25
KR20130099067A (ko) 2013-09-05
SI2605794T1 (sl) 2017-01-31
CL2013000445A1 (es) 2013-11-22

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired