CN102824565B - Medicine for treating osteoporosis and preparation method thereof - Google Patents
Medicine for treating osteoporosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines, in particular to a medicine for treating osteoporosis and a preparation method thereof. The invention aims to provide a medicine for treating osteoporosis, which is characterized by being prepared from the following raw materials in percentage by mass: 80-85% of fresh bone, 3.0-3.5% of bone calcium, 4.5-5.0% of caulis spatholobi, 3.0-3.5% of beautiful millettia root, 3.0-3.5% of eleusine indica and 0.4-0.5% of red date. The invention also aims to provide a preparation method of the medicine, which comprises the steps of extracting ossein, preparing bone calcium, preparing traditional Chinese medicine extract and the like. The medicine provided by the invention has obvious health care and adjuvant therapy effects on pain and discomfort caused by osteoporosis.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind ofly be used for the treatment of osteoporotic medicine and prepare the method for this medicine.
Background technology
Osteoporosis is a kind of general metabolism skeletal diseases, destroy as feature with bone amount minimizing, bone structure, show as that hone lamella is thinning, porous, bone trabecula attenuate, rupture, rare, the microstructural integrity of bone is impaired, connectivity reduces, cause bone strength reduction, the increase of bone fragility, very easily fracture, clinical symptoms: (1) pain: patient more than half has pain, be mainly multiple and general, modal is back ache, is secondly the shoulder back of the body, cervical region or wrist, ankle pain; (2) textured bone: hunch, stature becomes short; (3) fracture: vertebra, wrist (distal radius) and hip (neck of femur) are fractured common.
Osteoporosis is a kind of global disease, and in west, every 4 women or every 8 male just have 1 to suffer from this disease.And in China, according to the generaI investigation of 1999, the sickness rate of more than 60 years old crowd was up to 12.4%, wherein male accounts for 8.5%, and women accounts for 15.8%, total number of persons about 88,260,000.The current whole world has people more than 200,000,000 to suffer from this disease, and this number of patients is rank the 7th in various diseases.
For a long time, the mankind never stopped the exploration to osteoporosis, were that the traditional Chinese medical science or doctor trained in Western medicine have all founded many theories and theory, as: calcium deficiency is theoretical, estrogen lacks theory, suppress osteoclast activity theory, activate osteoblast theory etc.Under the guidance of and theory theoretical at these, market there is the osteoporotic medicine of various treatment, regrettably, these medicines take confirmation through patient, or invalid, or aggravate disease, What is more, caused other diseases, as estrogen causes cyclomastopathy, cardiac trigger of replenishing the calcium for a long time is sick.Even to this day, the mankind are not also completely clear to the pathogeny of osteoporosis, and therefore not yet develop the specific drug for the treatment of osteoporosis, the treatment of osteoporosis has become one of International Medical difficult problem.
Summary of the invention
An object of the present invention is to overcome above-mentioned the deficiencies in the prior art, provide a kind for the treatment of to osteoporosis to play the medicine of remarkable effect.
For achieving the above object, the invention provides one and treat osteoporotic medicine, it is characterized in that described medicine is made up of the raw material of following weight parts: for extracting the fresh bone 15000 of ossein, bone calcium 600, Caulis Spatholobi 800, Millettia Speciosa 600, Herba Eleusines Indicae 600, Fructus Jujubae 72;
Fresh bone for extracting ossein in said medicine is preferably Os Bovis seu Bubali or Os Sus domestica;
The dosage form of said medicine is preferably tablet, pill or capsule.
Another object of the present invention is to provide the preparation method of the osteoporotic medicine of above-mentioned treatment, comprises the following steps:
The extraction of I ossein: get fresh animal skeleton, removes the skin and flesh of attachment, smashes bone, reject bone marrow, by the ossein in the broken bone of acetic acid extraction, extracting solution, after recovery of acetic acid, adds deionized water, be heated to boil, again through decolouring, centrifugal, filter after filtrate, described filtrate is sieved through molecular sieve, collect molecular weight be 1 ~ 30,000 solution, being concentrated into proportion is 1.10, stand-by;
The preparation of II bone calcium: above-mentioned broken bone residue after acetic acid extraction ossein, is first 5 ~ 7 with tap water cleaning to pH value, then uses deionized water rinsing 2 ~ 3 times, dry, pulverize, cross 100 mesh sieves, stand-by;
The preparation of III Chinese medical concrete: after Caulis Spatholobi, Millettia Speciosa and Herba Eleusines Indicae are pulverized, soak 1 hour, be heated to boil, and keep micro-and boil 2.5 ~ 3 hours, filter waste, filtrate is concentrated into 1/2, is chilled to room temperature, adds ethanol, hold over night, getting supernatant concentration to proportion is 1.10, stand-by;
After IV extracting red date stone, dry, be ground into powder, stand-by;
The each component of V combining step I to step IV gained, adds pharmaceutically acceptable excipient and makes acceptable dosage form clinically.
Preferably, the concentration of the acetum used in above-mentioned steps I is 30%.
Preferably, in above-mentioned steps I by the method for 30% acetic acid extraction ossein be: the ratio of 1:3 adds the acetum of 30% in broken bone in mass ratio, after being heated to boil, reflux 48 hours, filter, filtrate is stand-by, the ratio of filtering residue 1:1.5 in mass ratio adds the acetum backflow 8 ~ 12 hours of 30%, filter, merge twice filtrate, obtain extracting solution.
Preferably, in above-mentioned steps I, the addition of deionized water is 5 times of the extracting solution weight after recovery of acetic acid.
Preferably, the bleaching process in above-mentioned steps I adopts active carbon, and the addition of described active carbon is 1.5% of the total solution weight after adding deionized water, and bleaching time is 20min.
Preferably, the addition of the ethanol in above-mentioned steps III is make the concentration of alcohol in solution reach 50% ~ 60%.
Fang Xie:
According to " orthomolecular medicine is theoretical ", the generation of any one disease, all follow the unbalance relevant of a certain material concentration when maintaining its health, under the guidance of the traditional Chinese medical science " with shape benefit shape " viewpoint, impel the present invention to expect from skeleton, find the material solving skeletal problem.The structure of analyzing bone, one of composition of skeleton is the skeletal tissue of Mineralization, its inside is hard network structure, the network structure of skeleton is formed by bone collagen fiber, the composition of mineral should be the various elements such as hydroxyapatite, interior calcic, phosphorus, magnesium, the combination of ossein and hydroxyapatite, be gathered in the network structure of skeleton, the armored concrete of our building industry is intended in pole.If ossein reduces, the ratio of this condensation, by disequilibrium, causes the air slaking phenomenon of similar rock, cement, so create the loss of hydroxyapatite, is generically called " loss of calcium ", little by little causes bone to loosen, thus causes various symptom.Therefore, finding real bone collagen, pin hydroxyapatite, do not allow it run off, is solve osteoporotic key!
Fresh bone, containing have an appointment 4% collagen, collagen is the active substance maintaining skeleton stalwartness, its structure is more similar to the collagen in people's bone, molecular sieve is adopted to obtain the part close with human bone tropocollagen molecule amount, as primary raw material of the present invention, for preventing the loss of human osteocalcin from being very effective, as monarch drug;
Caulis Spatholobi is the rattan of leguminous plant spatholobus suberectus, warm in nature, bitter in the mouth, micro-sweet, has that promoting the circulation of blood is enriched blood, effect of relaxing muscles and tendons and activating QI and blood in the collateral;
Millettia Speciosa, for the root of pulse family Millettia plant beautiful millettia is used as medicine, property is sweet, flat, has tonify deficiency lung moistening, effect that strong muscle is active;
Herba Eleusines Indicae, be the herb of standing grain section this yard grass platymiscium Herba Eleusines Indicae, property is sweet, light, flat, has effect of heat-clearing and toxic substances removing, expelling wind and removing dampness, dissipating blood stasis hemostasis;
Fructus Jujubae, be the fruit of Rhamnaceae jujube Fructus Jujubae, property is sweet, warm, has spleen reinforcing, QI invigorating, effect of nourishing heart, calming the nerves.
Usage and dosage:
Every day 3 times, each serving consumption by effective ingredient 2.1g, dose is by effective ingredient 3.5g first, ante cibum or one after each meal.
Beneficial effect:
The present invention breaks through theory and the theory of existing associated with osteoporosis disease, understands the pathogeny of osteoporosis by a kind of theory completely newly, and under the guidance of this theory, explore a kind of medicine effectively can treating osteoporosis.
Compared with prior art, the present invention has the following advantages:
1, medicine provided by the invention there is promoting the circulation of blood, enrich blood, effect of dampness removing, dissipating blood stasis, and the skeleton loosened is repaired gradually, therefore to the pain caused by skeleton bulking and the uncomfortable effect with significantly health care and auxiliary treatment;
2, confirm through clinical trial, medicine provided by the invention not only can prevent and treat osteoporosis, and has the effect of strengthening yang and invigorating kidney, and the people suffering from ED obstacle has had and is clearly better after taking this medicine;
3, medicine provided by the invention tries clothes through people more than 600, effective percentage reaches more than 90%, especially to waist, legs that postclimacteric middle and aged women causes because of deficiency of kidney-QI because of loss and the middle-aging male of bone calcium, has significant therapeutic effect, and instant effect, effect is lasting, stable.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail, and following examples are explanation of the invention, and the present invention is not limited to following examples.
Embodiment 1
The extraction of I ossein: get the Os Sus domestica that 15000g is fresh, removes the skin and flesh of attachment, smashes bone, reject bone marrow, the acetum of broken bone and 30% is put in enamel pan by the ratio of 1:3 in mass ratio, after being heated to boil, refluxes 48 hours, filter, filtrate is stand-by, and the acetum that the ratio of filtering residue 1:1.5 in mass ratio adds 30% refluxes 8 hours, filters, merge twice filtrate, obtain extracting solution; Extracting solution is after Acetic Acid Recovering Column recovery of acetic acid, add the deionized water of its weight 5 times amount, be heated to boil, add active carbon by 1.5% of gross weight, desolventing technology 20 minutes, then through centrifugal, filter after filtrate, filtrate is sieved through molecular sieve, collect the solution that molecular weight is 1 ~ 30,000, it is 1.10 that normal pressure is concentrated into proportion, stand-by.
The preparation of II bone calcium: above-mentioned broken bone residue after 30% acetic acid extraction ossein, be first 5 with tap water cleaning to pH value, then use deionized water rinsing 2 times, centrifuge dries, and dries 3 hours for 80 DEG C, pulverizes, crosses 100 mesh sieves, stand-by.
The preparation of III Chinese medical concrete: get 800g Caulis Spatholobi, 600g Millettia Speciosa and 600g Herba Eleusines Indicae, shred in rearmounted stainless-steel pan, add the tap water of gross weight 4 times amount, soaks after 1 hour, is heated to boil, and keeps micro-and boil 2.5 hours.Filter waste, filtrate normal pressure is concentrated into 1/2, is chilled to room temperature, and the ethanol adding 70% under stirring makes the concentration of alcohol in solution reach 50%, hold over night.On next day, Aspirate supernatant, in ethanol recovery tower, reclaims ethanol for lower batch, and in tower, residual liquid takes out normal pressure and is concentrated into the fluid extract that proportion is 1.10, stand-by.
IV get 72g extracting red date stone after, 60 DEG C of oven dry, are ground into powder, stand-by.
V gets step II gained bone calcium powder 600g; and each component of step I, step III and step IV gained; add the adjuvants such as starch, microcrystalline Cellulose, magnesium stearate; at trough-type mixture machine mix homogeneously; granulate with oscillating granulator, cross 14 mesh sieves, dry 4 hours for 60 DEG C; granulate tabletting machine, obtains tablet of the present invention.
Embodiment 2
The extraction of I ossein: get the Os Bovis seu Bubali that 8000g is fresh, removes the skin and flesh of attachment, smashes bone, reject bone marrow, the acetum of broken bone and 30% is put in enamel pan by the ratio of 1:3 in mass ratio, after being heated to boil, refluxes 48 hours, filter, filtrate is stand-by, and the acetum that the ratio of filtering residue 1:1.5 in mass ratio adds 30% refluxes 12 hours, filters, merge twice filtrate, obtain extracting solution; Extracting solution is after Acetic Acid Recovering Column recovery of acetic acid, add the deionized water of its weight 5 times amount, be heated to boil, add active carbon by 1.5% of gross weight, desolventing technology 20 minutes, then through centrifugal, filter after filtrate, filtrate is sieved through molecular sieve, collect the solution that molecular weight is 1 ~ 30,000, it is 1.10 that normal pressure is concentrated into proportion, stand-by.
The preparation of II bone calcium: above-mentioned broken bone residue after 30% acetic acid extraction ossein, be first 7 with tap water cleaning to pH value, then use deionized water rinsing 3 times, centrifuge dries, and dries 3 hours for 80 DEG C, pulverizes, crosses 100 mesh sieves, stand-by.
The preparation of III Chinese medical concrete: get 500g Caulis Spatholobi, 300g Millettia Speciosa and 350g Herba Eleusines Indicae, shred in rearmounted stainless-steel pan, add the tap water of gross weight 4 times amount, soaks after 1 hour, is heated to boil, and keeps micro-and boil 3 hours.Filter waste, filtrate normal pressure is concentrated into 1/2, is chilled to room temperature, and the ethanol adding 75% under stirring makes the concentration of alcohol in solution reach 60%, hold over night.On next day, Aspirate supernatant, in ethanol recovery tower, reclaims ethanol for lower batch, and in tower, residual liquid takes out normal pressure and is concentrated into the fluid extract that proportion is 1.10, stand-by.
IV get 50g extracting red date stone after, 60 DEG C of oven dry, are ground into powder, stand-by.
V gets step II gained bone calcium powder 300g; and each component of step I, step III and step IV gained is mixed; add the adjuvants such as starch, magnesium stearate, microcrystalline Cellulose; at trough-type mixture machine mix homogeneously; granulate with oscillating granulator, cross 14 mesh sieves, dry 4 hours for 60 DEG C; capsule-filling, obtains capsule of the present invention.
Embodiment 3
The extraction of I ossein: get the Os Bovis seu Bubali that 8200g is fresh, removes the skin and flesh of attachment, smashes bone, reject bone marrow, the acetum of broken bone and 30% is put in enamel pan by the ratio of 1:3 in mass ratio, after being heated to boil, refluxes 48 hours, filter, filtrate is stand-by, and the acetum that the ratio of filtering residue 1:1.5 in mass ratio adds 30% refluxes 10 hours, filters, merge twice filtrate, obtain extracting solution; Extracting solution is after Acetic Acid Recovering Column recovery of acetic acid, add the deionized water of its weight 5 times amount, be heated to boil, add active carbon by 1.5% of gross weight, desolventing technology 20 minutes, then through centrifugal, filter after filtrate, filtrate is sieved through molecular sieve, collect the solution that molecular weight is 1 ~ 30,000, it is 1.10 that normal pressure is concentrated into proportion, stand-by.
The preparation of II bone calcium: above-mentioned broken bone residue after 30% acetic acid extraction ossein, be first 6 with tap water cleaning to pH value, then use deionized water rinsing 3 times, centrifuge dries, and dries 3 hours for 80 DEG C, pulverizes, crosses 100 mesh sieves, stand-by.
The preparation of III Chinese medical concrete: get 480g Caulis Spatholobi, 350g Millettia Speciosa and 300g Herba Eleusines Indicae, shred in rearmounted stainless-steel pan, add the tap water of gross weight 4 times amount, soaks after 1 hour, is heated to boil, and keeps micro-and boil 3 hours.Filter waste, filtrate normal pressure is concentrated into 1/2, is chilled to room temperature, and the ethanol adding 70% under stirring makes the concentration of alcohol in solution reach 55%, hold over night.On next day, Aspirate supernatant, in ethanol recovery tower, reclaims ethanol for lower batch, and in tower, residual liquid takes out normal pressure and is concentrated into the fluid extract that proportion is 1.10, stand-by.
IV get 50g extracting red date stone after, 60 DEG C of oven dry, are ground into powder, stand-by.
V gets step II gained bone calcium powder 350g, together adds in trough-type mixture machine, then add appropriate water with each component of step I, step III and step IV gained, medicine is refined with medicine refining machine after mix homogeneously, use pellet processing machine pill again, dry 4 hours, obtain concentrated pill of the present invention for 60 DEG C.
It is as follows that the medicine obtained embodiment 1 does clinical test results:
Crowd selects: more than 40 years old, men and women did not limit, and detects bone density lower than normal level and present the uncomfortable persons that ache such as waist, the back of the body, lower limb through hospital;
Usage and dosage: every patient takes 5, embodiment 1 gained tablet first, each 3 later, every day 3 times, ante cibum, not to limit after meal, takes 1 month continuously;
The situation of taking gathers:
Model case:
1, Mrs Zhu: 55 years old, in August, 2006, regularly there is sharp pain in prolapse of lumbar intervertebral disc, through traction, massage, closes and takes various calcium preparation, though the short time is improved, effect is unstable, has a strong impact on work, study and the process to housework.In June, 2007 takes medicine of the present invention, and after taking three days, symptom obviously alleviates, and takes for 2 week continuously, so far more than 5 years, then does not occur above-mentioned symptom.
2, Mrs Liao: 76 years old, suffer from cervical spondylosis and have more than ten years, in March, 2008 takes medicine of the present invention, only three days, the transference cure of pain, takes 1 wheat harvesting period continuously afterwards, fully recovers, does not violate so far.
3, CHENNU scholar: 78 years old, because osteoporosis causes cervical vertebra, lumbar vertebra and leg etc. to ache, has had for many years, has taken calcium preparation in a large number, do not feel any better.In October, 2009 takes medicine of the present invention, and after three months, subjective symptom is obviously improved, and after half a year, measures bone density, and report claims bone density substantially to recover normal.
4, Mr. Xu: 62 years old, flank pain is unbearably, handicapped, and in April, 2010 takes medicine of the present invention, and after about 3 ~ 4 hours, flank pain is eliminated substantially, can be freely movable.Separately, after taking medicine of the present invention, this patient surprisingly finds to perplex oneself ED impairment property for many years and eliminates, and love life is harmonious happy.
5, Mrs Ye: 43 years old, certain association's accounting, can not bend over because of pain, have a strong impact on work, and in June, 2012 takes medicine of the present invention, and after 1 week, symptom obviously alleviates, and takes 2 months continuously, and symptom disappears completely.
Claims (9)
1. treat an osteoporotic medicine, it is characterized in that described medicine is made up of the raw material of following weight parts: for extracting the fresh bone 15000 of ossein, bone calcium 600, Caulis Spatholobi 800, Millettia Speciosa 600, Herba Eleusines Indicae 600, Fructus Jujubae 72.
2. the osteoporotic medicine for the treatment of according to claim 1, is characterized in that: the described fresh bone for extracting ossein is Os Bovis seu Bubali or Os Sus domestica.
3. the osteoporotic medicine for the treatment of according to claim 1, is characterized in that: the dosage form of described medicine is tablet, pill or capsule.
4. prepare a method for the osteoporotic medicine for the treatment of described in claims 1 to 3 any one, comprise the following steps:
The extraction of I ossein: get fresh animal skeleton, removes the skin and flesh of attachment, smashes bone, reject bone marrow, by the ossein in the broken bone of acetic acid extraction, extracting solution, after recovery of acetic acid, adds deionized water, be heated to boil, again through decolouring, centrifugal, filter after filtrate, described filtrate is sieved through molecular sieve, collect molecular weight be 1 ~ 30,000 solution, being concentrated into proportion is 1.10, stand-by;
The preparation of II bone calcium: above-mentioned broken bone residue after acetic acid extraction ossein, is first 5 ~ 7 with tap water cleaning to pH value, then uses deionized water rinsing 2 ~ 3 times, dry, pulverize, cross 100 mesh sieves, stand-by;
The preparation of III Chinese medical concrete: after Caulis Spatholobi, Millettia Speciosa and Herba Eleusines Indicae are pulverized, soak 1 hour, be heated to boil, and keep micro-and boil 2.5 ~ 3 hours, filter waste, filtrate is concentrated into 1/2, is chilled to room temperature, adds ethanol, hold over night, getting supernatant concentration to proportion is 1.10, stand-by;
After IV extracting red date stone, dry, be ground into powder, stand-by;
The each component of V combining step I to step IV gained, adds pharmaceutically acceptable excipient and makes acceptable dosage form clinically.
5. preparation method according to claim 4, is characterized in that: the concentration of the acetum used in described step I is 30%.
6. preparation method according to claim 5, it is characterized in that, be: the ratio of 1:3 adds the acetum of 30% in broken bone in mass ratio, after being heated to boil, reflux 48 hours by the method for 30% acetic acid extraction ossein in described step I, filter, filtrate is stand-by, and the ratio of filtering residue 1:1.5 in mass ratio adds the acetum backflow 8 ~ 12 hours of 30%, filters, merge twice filtrate, obtain extracting solution.
7. preparation method according to claim 4, is characterized in that: in described step I, the addition of deionized water is 5 times of the extracting solution weight after recovery of acetic acid.
8. preparation method according to claim 4, is characterized in that: the bleaching process in described step I adopts active carbon, and the addition of described active carbon is 1.5% of the total solution weight after adding deionized water, and bleaching time is 20min.
9. preparation method according to claim 4, is characterized in that: the addition of the ethanol in described step III is make the concentration of alcohol in solution reach 50% ~ 60%.
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| CN101524474A (en) * | 2009-03-24 | 2009-09-09 | 李永胜 | Deer bone ossein tendon-and-bone strengthening calcium for tonifying kidney, promoting vital essence and blood generation |
| CN101524475A (en) * | 2009-03-24 | 2009-09-09 | 李永胜 | Sheep ossein tendon-and-bone strengthening calcium for preventing fatigue and tonifying kidney |
| CN101731470A (en) * | 2008-11-04 | 2010-06-16 | 上海国维高科技有限公司 | Drug combination for pet health and preparation method thereof |
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| CN101731470A (en) * | 2008-11-04 | 2010-06-16 | 上海国维高科技有限公司 | Drug combination for pet health and preparation method thereof |
| CN101524474A (en) * | 2009-03-24 | 2009-09-09 | 李永胜 | Deer bone ossein tendon-and-bone strengthening calcium for tonifying kidney, promoting vital essence and blood generation |
| CN101524475A (en) * | 2009-03-24 | 2009-09-09 | 李永胜 | Sheep ossein tendon-and-bone strengthening calcium for preventing fatigue and tonifying kidney |
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