CN102641472B - Chinese herbal preparation for curing osteoporosis - Google Patents
Chinese herbal preparation for curing osteoporosis Download PDFInfo
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Abstract
Provided is a Chinese herbal preparation for curing osteoporosis. The Chinese herbal preparation is prepared by the following raw materials by parts of weight: 1-10 parts of rhizome cibotii, 1-10 parts of herba epimedii, 1-10 parts of rhizoma nardostachyos, 1-10 parts of Chinese magnoliavine fruit, 1-10 parts of fructus evodiae, 1-10 parts of curcuma zedoary and addition ingredients. The Chinese herba preparation breaks through a traditional method, adopts a novel curing law, chooses drug according to international food and drug standards to be used as effective ingredients, has good curing effects on osteoporosis of human bodies, achieves unique and special results in clinical curing and researches, and resolves the difficult problem that the osteoporosis is universal and worldwide to humans.
Description
Technical field
The present invention relates to the Chinese medicine preparation technical field, be specifically related to a kind of Chinese medicine preparation for the treatment of osteoporosis.
Background technology
At present, osteoporosis is that the mankind have universality and global problem, and sickness rate is high, is more common in Middle Age and Aged Patients, within general 40～60 years old, account for 30%, 60～70 years old and account for 60%～70%, the male be greater than 60 years old in the majority.Pain is the modal symptom of primary osteoporosis, common with neck, breast, waist, gonalgia, accounts for 70%～80% in pain patients.Osteoporosis is the skeletal bones amount minimizing caused due to many reasons, and the bone fine structure destroys, the general osteopathia that bone fragility increases and fracture risk increases.
The inventor analyses in depth both at home and abroad the osteoporotic theory for the treatment of and method at present, finds existing medical treatment effect imperfect.Mostly doctor trained in Western medicine is to adopt the Therapeutic Principle replenish the calcium, and " what lacks what is mended ", overemphasize the specific aim of medication to source of disease, lessly take the damage of medication to other organs into account.Mostly the treatment of traditional Chinese medical science traditional approach is to adopt the kidney invigorating.We, are furtherd investigate and are inquired in conjunction with other theory of medicine by Traditional Chinese medical theory, and the theory of Chinese medical science of take is thought as relying on: " the kidney being the origin of congenital constitution, the spleen being the foundation of acquired constitution ", " The spleen has the function to transport and transform nutrients, kidney governing bones ".The strong of skeleton must have normal nutrition supply, could not weak not regression.Kidney governing bones, the vital essence in kidney derives from the essence of water and grain that The spleen has the function to transport and transform nutrients, so the disease for the treatment of bone must be strengthened the function of spleen, could support good kidney and cure bone, and have the method for blood circulation promoting and blood stasis dispelling, dredging the meridian to combine, and just can reach desirable therapeutic effect.Therefore need the rational Chinese medicine preparation of a kind of composition and ratio of research, to play the osteoporotic ideal effect for the treatment of, solve osteoporosis the mankind are had to universality and a global difficult problem.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine preparation for the treatment of osteoporosis, it forms clear and definite, reasonable mixture ratio, reach the result of unique and special effect in clinical treatment and observation, thereby eliminate the Chinese medicine preparation that there is no component, reasonable mixture ratio in the above-mentioned background technology, to complete strong spleen, supported the defect that kidney is controlled bone.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A kind of Chinese medicine preparation for the treatment of osteoporosis, described Chinese medicine preparation is prepared from by the raw material that comprises following weight portion:
Rhizoma Cibotii 1～10 weight portion;
Herba Epimedii 1～10 weight portion;
Radix Et Rhizoma Nardostachyos 1～10 weight portion;
Fructus Schisandrae Chinensis 1～10 weight portion;
Fructus Evodiae 1～10 weight portion;
Rhizoma Curcumae 1～10 weight portion.
A kind of Chinese medicine preparation for the treatment of osteoporosis, described Chinese medicine preparation is prepared from by the raw material that comprises following weight portion:
Rhizoma Cibotii 1 weight portion;
Herba Epimedii 1 weight portion;
Radix Et Rhizoma Nardostachyos 1 weight portion;
Fructus Schisandrae Chinensis 1 weight portion;
Fructus Evodiae 1 weight portion;
Rhizoma Curcumae 1 weight portion.
Chinese medicine preparation provided by the invention, be that secret recipe handed down in the family, the combination the inventor used requirement and the standard of Chinese herbal medicine to improve in the world now, observed in clinical treatment and sum up and invent.
Chinese medicine preparation provided by the invention, in selected Chinese crude drug: Rhizoma Cibotii, main invigorating the liver and kidney, strong waist knee joint, clinical in the lassitude loin and legs, numb limbs and tense tendons, the effect of temperature compensation astringency inducing is arranged, and can treat frequent micturition, the enuresis, make essence etc., in this medicament, Rhizoma Cibotii directly plays skeleton and takes good care of and repair, because the functional rehabilitation of kidney qi directly shows that frequent micturition reduces and the aspect such as the minimizing of getting up in the night to urinate; Herba Epimedii, main kidney-replenishing, bone and muscle strengthening, for soreness of the waist and knees, the muscles and bones flaccidity is soft, and limbs joint pain is unable, walks with difficulty etc., and in this medicament, Herba Epimedii plays the anabolic effect that promotes medullary cell DNA, plays the osteoporotic effect of good control; Radix Et Rhizoma Nardostachyos, activating spleen and strengthening stomach, it is warm in nature logical, promoting the circulation of QI to relieve pain, in this medicament, Radix Et Rhizoma Nardostachyos has the effect of expanding blood vessel, and blood circulation is very helpful; Fructus Schisandrae Chinensis, main QI invigorating, tonifying for the deficiency, the effect of reinforcing YIN-essence benefit essence, for human body yin channel insufficiency of vital energy and blood, in this medicament, Fructus Schisandrae Chinensis plays the skeleton loss effect of taking a tonic or nourishing food to build up one's health; Fructus Evodiae, have warming middle-JIAO supporing yang, and the effect that dissipating depression of QIization is stagnant, for the yang-energy of warming the spleen kidney, promotes the absorption of essence of water and grain, and in this medicament, Fructus Evodiae is of value to the rehabilitation of skeleton; Rhizoma Curcumae, stasis-dispelling and pain-killing, lively atmosphere blood, the meridian dredging, in this medicament, Rhizoma Curcumae can impel the cyclic metabolism of skeleton.The disease of above application for the treatment of bone is strengthened the function of spleen, could support good kidney and cure bone, and have the method for blood circulation promoting and blood stasis dispelling, dredging the meridian to combine, and just can reach desirable therapeutic effect.Played the osteoporotic purpose for the treatment of.
The present invention breaks through traditional approach, adopts new treatment rule, selects new Chinese crude drug to use as the active component compatibility, and human body bone is loosened and has significant curative effect, has reached the effect of unique and special effect in clinical treatment and observation.
Preferably, add Radix Asparagi in described Chinese medicine preparation, described Radix Asparagi adds by 1～10 weight portion.Radix Asparagi, YIN nourishing and the production of body fluid promoting, except dry pathogenic fire reducing, take good care of effect to the human body deficiency of YIN, and yin-Yang is regulated, and is of value to the rehabilitation of skeletal diseases.Add Radix Asparagi in this medicament, in the situation that be of value to the rehabilitation of skeletal diseases, can play the body fluid balance, the effect of adjustment negative and positive.
Further preferred, add Radix Glycyrrhizae and Radix Ginseng in described Chinese medicine preparation, described Radix Glycyrrhizae and Radix Ginseng all add by 1～10 weight portion.Radix Ginseng, main strongly invigorating primordial QI, control impairment caused by overstrain deficient, and prolonged deficiency is not multiple, the diseases such as the empty loss of all bodies, the Radix Ginseng main component is the ginsenoside, Main Function, for improving microcirculation, improves anti-ageing waiting for a long time; Radix Glycyrrhizae, main invigorating the spleen and replenishing QI, the treatment spleen and stomach function goes down, and Radix Glycyrrhizae has cortex functions of hormones on similar kidney, promotes the absorption to the human body effective ingredient.Add Radix Glycyrrhizae and Radix Ginseng in this medicament, not only promoted the absorption of human body to the preparation effective ingredient, and played YIN and YANG balance regulating, QI invigorating also Tianjin, nurse taste, can effectively remove the strong of active component medical material, make it the property of medicine more identical.
Above medicine is after the part by weight compatibility according to providing, reached the healthy energy of taking good care of human body, essence of water and grain in human body is full, circulated and dredged, the conditioning kidney qi is vigorous, makes the alimentation metabolic function of skeleton normal, osteoporosis rehabilitation, limbs joint pain disappears, and has reached the purpose of very fast cure diseases.
Aforementioned pharmaceutical compositions of the present invention is by national pharmacy standard preparation, be fabricated to medicine, health product or food, medicine can manufacture any pharmaceutical dosage form that is suitable for using clinically, be preferably: pill, granule, tablet, capsule, mixture, suppository, powder, tincture, medicated wine, injection or oral liquid, as long as use pharmaceutical composition of the present invention, no matter adopt which kind of dosage form, within all belonging to protection scope of the present invention; When aforementioned pharmaceutical compositions is prepared into to medicament, according to the special requirement of preparation, can add again other excipient, such as: flavoring agent, solubilizing agent, diluent, disintegrating agent, lubricant etc.
Owing to having adopted technique scheme, the invention has the beneficial effects as follows:
The present invention is the phenomenons such as growth to human body, old and feeble variations, osteoporosis, breaks through traditional idea, adopts the Chinese medicine preparation of new treatment rule and new compatibility invention, at clinical treatment with reached the ideal effect of uniqueness and special effect in observing.
This Chinese medicine preparation forms, be all pure botanical herbs material, majority is all the tonic nutriment category, and whole medical materials used have passed through clinical observation for a long time, prove the Chinese medicine that has clear and definite curative effect and have no side effect, and met the international food drug standard.Through a large amount of clinical after, also confirmed that the combination of this medicament is really effectively, determined curative effect, without any side effects.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
Take off the Chinese crude drug of stating weight proportion:
Rhizoma Cibotii 50g;
Herba Epimedii 50g;
Radix Et Rhizoma Nardostachyos 50g;
Fructus Schisandrae Chinensis 50g;
Fructus Evodiae 50g;
Rhizoma Curcumae 50g.
By above-mentioned Chinese crude drug, according to conventional process of Chinese medicine preparation, by national pharmacy standard preparation, be prepared as capsule.As medicine is pulverized as powder, incapsulate in shell, be capsule.
Embodiment 2
Take off the Chinese crude drug of stating weight proportion:
Rhizoma Cibotii 43g;
Herba Epimedii 40g;
Radix Et Rhizoma Nardostachyos 42g;
Fructus Schisandrae Chinensis 45g;
Fructus Evodiae 40g;
Rhizoma Curcumae 41g;
Radix Asparagi 40g.
By above-mentioned Chinese crude drug, according to conventional process of Chinese medicine preparation, by national pharmacy standard preparation, be prepared as powder.Be about to medicine and pulverize as smalls, give to take by required dosage.
Embodiment 3
Take off the Chinese crude drug of stating weight proportion:
Rhizoma Cibotii 35g;
Herba Epimedii 50g;
Radix Et Rhizoma Nardostachyos 30g;
Fructus Schisandrae Chinensis 20g;
Fructus Evodiae 35g;
Rhizoma Curcumae 45g;
Radix Glycyrrhizae 40g;
Radix Ginseng 55g.
By above-mentioned Chinese crude drug, according to conventional process of Chinese medicine preparation, by national pharmacy standard preparation, be prepared as granule.Be about to medicine and pulverize or effective component extracting, the granulation agent, press required dosage and use.
Embodiment 4
Take off the Chinese crude drug of stating weight proportion:
Rhizoma Cibotii 102g;
Herba Epimedii 80g;
Radix Et Rhizoma Nardostachyos 85g;
Fructus Schisandrae Chinensis 70g;
Fructus Evodiae 82g;
Rhizoma Curcumae 95g;
Radix Asparagi 102g;
Radix Glycyrrhizae 110g;
Radix Ginseng 105g.
By above-mentioned Chinese crude drug, according to conventional process of Chinese medicine preparation, by national pharmacy standard preparation, be prepared as tablet.After medicine is pulverized, add appropriate film-making additive, after making tablet, press required dosage and use.
The present invention has carried out the contrast test observation:
100 people that choose at random in the volunteer carry out follow-up investigation, 30 years old to 50 years old 58 people wherein, 42 people after 50 years old.
The above persons are divided into two groups at random, and first group is matched group, takes placebo, take Chinese medicine preparation provided by the invention for second group.
Test period is three months, during go home separately, do not look after heartily separately.
Experiment shows: in first group, the symptom of clear and definite sufferers of osteoporosis face has the trend increased the weight of.
Changing appears in second group of health, and show as: lumbago obviously alleviates, and muscle power increases to some extent, and several have clear and definite sufferers of osteoporosis face that the sign significantly recovered is arranged, the one side development that bone structure, bone density, cartilage structure obviously trend towards.
The present invention has carried out clinical trial, and observation of curative effect is summed up:
Normally see and treat patients and have 110 routine patients with osteoporosis, do not screened case.Male's 68 examples, women's 42 examples, minimal ages 35 years old, maximum 81 years old age.Site of pathological change: cervical vertebra 26 examples, lumbar vertebra 53 examples, knee joint 16 examples, ankle joint 3 examples, calcaneus 12 examples.
Efficacy assessment standard: with reference to evaluations such as " Chinese osteoporosis magazine ", " practical orthopaedics and tranmstology ".Cure: clinical symptoms, sign disappear, and functional rehabilitation is normal, more than 1 year, does not recur; Produce effects: clinical symptoms, sign obviously alleviate, and it is normal that function is recovered substantially; Effectively: clinical symptoms, sign partly alleviate; Invalid: treat continuously more than 30 days, symptom, sign are without change.
Efficacy analysis: cure 95 examples, account for 86%; Produce effects 11 examples, account for 10%; Effective 4 examples, account for 3.6%; Invalid 0 example, account for 0%.Total effective rate 100%.
Model case summary 1:
Lee so-and-so, the female, 68 years old, the retired cadre, medical on February 10th, 2011.
The main suit: lumbago more than 30 years, the time heavy when light, nearly one month aggravation.The patient flank pain occurred before more than 30 years, gradually increased the weight of, whenever movable tired rear pain increases the weight of, every year is aggravation around the Spring Festival, disease relapse closely a little more than a month ago, and lumbago is unbearably, and to two hips and numbness of lower limbs pain, can not stand for a long time sitting and normal Ambulatory Activity, the waist lower limb is afraid of cold obviously, and right lower limb is obvious, sleep not good enough, diet is general, the urine normal, and stool is normal.Once took Chinese medicine and western medicine and acupuncture and moxibustion therapy, when stopping treating, the state of an illness recurs again.Therefore seek medical advice.The light purplish tongue tongue is white, stringy and tense pulse.The lumbar X mating plate shows: lumbar physiological-curvature straightens, and vertebral body all has " lip sample " hypertrophy, narrowing of intervertebral space.Be diagnosed as: the lumbar vertebrae bone osteoporosis.
Process: after giving this preparation medicine and pulverizing, incapsulate, each 3, every day 3 times, take one day after sx↓, take altogether 30 days symptoms and all disappear, not recurrence of the state of an illness is more than a year observed so far in drug withdrawal, is to cure.
Model case summary 2:
The king so-and-so, the man, 76 years old, the retired worker, medical on January 19th, 2011.
The main suit: lumbago pain 35 years, outbreak, increase the weight of in nearly 2 months repeatedly.The patient is engaged in physical work for a long time, occurs before 35 years that lumbago and skelalgia gradually increases the weight of, when fatigue, increase the weight of, but after retirement without heavy physical labour, when after for a long time station sitting, normal Ambulatory Activity while standing, be in a bad way and show effect 3～5 times every year.Nearly 2 months disease relapses are not clearly better through the treatment such as take medicine, therefore carry out diagnosis and treatment, now feel that waist aches unbearably, two numbness of lower limbs pain, after sitting posture surpasses 15 minutes, difficulty while standing, could walk by straight waist after the suitable activity of must slowly standing, waist was ached and was afraid of cold night, long-term insomnia, diet is general, and color is clear frequently for urine, get up in the night to urinate night 34 times, stool is normal.The light purplish tongue white and thin fur, stringy and tense pulse.Through X-ray, show: lumbar curvature straightens, and the hyperosteogeny hyperosteogeny is " beak shape ", narrowing of intervertebral space.Examination urine is normal.Be diagnosed as: senile osteoporosis.
Process: encapsulated after giving Chinese medicine preparation of the present invention and pulverizing, each 3 every days 3 times, take medicine two days later; lumbago and skelalgia alleviates gradually; after taking 10 days, when sitting posture, more than 30 minutes, get final product normal activity while standing; urine symptom is frequently reduced; continue to take 20 days, pain symptom all disappears, and urine disappears frequently; get up in the night to urinate 1～2 time every night, therapeutic outcome is for curing.Continue to take 30 days, consolidate curative effect.After 1 year, follow up a case by regular visits to, the state of an illness is recurrence not, health with compare the year before healthy strong.
The present invention is not limited to the above-mentioned specific embodiment, and all are based on technical conceive of the present invention, and the structural improvement of having done, all fall among protection scope of the present invention.
Claims (3)
1. a Chinese medicine preparation for the treatment of osteoporosis, it is characterized in that: described Chinese medicine preparation is prepared from by the raw material of following weight portion:
2. a kind of Chinese medicine preparation for the treatment of osteoporosis as claimed in claim 1, it is characterized in that: described Chinese medicine preparation is prepared from by the raw material of following weight portion:
3. the Chinese medicine preparation of any treatment osteoporosis as claimed in claim 1 or 2, is characterized in that the dosage form of described Chinese medicine preparation is: pill, granule, tablet, capsule, mixture, suppository, powder, Yao Jiu ﹑ Ding Ji ﹑ injection or oral liquid.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485726A (en) * | 2008-01-14 | 2009-07-22 | 浙江省新华医院 | Chinese medicine for osteoporosis and healing waistband |
| CN101829163A (en) * | 2009-03-13 | 2010-09-15 | 东莞赫尔逊生物科技有限公司 | Application of rhizoma nardostachyos in preparing medicine for preventing and treating osteoporosis |
| CN101979071A (en) * | 2010-02-03 | 2011-02-23 | 黄汉怀 | Medicinal composition for treating osteoporosis and preparation method thereof |
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2012
- 2012-04-27 CN CN2012101282754A patent/CN102641472B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485726A (en) * | 2008-01-14 | 2009-07-22 | 浙江省新华医院 | Chinese medicine for osteoporosis and healing waistband |
| CN101829163A (en) * | 2009-03-13 | 2010-09-15 | 东莞赫尔逊生物科技有限公司 | Application of rhizoma nardostachyos in preparing medicine for preventing and treating osteoporosis |
| CN101979071A (en) * | 2010-02-03 | 2011-02-23 | 黄汉怀 | Medicinal composition for treating osteoporosis and preparation method thereof |
Non-Patent Citations (6)
| Title |
|---|
| 中医药防治骨质疏松症的研究概况;齐尚锋等;《中国骨质疏松杂志》;20090331;第15卷(第3期);第230-235页 * |
| 中药治疗骨质疏松症的用药规律探析;杨帆等;《广东药学院学报》;20030331;第19卷(第1期);第71页左栏第5、6段 * |
| 中西医结合治疗骨质疏松症临床观察;马灿泽;《新中医》;20110930;第43卷(第9期);第56页第2.2节 * |
| 杨帆等.中药治疗骨质疏松症的用药规律探析.《广东药学院学报》.2003,第19卷(第1期),第71页左栏第5、6段. |
| 马灿泽.中西医结合治疗骨质疏松症临床观察.《新中医》.2011,第43卷(第9期),第56页第2.2节. |
| 齐尚锋等.中医药防治骨质疏松症的研究概况.《中国骨质疏松杂志》.2009,第15卷(第3期),第230-235页. |
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