CN101731470B - Drug combination for pet health and preparation method thereof - Google Patents
Drug combination for pet health and preparation method thereof Download PDFInfo
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- CN101731470B CN101731470B CN200810202198A CN200810202198A CN101731470B CN 101731470 B CN101731470 B CN 101731470B CN 200810202198 A CN200810202198 A CN 200810202198A CN 200810202198 A CN200810202198 A CN 200810202198A CN 101731470 B CN101731470 B CN 101731470B
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Abstract
The invention discloses a drug combination for pet health, which can be manufactured into particles or medicinal powders so as to be filled into capsules. The drug combination comprises a ginseng fine flour, a ginsenoside powder, bone collagen or a bone calcium powder, vitamin A, dextrin and the like; in addition, a honeybee pupa powder, a meat and bone meal, a fish powder and vitamin C also can be added. The invention also discloses a preparation method of the drug combination for the pet health. A result of feeding observation for more than 2 years shows that the drug combination for pet health can achieve the effects of enhancing the immune function of a pet, strengthening the constitution of the pet and delaying ageing of the pet, has remarkable health treatment effects of preventing and treating cancers, cardiovascular diseases or respiratory diseases and the like of the pet and provides a basis of prolonging the life of the pet.
Description
Technical field
The invention belongs to the technical field of pharmaceuticals that relates to animal health, be specifically related to a kind ofly can improve immunity of pets, anti-ageing, the pharmaceutical composition of the pet care of disease-resistant anti-cancer.The invention also discloses this preparation of drug combination method.
Background technology
The pet that it has often been said in the past generally is meant the animal that family feeds, and to relatively more atypical scorpion, spider, lizard etc., all is everybody extensively raising of institute from common dog, cat, pet fish, rabbit, tortoise.
Today pet feeding idea and differed widely in the past, dog and cat no longer play the part of the role who guards the gate and catch mouse, but the playfellow during human leisure; Along with the affluence of material life, People more and more is paid attention to the cultivation of recreation temperament and interest; Along with the variation of traditional-family's structure, the increase of operating pressure, interpersonal relationships is tending towards desalination gradually, and increasing people is bet emotion on one's body the pet, and the dependence between people and pet will be dense with the passing of time and day by day.
In China; The people who keeps a pet is more and more, and Beijing, Shanghai, Guangzhou, Chongqing and Wuhan are five big " the pet cities " that China generally acknowledges at present, and China has 100,000,000 of pets (bar) at least at present; And following 10 years, the explosive growth will appear in the raising pets number of China.
Be accompanied by the growth of pet quantity; Produced a series of related industry around pet economy; Like pet food, pet supplies, pet medical treatment, pet grooming industry etc.; Also emerged in these several years as pet matchmaking service, pet funeral and interment, pet and very new industry such as entrust one's child to the care of sb., meanwhile the huge market of also having arisen at the historic moment, pet health field.Domestic pet care food is main with nutriment mainly at present; Increase calcareous or vitamin etc.; But really with the required component pet health food of the important medicinal material extract pet of the Chinese medicine blank in market just, thus the present invention to be intended to process pet care food with regard to the Chinese medical extract preparation be research object.
Summary of the invention
One of technical problem to be solved by this invention is in feed for pet, to add to have immunoloregulation function; The pharmaceutical composition of the pet care of the integration of drinking and medicinal herbs such as genseng of the effects such as delaying senility that can give protection against cancer again, this pharmaceutical composition can process particle or the medicine powder can becomes capsule.
Two of technical problem to be solved by this invention provides the preparation method of aforementioned pharmaceutical compositions.
As the pharmaceutical composition of the pet care of first aspect present invention, form by the raw material of following weight portion:
0.05～0.5 part in panax ginseng extractum powder, 0.03～0.5 part in panaxoside powder, 0.5～5 part of ossein, 0.002～0.020 part of vitamin A, 0.1～1 part in dextrin, flavor enhancement are an amount of.
In above-mentioned prescription, said ossein can use the bone calcium powder to replace.
In above-mentioned prescription, can also add weight portion and be 0.03～0.3 part bee pupa powder, further be that to add weight portion again be the vitamin C that 0.3 part fish meal and weight portion is 0.01 part.
In above-mentioned prescription, adding weight portion is 1～10 portion of meat meal tankage.
The flavor enhancement that the present invention adopts is one or both and the two or more combination in monosodium glutamate, pork essence, beef flavor, the flesh of fish essence.
The panax ginseng extractum powder that the present invention adopted, panaxoside powder and bee pupa powder are extract voluntarily, and vitamin A, ossein, bone calcium powder, fish meal and meat meal tankage, dextrin, flavor enhancement are commercial.
A kind of preparation method as the pharmaceutical composition of pet care of the present invention comprises the steps:
1, the preparation process of panax ginseng extractum powder: get the Chinese medicine genseng, section, pulverizing 5～10 orders, using weight percent concentration is that 95% ethanol immerses, filters, reclaims ethanol; Alcohol extract is subsequent use; Its dregs of a decoction double-deck cooker of packing into is added the water cover face, add the steam poach, cross and filter the water extract; Merge alcohol extract and water extract, filtering and impurity removing matter gets the genseng supernatant, centrifugal genseng supernatant, and decompression concentrates, and spray-drying gets the panax ginseng extractum powder;
2, the preparation process of panaxoside powder: genseng is pulverized, and the ginseng raw material's hot water lixiviate after the pulverizing refluxed 3 hours in extracting filling, filtered, and filter residue is brought up again 1～3 time, merging filtrate, and decompression concentrates, and spray-drying obtains extract powder.
3, step is produced in mixing: get panax ginseng extractum powder 0.05～0.5 weight portion, panaxoside powder 0.03～0.5 weight portion, ossein or ossein 0.5～5 weight portion, vitamin A 0.002～0.020 weight portion, dextrin 0.1～1 weight portion; Mix; Stir, sieve, process particle formulation or pulvis with 20 order granulators; Spray into an amount of flavor enhancement after the oven dry, the can capsule.
In above-mentioned a kind of preparation method, mixing is produced and can also be added meat meal tankage 1～10 weight portion in the step.
A kind of preparation method as the pharmaceutical composition of pet care of the present invention comprises the steps:
1, the preparation process of panax ginseng extractum powder: get the Chinese medicine genseng, section, pulverizing 5～10 orders, using weight percent concentration is that 95% ethanol immerses, filters, reclaims ethanol; Alcohol extract is subsequent use; Its dregs of a decoction double-deck cooker of packing into is added the water cover face, add the steam poach, cross and filter the water extract; Merge alcohol extract and water extract, filtering and impurity removing matter gets the genseng supernatant, centrifugal genseng supernatant, and decompression concentrates, and spray-drying gets the panax ginseng extractum powder;
2, the preparation process of panaxoside powder: genseng is pulverized, and the ginseng raw material's hot water lixiviate after the pulverizing refluxed 3 hours in extracting filling, filtered, and filter residue is brought up again 1～3 time, merging filtrate, and decompression concentrates, and spray-drying obtains extract powder.
3, the preparation process of bee pupa powder: the bee pupa raw material hot water lixiviate after will pulverizing refluxed 3 hours in extracting filling, filtered, and filter residue is brought up again 1～3 time, merging filtrate, and decompression concentrates, and spray-drying obtains extract powder.
4, step is produced in mixing: get panax ginseng extractum powder 0.05～0.5 weight portion, panaxoside powder 0.03～0.5 weight portion, ossein or ossein 0.5～5 weight portion, bee pupa powder 0.03～0.3 weight portion, vitamin A 0.002～0.020 weight portion, dextrin 0.1～1 weight portion; Mix; Stir, sieve, process particle formulation or pulvis with 20 order granulators; Spray into an amount of flavor enhancement after the oven dry, the can capsule.
In above-mentioned a kind of preparation method, mixing is produced and can also be added fish meal 0.3 weight portion and vitamin C 0.01 weight portion in the step.
Among the above-mentioned preparation method, every capsules drug composition 0.35 gram, 2-6 capsules of the present invention; It is edible to be used for all ages and classes pet care.
The said pet of the present invention is pet dog and pet cat.
Process the pharmaceutical composition of particle formulation or pulvis pet care through following method,, calculate by one 10 kg body weight according to the body weight of different pets, every day dosage 5～15 grams ratio, be added in the feed for pet.
Genseng used in the present invention is as one of the most famous Chinese medicine, and always China and western scholar are paid attention to.As far back as 19 end of the centurys, western scholar is just studied the chemical composition of genseng.Along with the continuous development of science, analyzed now the various compositions of genseng reached 300 surplus kind.Wherein topmost composition is panaxoside, 20 several amino acids, various active polypeptide, materials such as kind of volatile ingredient, vitamin, trace element, organic acid, organized enzyme, sterol and carbohydrate surplus in the of 130, and wherein major part all has different biologically actives and medical value.Genseng mainly shows raising immunity, the adaptability of enhancing body and the anti-ageing aspect of waiting for a long time as the most famous strengthening by means of tonics medicine.After taking genseng, can improve a poor appetite enhance immunity power; Be better still that panaxoside can reduce blood fat, lower the peripheral resistance of blood vessel; Angiocardiopathy there is obvious benefit. in addition; TSPG also can be removed ultra-oxygen anion free radical effectively, recovers the balance of old body Radical Metabolism, thereby shows tangible anti-aging effects.It is reported that the medical value of genseng derives from wherein each kind of panaxoside." saponin " is the compound that extensively is present in botanic one type of complicacy, because of it has bigger surface-active, can produce gluey solution and many continuation foams when in water, vibrating, so gain the name this.Panaxoside is the topmost active ingredient of genseng, experiment showed, that panaxoside has tangible regulating action to the mankind's nervous system, the intelligence development of calming the nerves.When low dose of, can excited cerebral cortex, promotion and reinforcement memory and susceptibility.When heavy dose of, show as again, as Shennong's Herbal so-called " peace spirit ... order palpitation with fear " corticocerebral inhibition.Here it is, and panaxoside has tangible excitation to the second signal system, shows as the reinforcement of excited process flexibility, and the exhaustibility reduction, so genseng has the various unable syndromic antifatigue effects of elimination.This excitation just shows byer force on the basis of alleviating fatigue.
LAT director, the pharmacy doctor Dr.Christa Tittle of University of Munich introduce, and find that in lasting the research process of several years the ginsenoside content can promote immunity, and suppress cancer cell and grow up; Can protect cell membrane and prevent cell senescence, hemangiectasis brings high blood pressure down and blood sugar; It is synthetic to improve liver cell protein and DNA. be especially unexpectedly; Ginseng flower bud contains unique ginseng flower bud 9 peptides and ginseng flower bud 11 peptides unexpectedly, all belongs to small-molecular peptides, can be absorbed by body 100%; Be called as the correction peptide, rapidly and exactly the various C-C balance in the cognitron body cell.The famous physiologist Sutherland of the U.S. discovers, has two kinds of particular matter: cAMP and cGMP in the cell, i.e. CAMP and cyclic guanosine monophosphate, and the two-way interaction keeps the cellular metabolism balance, makes the body state of keeping fit.Therefore Sutherland obtained Nobel Prize in medicine in 1971.
The sense of smell of pet is sensitivity, particularly dog very, and it exceeds 1200 times of people.But the genseng bitter of important preparation, in the dense direct adding feed of flavour of a drug, pet often is reluctant to eat.Therefore, the present invention is according to the characteristics of pet ginseng health product. and through experiment repeatedly, adopt special nourishing additive agent to mix mutually with ginseng extract; Let pet produce appetite at once, and the sense of taste of dog general if, once inlet; Just can chew like common food, thereby reach the effect of feeding and health care.
The pharmaceutical composition of pet care of the present invention through getting breeding observing more 2 years, the result shows, can reach the immunologic function that improves pet; Build up health; The effect that delays senility, and to prevention, treatment pet cancer; Angiocardiopathy or respiratory disease etc. have significant care treatment effect, and the effect in pet life-span is provided the foundation.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect and be easy to understand and understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
The preparation of panax ginseng extractum powder: get the Chinese medicine genseng, 5～10 orders are pulverized in section, immerse 36 hours with 95% ethanol, filter, and reclaim ethanol, and alcohol extract is subsequent use; Its dregs of a decoction double-deck cooker of packing into is added the water cover face, adds the steam water poach, 90-95 ℃ of temperature, 180 minutes time, after the filtration the water extract; Merge alcohol extract and water extract, remove impurity, get supernatant through plate and frame filter or microporous filter; Supernatant is evaporated to 25-40% concentrate of stoste volume, 25-40% concentrate spray-dried the panax ginseng extractum powder, during spray-drying: pressure 3-5kg/cm, 60-70 ℃ of bake out temperatures.Outward appearance: faint yellow or yellow-white powder, mildly bitter flavor, tool hygroscopicity.Granularity>100 orders, total salidroside content: 75～95%, moisture :≤6.0%, ash content :≤1.5%, weight differential: ± 0.1%, heavy metal :≤10ppm, residues of pesticides :≤10ppb, bacterium: 1000/g, mould: 100/g, Escherichia coli: do not have.
Embodiment 2
The preparation of panaxoside powder: genseng is pulverized, and the ginseng raw material's hot water lixiviate after the pulverizing refluxed 3 hours in extracting filling, filtered, and filter residue is brought up again 1～3 time, merging filtrate, and decompression concentrates, and spray-drying obtains extract powder.
Embodiment 3
The preparation of bee pupa powder: the bee pupa raw material hot water lixiviate after will pulverizing refluxed 3 hours in extracting filling, filtered, and filter residue is brought up again 1～3 time, merging filtrate, and decompression concentrates, and spray-drying obtains extract powder.
Embodiment 4
Take by weighing the pharmaceutical composition (daily dose) that each composition prepares pet dog or cat health care by following weight proportion:
Get panax ginseng extractum powder 0.05～0.5g, panaxoside powder 0.03～0.5g, ossein 0.5～5g, dehydroretinol～20mg, dextrin 0.1～1g; Mix; Stir, sieve, process particle formulation or pulvis with 20 order granulators; In oven dry back spray monosodium glutamate, pork essence, beef flavor, the flesh of fish essence one or both and two or more combinations, the can capsule.Finished product sterilization was with 40-50 ten thousand rad Co60r-radiation exposures 24-48 hours.
In this embodiment; The lower limit of panax ginseng extractum powder can be 0.06g, 0.07g, 0.08g, 0.09g, 0.10g, 0.11g, 0.12g, 0.13g, 0.14g, 0.15g, 0.16g, 0.17g, 0.18g, 0.19g, and higher limit is 0.49g, 0.48g, 0.47g, 0.46g, 0.45g, 0.44g, 0.43g, 0.42g, 0.41g, 0.40g, 0.39g, 0.38g, 0.37g, 0.36g, 0.35g, 0.34g, 0.33g, 0.32g, 0.31g, 0.30g, 0.29g, 0.28g, 0.27g, 0.26g, 0.25g, 0.24g, 0.23g, 0.22g, 0.21g.Panax ginseng extractum powder preferred amounts is 0.20g
The lower limit of panaxoside powder can be 0.04g, 0.05g, 0.06g, 0.07g, 0.08g, 0.09g, and higher limit is 0.49g, 0.48g, 0.47g, 0.46g, 0.45g, 0.44g, 0.43g, 0.42g, 0.41g, 0.40g, 0.39g, 0.38g, 0.37g, 0.36g, 0.35g, 0.34g, 0.33g, 0.32g, 0.31g, 0.30g, 0.29g, 0.28g, 0.27g, 0.26g, 0.25g, 0.24g, 0.23g, 0.22g, 0.21g, 0.20g, 0.19g, 0.18g, 0.17g, 0.16g, 0.15g, 0.14g, 0.13g, 0.12g, 0.11g.Panaxoside powder preferred amounts is 0.10g.
The ossein lower limit can be 0.6g, 0.7g, 0.8g, 0.9g, 1.0g, 1.1g; Higher limit is 4.9g, 4.8g, 4.7g, 4.6g, 4.5g, 4.4g, 4.3g, 4.2g, 4.1g, 4.0g, 3.9g, 3.8g, 3.7g, 3.6g, 3.5g, 3.4g, 3.3g, 3.2g, 3.1g, 3.0g, 2.9g, 2.8g, 2.7g, 2.6g, 2.5g, 2.4g, 2.3g, 2.2g, 2.1g, 2.0g, 1.9g, 1.8g, 1.7g, 1.6g, 1.5g, 1.4g, 1.3g, and the preferred amounts of ossein is 1.2g.Ossein can be replaced by the bone calcium powder.
The preferred weight proportioning of this embodiment is: panax ginseng extractum powder 0.2g, panaxoside powder 0.1g, retinol1 0mg, bone calcium powder 1.2g, dextrin 0.4g.In flavor enhancement monosodium glutamate, pork essence, beef flavor, the flesh of fish essence one or both and two or more combinations.
Embodiment 5
Take by weighing the pharmaceutical composition (daily dose) that each composition prepares pet dog or cat health care by following weight proportion:
Get panax ginseng extractum powder 0.05～0.5g, panaxoside powder 0.03～0.5g, bone calcium powder 0.5～5g, bee pupa powder 0.03～0.3g, dehydroretinol～20mg, dextrin 0.1～1g; Mix; Stir, sieve, process particle formulation or pulvis with 20 order granulators; In oven dry back spray monosodium glutamate, pork essence, beef flavor, the flesh of fish essence one or both and two or more combinations, the can capsule.Finished product sterilization was with 40-50 ten thousand rad Co60r-radiation exposures 24-48 hours.
The value of panax ginseng extractum powder, panaxoside powder, bone calcium powder is with embodiment 4.
The lower limit of bee pupa powder can be 0.04g, 0.05g, 0.06g, 0.07g, 0.08g, 0.09g, and higher limit is 0.29g, 0.28g, 0.27g, 0.26g, 0.25g, 0.24g, 0.23g, 0.22g, 0.21g, 0.20g, 0.19g, 0.18g, 0.17g, 0.16g, 0.15g, 0.14g, 0.13g, 0.12g, 0.11g.Bee pupa powder preferred amounts is 0.10g.
The preferred weight proportioning of this embodiment is: panax ginseng extractum powder 0.2g, panaxoside powder 0.1g, retinol1 0mg, bone calcium powder 1.2g, bee pupa powder 0.1g, dextrin 0.4g.In flavor enhancement monosodium glutamate, pork essence, beef flavor, the flesh of fish essence one or both and two or more combinations.
Embodiment 6
Take by weighing the pharmaceutical composition (daily dose) that each composition prepares pet dog or cat health care by following weight proportion:
Get panax ginseng extractum powder 0.05～0.5g, panaxoside powder 0.03～0.5g, bone calcium powder 0.5～5g, meat meal tankage 1～10g, dehydroretinol～20mg, dextrin 0.1～1g; Mix; Stir, sieve, process particle formulation or pulvis with 20 order granulators; In oven dry back spray monosodium glutamate, pork essence, beef flavor, the flesh of fish essence one or both and two or more combinations, the can capsule.Finished product sterilization was with 40-50 ten thousand rad Co60r-radiation exposures 24-48 hours.
The value of panax ginseng extractum powder, panaxoside powder, bone calcium powder is with embodiment 4.
The lower limit of meat meal tankage can be 1.1g, 1.2g, 1.3g, 1.4g, 1.5g, 1.6g, 1.7g, 1.8g, 1.9g, 2.0g, 2.1g, and higher limit is 9.9g, 9.8g, 9.7g, 9.6g, 9.5g, 9.4g, 9.3g, 9.2g, 9.1g, 9.0g, 8.9g, 8.8g, 8.7g, 8.6g .5g, 8.4g, 8.3g, 8.2g, 8.1g, 8.0g, 7.9g, 7.8g, 7.7g, 7.6g, 7.5g, 7.4g, 7.3g, 7.2g, 7.1g, 7.0g, 6.9g, 6.8g, 6.5g, 6.4g, 6.3g, 6.2g, 6.1g, 6.0g, 5.9g, 5.8g, 5.7g, 5.6g, 5.5g, 5.4g, 5.3g, 5.2g, 5.1g, 5.0g, 4.9g, 4.8g, 4.7g, 4.6g, 4.5g, 4.4g, 4.3g, 4.2g, 4.1g, 4.0g, 3.9g, 3.8g, 3.7g, 3.6g, 3.5g, 3.4g, 3.3g, 3.2g, 3.1g, 3.0g, 2.9g, 2.8g, 2.7g, 2.6g, 2.5g, 2.4g, 2.3g.The meat meal tankage preferred amounts is 2.2g.
The preferred weight proportioning of this embodiment is: panax ginseng extractum powder 0.2g, panaxoside powder 0.1g, retinol1 0mg, bone calcium powder 1.2g, meat meal tankage 2.2g, dextrin 0.4g.In flavor enhancement monosodium glutamate, pork essence, beef flavor, the flesh of fish essence one or both and two or more combinations.
Embodiment 7
Take by weighing the pharmaceutical composition (daily dose) that each composition prepares pet dog or cat health care by following weight proportion:
Get panax ginseng extractum powder 0.05～0.5g, panaxoside powder 0.03～0.5g, bone calcium powder 0.5～5g, bee pupa powder 0.03～0.3g, fish meal 0.3g, vitamin C 10mg, dehydroretinol～20mg, dextrin 0.1～1g; Mix; Stir, sieve, process particle formulation or pulvis with 20 order granulators; In oven dry back spray monosodium glutamate, pork essence, beef flavor, the flesh of fish essence one or both and two or more combinations, the can capsule.Finished product sterilization was with 40-50 ten thousand rad Co60r-radiation exposures 24-48 hours.
The value of panax ginseng extractum powder, panaxoside powder, bone calcium powder is with embodiment 4.The value of bee pupa powder is with embodiment 5.
The higher limit of fish meal is 8%, and lower limit is 5%, and the fish meal preferred amounts is 0.3g
The preferred weight proportioning of this embodiment is: panax ginseng extractum powder 0.2g, panaxoside powder 0.1g, retinol1 0mg, bone calcium powder 1.2g, bee pupa powder 0.10g, fish meal 0.3g, vitamin C 10mg dextrin 0.4g.In flavor enhancement monosodium glutamate, pork essence, beef flavor, the flesh of fish essence one or both and two or more combinations.
Embodiment 8
Take by weighing the pharmaceutical composition (daily dose) that each composition prepares pet dog or cat health care by following weight proportion:
Get panax ginseng extractum powder 0.05～0.5g, panaxoside powder 0.03～0.5g, bone calcium powder 0.5～5g, bee pupa powder 0.03～0.3g, meat meal tankage 1～10g, fish meal 0.3g, vitamin C 10mg, dehydroretinol～20mg, dextrin 0.1～1g; Mix; Stir, sieve, process particle formulation or pulvis with 20 order granulators; In oven dry back spray monosodium glutamate, pork essence, beef flavor, the flesh of fish essence one or both and two or more combinations, the can capsule.Finished product sterilization was with 40-50 ten thousand rad Co60r-radiation exposures 24-48 hours.
The value of panax ginseng extractum powder, panaxoside powder, bone calcium powder is with embodiment 4.The value of bee pupa powder is with embodiment 5.The value of meat meal tankage is with embodiment 6.The value of fish meal is with embodiment 7.
The preferred weight proportioning of this embodiment is: panax ginseng extractum powder 0.2g, panaxoside powder 0.1g, retinol1 0mg, bone calcium powder 1.2g, bee pupa powder 0.10g, meat meal tankage 2.2g, fish meal 0.3g, vitamin C 10mg dextrin 0.4g.In flavor enhancement monosodium glutamate, pork essence, beef flavor, the flesh of fish essence one or both and two or more combinations.
Embodiment 9 animal pets experiments
(1) toxicity detects: result's demonstration has no side effect
1. chronic toxicological experiment: to the mouse 10g that feeds every day, the present composition, observe after 30 days: body weight gain, extract the blood testing red blood cell count(RBC); White blood cell count(WBC), glutamic-pyruvic transaminase, urea nitrogen; Cholesterol, triglyceride, albumin; The inspection of indexs such as glucose, all no abnormal, the anatomy and pathology histological inspection is not found pathological change yet.
2. acute toxicological experiment: with feeding every day 5 times of normal dose, feed to raise after 7 days continuously and observe small white mouse, not seeing has the poisoning mutation effect.
(2) the disease-resistant experiment one of pet raise immunity
Experiment one
1. pet children dog: 30: divide three groups of A B C
(1) the A group is 10: (12 months ages of dog), the present invention+feed of feeding.
(2) the B group is 10: (12 months ages of dog), the gartilage powder+feed of feeding.
(3) the C group is 10: (12 months ages of dog), feeding feed stuff.
2. 180 days observation periods, disease-resistant result is efficient, and the result shows that this health medicine of pet pet dog immunocompetence of feeding obviously strengthens.The result sees table 1.
The disease-resistant experimental result of table 1 pet raise immunity
| Group | Feed material | Fate | Hair luster | The growth of bone and tooth | Appetite | Expression | Immunity | The excreta peculiar smell | Efficient |
| The A group | Pet care article+feed (10g) (in right amount) | 180 days | Shinny | Comparatively fast | By force | Vivaciously | Strengthen, anosis | Basically do not have | 100％ |
| The B group | Gartilage powder+the feed (10g) (in right amount) of feeding | 180 days | Generally | Normally | Generally | More active | General sick 4 | Have | 70％ |
| The C group | Feeding feed stuff (10g) (in right amount) | 180 days | Generally | Generally | Apocleisis | Generally | Sick 5 | Heavier | 50％ |
Experiment two
1. pet adult dog: 30: divide three groups of A B C
(1) the A group is 10: (5 years ages of dog), the present invention+feed of feeding.
(2) the B group is 10: (5 years ages of dog), the gartilage powder+feed of feeding.
(3) the C group is 10: (5 years ages of dog), feeding feed stuff.
2. 180 days observation periods, disease-resistant result is efficient, and the result shows that this health medicine of pet pet dog resistance against diseases of feeding obviously strengthens.The result sees table 2.
Table 2 is the disease-resistant experimental results of pet raise immunity
| Group | Feed material | Fate | Hair luster | The figure | Appetite | Expression | Immunity | The excreta peculiar smell | Efficient |
| The A group | Pet care article+feed (10g) (in right amount) | 180 days | Shinny | Healthy and strong | By force | Vivaciously | Strengthen, anosis | Basically do not have | 100％ |
| The B group | Gartilage powder+the feed (10g) (in right amount) of feeding | 180 days | Generally | Better | Generally | More active | General sick 3 | Have | 70％ |
| The C group | Feeding feed stuff (10g) (in right amount) | 180 days | Generally | Generally | Apocleisis | Generally | Sick 5 | Heavier | 50％ |
Experiment three
1. pet geriatric dog: 30: divide three groups of A B C
(1) the A group is 10: (12 years ages of dog), the present invention+feed of feeding.
(2) the B group is 10: (12 years ages of dog), the gartilage powder+feed of feeding.
(3) the C group is 10: (12 years ages of dog), feeding feed stuff.
2. 180 days observation periods, disease-resistant result is efficient, and the result shows that this health medicine of pet pet dog antifatigue and the anti-ageing ability of feeding strengthens, and the result sees table 3
Table 3 pet strengthens the myocardial viability experimental result
| Group | Feed material | Fate | The rhythm of the heart | Eyesight | Appetite | Agility | Immunity | The excreta peculiar smell | Efficient |
| The A group | Pet care article+feed (10g) (in right amount) | 180 days | Basically normal | Well | By force | Well | Strengthen | Basically do not have | 100％ |
| The B group | Gartilage powder+the feed (10g) (in right amount) of feeding | 180 days | Generally | Generally | Generally | Generally | General sick 3 | Generally | 70％ |
| The C group | Feeding feed stuff (10g) (in right amount) | 180 days | In heart failure | Relatively poor | Apocleisis | Generally | Sick 6 | Heavier | 50％ |
Experiment four
Pet resisting oxidation and delaying senility function test
Aged small white mouse antioxidation is measured the result and is shown: with feed aged small white mouse 60 days of this pet care article; Extract mice serum; The result shows; Lipid peroxide degradation product MDA (MDA) content in the serum is lower than control group (P < 0.05), and superoxide dismutase in the serum (SOD) vigor shows that apparently higher than control group product of the present invention has antioxidation.
The drosophila survival result of the test shows: this pet care article group male drosophila and control group relatively show to prolong 8～10 days that the female fruit bat control group of this pet care article relatively shows prolongation 5～7 days, and the result shows that product of the present invention has function in delaying senility.
Experiment five
Pet care food shows that to the experimental result that influences of mouse S180 sarcoma growth tumour inhibiting rate can be found out, adopts cyclophosphamide combined obviously good with the tumor killing effect of this pet care article.The result sees table 4
Table 4 is this pet care medicine experimental results that influence to the growth of mouse S180 sarcoma
| Group | Dosage (g/kg) | Number of animals (only) | The toxic agent reaction | Tumour inhibiting rate | The result |
| The contrast of lotus knurl | — | 10 | — | 5％ | No tumor-inhibiting action |
| Endoxan | 0.035g/kg | 10 | (by force) depilation, apocleisis, torpescence | 56％ | Tumor-inhibiting action is better |
| The pet care article | 0.4g/kg | 10 | (weak) do not lose hair or feathers, and no apocleisis is active | 53％ | Tumor-inhibiting action is better |
| Endoxan+pet care article | 0.035+0.4g/kg | 10 | (weak) a small amount of depilation, no apocleisis, active | 86％ | Tumor-inhibiting action is strong |
| Normal control | — | 10 | — | — | — |
More than show and described basic principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; The present invention is not restricted to the described embodiments; That describes in the foregoing description and the specification just explains principle of the present invention; The present invention also has various changes and modifications under the prerequisite that does not break away from spirit and scope of the invention, and these variations and improvement all fall in the scope of the invention that requires protection.The present invention requires protection domain to be defined by appending claims and equivalent thereof.
Claims (14)
1. the pharmaceutical composition of pet care is characterized in that, is made up of the raw material of following weight portion:
0.05～0.5 part in panax ginseng extractum powder, 0.03～0.5 part in panaxoside powder, 0.5～5 part of ossein, 0.002～0.020 part of vitamin A, 0.1～1 part in dextrin, flavor enhancement are an amount of;
Said pet is pet dog and pet cat;
The preparation process of said panax ginseng extractum powder: get the Chinese medicine genseng, section, pulverizing 5～10 orders, using weight percent concentration is that 95% ethanol immerses, filters, reclaims ethanol; Alcohol extract is subsequent use; Its dregs of a decoction double-deck cooker of packing into is added the water cover face, add the steam poach, cross and filter the water extract; Merge alcohol extract and water extract, filtering and impurity removing matter gets the genseng supernatant, centrifugal genseng supernatant, and decompression concentrates, and spray-drying gets the panax ginseng extractum powder;
The preparation process of said panaxoside powder: genseng is pulverized, and the ginseng raw material's hot water lixiviate after the pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, and decompression concentrates, and spray-drying obtains extract powder.
2. the pharmaceutical composition of pet care according to claim 1 is characterized in that, said ossein replaces with the bone calcium powder.
3. the pharmaceutical composition of pet care according to claim 1 is characterized in that, described composition weight proportioning is: panax ginseng extractum powder 0.2g, panaxoside powder 0.2g, ossein 1.2g, vitamin A 10mg, dextrin 0.4g.
4. the pharmaceutical composition of pet care is characterized in that, is made up of the raw material of following weight portion:
0.05～0.5 part in panax ginseng extractum powder, 0.03～0.5 part in panaxoside powder, 0.5～5 part of bone calcium powder, 0.002～0.020 part of vitamin A, 0.1～1 part in dextrin, 0.03～0.3 part in bee pupa powder, flavor enhancement are an amount of;
Said pet is pet dog and pet cat;
The preparation process of said panax ginseng extractum powder: get the Chinese medicine genseng, section, pulverizing 5～10 orders, using weight percent concentration is that 95% ethanol immerses, filters, reclaims ethanol; Alcohol extract is subsequent use; Its dregs of a decoction double-deck cooker of packing into is added the water cover face, add the steam poach, cross and filter the water extract; Merge alcohol extract and water extract, filtering and impurity removing matter gets the genseng supernatant, centrifugal genseng supernatant, and decompression concentrates, and spray-drying gets the panax ginseng extractum powder;
The preparation process of said panaxoside powder: genseng is pulverized, and the ginseng raw material's hot water lixiviate after the pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, and decompression concentrates, and spray-drying obtains extract powder;
The preparation process of said bee pupa powder: the bee pupa raw material hot water lixiviate after will pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, and decompression concentrates, and spray-drying obtains extract powder.
5. the pharmaceutical composition of pet care according to claim 4 is characterized in that, described composition weight proportioning is: panax ginseng extractum powder 0.2g, bee pupa powder 0.1g, panaxoside powder 0.1g, vitamin A 10mg, bone calcium powder 1.2g, dextrin 0.4g.
6. the pharmaceutical composition of pet care is characterized in that, is made up of the raw material of following weight portion:
0.05～0.5 part in panax ginseng extractum powder, 0.03～0.5 part in panaxoside powder, 0.5～5 part of bone calcium powder, 0.002～0.020 part of vitamin A, 0.1～1 part in dextrin, 1～10 part of meat meal tankage, flavor enhancement are an amount of;
Said pet is pet dog and pet cat;
The preparation process of said panax ginseng extractum powder: get the Chinese medicine genseng, section, pulverizing 5～10 orders, using weight percent concentration is that 95% ethanol immerses, filters, reclaims ethanol; Alcohol extract is subsequent use; Its dregs of a decoction double-deck cooker of packing into is added the water cover face, add the steam poach, cross and filter the water extract; Merge alcohol extract and water extract, filtering and impurity removing matter gets the genseng supernatant, centrifugal genseng supernatant, and decompression concentrates, and spray-drying gets the panax ginseng extractum powder;
The preparation process of said panaxoside powder: genseng is pulverized, and the ginseng raw material's hot water lixiviate after the pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, and decompression concentrates, and spray-drying obtains extract powder.
7. the pharmaceutical composition of pet care according to claim 6 is characterized in that, described composition weight proportioning is: panax ginseng extractum powder 0.2g, meat meal tankage 2.2g, panaxoside powder 0.2g, bone calcium powder 0.5g, dextrin 0.4g, vitamin A 10mg.
8. the pharmaceutical composition of pet care is characterized in that, is made up of the raw material of following weight portion:
0.05～0.5 part in panax ginseng extractum powder, 0.03～0.5 part in panaxoside powder, 0.5～5 part of bone calcium powder, 0.002～0.020 part of vitamin A, 0.1～1 part in dextrin, 0.03～0.3 part in bee pupa powder, 0.3 part of fish meal, 0.01 part of vitamin C, flavor enhancement are an amount of;
Said pet is pet dog and pet cat;
The preparation process of said panax ginseng extractum powder: get the Chinese medicine genseng, section, pulverizing 5～10 orders, using weight percent concentration is that 95% ethanol immerses, filters, reclaims ethanol; Alcohol extract is subsequent use; Its dregs of a decoction double-deck cooker of packing into is added the water cover face, add the steam poach, cross and filter the water extract; Merge alcohol extract and water extract, filtering and impurity removing matter gets the genseng supernatant, centrifugal genseng supernatant, and decompression concentrates, and spray-drying gets the panax ginseng extractum powder;
The preparation process of said panaxoside powder: genseng is pulverized, and the ginseng raw material's hot water lixiviate after the pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, and decompression concentrates, and spray-drying obtains extract powder;
The preparation process of said bee pupa powder: the bee pupa raw material hot water lixiviate after will pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, and decompression concentrates, and spray-drying obtains extract powder.
9. the pharmaceutical composition of pet care according to claim 8; It is characterized in that described composition weight proportioning is: panax ginseng extractum powder 0.2g, bee pupa powder 0.1g, panaxoside powder 0.1g, vitamin A 10mg, bone calcium powder 1.2g, fish meal 0.3g, vitamin C 10mg, dextrin 0.4g.
10. according to the pharmaceutical composition of the described pet care of each claim of claim 1-9, it is characterized in that said flavor enhancement is one or more the combination in monosodium glutamate, pork essence, beef flavor, the flesh of fish essence.
11. the preparation of drug combination method of a pet care is characterized in that, comprises the steps:
(1), the preparation process of panax ginseng extractum powder: get the Chinese medicine genseng, cut into slices, pulverize 5～10 orders, using weight percent concentration is that 95% ethanol immerses, filters, reclaims ethanol; Alcohol extract is subsequent use; Its dregs of a decoction double-deck cooker of packing into is added the water cover face, add the steam poach, cross and filter the water extract; Merge alcohol extract and water extract, filtering and impurity removing matter gets the genseng supernatant, centrifugal genseng supernatant, and decompression concentrates, and spray-drying gets the panax ginseng extractum powder;
(2), the preparation process of panaxoside powder: genseng is pulverized, and the ginseng raw material's hot water lixiviate after the pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, decompression is concentrated, spray-drying obtains extract powder;
(3), step is produced in mixing: get panax ginseng extractum powder 0.05～0.5 weight portion, panaxoside powder 0.03～0.5 weight portion, ossein 0.5～5 weight portion, vitamin A 0.002～0.020 weight portion, dextrin 0.1～1 weight portion; Mix; Stir, sieve, process particle formulation or pulvis with 20 order granulators; Spray into an amount of flavor enhancement after the oven dry, the can capsule.
12. the preparation of drug combination method of a pet care is characterized in that, comprises the steps:
(1), the preparation process of panax ginseng extractum powder: get the Chinese medicine genseng, cut into slices, pulverize 5～10 orders, using weight percent concentration is that 95% ethanol immerses, filters, reclaims ethanol; Alcohol extract is subsequent use; Its dregs of a decoction double-deck cooker of packing into is added the water cover face, add the steam poach, cross and filter the water extract; Merge alcohol extract and water extract, filtering and impurity removing matter gets the genseng supernatant, centrifugal genseng supernatant, and decompression concentrates, and spray-drying gets the panax ginseng extractum powder;
(2), the preparation process of panaxoside powder: genseng is pulverized, and the ginseng raw material's hot water lixiviate after the pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, decompression is concentrated, spray-drying obtains extract powder;
(3), step is produced in mixing: get panax ginseng extractum powder 0.05～0.5 weight portion, panaxoside powder 0.03～0.5 weight portion, ossein 0.5～5 weight portion, vitamin A 0.002～0.020 weight portion, meat meal tankage 1～10 weight portion, dextrin 0.1～1 weight portion; Mix; Stir, sieve, process particle formulation or pulvis with 20 order granulators; Spray into an amount of flavor enhancement after the oven dry, the can capsule.
13. the preparation of drug combination method of a pet care is characterized in that, comprises the steps:
(1), the preparation process of panax ginseng extractum powder: get the Chinese medicine genseng, cut into slices, pulverize 5～10 orders, using weight percent concentration is that 95% ethanol immerses, filters, reclaims ethanol; Alcohol extract is subsequent use; Its dregs of a decoction double-deck cooker of packing into is added the water cover face, add the steam poach, cross and filter the water extract; Merge alcohol extract and water extract, filtering and impurity removing matter gets the genseng supernatant, centrifugal genseng supernatant, and decompression concentrates, and spray-drying gets the panax ginseng extractum powder;
(2), the preparation process of panaxoside powder: genseng is pulverized, and the ginseng raw material's hot water lixiviate after the pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, decompression is concentrated, spray-drying obtains extract powder;
(3), the preparation process of bee pupa powder: the bee pupa raw material hot water lixiviate after will pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, decompression concentrates, spray-drying obtains extract powder;
(4), step is produced in mixing: get panax ginseng extractum powder 0.05～0.5 weight portion, panaxoside powder 0.03～0.5 weight portion, ossein 0.5～5 weight portion, bee pupa powder 0.03～0.3 weight portion, vitamin A 0.002～0.020 weight portion, dextrin 0.1～1 weight portion; Mix; Stir, sieve, process particle formulation or pulvis with 20 order granulators; Spray into an amount of flavor enhancement after the oven dry, the can capsule.
14. the preparation of drug combination method of a pet care is characterized in that, comprises the steps:
(1), the preparation process of panax ginseng extractum powder: get the Chinese medicine genseng, cut into slices, pulverize 5～10 orders, using weight percent concentration is that 95% ethanol immerses, filters, reclaims ethanol; Alcohol extract is subsequent use; Its dregs of a decoction double-deck cooker of packing into is added the water cover face, add the steam poach, cross and filter the water extract; Merge alcohol extract and water extract, filtering and impurity removing matter gets the genseng supernatant, centrifugal genseng supernatant, and decompression concentrates, and spray-drying gets the panax ginseng extractum powder;
(2), the preparation process of panaxoside powder: genseng is pulverized, and the ginseng raw material's hot water lixiviate after the pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, decompression is concentrated, spray-drying obtains extract powder;
(3), the preparation process of bee pupa powder: the bee pupa raw material hot water lixiviate after will pulverizing refluxed in extractor 3 hours, filtered, and filter residue is brought up again 1～3 time, merging filtrate, decompression concentrates, spray-drying obtains extract powder;
(4), step is produced in mixing: get panax ginseng extractum powder 0.05～0.5 weight portion, panaxoside powder 0.03～0.5 weight portion, ossein 0.5～5 weight portion, bee pupa powder 0.03～0.3 weight portion, vitamin A 0.002～0.020 weight portion, fish meal 0.3 weight portion, vitamin C 0.01 weight portion, dextrin 0.1～1 weight portion; Mix; Stir, sieve, process particle formulation or pulvis with 20 order granulators; Spray into an amount of flavor enhancement after the oven dry, the can capsule.
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| CN104206655A (en) * | 2014-08-19 | 2014-12-17 | 徐州福润禽业食品有限公司 | Pet dog food |
| CN111567695A (en) * | 2020-05-09 | 2020-08-25 | 上海耐威克宠物用品有限公司 | Pet food composition for improving immunity and preparation method thereof |
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| CN1325693A (en) * | 2000-05-29 | 2001-12-12 | 厦门中卫多糖研究所 | Process for preparing ginseng extract powder |
| CN1618343A (en) * | 2003-11-19 | 2005-05-25 | 上海天年高科技有限公司 | Health-care food for regulating immunity of organism effectively and anti-mutation, and its prepn. method |
| CN1648133A (en) * | 2004-02-23 | 2005-08-03 | 黄亚平 | Method for preparing ginsenoside RH2 |
| CN101292710A (en) * | 2007-12-20 | 2008-10-29 | 刘蒙榕 | Panax ginseng nutrition health care pet feedstuff |
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| CN1325693A (en) * | 2000-05-29 | 2001-12-12 | 厦门中卫多糖研究所 | Process for preparing ginseng extract powder |
| CN1618343A (en) * | 2003-11-19 | 2005-05-25 | 上海天年高科技有限公司 | Health-care food for regulating immunity of organism effectively and anti-mutation, and its prepn. method |
| CN1648133A (en) * | 2004-02-23 | 2005-08-03 | 黄亚平 | Method for preparing ginsenoside RH2 |
| CN101292710A (en) * | 2007-12-20 | 2008-10-29 | 刘蒙榕 | Panax ginseng nutrition health care pet feedstuff |
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