CN103766500A - Anti-fatigue milk tablet - Google Patents

Anti-fatigue milk tablet Download PDF

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Publication number
CN103766500A
CN103766500A CN201210407503.1A CN201210407503A CN103766500A CN 103766500 A CN103766500 A CN 103766500A CN 201210407503 A CN201210407503 A CN 201210407503A CN 103766500 A CN103766500 A CN 103766500A
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dry
milk
antifatigue
parts
extract
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CN201210407503.1A
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CN103766500B (en
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李丹榕
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Abstract

The invention discloses an anti-fatigue milk tablet, which is prepared from the following raw materials by weight: 2-15 parts of a rhodiola rosea extract, 3-10 parts of a Ginkgo extract, 1-5 parts of tea polyphenol, 40-80 parts of milk powder, 3-10 parts of protein powder, 5-15 parts of glucose powder, 0.01-1 part of citric acid, and 0.15-0.5 part of magnesium stearate. On the basis of an ordinary milk tablet formula, the anti-fatigue milk tablet is added with the rhodiola rosea extract, the Ginkgo extract and tea polyphenol as anti-fatigue active substances, and is suitable for people having a fast pace of life, overstraining the brain and being fatigable and the middle-aged and the elderly.

Description

A kind of antifatigue milk sheet
Technical field
The invention belongs to food processing technology field, relate generally to a kind of antifatigue milk sheet.
Background technology
Milk sheet is a kind of dairy products that form take milk powder as primary raw material is repressed, contains rich in protein, butter oil and mineral matter, is a kind of simple, delicious leisure food of nutrition easy to carry, edible.Milk sheet is edible with solid form, in oral cavity and stomach, can sneak into a large amount of alkaline saliva, can in and hydrochloric acid in gastric juice, prevent that indigestion and hydrochloric acid in gastric juice are heartburn, liked by consumer.
Fatigue is a kind of sub-health state between disease and health, has a strong impact on people's quality of life.Tired symptom mainly contain feel dizzy, ache all over, limbs fatigue, insomnia, decrease of memory etc., be generally due to long-term muscle power overdraw, overstrain one's nerves, stress excessive due to.The mankind are in order to resist physical fatigue, to improve physical function, do a large amount of research and innovation, had Antifatigue oral liquid, tablet, capsule etc., although these medicines can effectively be eliminated fatigue, strengthen body immunity, but long-term taking there is certain toxic and side effect to human body.And most of crowd easily ignore that health discharges inferior health signal, think that this is not disease, do not need drug administration, the repulsion sense that instinct must can be strong to medicine.
Using milk sheet as carrier, suitably add certain anti-fatigue active composition, make the milk sheet with health care, can resist physical fatigue, strengthen body immunity, nutrition delicious food, instant edible again, such health food will more can cater to consumer's multiple demands than general general food, in day by day fierce Market Competition, win initiative.
Summary of the invention
The technical problem to be solved in the present invention is for city sub-health population, and fatiguability, the poor symptom of body immunity etc. provides a kind of milk sheet with health care.
The technical scheme that the present invention will provide is a kind of antifatigue milk sheet, and it comprises that the raw material of following weight portion makes: 2~15 parts of gadol extracts, 3~10 parts of ginkgo biloba extracts, 1~5 part of Tea Polyphenols, 40~80 parts of milk powder, 3~10 parts of albumen powders, 5~15 parts of powdered glucoses, 0.01~1 part of citric acid, 0.15~0.5 part of dolomol.
The preparation method of above-mentioned gadol extract is as follows: take rhodiola root dry rhizome fine powder and be placed in container, add the ethanolic solution of 20~40 times of the volumes of feeding intake, ultrasonic-leaching is lixiviate 7~12 hours under 40~50 ℃ of water bath condition again after 20~40 minutes, filter, get filtrate concentrated, dry, to obtain final product.
The volumetric concentration of above-mentioned ethanol is 60%~80%.
The preparation method of above-mentioned ginkgo biloba extract is as follows: gets dry ginkgo leaf, pulverizes, and with 40~95% alcohol steep 1~3 time, each 1~3 hour, merge extract, reduced pressure concentration recovery ethanol, obtains concentrate; Concentrate is added water and staticly settled, filter, get filtrate and carry out ultrafiltration membrance filter, by ultrafiltrate reduced pressure concentration, dry, be ginkgo biloba extract.
Above-mentioned milk powder be whole milk powder, skimmed milk power and sour milk powder in one or more.
Above-mentioned antifatigue milk sheet, it is to prepare in accordance with the following methods:
1) be dry mixed: the weight portion proportioning according to each component mixes gadol extract, ginkgo biloba extract, Tea Polyphenols, milk powder, albumen powder, powdered glucose, citric acid;
2) granulation: spray the water of material gross weight 8~15% to the material being dry mixed, stir, dry, sieve, send into comminutor and carry out granulation, obtain dried particles;
3) compressing tablet: add dolomol according to weight proportion in dried particles, send into tablet press machine compacting after mixing in flakes, be antifatigue milk sheet.
Above-mentioned sieving referred to 20~100 mesh sieves.
Above-mentioned oven dry refers to toasts 10~30 minutes at 40~60 ℃.
In anti-fatigue active component of the present invention, ginkgo biloba p.e not only has astringing the lung, relievings asthma, promoting blood circulation and removing blood stasis, pain relieving, stimulate circulation, prevent cardiovascular disease, improve the function such as brain function and peripheral circulation disorders, also has very strong removing free radical and oxidation resistant effect.Rhodiola root is a kind of rare wild plant that grows in plateau; taste is sweet, puckery, cold; its main chemical compositions comprises rhodioside, organic acid, volatile oil, trace element etc.; wherein rhodioside is main active; there is significant antifatigue, radioresistance, anti-ageing, anti-anoxic and immunoregulatory effect, cardiovascular system, liver, kidney, nerve cell are had to protective effect.Its mechanism of action is mainly in blood and skeletal muscle, generated and piled up by minimizing free radical, LD, reduces the decomposition of glycogen, strengthens activities of antioxidant enzymes, improves the content of hemoglobin, accelerates metabolite removing, regulates the approach such as internal system to realize.Tea Polyphenols is the complex of the polyphenol compound of separating-purifying from tealeaves, and its active component is Flavonoid substances.Research is found, in tealeaves, contain the composition such as catechin, fat polyacid and be referred to as Tea Polyphenols, Tea Polyphenols is a kind of natural with superior antioxygenic property, there is effect anti-, that radioresistance injures and radiotherapy injures, the hematopoietic function of health is had to obvious gain effect, can increase white blood cell, have anticancer, anti-ageing, remove a series of pharmacological actions such as human free radical, hypoglycemic, hypotensive, reducing blood lipid and bactericidal antiphlogistic.
The present invention has added gadol extract, ginkgo biloba extract and Tea Polyphenols as anti-fatigue active material on the basis at common milk slice prescription, these active materials all extract the integration of drinking and medicinal herbs class plant from pure natural, pass through rational proportion, give full play to the functional activity of three kinds of extracts, produce synergistic function, strengthened the antifatigue effect of this milk sheet.This product has the advantages such as nutrition delicious food, instant and safety non-toxic, is applicable to fast, the overstrain one's nerves fatiguability person of rhythm of life and mid-aged population edible for a long time.
For proving effect of antifatigue of the present invention, carry out following antifatigue experimental test, select 40 of Male Kunming strain mice, be divided at random negative control group and administration group by body weight, every group 20, freely ingest and drink water, administration group mouse gavages product of the present invention (twice of every day through stomach tube respectively, each 1g/kg body weight, gavage early morning).Gavage and raising 1 one months continuously.After gavage after half an hour, mouse is carried out to Loaned swimming test and pole-jump test the last time.
Loaned swimming test: mouse is put into swimming trunk went swimming, depth of water 30cm, 25 ± 0.5 ℃ of water temperatures, the load sheet lead of 5% body weight of mouse root of the tail portion, records mouse and starts to the dead time, as mouse swimming time from swimming, between two groups of mouse, carry out paired observation, result of the test is in table 1.
Pole-jump test: mouse is placed on the perspex bar of pole-climbing frame, make its muscle in static(al) tense situation, record the time that mouse drops down from perspex bar due to muscular fatigue, termination test while falling for the third time, the time of accumulating three times is the pole-climbing time, between two groups of mouse, carry out paired observation, result of the test is in table 2.
Table 1 Loaned swimming test result
Group Quantity (only) Swimming time (second)
Test group 10 62.1±3.3
Negative control group 10 35.6±5.2
Table 2 pole-jump test
Group Quantity (only) The pole-climbing time (second)
Test group 10 43.3±5.4
Negative control group 10 32.7±5.1
Above-mentioned result of the test shows, the swimming with a load attached to the body time of test group mouse is significantly longer than negative control group (P < 0.05), the pole-climbing time of test group mouse is significantly longer than negative control group P < 0.05), the present invention can extend mice burden swimming time and pole-climbing time, and antifatigue effect is better.
The specific embodiment
With following embodiment, the present invention is further elaborated, but not as a limitation of the invention.
Following concentration is volumetric concentration.
Embodiment 1
1) preparation of gadol extract: take rhodiola root dry rhizome fine powder and be placed in container, add the ethanolic solution of the 20 times of bodies 60% of volume that feed intake, ultrasonic-leaching is lixiviate 7 hours under 40 ℃ of water bath condition again after 20 minutes, filter, get filtrate concentrated, dry, to obtain final product.
2) the preparation side of ginkgo biloba extract: get dry ginkgo leaf, pulverize, with 40% alcohol steep 1 time, each 1 hour, merge extract, reduced pressure concentration recovery ethanol, obtains concentrate; Concentrate is added water and staticly settled, filter, get filtrate and carry out ultrafiltration membrance filter, by ultrafiltrate reduced pressure concentration, dry, be ginkgo biloba extract.
3) be dry mixed: take gadol extract 2kg, ginkgo biloba extract 3kg, Tea Polyphenols 1kg, whole milk powder 40kg, albumen powder 3kg, powdered glucose 5kg, citric acid 0.01kg mixes;
4) granulation: spray the water of material gross weight 8% to the material being dry mixed, stir, toast at 40 ℃ 10 minutes, cross 20 mesh sieves, send into comminutor and carry out granulation, obtain dried particles;
5) compressing tablet: add 0.15kg dolomol in dried particles, send into tablet press machine compacting after mixing in flakes, be antifatigue milk sheet.
Embodiment 2
1) preparation of gadol extract: take rhodiola root dry rhizome fine powder and be placed in container, add the ethanolic solution that the 40 times of volumetric concentrations of volume that feed intake are 80%, ultrasonic-leaching is lixiviate 12 hours under 50 ℃ of water bath condition again after 40 minutes, filter, get filtrate concentrated, dry, to obtain final product.
2) the preparation side of ginkgo biloba extract: get dry ginkgo leaf, pulverize, with 95% alcohol steep 3 times, each 3 hours, merge extract, reduced pressure concentration recovery ethanol, obtains concentrate; Concentrate is added water and staticly settled, filter, get filtrate and carry out ultrafiltration membrance filter, by ultrafiltrate reduced pressure concentration, dry, be ginkgo biloba extract.
3) be dry mixed: take gadol extract 15kg, ginkgo biloba extract 10kg, Tea Polyphenols 5kg, skimmed milk power 80kg, albumen powder 10kg, powdered glucose 15kg, citric acid 1kg mixes;
4) granulation: spray the water of material gross weight 15% to the material being dry mixed, stir, toast at 60 ℃ 30 minutes, cross 100 mesh sieves, send into comminutor and carry out granulation, obtain dried particles;
5) compressing tablet: add 0.5kg dolomol in dried particles, send into tablet press machine compacting after mixing in flakes, be antifatigue milk sheet.
Embodiment 3
1) preparation of gadol extract: take rhodiola root dry rhizome fine powder and be placed in container, add the ethanolic solution that the 30 times of volumetric concentrations of volume that feed intake are 70%, ultrasonic-leaching is lixiviate 10 hours under 45 ℃ of water bath condition again after 30 minutes, filter, get filtrate concentrated, dry, to obtain final product.
2) the preparation side of ginkgo biloba extract: get dry ginkgo leaf, pulverize, with 60% alcohol steep 2 times, each 2 hours, merge extract, reduced pressure concentration recovery ethanol, obtains concentrate; Concentrate is added water and staticly settled, filter, get filtrate and carry out ultrafiltration membrance filter, by ultrafiltrate reduced pressure concentration, dry, be ginkgo biloba extract.
3) be dry mixed: take gadol extract 8kg, ginkgo biloba extract 6kg, Tea Polyphenols 3kg, sour milk powder 60kg, albumen powder 5kg, powdered glucose 10kg, citric acid 0.5kg mixes;
4) granulation: spray the water of material gross weight 12% to the material being dry mixed, stir, toast at 50 ℃ 20 minutes, cross 80 mesh sieves, send into comminutor and carry out granulation, obtain dried particles;
5) compressing tablet: add 0.3kg dolomol in dried particles, send into tablet press machine compacting after mixing in flakes, be antifatigue milk sheet.
Embodiment 4
1) preparation of gadol extract: take rhodiola root dry rhizome fine powder and be placed in container, add the ethanolic solution that the 20 times of volumetric concentrations of volume that feed intake are 80%, ultrasonic-leaching is lixiviate 7 hours under 50 ℃ of water bath condition again after 20 minutes, filter, get filtrate concentrated, dry, to obtain final product.
2) the preparation side of ginkgo biloba extract: get dry ginkgo leaf, pulverize, with 95% alcohol steep 1 time, each 3 hours, merge extract, reduced pressure concentration recovery ethanol, obtains concentrate; Concentrate is added water and staticly settled, filter, get filtrate and carry out ultrafiltration membrance filter, by ultrafiltrate reduced pressure concentration, dry, be ginkgo biloba extract.
3) be dry mixed: mixture 80kg, the albumen powder 3kg, powdered glucose 15kg, the citric acid 0.01kg that take gadol extract 2k g, ginkgo biloba extract 10kg, Tea Polyphenols 1kg, whole milk powder, skimmed milk power and sour milk powder mix;
4) granulation: spray the water of material gross weight 15% to the material being dry mixed, stir, toast at 40 ℃ 30 minutes, cross 20 mesh sieves, send into comminutor and carry out granulation, obtain dried particles;
5) compressing tablet: add 0.5kg dolomol in dried particles, send into tablet press machine compacting after mixing in flakes, be antifatigue milk sheet.

Claims (8)

1. an antifatigue milk sheet, is characterized in that: it comprises that the raw material of following weight portion makes: 2~15 parts of gadol extracts, 3~10 parts of ginkgo biloba extracts, 1~5 part of Tea Polyphenols, 40~80 parts of milk powder, 3~10 parts of albumen powders, 5~15 parts of powdered glucoses, 0.01~1 part of citric acid, 0.15~0.5 part of dolomol.
2. antifatigue milk sheet according to claim 1, it is characterized in that: the preparation method of described gadol extract is as follows: take rhodiola root dry rhizome fine powder and be placed in container, add the ethanolic solution of 20~40 times of the volumes of feeding intake, ultrasonic-leaching is lixiviate 7~12 hours under 40~50 ℃ of water bath condition again after 20~40 minutes, filter, get filtrate concentrated, dry, to obtain final product.
3. antifatigue milk sheet according to claim 2, is characterized in that: the volumetric concentration of described ethanol is 60%~80%.
4. antifatigue milk sheet according to claim 1, is characterized in that: the preparation method of described ginkgo biloba extract is as follows: get dry ginkgo leaf, pulverize, with 40~95% alcohol steep 1~3 time, each 1~3 hour, merge extract, reduced pressure concentration reclaims ethanol, obtains concentrate; Concentrate is added water and staticly settled, filter, get filtrate and carry out ultrafiltration membrance filter, by ultrafiltrate reduced pressure concentration, dry, be ginkgo biloba extract.
5. antifatigue milk sheet according to claim 1, is characterized in that: described milk powder be whole milk powder, skimmed milk power and sour milk powder in one or more.
6. according to the antifatigue milk sheet described in any one in claim 1~5, it is characterized in that: it is to prepare in accordance with the following methods:
1) be dry mixed: the weight portion proportioning according to each component mixes gadol extract, ginkgo biloba extract, Tea Polyphenols, milk powder, albumen powder, powdered glucose, citric acid;
2) granulation: spray the water of material gross weight 8~15% to the material being dry mixed, stir, dry, sieve, send into comminutor and carry out granulation, obtain dried particles;
3) compressing tablet: add dolomol according to weight proportion in dried particles, send into tablet press machine compacting after mixing in flakes, be antifatigue milk sheet.
7. antifatigue milk sheet according to claim 6, is characterized in that: described sieving referred to 20~100 mesh sieves.
8. antifatigue milk sheet according to claim 6, is characterized in that: described oven dry refers to toasts 10~30 minutes at 40~60 ℃.
CN201210407503.1A 2012-10-23 2012-10-23 A kind of antifatigue milk sheet Expired - Fee Related CN103766500B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109832334A (en) * 2017-11-28 2019-06-04 东阿阿胶股份有限公司 A kind of donkey milk piece of strengthen immunity and preparation method thereof
CN115736260A (en) * 2022-12-01 2023-03-07 惠州市竟为健康产业有限公司 Old-age tea polyphenol composite nutrition powder and preparation method thereof

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1582689A (en) * 2003-08-19 2005-02-23 黑龙江省阿城金都绿色食品厂 Milk pellets
CN1593168A (en) * 2004-06-22 2005-03-16 王美岭 Pawpaw milk slice production method
CN1666623A (en) * 2004-03-08 2005-09-14 郭志忠 Anti-senescence medical food milk powder candy and making method thereof
CN1817151A (en) * 2006-03-07 2006-08-16 山西大学 Milk tablets with lucid ganoderma and production thereof
CN101019576A (en) * 2006-12-31 2007-08-22 内蒙古伊利实业集团股份有限公司 Beatifying milk tablet
CN101715828A (en) * 2009-11-16 2010-06-02 丁相军 Barley bud milk slice
CN101715830A (en) * 2009-12-13 2010-06-02 丁相军 Balsam pear dairy product and preparation method thereof
CN102057987A (en) * 2009-11-16 2011-05-18 刘沛 Method for producing milk slices
CN102090454A (en) * 2010-09-06 2011-06-15 山东好当家海洋发展股份有限公司 Seaweed, fruit and vegetable milk slice and production method thereof
CN102511556A (en) * 2011-12-08 2012-06-27 内蒙古伊利实业集团股份有限公司 Milk tablet and its preparation method

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1582689A (en) * 2003-08-19 2005-02-23 黑龙江省阿城金都绿色食品厂 Milk pellets
CN1666623A (en) * 2004-03-08 2005-09-14 郭志忠 Anti-senescence medical food milk powder candy and making method thereof
CN1593168A (en) * 2004-06-22 2005-03-16 王美岭 Pawpaw milk slice production method
CN1817151A (en) * 2006-03-07 2006-08-16 山西大学 Milk tablets with lucid ganoderma and production thereof
CN101019576A (en) * 2006-12-31 2007-08-22 内蒙古伊利实业集团股份有限公司 Beatifying milk tablet
CN101715828A (en) * 2009-11-16 2010-06-02 丁相军 Barley bud milk slice
CN102057987A (en) * 2009-11-16 2011-05-18 刘沛 Method for producing milk slices
CN101715830A (en) * 2009-12-13 2010-06-02 丁相军 Balsam pear dairy product and preparation method thereof
CN102090454A (en) * 2010-09-06 2011-06-15 山东好当家海洋发展股份有限公司 Seaweed, fruit and vegetable milk slice and production method thereof
CN102511556A (en) * 2011-12-08 2012-06-27 内蒙古伊利实业集团股份有限公司 Milk tablet and its preparation method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王玮等: "抗运动性疲劳单味中药研究概述", 《中药材》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109832334A (en) * 2017-11-28 2019-06-04 东阿阿胶股份有限公司 A kind of donkey milk piece of strengthen immunity and preparation method thereof
CN115736260A (en) * 2022-12-01 2023-03-07 惠州市竟为健康产业有限公司 Old-age tea polyphenol composite nutrition powder and preparation method thereof

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