CN103751433A - Anti-suppuration disinfectant - Google Patents
Anti-suppuration disinfectant Download PDFInfo
- Publication number
- CN103751433A CN103751433A CN201310750086.5A CN201310750086A CN103751433A CN 103751433 A CN103751433 A CN 103751433A CN 201310750086 A CN201310750086 A CN 201310750086A CN 103751433 A CN103751433 A CN 103751433A
- Authority
- CN
- China
- Prior art keywords
- parts
- suppuration
- disinfectant solution
- ethanol
- natural gum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- JXOHGGNKMLTUBP-HSUXUTPPSA-N shikimic acid Chemical compound O[C@@H]1CC(C(O)=O)=C[C@@H](O)[C@H]1O JXOHGGNKMLTUBP-HSUXUTPPSA-N 0.000 description 1
- JXOHGGNKMLTUBP-JKUQZMGJSA-N shikimic acid Natural products O[C@@H]1CC(C(O)=O)=C[C@H](O)[C@@H]1O JXOHGGNKMLTUBP-JKUQZMGJSA-N 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
- 210000001032 spinal nerve Anatomy 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- GWBUNZLLLLDXMD-UHFFFAOYSA-H tricopper;dicarbonate;dihydroxide Chemical compound [OH-].[OH-].[Cu+2].[Cu+2].[Cu+2].[O-]C([O-])=O.[O-]C([O-])=O GWBUNZLLLLDXMD-UHFFFAOYSA-H 0.000 description 1
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- 239000000341 volatile oil Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses an anti-suppuration disinfectant. The disinfectant is prepared from the following raw materials in parts by weight: 0.5-1.5 parts of lemon-scented gum, 2-4 parts of Chinese violet, 10-15 parts of purple flower holly leaf, 1-5 parts of gallnut, and 74.5-86.5 parts of 40 percent ethanol, wherein the lemon-scented gum, Chinese violet, purple flower holly leaf and gallnut are soaked in ethanol and filtered to obtain the disinfectant. The anti-suppuration disinfectant selects drug-food homologous natural plants as raw materials, is harmless to human bodies, can be used for accelerating the skin tissue repairing and growing speed of epithelial cells, strengthening the skin resistance and promoting wound healing, can be used for effectively treating wound suppuration, herpes zoster and the like, and can be used for remarkably reducing wound suppuration and pains of patients with herpes zoster. Furthermore, the invention also discloses application of the anti-suppuration disinfectant in preparing a medicine for preventing or treating wound suppuration and herpes zoster.
Description
Technical field
The present invention relates to a kind of anti-suppuration disinfectant solution, relate in particular to a kind of anti-suppuration disinfectant solution of making, be used for the treatment of wound suppuration, herpes zoster take plant as raw material.
Background technology
Wound suppuration is because the pathological change that damaged wound or tissue are occurred by courses of infection, the 70%th, be directly subject to the infection being caused by micrococcus scarlatinae.By Gram staining method, suppurative hammer antibacterial is divided for gram positive bacteria and gram negative bacteria, gram positive bacteria comprises staphylococcus, streptococcus etc., and gram negative bacteria comprises escherichia coli, eisseria, Moraxella etc.What wherein harm was maximum is gram positive bacteria---staphylococcus aureus, after this pathogenic bacteria enters wound breeding very fast, and discharge a kind of hyaluronidase and digest subcutaneous tissue and supply nutrients to oneself.Meanwhile, the immune system of body also starts reaction, to resist the invasion of the pathogenic bacterium such as staphylococcus aureus.The leukocytic quantity in blood with phagocytic activity increases very soon, and swim out of one after another blood vessel, infiltrate wound site and engulf pathogenic bacteria, discharge some enzymes simultaneously and digest the tissue that those have been destroyed by pathogenic bacteria, body is resisted inhibition pathogenic bacteria by adjusting and is further spread, and the position that is confined to suppurate is progressively eliminated.Suppuration position is due to the congestion of blood vessel, and the blood of diffluence is more, thereby looks rubescent; The leukocytosis of being swum out of by blood vessel adds that the liquid oozing out increases, and swelling appears in part; The leukocyte of running sore and antibacterial heavy fighting, used a large amount of " chemical weapons ", thereby the heat producing is a lot, feels awfully hot; Due to running sore swelling, oppress hypodermic nerve and produce pain, thereby suppuration position makes human body very uncomfortable.Particularly, for severe traumatic patient, wound suppuration often causes severe wound not heal for a long time, to patient, brings great misery.
Herpes zoster is caused by varicella zoster virus a kind of along neural troop herpes and the viral dermatosis take neuralgia as feature distributing.After infected without the child of immunity to this virus, there is chickenpox.After some patients were is infected, become carrier and symptom does not occur.Because virus has neurotropism, after infection, can hide for a long time in the neuron of spinal nerves posterior root ganglion, when lower for the resistance or tired, infection, flu, virus can regrow breeding, and move to skin along nerve fiber, make nerve and the skin of being invaded produce strong inflammation.The feature that erythra generally has one-sided property and distributes by nerve segment, is comprised of the herpes of collection bunch property, and with pain; Age is larger, and neuralgia is heavier.Primary disease is apt to occur in adult, and season in spring and autumn is common.Sickness rate increased and is remarkable rising with the age.
Herpes zoster can also cause multiple complications, as bring out post herpetic neuralgia etc. after keratitis, corneal ulcer, conjunctivitis, herpes, more than sustainable several months of some patients were neuralgia or year, can have a strong impact on sleep and emotion, pain degree is heavier, and the persistent period can cause the performances such as anxiety, depression compared with elder.Therefore, in nursing process, how to control the infection of local wound and the processing of wound, shorten healing time, ease the pain and become medical personnel and patient's question of common concern.
Herpes zoster is by the viral dermatosis due to varicella zoster virus, the traditional Chinese medical science is referred to as " herpes zoster ", " herpes zoster ", and think the pent-up fire-transformation due to institute, spleen channel retention of damp-heat in the interior, excessive skin and giving birth to, or diseases caused by exogenous pathogenic factor poison is evil, and damp and hot fire accumulates skin and causes, its clinical cardinal symptom: one is erythra, and one is pain.Doctor trained in Western medicine is to do virus, pain relieving trophic nerve as principle, and the traditional Chinese medical science is take heat clearing away, removing toxic substances, pain relieving as main.Solution of the present invention is the understanding to herpes zoster and Therapeutic Principle based on above-mentioned theory of Chinese medical science just, with reference to modern pharmacological research, achieve, from motherland's medicine treasure-house, chosen and there is heat-clearing and toxic substances removing, the Herba Violae of removing heat from blood detumescence, there is antibacterial, to do virus, antiinflammatory, granulation promoting mountain azurite and there is the eucalyptus citriodora natural gum of resisting gram-positive antibacterial, according to tcm theory prescription, skim the cream off milk, make its performance accelerate repairing skin tissue, accelerate the epithelial speed of growth, strengthen skin resistance, the effect of wound healing simultaneously.
Summary of the invention
The object of the invention is to overcome above-mentioned the deficiencies in the prior art part and a kind of anti-suppuration disinfectant solution that can fast, effectively treat wound suppuration and herpes zoster is provided; In addition, another object of the present invention is to provide the application of a kind of described anti-suppuration disinfectant solution in the medicine for the preparation of prevention or treatment wound suppuration, herpes zoster.
For achieving the above object, the technical scheme that the present invention takes is: a kind of anti-suppuration disinfectant solution, described anti-suppuration disinfectant solution is made by the raw material of following weight portion: 74.5～86.5 parts of the ethanol that 0.5～1.5 part of eucalyptus citriodora natural gum, 2～4 parts of Herba Violaes, 10～15 parts of Folium Ilicis Purpureae, 1～5 part of Galla Chinensis, mass fraction are 40%, and described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
Present inventor is through a large amount of development tests, unexpected discovery, the disinfectant solution that adopts each raw material of weight portion described above to be prepared from, can effectively accelerate repairing skin tissue, wound healing, especially has significant effect for the treatment of wound suppuration, herpes zoster.
As the preferred implementation of a kind of anti-suppuration disinfectant solution of the present invention: described anti-suppuration disinfectant solution is made by the raw material of following weight portion: 78～82 parts of the ethanol that 0.8～1.2 part of eucalyptus citriodora natural gum, 2～3 parts of Herba Violaes, 12～14 parts of Folium Ilicis Purpureae, 2～4 parts of Galla Chinensiss, mass fraction are 40%, described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
As the preferred implementation of a kind of anti-suppuration disinfectant solution of the present invention: described anti-suppuration disinfectant solution is made by the raw material of following weight portion: 75 parts of the ethanol that 0.5 part of eucalyptus citriodora natural gum, 4 parts of Herba Violaes, 14 parts of Folium Ilicis Purpureae, 2 parts of Galla Chinensiss, mass fraction are 40%, described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
As the preferred implementation of a kind of anti-suppuration disinfectant solution of the present invention: described anti-suppuration disinfectant solution is made by the raw material of following weight portion: 80 parts of the ethanol that 1 part of eucalyptus citriodora natural gum, 3 parts of Herba Violaes, 13 parts of Folium Ilicis Purpureae, 3 parts of Galla Chinensiss, mass fraction are 40%, described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
As the preferred implementation of a kind of anti-suppuration disinfectant solution of the present invention: described anti-suppuration disinfectant solution is made by the raw material of following weight portion: 82 parts of the ethanol that 1.5 parts of eucalyptus citriodora natural gum, 2 parts of Herba Violaes, 12 parts of Folium Ilicis Purpureae, 4 parts of Galla Chinensiss, mass fraction are 40%, described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
In addition, another object of the present invention is to provide a kind of as above arbitrary described anti-suppuration disinfectant solution in the application for the preparation of in prevention or treatment wound suppuration, herpes zoster medicine.
Eucalyptus citriodora, Latin literary fame Eucalyptus citriodora, is summer rainfall pattern seeds, Myrtaceae Eucalyptus.Main Ingredients and Appearance: volatile oil 0.5-2.0%, wherein main component is citronellal (Citronellal, citronellol (Citronellol, Geraniol (Gera-nio1), isopulegol (IsoPulegol), l, 8-cineole (Cineole) and guaiol (Guaiol).Still containing globulariacitrin (Rutin), quercitrin (Querce-trin), Quercetin (Quercetin), shikimic acid (Shikimieacid), quininic acid (Quinicacid), 1,3-propanedicarboxylic acid, succinic acid, malic acid, citric acid and a kind of Eucalyptin (EucaIyptin), may be the derivant of coumarin.The natural gum obtaining from this plant, there is the effect of resisting gram-positive antibacterial, wherein containing 5 kinds of compositions: aromadendrin 7-methyl ether (Aromadendrin7-monome-tbylether), nimbecetin-7-methyl ether (Kaempferol-7-monomethylether), benzoaric acid (Ellagicacid), aromadendrin dimethyl ether (Aro-madendrindimethylether) and citriodorol (Citriodorol).
Herba Violae, releases name: arrow grass, the tiger of walking alone, Cornu Caprae seu Ovis, rice cloth bag, abnormal smells from the patient: bitter, acrid, cold, nontoxic.This product is the dry herb of Violaceae Chinese violet Viola yedoensis Makino, and spring, Qiu Erji gather, and remove impurity, dry.Herb hyoscine, energy heat-clearing and toxic substances removing, removing heat from blood detumescence.
Ilex purpurea Hassk.[I.chinensis Sims is the plant that belongs to Aquifoliaceae.Be distributed in various places on the south China the Changjiang river, often grow in sparse woods.Its root, leaf all can pharmacy, and main effect is heat-clearing and toxic substances removing; Promoting tissue regeneration and ulcer healing; Promoting blood circulation and hemostasis.
Galla Chinensis has another name called hundred worm storehouses, Mass Galla chinesis et camelliae Fermentata, gall, for the Chinese Nut-gall aphid of Homoptera aphid section or the female worm of melaphis peitan Tsai et Tang parasitize Anacardiaceae plant " Fructus rhois chinensis " and belong to tender leaf or the petiole of other plant together, stab and generate a kind of cryptomere consor thing insect gall, gained after baking is doubly dry, there is convergence, antibacterial, Detoxication.
Ethanol in the anti-suppuration disinfectant solution of the present invention is both as solvent, and itself also has the disinfective action on medical usage.
Anti-suppuration disinfectant solution of the present invention, adopt the combination of the component of described specified weight umber to be prepared from, between described each component, produce the effect that influences each other, mutually promotes, make the anti-suppuration disinfectant solution being finally prepared from can accelerate repairing skin tissue and the epithelial speed of growth, strengthen skin resistance, wound healing simultaneously, is effective to prevention or treatment wound suppuration, herpes zoster.Anti-suppuration disinfectant solution result in clinical application of the present invention shows, there is following advantage: 1, to select the natural plants of medicated diet homology be raw material in the present invention, each component meets pharmaceutical control law regulation, utilizes comprehensive function treatment wound suppuration, the herpes zoster of each taste Chinese medicine, nontoxic to human body.2, the anti-suppuration disinfectant solution of the present invention, can be used separately, does not need the program of using again normal saline, hydrogen peroxide, potassium permanganate, heat lamp irradiation etc. complicated.3, anti-suppuration disinfectant solution of the present invention can be accelerated repairing skin tissue, accelerates the epithelial speed of growth, strengthen skin resistance, wound healing simultaneously.4, the anti-suppuration disinfectant solution of the present invention is easy to use, safe and reliable, and curative effect is fast, can significantly alleviate patient suffering, and body is had no adverse reaction, and can be used as the conventional treatments of wound suppuration, herpes zoster, and clinic is promoted.
The specific embodiment
For the object, technical solutions and advantages of the present invention are better described, below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
A kind of embodiment of the anti-suppuration disinfectant solution of the present invention, anti-suppuration disinfectant solution is prepared from according to the following stated method by the component of following weight portion described in the present embodiment:
75 parts of the ethanol that 0.5 part of eucalyptus citriodora natural gum, 4 parts of Herba Violaes, 14 parts of Folium Ilicis Purpureae, 2 parts of Galla Chinensiss, mass fraction are 40%, put into described ethanol by described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis and soak, filter and make.
Embodiment 2
A kind of embodiment of the anti-suppuration disinfectant solution of the present invention, anti-suppuration disinfectant solution is prepared from according to the following stated method by the component of following weight portion described in the present embodiment:
80 parts of the ethanol that 1 part of eucalyptus citriodora natural gum, 3 parts of Herba Violaes, 13 parts of Folium Ilicis Purpureae, 3 parts of Galla Chinensiss, mass fraction are 40%, put into described ethanol by described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis and soak, filter and make.
Embodiment 3
A kind of embodiment of the anti-suppuration disinfectant solution of the present invention, anti-suppuration disinfectant solution is prepared from according to the following stated method by the component of following weight portion described in the present embodiment:
82 parts of the ethanol that 1.5 parts of eucalyptus citriodora natural gum, 2 parts of Herba Violaes, 12 parts of Folium Ilicis Purpureae, 4 parts of Galla Chinensiss, mass fraction are 40%, put into described ethanol by described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis and soak, filter and make.
Embodiment 4
A kind of embodiment of the anti-suppuration disinfectant solution of the present invention, anti-suppuration disinfectant solution is prepared from according to the following stated method by the component of following weight portion described in the present embodiment:
86.5 parts of the ethanol that 0.8 part of eucalyptus citriodora natural gum, 3 parts of Herba Violaes, 15 parts of Folium Ilicis Purpureae, 5 parts of Galla Chinensiss, mass fraction are 40%, put into described ethanol by described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis and soak, filter and make.
Embodiment 5
A kind of embodiment of the anti-suppuration disinfectant solution of the present invention, anti-suppuration disinfectant solution is prepared from according to the following stated method by the component of following weight portion described in the present embodiment:
78 parts of the ethanol that 1.2 parts of eucalyptus citriodora natural gum, 2 parts of Herba Violaes, 11 parts of Folium Ilicis Purpureae, 1 part of Galla Chinensis, mass fraction are 40%, put into described ethanol by described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis and soak, filter and make.
Embodiment 6
A kind of embodiment of the anti-suppuration disinfectant solution of the present invention, anti-suppuration disinfectant solution is prepared from according to the following stated method by the component of following weight portion described in the present embodiment:
74.5 parts of the ethanol that 1.4 parts of eucalyptus citriodora natural gum, 4 parts of Herba Violaes, 10 parts of Folium Ilicis Purpureae, 3 parts of Galla Chinensiss, mass fraction are 40%, put into described ethanol by described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis and soak, filter and make.
Embodiment 7
The therapeutic test of the anti-suppuration disinfectant solution of the present invention to wound suppuration
Test arranges invention group and matched group, and invention component is invention group 1-6, the anti-suppuration disinfectant solution that invention group 1-6 adopts respectively embodiment 1-6 to prepare.Matched group is divided into matched group 1-5, and matched group 1-5 adopts respectively anti-suppuration disinfectant solution as described below:
The anti-suppuration disinfectant solution that matched group 1 adopts is prepared from according to the following stated method by the component of following weight portion: 80 parts of the ethanol that 3 parts of Herba Violaes, 13 parts of Folium Ilicis Purpureae, 3 parts of Galla Chinensiss, mass fraction are 40%, and described Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
The anti-suppuration disinfectant solution that matched group 2 adopts is prepared from according to the following stated method by the component of following weight portion: 80 parts of the ethanol that 1 part of eucalyptus citriodora natural gum, 13 parts of Folium Ilicis Purpureae, 3 parts of Galla Chinensiss, mass fraction are 40%, and described eucalyptus citriodora natural gum, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
The anti-suppuration disinfectant solution that matched group 3 adopts is prepared from according to the following stated method by the component of following weight portion: 80 parts of the ethanol that 1 part of eucalyptus citriodora natural gum, 3 parts of Herba Violaes, 3 parts of Galla Chinensiss, mass fraction are 40%, and described eucalyptus citriodora natural gum, Herba Violae and Galla Chinensis are put into described ethanol and soak, filter and make.
The anti-suppuration disinfectant solution that matched group 4 adopts is prepared from according to the following stated method by the component of following weight portion: 80 parts of the ethanol that 1 part of eucalyptus citriodora natural gum, 3 parts of Herba Violaes, 13 parts of Folium Ilicis Purpureae, mass fraction are 40%, and described eucalyptus citriodora natural gum, Herba Violae and Folium Ilicis Purpureae are put into described ethanol and soak, filter and make.
For the therapeutic effect of this bright anti-suppuration disinfectant solution of checking to wound suppuration, clinical trial severe wound does not heal for a long time, the patient of wound suppuration totally 300 examples, wherein male's 213 examples, women's 87 examples, age 30～85(61.5+/-10.3) year, be divided at random 10 groups, every group of each 30 examples, be respectively invention group 1-6 and matched group 1-4,10 groups at aspect comparing difference not statistically significants (p>0.05) such as sex, age, wound surfaces.
Therapeutic Method: invention group 1-6 and matched group 1-4, the skin area at wound suppuration position occurs, adopt corresponding anti-suppuration disinfectant solution to spread upon wound surface, makes it to absorb, and forbids massage, every day 4～6 times, continues 2 weeks.
Efficacy assessment standard: observe and record skin area local pain, redness and the wound surface area of wound suppuration wound surface before treatment with after treatment, every index with light, in, weight classification Ti, remember respectively 1,2,3 point, every index integration sum is patient clinical symptom integral.Clinical symptoms integration * 100% before therapeutic index=(the rear clinical symptoms integration of clinical symptoms integration-treatment before treatment)/treatment.Effective is wound healing situation, and therapeutic index is >=78%; Be effectively wound healing situation, therapeutic index is 24～77%; Invalid is that wound healing is not obvious, therapeutic index <24%; Effective+be effectively effectively total.
By clinical trial, measured the relevant data that uses the anti-suppuration disinfectant solution of embodiment of the present invention 1-6 gained and use matched group 1-4 treatment wound suppuration, in Table 1.
Table 1 is treated the curative effect comparison of wound suppuration
| Group | Total number of persons | Effective | Effectively | Invalid | Effective percentage (%) |
| Matched group 1 | 30 | 5 | 7 | 18 | 40 |
| Matched group 2 | 30 | 6 | 6 | 20 | 33 |
| Matched group 3 | 30 | 4 | 8 | 19 | 37 |
| Matched group 4 | 30 | 5 | 7 | 18 | 40 |
| Invention group 1 | 30 | 10 | 15 | 5 | 83 |
| Invention group 2 | 30 | 12 | 17 | 1 | 97 |
| Invention group 3 | 30 | 11 | 15 | 4 | 87 |
| Invention group 4 | 30 | 9 | 18 | 3 | 90 |
| Invention group 5 | 30 | 9 | 16 | 5 | 83 |
| Invention group 6 | 30 | 10 | 17 | 3 | 90 |
As shown in Table 1, the invention group of the anti-suppuration disinfectant solution of employing the present invention is to the effective percentage for the treatment of wound suppuration apparently higher than matched group 1-4, and the anti-suppuration disinfectant solution of especially invention group 2 increases significantly to the effective percentage for the treatment of wound suppuration.
Embodiment 8
The therapeutic test of the anti-suppuration disinfectant solution of the present invention to herpes zoster
Test arranges invention group and matched group, and invention component is invention group 1-6, the anti-suppuration disinfectant solution that invention group 1-6 adopts respectively embodiment 1-6 to prepare.Matched group is divided into matched group 1-5, and matched group 1-5 adopts respectively anti-suppuration disinfectant solution as described below:
The anti-suppuration disinfectant solution that matched group 1 adopts is prepared from according to the following stated method by the component of following weight portion: 80 parts of the ethanol that 3 parts of Herba Violaes, 13 parts of Folium Ilicis Purpureae, 3 parts of Galla Chinensiss, mass fraction are 40%, and described Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
The anti-suppuration disinfectant solution that matched group 2 adopts is prepared from according to the following stated method by the component of following weight portion: 80 parts of the ethanol that 1 part of eucalyptus citriodora natural gum, 13 parts of Folium Ilicis Purpureae, 3 parts of Galla Chinensiss, mass fraction are 40%, and described eucalyptus citriodora natural gum, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
The anti-suppuration disinfectant solution that matched group 3 adopts is prepared from according to the following stated method by the component of following weight portion: 80 parts of the ethanol that 1 part of eucalyptus citriodora natural gum, 3 parts of Herba Violaes, 3 parts of Galla Chinensiss, mass fraction are 40%, and described eucalyptus citriodora natural gum, Herba Violae and Galla Chinensis are put into described ethanol and soak, filter and make.
The anti-suppuration disinfectant solution that matched group 4 adopts is prepared from according to the following stated method by the component of following weight portion: 80 parts of the ethanol that 1 part of eucalyptus citriodora natural gum, 3 parts of Herba Violaes, 13 parts of Folium Ilicis Purpureae, mass fraction are 40%, and described eucalyptus citriodora natural gum, Herba Violae and Folium Ilicis Purpureae are put into described ethanol and soak, filter and make.
Matched group 5 adopts acyclovir ointment, is directly purchased from market.
For the therapeutic effect of this bright anti-suppuration disinfectant solution of checking to herpes zoster, the patient of clinical trial herpes zoster is totally 253 examples, wherein male's 169 examples, women's 84 examples, age 30～85(61.5+/-10.3) year, there is herpes wound position: abdominal part 121 examples, head 55 examples, chest 33 examples, 33 examples after cervical region gill, arm 27 examples, shank 27 examples, totally 296 wound surface, be divided at random 11 groups, every group of each 23 examples, be respectively invention group 1-6 and matched group 1-5, 11 groups in sex, age, the aspect comparing difference not statistically significants (p>0.05) such as herpes wound surface.
Therapeutic Method: invention group 1-6 and matched group 1-4 are when the skin area at herpes zoster position occurring, produce blister as part, first with after syringe pump, adopt again corresponding anti-suppuration disinfectant solution to spread upon wound surface, make it to absorb, forbid massage, every day 4～6 times, continue 2 weeks.Matched group 5 acyclovir ointments, every day 4～6 times, continue 2 weeks.When finish the course for the treatment of, carrying out curative effect finally evaluates.
Efficacy assessment standard: before treatment with after treatment, observe and record the skin area local pain of herpes wound surface, red and swollen and wound surface area, every index with gently, in, weight classification Ti, remember respectively 1,2,3 point, every index integration sum is patient clinical symptom integral.Clinical symptoms integration * 100% before therapeutic index=(the rear clinical symptoms integration of clinical symptoms integration-treatment before treatment)/treatment.Effective is wound healing situation, and therapeutic index is >=78%; Be effectively wound healing situation, therapeutic index is 24～77%; Invalid is that wound healing is not obvious, therapeutic index <24%; Effective+be effectively effectively total.
By clinical trial, measured the relevant data that uses the anti-suppuration disinfectant solution of embodiment of the present invention 1-6 gained and use matched group 1-5 treatment herpes zoster, in Table 2.
Table 2 is treated the curative effect comparison of herpes zoster
| Group | Total number of persons | Effective | Effectively | Invalid | Effective percentage (%) |
| Matched group 1 | 23 | 4 | 6 | 13 | 43 |
| Matched group 2 | 23 | 5 | 6 | 12 | 48 |
| Matched group 3 | 23 | 3 | 7 | 13 | 43 |
| Matched group 4 | 23 | 4 | 8 | 11 | 52 |
| Matched group 5 | 23 | 5 | 8 | 10 | 57 |
| Invention group 1 | 23 | 9 | 10 | 4 | 83 |
| Invention group 2 | 23 | 10 | 12 | 1 | 96 |
| Invention group 3 | 23 | 8 | 11 | 4 | 83 |
| Invention group 4 | 23 | 9 | 11 | 3 | 87 |
| Invention group 5 | 23 | 7 | 13 | 3 | 87 |
| Invention group 6 | 23 | 9 | 10 | 4 | 83 |
As shown in Table 2, the invention group of the anti-suppuration disinfectant solution of employing the present invention is to the effective percentage for the treatment of herpes zoster apparently higher than matched group 1-5, and the anti-suppuration disinfectant solution of especially invention group 2 increases significantly to the effective percentage for the treatment of herpes zoster.
Last institute should be noted that; above embodiment is only in order to illustrate technical scheme of the present invention but not limiting the scope of the invention; although the present invention is explained in detail with reference to preferred embodiment; those of ordinary skill in the art is to be understood that; can modify or be equal to replacement technical scheme of the present invention, and not depart from essence and the scope of technical solution of the present invention.
Claims (6)
1. an anti-suppuration disinfectant solution, it is characterized in that, described anti-suppuration disinfectant solution is made by the raw material of following weight portion: 74.5～86.5 parts of the ethanol that 0.5～1.5 part of eucalyptus citriodora natural gum, 2～4 parts of Herba Violaes, 10～15 parts of Folium Ilicis Purpureae, 1～5 part of Galla Chinensis, mass fraction are 40%, and described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
2. the anti-suppuration disinfectant solution of one according to claim 1, it is characterized in that, described anti-suppuration disinfectant solution is made by the raw material of following weight portion: 78～82 parts of the ethanol that 0.8～1.2 part of eucalyptus citriodora natural gum, 2～3 parts of Herba Violaes, 12～14 parts of Folium Ilicis Purpureae, 2～4 parts of Galla Chinensiss, mass fraction are 40%, and described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
3. the anti-suppuration disinfectant solution of one according to claim 1, it is characterized in that, described anti-suppuration disinfectant solution is made by the raw material of following weight portion: 75 parts of the ethanol that 0.5 part of eucalyptus citriodora natural gum, 4 parts of Herba Violaes, 14 parts of Folium Ilicis Purpureae, 2 parts of Galla Chinensiss, mass fraction are 40%, and described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
4. the anti-suppuration disinfectant solution of one according to claim 1, it is characterized in that, described anti-suppuration disinfectant solution is made by the raw material of following weight portion: 80 parts of the ethanol that 1 part of eucalyptus citriodora natural gum, 3 parts of Herba Violaes, 13 parts of Folium Ilicis Purpureae, 3 parts of Galla Chinensiss, mass fraction are 40%, and described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
5. the anti-suppuration disinfectant solution of one according to claim 1, it is characterized in that, described anti-suppuration disinfectant solution is made by the raw material of following weight portion: 82 parts of the ethanol that 1.5 parts of eucalyptus citriodora natural gum, 2 parts of Herba Violaes, 12 parts of Folium Ilicis Purpureae, 4 parts of Galla Chinensiss, mass fraction are 40%, and described eucalyptus citriodora natural gum, Herba Violae, Folium Ilicis Purpureae and Galla Chinensis are put into described ethanol and soak, filter and make.
One kind as arbitrary in claim 1-5 as described in the application of anti-suppuration disinfectant solution in the medicine for the preparation of prevention or treatment wound suppuration, herpes zoster.
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| CN104274700A (en) * | 2014-09-22 | 2015-01-14 | 济南伟传信息技术有限公司 | Traditional Chinese medicinal disinfectant for nursing and preparation method thereof |
| CN104306626A (en) * | 2014-09-22 | 2015-01-28 | 济南伟传信息技术有限公司 | Traditional Chinese medicine composition for disinfecting and preparation method thereof |
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| CN104274700A (en) * | 2014-09-22 | 2015-01-14 | 济南伟传信息技术有限公司 | Traditional Chinese medicinal disinfectant for nursing and preparation method thereof |
| CN104306626A (en) * | 2014-09-22 | 2015-01-28 | 济南伟传信息技术有限公司 | Traditional Chinese medicine composition for disinfecting and preparation method thereof |
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| CN103751433B (en) | 2018-12-04 |
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