CN100459984C - Medicinal composition for pet care and its preparing method - Google Patents
Medicinal composition for pet care and its preparing method Download PDFInfo
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- CN100459984C CN100459984C CNB2005101107581A CN200510110758A CN100459984C CN 100459984 C CN100459984 C CN 100459984C CN B2005101107581 A CNB2005101107581 A CN B2005101107581A CN 200510110758 A CN200510110758 A CN 200510110758A CN 100459984 C CN100459984 C CN 100459984C
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Abstract
The present invention relates to a health-care medicine composition for pet animals of dog and cat and its preparation method. Said medicine composition includes ganoderma extract, auxiliary material and special flavouring additive, it can be added into feed of pet animal, and can obtain the effects of raising immunological function of pet animal, building up pet animal's health and delaying senility of pet animal.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to the medicine of animal health, be specifically related to a kind of pharmaceutical preparation that can improve house pet antioxidation, defying age, raise immunity, disease-resistant and anti-cancer.
Background technology
In very long historical long river, human and many animals have interdependent intimacy, wherein Zhong Cheng Canis familiaris L. and docile cat have become current people and have raised maximum house pets, and they have surmounted relation of " supporting " and " object for appreciation " to a great extent with human relation.Especially along with the aggravation of global economic integration, competition is constantly risen rate of unemployment, divorce rate, violence, terrorist incident etc., and fertility rate constantly descends, people lack tender feeling, feeling of lonely increases, increasing people has selected to raise the life that house pets such as Canis familiaris L., cat are enriched oneself, and there are plenty of such people as one of kinsfolk with house pet.Have the statistics of closing, the average life of Canis familiaris L. has only 12.8, and life-prolonging Canis familiaris L. lives through 29 years 05 months, and the life-span of cat is slightly grown than Canis familiaris L., also has only the sixth of human longevity.Cultivated children's love and inter personal contact in feeding process, alleviated people's feeling of lonely, particularly old people, pet feeding is to enriching its cultural life, and life lengthening has the buddhist benefit.
Along with increasingly sharpening of environmental pollution, house pet is fallen ill as cancer, cardiovascular diseases, old and feeble weak etc. probability also in continuous rising, people more and more are concerned about pet health and the life-time dilatation that oneself is fed, and this care can only be embodied on the health product of house pet, and those have the pet care product of specific function to be subjected to people's welcome deeply.
General in the market feed for pet is made up of animal fodder, plant feed and mineral feed, can only guarantee the normally necessary nutritional factors of house pet.Because animal is the characteristic of house pet especially, when the treatment house pet is sick, in feedstuff, add medicine, after smelling, Canis familiaris L. do not eat, and implement and force medicine feed very difficult, even have house pet that owner is scratched.Research had not only reached the feeding thing but also had fed the purpose of pet care product, makes house pet can prolong life, defying age, increase immunity, resisted the pet care food of all kinds of diseases and cancer or the focus of attention that medicine becomes relevant research worker,
Show according to the domestic and international market investigation, yet there are no the report of exploitation natural drug pet care product.
Summary of the invention
The pharmaceutical composition that the purpose of this invention is to provide a kind of pet care.
Another object of the present invention provides the preparation of drug combination method of described pet care.
The present invention adds in feed for pet and has raise immunity, again can cancer-resisting and the drug extract of the integration of edible and medicinal herbs such as Ganoderma of the anti-ageing effect of waiting for a long time, make granule dosage form or powder.
According to Chinese ancient medicine treasured book, no matter be the Compendium of Material Medica of Shennong's Herbal or the Ming Dynasty before more than 2,000 year, medicines that Ganoderma lucidum seu Japonicum is regarded as all, ancient Chinese medicine doctor is all treated various diseases with Ganoderma, and title " Ganoderma is controlled all kinds of diseases and ailments " is arranged.Compendium of Material Medica record Ganoderma cures mainly deafness, sharp joint, protects refreshing, the beneficial motive, invigorating middle warmer, increases wisdom, beneficial vital essence, hard smart bone, and good color, clothes are gently not old for a long time, the effects such as angle of prolonging life." the Hangzhou medicine is planted will " carries " controlling gastropathy for many years " again.Particularly the unique effect of Ganoderma " strengthening the body resistance, strengthening by means of tonics " is subjected to people and payes attention to greatly.In recent years, medicine man use modern pharmacology that the drug effect of Ganoderma has been carried out comprehensive research, on the imitative cultivation naturally of Ganoderma and medicinal extraction process technology, improve especially, press scientific formula, obtained breakthrough.The animal and the clinical and experimental study of relevant Ganoderma drug effect show that Ganoderma is powerful on the many difficult and complicated illness of treatment, and think that the effect of Ganoderma belongs to " two-phase adjusting " complex effect and the effect of holding mutually, and have no side effect.Slow down aging is arranged, improve one's memory, the effect of raise immunity, anti-multiple disease.Detoxifcation, kidney tonifying arranged, protect the liver, heart tonifying, calm the nerves, antiinflammatory, pain relieving, anticancer, anti-cancer, effects such as human body immunity improving function.
The olfactory sensation of Canis familiaris L. is very sensitive, and higher 1200 times than the people, because of the Ganoderma preparation bitter in the mouth, flavour of a drug are dense, directly adds in the feedstuff, and Canis familiaris L. often one is reluctant after smelling in the wedging mouth.Implement and force medicine feed very difficult, even have house pet that owner is scratched.In order to solve the medicine feed difficult problem, the present invention is according to the characteristics of house pet Ganoderma preparation health product, through experiment repeatedly, adopt special odor additive and Ganoderma extract etc. to mix after, add in the feedstuff, after Canis familiaris L. smells, produce appetite immediately, and like very much to eat, and the taste function of Canis familiaris L. a little less than, food will " be gobbled up " once inlet, thereby reaches not only feeding thing but also feed the purpose of pet care product.
The present invention adopts following weight proportioning Chinese crude drug and component to make the pharmaceutical composition of pet care.:
The smart powder 0.05～0.5g of Ganoderma Ganoderma spore powder 0.05～0.5g chelating calcium powder 1～10g
Cartilage powder 0.5～5g vitamin C 2～20mg adjuvant 0.1～1g
Flavouring additive is an amount of;
Or:
The smart powder 0.05～0.5g of Ganoderma Cordyceps powder 0.03～0.3g Ganoderma epispore-seed-powder 0.03～0.3g
Vitamin C 2～20mg chelating calcium powder 1～10g Cartilage powder 0.5～5g
Adjuvant 0.1～1g flavouring additive is an amount of.
Described Ganoderma spore powder is a broken wall treatment, and Cordyceps powder, vitamin C, chelating calcium powder, Cartilage powder or fish flour and adjuvant are commercial.Described adjuvant is selected dextrin for use, and flavouring additive adopts monosodium glutamate, pork essence and/or beef flavor.
Make the pharmaceutical composition of granule dosage form or the health care of powder pet dog by following method, according to the body weight of different pet dogs, calculate by one 10 kg body weight, the ratio that every day, dosage 5-15 restrained is added in the feed for pet.
The pharmaceutical composition of pet dog health care of the present invention prepares by following method:
Get Chinese medicine (Wuyi Mountain is segment wood cultivated) red ganoderma, cut into slices, pulverize 5～10 orders, immerse with 95% ethanol, filter, reclaim ethanol, extracting solution is standby, and its medicinal residues double-deck cooker of packing into is added the water cover face, adds the steam decocting in water, filter, merge alcohol extract, water extract, filtering and impurity removing matter gets supernatant, centrifugal Ganoderma supernatant, the Bc spray drying, the smart powder of red ganoderma; With the smart powder of Ganoderma, Ganoderma spore powder (broken wall treatment), Cordyceps powder, vitamin C, chelating calcium powder, Cartilage powder or fish flour and adjuvant; mix, stir, sieve; make granule dosage form or powder with 20 order granulation machine, spray into special flavouring additive after the oven dry, pack.The finished product sterilization.
Prescription dosage is every pouch 2～20g; It is edible to be used for all ages and classes pet care.
Or: adopt following weight proportioning Chinese crude drug and component to make the pharmaceutical composition of cat pet care:
The smart powder 0.05～0.5g of Ganoderma Ganoderma epispore-seed-powder 0.05～0.5g fish flour 1～10g
Cartilage powder 0.5～5g chelating calcium powder 1～10g vitamin C 2～20mg
Adjuvant 0.1～1g flavouring additive is an amount of;
Or,
The smart powder 0.05～0.3g of Ganoderma Cordyceps powder 0.03～0.3g Ganoderma epispore-seed-powder 0.03～0.3g
Vitamin C 2～20mg fish flour 2～10g adjuvant 0.2～2g Cartilage powder 0.5～5g
Chelating calcium powder 1～10g monosodium glutamate, flesh of fish essence flavouring additive are an amount of
The pharmaceutical composition of pet care of the present invention is observed through the pet feeding more than 2 years, the result shows, can reach the immunologic function that improves house pet, health invigorating, the effect of slow down aging, and diseases such as prevention, treatment house pet cancer, cardiovascular diseases or digestive tract pathological changes there is significant health protection and therapeutic action, provides the foundation reaching the effect that prolongs the house pet life-span.
The specific embodiment
Embodiment 1
Take by weighing the pharmaceutical composition (daily dose) that each composition prepares the pet dog health care by following weight proportion:
The smart powder 0.05～0.5g of Ganoderma Ganoderma born of the same parents seed powder 0.05～0.5g chelating calcium powder 1～10g
Cartilage powder 0.5～5g vitamin C 2～20mg dextrin 0.1～1g
Monosodium glutamate, pork essence and/or beef flavor flavouring additive are an amount of,
The preferred weight proportioning is:
The smart powder 0.2g of Ganoderma Ganoderma born of the same parents seed powder 0.2g chelating calcium powder 3g
Cartilage powder 1.5g vitamin C 10mg dextrin 0.4g
Monosodium glutamate, pork essence, beef flavor flavouring additive are an amount of,
Get Chinese medicine (Wuyi Mountain is segment wood cultivated) red ganoderma, cut into slices, pulverize 5～10 orders, immerse 36 hours with 95% ethanol, filter, reclaim ethanol, extracting solution is standby, its medicinal residues double-deck cooker of packing into is added the water cover face, adds the steam decocting in water, temperature≤90-95 ℃, 180 minutes time, filter, merge alcohol extract, water extract, remove impurity through plate and frame filter or microporous filter, get supernatant, concentrate the Ganoderma supernatant, be concentrated into 25-40% with centrifugal-film evaporator.Bc spray drying, pressure 0.294-0.490MPa (3-5kg f/cm
2), bake out temperature 60-70 ℃, get the smart powder of red ganoderma.With the smart powder of gained Ganoderma, Ganoderma spore powder (broken wall treatment), vitamin C, chelating calcium powder, Cartilage powder and adjuvant etc., mix, stir, sieve, make granule dosage form or powder with 20 order granulation machine, oven dry back spray flavouring additive, pack.The finished product sterilization was shone 24-48 hour with 40-50 ten thousand rad Co60 gamma-radiations.
Embodiment 2
Take by weighing each composition by following weight proportion: (daily dose)
The smart powder 0.05～0.5g of Ganoderma Cordyceps powder 0.03～0.3g Ganoderma born of the same parents seed powder 0.03～0.3g
Vitamin C 2～20mg chelating calcium powder 1～10g Cartilage powder 0.5～5g
Dextrin) 0.1～1g monosodium glutamate, pork essence and/or beef flavor flavouring additive are an amount of,
The preferred weight proportioning is
The smart powder 0.2g of Ganoderma Cordyceps powder 0.1g Ganoderma born of the same parents seed powder 0.1g
Vitamin C 10mg chelating calcium powder 3g Cartilage powder 1.2g
Dextrin 0.4g monosodium glutamate, pork essence and/or beef flavor flavouring additive are an amount of,
The pharmaceutical composition for preparing the pet dog health care by the method for embodiment 1.
Embodiment 3
Take by weighing each composition by following weight proportion: (daily dose)
The smart powder 0.05～0.5g of Ganoderma fish flour 1～10g Ganoderma born of the same parents seed powder 0.05～0.5g
Vitamin C 2～20mg chelating calcium powder 1～10g Cartilage powder 0.5～5g
Dextrin 0.1～1g monosodium glutamate and/or flesh of fish essence flavouring additive are an amount of,
The preferred weight proportioning is:
The smart powder 0.2g of Ganoderma fish flour 2.2g Ganoderma born of the same parents seed powder 0.2g
Vitamin C 10mg chelating calcium powder 2g Cartilage powder 0.5g
Dextrin 0.4g monosodium glutamate and/or flesh of fish essence flavouring additive are an amount of,
Get Chinese medicine (Wuyi Mountain is segment wood cultivated) red ganoderma, through cutting into slices, pulverize 5～10 orders, immersing 36 hours with 95% ethanol, filter, reclaim ethanol, extracting solution is standby, its medicinal residues double-deck cooker of packing into is added water (capping), adds the steam decocting in water, temperature≤90-95 ℃, 180 minutes time, filter, merge alcohol extract, water extract, remove impurity through plate and frame filter or microporous filter, draw clear liquid, concentrate the Ganoderma supernatant, be concentrated into 25-40 ° of Bc spray drying, pressure 0.294-0.490MPa (3-5kg f/cm with centrifugal-film evaporator
2), bake out temperature 60-70 ℃, obtain the smart powder of red ganoderma.Press scientific formula again: the smart powder of Ganoderma, Ganoderma spore powder (broken wall treatment), Cordyceps powder, vitamin C, chelating calcium powder, Cartilage powder or fish flour and adjuvant etc.; mix, stir, sieve; make granule dosage form or powder with 20 order granulation machine, make the pharmaceutical composition of pet cat health care.Spray into special flavouring additive after the oven dry, pack.The finished product sterilization was shone 24-48 hour with 40-50 ten thousand rad Co60 gamma-radiations.
Embodiment 4
Take by weighing each composition by following weight proportion: (daily dose)
The smart powder 0.05～0.3g of Ganoderma Cordyceps powder 0.03～0.3g Ganoderma born of the same parents seed powder 0.03～0.3g
Vitamin C 2～20mg fish flour 2～10g dextrin 0.2～2g Cartilage powder 0.5～5g
Chelating calcium powder 1～10g monosodium glutamate and/or flesh of fish essence flavouring additive are an amount of,
The preferred weight proportioning is:
The smart powder 0.2g of Ganoderma Cordyceps powder 0.1g Ganoderma born of the same parents seed powder 0.1g
Vitamin C 10mg fish flour 2.2g dextrin 0.4g
Cartilage powder 0.5g chelating calcium powder 2g monosodium glutamate and/or flesh of fish essence flavouring additive are an amount of,
The pharmaceutical composition for preparing the pet cat health care as stated above.
The every experiment of embodiment 5 animal pets
(1) toxicity detects: result's demonstration has no side effect.
1, chronic toxicological experiment: to the mice 10g present composition of feeding every day, observe after 30 days: body weight gain, extract index inspections such as blood testing red blood cell count(RBC), numeration of leukocyte, glutamate pyruvate transaminase, blood urea nitrogen, cholesterol, triglyceride, albumin, glucose, all no abnormal, the anatomy and pathology histological inspection is not found pathological change yet.
2, acute toxicological experiment: with feeding every day 5 times of normal dose, feed was observed white mice after 7 days continuously, and not seeing has the poisoning mutation effect.
(2) the disease-resistant experiment of house pet raise immunity
1. pet dog: 30: divide three groups of A, B, C.
(1) 10 of A groups, (5 years ages of Canis familiaris L.), the present invention+feedstuff of feeding
(2) 10 of B groups, (5 years ages of Canis familiaris L.), the Cartilage powder+feedstuff of feeding
(3) 10 of C groups, (5 years ages of Canis familiaris L.), feeding feed stuff
2. 180 days observation periods, disease-resistant result is an effective percentage, and the result shows that this health care medicine of house pet pet dog resistance against diseases of feeding obviously strengthens.Table 1 is the disease-resistant experimental result of house pet raise immunity.
Table 1
| Group | Feed material | Natural law | Hair luster | The figure | Appetite | Expression | Immunity | Effective percentage |
| The A group | Pet care product+feedstuff (10g) (in right amount) | 180 days | Shinny | Healthy and strong | By force | Vivaciously | Enhancing, anosis | 100％ |
| The B group | Cartilage powder+the feedstuff (10g) (in right amount) of feeding | 180 days | Generally | Better | Generally | More active | General sick 3 | 70％ |
| The C group | Feeding feed stuff (in right amount) | 180 days | Generally | Generally | Anorexia | Generally | More weak sick 5 | 50％ |
(3) house pet resisting oxidation and delaying senility function test
Aged white mice antioxidation measurement result shows: with feed aged white mice 60 days of this pet care product, extract mice serum, the result shows, lipid peroxide degradation product malonaldehyde (MDA) content in the serum is lower than matched group (P＜0.05), superoxide dismutase in the serum (SOD) vigor shows that apparently higher than matched group product of the present invention has antioxidation.
The drosophila survival result of the test shows: this pet care product group male drosophila and matched group relatively show to prolong 8-10 days that the female fruit bat matched group of this pet care product relatively shows prolongation 5-7 days, and the result shows that product of the present invention has function in delaying senility.
(4) this pet care medicine shows the experimental result that influences of mice S180 sarcoma growth, and tumour inhibiting rate adopts cyclophosphamide combined obviously good with the tumor killing effect of this pet care product as can be seen.Table 2 is this pet care medicine experimental results that influence to the growth of mice S180 sarcoma.
Table 2
| Group | Dosage (g/kg) | Number of animals (only) | The toxic agent reaction | Tumour inhibiting rate | The result |
| The contrast of lotus tumor | —— | 10 | —— | 5％ | No tumor-inhibiting action |
| Cyclophosphamide | 0.035g/kg | 10 | (by force) depilation, anorexia, torpescence | 56％ | Tumor-inhibiting action is better |
| The pet care product | 0.4g/kg | 10 | (weak) do not lose hair or feathers, no anorexia, active | 53％ | Tumor-inhibiting action is better |
| Cyclophosphamide+pet care product | 0.035+0.4g/kg | 10 | (weak) a small amount of depilation, no anorexia, active | 86％ | Tumor-inhibiting action is strong |
| Normal control | —— | 10 | —— | —— | —— |
Claims (10)
1. the compositions of a pet care is characterized in that containing following components in weight percentage, daily dose:
The smart powder 0.05～0.5g of Ganoderma Ganoderma born of the same parents seed powder 0.05～0.5g chelating calcium powder 1～10g
Cartilage powder 0.5～5g vitamin C 2～20mg dextrin 0.1～1g
Monosodium glutamate, pork essence and/or beef flavor flavouring additive are an amount of; Described Ganoderma born of the same parents seed powder is a broken wall treatment.
2. by the compositions of the described pet care of claim 1, it is characterized in that described composition weight proportioning is:
The smart powder 0.2g of Ganoderma Ganoderma born of the same parents seed powder 0.2g chelating calcium powder 3g
Cartilage powder 1.5g vitamin C 10mg dextrin 0.4g
Monosodium glutamate, pork essence and/or beef flavor flavouring additive are an amount of.
3. by the compositions of the described pet care of claim 1, it is characterized in that also containing Cordyceps powder, the weight proportion of described component is daily dose:
The smart powder 0.05～0.5g of Ganoderma Cordyceps powder 0.03～0.3g Ganoderma born of the same parents seed powder 0.03～0.3g
Vitamin C 2～20mg chelating calcium powder 1～10g Cartilage powder 0.5～5g
Dextrin 0.1～1g monosodium glutamate, pork essence and/or beef flavor flavouring additive are an amount of.
4. by the compositions of the described pet care of claim 3, it is characterized in that described composition weight proportioning is:
The smart powder 0.2g of Ganoderma Cordyceps powder 0.1g Ganoderma born of the same parents seed powder 0.1g
Vitamin C 10mg chelating calcium powder 3g Cartilage powder 1.2g
Dextrin 0.4g monosodium glutamate, pork essence and/or beef flavor flavouring additive are an amount of.
5. by the compositions of the described pet care of claim 1, it is characterized in that described component also contains fish flour, its daily dose weight proportion is:
The smart powder 0.05～0.5g of Ganoderma fish flour 1～10g Ganoderma born of the same parents seed powder 0.05～0.5g
Vitamin C 2～20mg chelating calcium powder 1～10g Cartilage powder 0.5～5g
Dextrin 0.1～1g monosodium glutamate and/or flesh of fish essence flavouring additive are an amount of.
6. by the compositions of the described pet care of claim 5, it is characterized in that the weight proportion of described component is:
The smart powder 0.2g of Ganoderma fish flour 2.2g Ganoderma born of the same parents seed powder 0.2g
Vitamin C 10mg chelating calcium powder 2g Cartilage powder 0.5g
Dextrin 0.4g monosodium glutamate and/or flesh of fish essence flavouring additive are an amount of.
7. by the compositions of the described pet care of claim 3, it is characterized in that described component also contains fish flour, its daily dose weight proportion is:
The smart powder 0.05～0.3g of Ganoderma Cordyceps powder 0.03～0.3g Ganoderma born of the same parents seed powder 0.03～0.3g
Vitamin C 2～20mg fish flour 2～10g dextrin 0.2～2g Cartilage powder 0.5～5g
Chelating calcium powder 1～10g monosodium glutamate and/or flesh of fish essence flavouring additive are an amount of.
8. by the compositions of the described pet care of claim 7, it is characterized in that the weight proportion of described component is:
The smart powder 0.2g of Ganoderma Cordyceps powder 0.1g Ganoderma born of the same parents seed powder 0.1g
Vitamin C 10mg fish flour 2.2g dextrin 0.4g Cartilage powder 0.5g
Chelating calcium powder 2g monosodium glutamate and/or flesh of fish essence flavouring additive are an amount of.
9. by the preparation of compositions method of the described pet care of claim 1, by following step:
Get the segment wood cultivated Chinese medicine red ganoderma in Wuyi Mountain, cut into slices, pulverize 5～10 orders, immerse with 95% ethanol, filter, reclaim ethanol, extracting solution is standby, its medicinal residues double-deck cooker of packing into is added the water cover face, adds the steam decocting in water, filter, merge alcohol extract, water extract, filtering and impurity removing matter, get supernatant, centrifugal Ganoderma supernatant concentrates, the Bc spray drying, the smart powder of Ganoderma; With Ganoderma spore powder, vitamin C, chelating calcium powder, Cartilage powder and adjuvant, mix, stir, sieve, make granule dosage form or medicine powder compositions with 20 order granulation machine, spray into flavouring additive after the oven dry, pack, sterilization.
10. by the preparation of compositions method of the described pet care of claim 3, by following step:
Get the segment wood cultivated Chinese medicine red ganoderma in Wuyi Mountain, cut into slices, pulverize 5～10 orders, immerse with 95% ethanol, filter, reclaim ethanol, extracting solution is standby, its medicinal residues double-deck cooker of packing into is added the water cover face, adds the steam decocting in water, filter, merge alcohol extract, water extract, filtering and impurity removing matter, get supernatant, centrifugal Ganoderma supernatant concentrates, the Bc spray drying, the smart powder of Ganoderma; With Ganoderma spore powder, Cordyceps powder, vitamin C, chelating calcium powder, Cartilage powder and adjuvant, mix, stir, sieve, make granule dosage form or medicine powder compositions with 20 order granulation machine, spray into flavouring additive after the oven dry, pack, sterilization.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101167526B (en) * | 2006-10-26 | 2011-07-20 | 天津瑞普生物技术股份有限公司 | Health product for dog and cat with growth promoting function |
| CN103549152A (en) * | 2013-11-07 | 2014-02-05 | 天津市晨辉饲料有限公司 | 0.5% natural supervital compound premix feed for pet |
| CN111567695A (en) * | 2020-05-09 | 2020-08-25 | 上海耐威克宠物用品有限公司 | Pet food composition for improving immunity and preparation method thereof |
| CN113455592A (en) * | 2021-08-14 | 2021-10-01 | 河南益湃生物科技有限公司 | Pet nutritional supplement containing ganoderma lucidum spore powder |
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| CN1202733C (en) * | 1999-09-06 | 2005-05-25 | 埃弗姆食品有限公司 | Food product and process for manufacturing same |
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