CN1277560C - Sanhuang capsules and preparation thereof - Google Patents
Sanhuang capsules and preparation thereof Download PDFInfo
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- CN1277560C CN1277560C CNB2005100416677A CN200510041667A CN1277560C CN 1277560 C CN1277560 C CN 1277560C CN B2005100416677 A CNB2005100416677 A CN B2005100416677A CN 200510041667 A CN200510041667 A CN 200510041667A CN 1277560 C CN1277560 C CN 1277560C
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Abstract
The present invention relates to sanhuang capsules and a preparation technology thereof. The medicine and the preparation technology are provided for patients with osteoporosis. The Chinese medicine preparation is made from four traditional Chinese medicinal materials of soybean isoflavone, rhubarb, unprocessed rehmannia root, etc. The preparation technology for preparing the sanhuang capsules comprises four technologies that two kinds of medicine are made into powder, two kinds of medicine are decocted to thick paste, the powder and the thick paste are mixed to soft materials and pelletized, and granules are filled into the capsules. The sanhuang capsules have the advantages of less prescription medicine, simple preparation technology, low cost and convenience for oral administration. The present invention not only has significant curative effect on osteoporosis, but also has significant curative effect on climacteric syndrome and gonadal tumor diseases for women of middle and old age.
Description
Affiliated technical field
Sanhuang capsules of the present invention and preparation technology thereof belong to medicine and the preparation technology thereof who treats orthopaedic disease, relate in particular to Chinese medicine preparation and preparation technology thereof with Chinese prescription treatment osteoporosis.
Background technology
Osteoporosis is meant that the osseous tissue amount of normal calcification in certain unit volume reduces, with pain along the spinal column and deformity or to merge fracture be the disease of main clinic symptoms, primary disease belongs to the atrophic debility of bones of the traditional Chinese medical science, sick category such as rheumatism involving the bone, differential diagnosis in tcm is divided into deficiency of the liver and kindey card and syndrome of deficiency of spleen qi and stomach qi, its symptom characteristic is a lumbar vertebrae pain, aching and limp few power, can not be prudent, muscle is withered very thin, tired, anorexia and loose stool, or incessant chronic diarrhea, asthenia facial edema is simple and unadorned, palpitation and insomnia, person's aversion to cold and cold limbs very, patient's pain is based on vertebra and pelvic region and fracture, and more so, the body activity is subjected to obvious obstacle when Yu Denglou or Body Position Change, lower limb muscles often has atrophy in various degree long afterwards, if any compression fracture of the spine, patient's height can shorten, and can cause sciatica and influence cardiac function when serious, after menopause the women and after 55 years old the male the most common, the patient is many, and genus is weak and sickly, endocrine disturbance, immunity degradation, it is bad that body internal protein shortage causes organic generation, hydrocortisone increases, hyperthyroidism, and the ossein disorganization increases, bone calcium conversion ratio increases, urethra coprodaecum calcium excretion amount increases, and makes the maturation generation obstacle of calcium basic stitch, and patients ' life quality is low, medicine is but based on calcium preparation at present, endocrine disturbance and immunity degradation and nutritional substance lacked does not still have influence, unsatisfactory to the senile osteoporosis effect, when use vitamin and calcium preparation, easily suffer from diseases such as calculus of urethra again, market lacks raising immunity, improve endocrine, the nourish one's nature treatment osteoporosis agents of material of Replacement Battalion.
Summary of the invention
The objective of the invention is: give suffer from patients with osteoporosis provide scientific formulation, prescription YAOJING few, can reach reinforcing the kidney to strengthen the bone, smart marrow, the nourishing YIN for suppressing the hyperactive YANG of giving birth to of benefit, effectively treat the compound Chinese medicinal preparation of osteoporosis, and have no side effect, evident in efficacy, production technology is easy, and is with low cost.
In order to realize the foregoing invention purpose, the technical solution adopted in the present invention is: Sanhuang capsules is according to the main etiology and pathogenesis of osteoporosis, with reinforcing the kidney to strengthen the bone, the smart living marrow of benefit, nourishing YIN for suppressing the hyperactive YANG is principle of treatment, the crude drug total amount is 640 grams in the prescription, is made up of soybean isoflavone 20 grams, Radix Et Rhizoma Rhei 220 grams, Radix Rehmanniae 220 grams, Carapax Et Plastrum Testudinis 100 grams, Cortex Cinnamomi 80 grams.The preparation technology of Sanhuang capsules is divided into Cortex Cinnamomi and Carapax Et Plastrum Testudinis powder process medicine, Radix Et Rhizoma Rhei and Radix Rehmanniae decocting to thick ointment, soybean isoflavone and powder medicine and the thick paste soft material that is mixed, granulate and adorn capsule four road technologies, getting Cortex Cinnamomi and Carapax Et Plastrum Testudinis two flavor pulverizing medicinal materials earlier crosses 80 mesh sieves and is mixed into the fine powder medicine, get Radix Et Rhizoma Rhei again, Radix Rehmanniae two flavor medicines add 8 times of water gagings respectively and decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filters, being concentrated into relative density is the thick paste of about 1.30 (60 ℃), at last with thick paste, the fine powder medicine, soybean isoflavone crystalline flour mixing is made soft material, crossing 14 order nylon mesh granulates, 80 ℃ of oven dry, No. 1 capsule of packing into gets patent medicine.Chinese medicine thinks that osteoporosis is because of due to deficiency of the liver and kindey and the deficiency of spleen-QI and stomach-QI, modern Chinese medicine research confirms: soybean isoflavone contains daidzin, daidzein, syringic acid isoreactivity composition, have and invigorate blood circulation, diuretic, dispel the wind, detoxify, control migratory arthralgia clonic spasm of the muscle effect, can improve coronary circulation, nervus centralis is had analgesic activity; Radix Et Rhizoma Rhei has attacks stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, detoxicating functions, can significantly reverse hepatic tissue fatty infiltration and fibrosis that carbon tetrachloride causes, have and protect the liver function significantly, emodin has strong inhibitory action to murine melanoma, chrysophanic acid also has inhibitory action to ehrlich carcinoma, emodin also has inhibitory action to breast carcinoma, and its mechanism of action mainly is the oxidation and the dehydrogenation of anticancer, can obviously promote activated lymphocyte of cutter globulin and proteinic biosynthesis; The Radix Rehmanniae decoct is irritated stomach to rabbit can resist the decline of taking plasma corticosterone concentration behind the dexamethasone continuously, and can prevent the adrenal cortex atrophy, hypophysis one hypoadrenocorticism that occurs when but the part antagonist hormonal uses separately can be accelerated multi-functional hematopoietic stem cell, the propagation of bone marrow hemopoietic progenitor cell of red blood cell line, differentiation; Carapax Et Plastrum Testudinis has nourishing YIN for suppressing the hyperactive YANG, reinforcing the kidney to strengthen the bone, heart tonifying and tranquilizing, controls hectic fever due to YIN-deficiency consumptive fever effect, taking the Carapax Et Plastrum Testudinis decoct can impel the thyroid of atrophy to recover growth, quantity of leucocyte is obviously raise, can make the thymus of atrophy recover growth, lymhocyte transformation rate is improved, also can impel adrenal cortex to recover growth, the cortex glomerular zone thickens, and zona fasciculata unit are cell cell space increases, and endochylema is plentiful, adrenal gland's weight increases, and effectively improves cellular immunization and humoral immune function; Cortex Cinnamomi have mend that fire is supporing yang, let the fire back to its origin, dispersing cold for relieving pain, warming the meridian and promoting blood circulation effect, contained Cortex cinnamomi japonici (Ramulus Cinnamomi) polysaccharide can obviously improve the phagocytic activity of reticuloendothelial system to carbon granules, natrium cinnamicum has the effect of leukocyte increasing, cinnamic aldehyde can suppress viral resulted tumour fully, generation that can also the induced tumor necrosin.Select above-mentioned prescription medicine compatibility for use, it is the etiology and pathogenesis that lacks according to patients with osteoporosis immunity degradation, endocrine disturbance, nutrient substance, with reinforcing the kidney to strengthen the bone, the smart living marrow of benefit, nourishing YIN for suppressing the hyperactive YANG is principle of treatment, the effect of play raising immunity altogether, improve endocrine, Replacement Battalion being nourished one's nature material, effectively treat osteoporosis, and effective in cure to middle aged and aged women syndrome in menopause and gonad tumor simultaneously.
To cure mainly relevant pharmacodynamics test verified evident in efficacy with function in preclinical study for Sanhuang capsules, recommends clinical adult's oral dose 3 times on the one, each 3.
The invention has the beneficial effects as follows: the prescription YAOJING is few in the prescription, by the effective ingredient complementation, Sanhuang capsules has reinforcing the kidney to strengthen the bone, the smart effect of giving birth to marrow, nourishing YIN for suppressing the hyperactive YANG of benefit, can effectively improve patient body immunity, improves the endocrine disturbance, increase the endotrophic material, evident in efficacy to osteoporosis, production technology is easy, and is with low cost, convenient oral, effective in cure to middle aged and aged women syndrome in menopause and gonadal tumor simultaneously.
Specific embodiments:
1, the Sanhuang capsules prescription is made up of soybean extract and four flavor Chinese crude drugs, wherein soybean isoflavone 20 grams, Radix Et Rhizoma Rhei 220 grams, Radix Rehmanniae 220 grams, Carapax Et Plastrum Testudinis 100 grams, Cortex Cinnamomi 80 restrain, it is standby that soybean isoflavone is purchased finished product raw material crystalline flour, and weighing is standby respectively behind all the other Chinese crude drug enchashment row prepared slices of Chinese crude drugs roguing well sifteds.
2, Sanhuang capsules preparation technology:
1. getting Cortex Cinnamomi, Carapax Et Plastrum Testudinis two flavor pulverizing medicinal materials crosses 80 mesh sieves and becomes the fine powder medicine standby.
2. get Radix Et Rhizoma Rhei, Radix Rehmanniae two flavor Chinese herbal medicine and add 8 times of water gagings at every turn and decoct secondaries, be respectively 1.5 hours and 1 hour, the collecting decoction filtration, being concentrated into relative density is the thick paste of about 1.30 (60 ℃).
3. thick paste and standby fine powder medicine and soybean isoflavone crystalline flour mixing, make soft material, cross 14 order nylon mesh and granulate, 80 ℃ of oven dry are sub-packed in No. 1 capsule and get patent medicine.
Claims (2)
1, a kind of Sanhuang capsules is characterized in that: the raw material total amount is 640 grams in the prescription, is made up of soybean isoflavone 20 grams, Radix Et Rhizoma Rhei 220 grams, Radix Rehmanniae 220 grams, Carapax Et Plastrum Testudinis 100 grams, Cortex Cinnamomi 80 grams.
2, Sanhuang capsules preparation technology according to claim 1, it is characterized in that: get Cortex Cinnamomi and Carapax Et Plastrum Testudinis two flavor pulverizing medicinal materials earlier and cross 80 mesh sieves and be mixed into the fine powder medicine, get Radix Et Rhizoma Rhei, Radix Rehmanniae two flavor medicines again and add 8 times of water gagings respectively and decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filters, relative density is 1.30 thick paste when being concentrated into 60 ℃, at last thick paste, fine powder medicine, soybean isoflavone crystalline flour mixing is made soft material, crosses 14 order nylon mesh and granulates, 80 ℃ of oven dry, No. 1 capsule of packing into gets patent medicine.
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CNB2005100416677A CN1277560C (en) | 2005-01-31 | 2005-01-31 | Sanhuang capsules and preparation thereof |
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CNB2005100416677A CN1277560C (en) | 2005-01-31 | 2005-01-31 | Sanhuang capsules and preparation thereof |
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CN1679836A CN1679836A (en) | 2005-10-12 |
CN1277560C true CN1277560C (en) | 2006-10-04 |
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CN105687317B (en) * | 2016-03-08 | 2021-01-01 | 宁夏医科大学 | Application of total flavonoids of cinnamomum burmannii leaves in preparation of medicine for treating osteoporosis and medicine composition |
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