CN113713022A

CN113713022A - Eye protection liquid and preparation method and application thereof

Info

Publication number: CN113713022A
Application number: CN202111066490.1A
Authority: CN
Inventors: 彭素文
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-09-13
Filing date: 2021-09-13
Publication date: 2021-11-30

Abstract

The invention discloses an eye-protecting solution and a preparation method and application thereof, wherein the eye-protecting solution comprises raw material medicines, wherein the raw material medicines comprise 85-95% by mass of a first raw material medicine and 5-15% by mass of a second raw material medicine; the first raw material medicine comprises: radix bupleuri, paniculate swallowwort root, Japanese ardisia herb, chrysanthemum, radix isatidis, liquorice, mulberry leaf, Chinese angelica, red paeony root and lithospermum; the second raw material medicine comprises: sichuan pepper, clove bud stem, frankincense, myrrh, figwort root and cassia seed. The preparation method of the eye-protecting liquid comprises the following steps: weighing raw materials, steeping liquor and ganoderma lucidum powder; putting the raw materials into the steeping liquor to be steeped for 10-20 days to obtain a semi-finished product; adding Ganoderma powder into the semi-finished product, mixing, soaking for 2-4 days, and filtering to obtain eye protecting solution. The eye protecting liquid can increase eye blood circulation, promote ciliary muscle reset caused by spasm or fatigue, and improve vision rapidly, and is especially suitable for treating presbyopia, myopia, astigmatism and glaucoma.

Description

Eye protection liquid and preparation method and application thereof

Technical Field

The invention discloses eye protection liquid and a preparation method and application thereof, and belongs to the technical field of medicines.

Background

Metabolites produced during eye fatigue are usually deposited in the capillaries of the eye and around the eye. The accumulation of free radicals over the years causes the elasticity of muscles around eyes to be reduced, the function of ciliary muscles of the eyes is degraded, the adjusting capability is reduced, and symptoms such as visual deterioration, eye pain, eye swelling and the like are caused, thus causing various eye diseases seriously.

Eye diseases bring inconvenience to normal work and life of people, and are more feared to cause the degeneration of fundus maculopathy and retinal detachment when the high myopia is developed, so that the visual function is influenced, and the eye diseases are one of the main causes of blindness.

Fatigue can be relieved by pressing the periocular or ocular acupoints, but the relieving effect is not good.

Disclosure of Invention

The application aims to provide eye protection liquid and a preparation method and application thereof so as to solve the technical problem that the existing method for relieving eye fatigue is poor in relieving effect.

The first aspect of the invention provides eye protection liquid, which comprises raw material medicines, wherein the raw material medicines comprise 85-95% of a first raw material medicine and 5-15% of a second raw material medicine by mass percentage;

the first raw material medicine comprises the following components: radix bupleuri, paniculate swallowwort root, Japanese ardisia herb, chrysanthemum, radix isatidis, liquorice, mulberry leaf, Chinese angelica, red paeony root and lithospermum;

the second raw material medicine comprises the following components: sichuan pepper, clove bud stem, frankincense, myrrh, figwort root and cassia seed.

Preferably, the respective components in the first bulk drug are equal in mass.

Preferably, the mass of each component in the second bulk drug is equal.

Preferably, the eye-protecting solution further comprises a soaking solution;

the mass ratio of the steeping fluid to the bulk drugs is 10: 1.

Preferably, the steeping fluid is rice wine or white spirit.

Preferably, the degree of the rice wine or the white spirit is more than 40 degrees.

Preferably, the eye protection liquid also comprises ganoderma lucidum powder;

the mass ratio of the total mass of the raw material medicines and the steeping liquid to the ganoderma lucidum powder is 175-190: 1.

The second aspect of the invention provides a preparation method of the eye-protecting liquid, which comprises the following steps:

weighing the raw material medicines, the steeping liquor and the ganoderma lucidum powder according to the mass ratio;

putting the raw material medicines into the steeping liquor, and steeping for 10-20 days to obtain a semi-finished product;

and (3) putting the ganoderma lucidum powder into the semi-finished product, uniformly mixing, soaking for 2-4 days, and filtering out the raw material medicine to obtain eye protection liquid.

Preferably, after obtaining the eye-protecting liquid, the method further comprises the following steps:

standing the eye protection solution in water for 7-10 days, and filtering out precipitate to obtain the final product of eye protection solution.

The third aspect of the invention provides an application of at least one of the eye protection liquid and the eye protection liquid prepared by the method in treating presbyopia, myopia, astigmatism and glaucoma.

Compared with the prior art, the eye protection solution and the preparation method and the application thereof have the following beneficial effects:

the eye protection solution can increase the blood circulation of eyes and promote the restitution of spastic or tired ciliary muscles, thereby quickly improving the eyesight; in addition, the eye protecting liquid can also quickly adjust the focal distance between the eyeground and the pupil, accelerate the optic nerve conduction speed, and is particularly suitable for the patients with eye diseases such as presbyopia, myopia, astigmatism, glaucoma and the like.

The preparation method of the care solution is simple in preparation, convenient to operate and short in period.

Drawings

Fig. 1 is a flow chart of a preparation method of eye-protecting liquid.

Detailed Description

In the following description, for purposes of explanation and not limitation, specific details are set forth, such as particular system structures, techniques, etc. in order to provide a thorough understanding of the embodiments of the invention. It will be apparent, however, to one skilled in the art that the present invention may be practiced in other embodiments that depart from these specific details. In other instances, detailed descriptions of well-known systems, devices, circuits, and eye-protecting solutions are omitted so as not to obscure the description of the present invention with unnecessary detail.

The first aspect of the invention provides eye protection liquid which comprises raw material medicines, wherein the raw material medicines comprise 85-95% of first raw material medicine and 5-15% of second raw material medicine by mass percentage;

The effects of the raw materials in the application are as follows:

bupleurum root: pungent, bitter and slightly cold in nature; harmonizing exterior and interior, soothing liver-qi stagnation, lifting yang and sinking, allaying fever and checking malaria;

paniculate swallowwort root: pungent and warm; dispelling pathogenic wind, eliminating dampness, promoting qi circulation, and dredging collaterals;

gold dragon entering the ground: pungent and bitter with warm taste; dispelling pathogenic wind, dredging collaterals, relieving swelling and pain;

chrysanthemum: bitter and sweet in taste, slightly cold in nature; dispelling wind and clearing heat, calming liver and improving eyesight, and clearing heat and detoxicating;

radix isatidis: bitter taste and cold nature; clearing away heat and toxic materials, cooling blood, and relieving sore throat;

licorice root: light smell and sweet taste; clearing away heat and toxic materials, eliminating phlegm, and relieving cough;

mulberry leaf: bitter and sweet in taste and cold in nature; disperse wind-heat, clear lung-heat and moisten dryness, calm liver and improve vision, cool blood and stop bleeding;

chinese angelica: sweet, pungent and warm; enriching blood, promoting blood circulation, regulating menstruation, relieving pain, moistening dryness and lubricating intestines;

red peony root: slightly cold in nature, bitter in taste, sour in taste; nourishing blood, astringing yin, suppressing liver yang, softening liver and relieving pain;

lithospermum: sweet, salty, cold; cooling blood, promoting blood circulation, removing toxic substance and promoting eruption;

sichuan pepper: warming the middle-jiao to dispel cold, removing dampness, relieving pain, killing parasite, and removing fishy smell;

1, Erycibe stems: pungent taste and warm nature; dispelling pathogenic wind, removing dampness, relieving swelling and pain;

frankincense: pungent, bitter and warm; promoting blood circulation, activating qi-flowing, relieving pain, relieving swelling, and promoting granulation;

myrrh: pungent, bitter and neutral in flavor; removing blood stasis, relieving pain, eliminating swelling, and promoting granulation;

figwort root: sweet, bitter, salty, and slightly cold; clearing heat and cooling blood; nourishing yin to reduce pathogenic fire; detoxify and dissipate stagnation;

cassia seed: sweet, bitter, cold in nature, slightly salty; clear liver and improve vision, moisten intestines and relax bowels.

The raw materials have synergistic effect, so that the blood circulation of eyes can be increased, and the restitution of spastic or tired ciliary muscles is promoted, thereby quickly improving the eyesight; furthermore, the eye protection liquid can also quickly adjust the focal distance from the eyeground to the pupil and accelerate the optic nerve conduction speed, and is particularly suitable for the patients with eye diseases such as presbyopia, myopia, astigmatism, glaucoma and the like.

The eye protection liquid disclosed by the invention is mild in drug property and can be used for a long time.

Further, the components in the first raw material medicament have equal mass; the mass of each component in the second raw material medicine is equal. The eye-protecting liquid with the components and the quality has the best effect.

The eye-protecting solution also comprises a steeping solution; the steeping liquor is used for steeping the raw material medicines, so that the medicine properties of the raw material medicines are exerted to the maximum extent. Wherein the mass ratio of the steeping liquid to the bulk drugs is 10: 1.

In the embodiment, the steeping fluid is rice wine or white spirit, and the degree of the rice wine or the white spirit is more than 40 degrees. The rice wine or the white spirit with the alcohol content of more than 40 degrees can not only bring the medicinal properties of the raw material medicines into play, but also play a certain role in prolonging the shelf life. In addition, the rice wine or the white spirit has the efficacy of promoting blood circulation to remove blood stasis, so that the eye protection liquid has better efficacy.

The eye protection solution also comprises ganoderma lucidum powder; wherein the mass ratio of the total mass of the raw material medicines and the steeping liquid to the ganoderma lucidum powder is 175-190: 1.

The ganoderma lucidum powder has the effects of nourishing yin and tonifying yang, and benefiting qi and nourishing blood, and is applied to the eye protection liquid, so that the ganoderma lucidum powder and the raw material medicine of the invention exert a synergistic effect, and the elasticity of muscles around eyes is enhanced, so that the eye protection liquid of the invention can quickly adjust the focal distance between the eyeground and the pupil, and accelerate the optic nerve conduction speed.

step 1, weighing raw material medicines, an impregnation liquid and lucid ganoderma powder according to a mass ratio;

step 2, putting the raw material medicines into the steeping liquor, and steeping for 10-20 days to obtain a semi-finished product; preferably for 15 days;

and 3, putting the ganoderma lucidum powder into the semi-finished product, uniformly mixing, soaking for 2-4 days, and filtering out the raw material medicines to obtain the eye-protecting liquid. The optimal time for impregnation in this step is 3 days;

after obtaining the eye-protecting liquid, the method also comprises the following steps:

and 4, standing the eye protection solution in water for 7-10 days, and filtering out precipitates to obtain a finished product of eye protection solution. The optimal standing time is 7 days, and the water temperature is 20-25 ℃.

The use method of the eye protection liquid comprises the following steps: three times a day, 2-3 drops once, can be applied to the periphery of eyes, into eyes or externally applied to eyes, and the dosage needs to be increased when the eye is externally applied. The eye protection liquid disclosed by the invention is used for 15 days in one course of treatment, and after one course of treatment, the eye fatigue of a patient can be greatly relieved, and the eyesight can be improved.

The present invention will be further described with reference to specific examples and comparative examples.

Example 1

An eye-protecting liquid comprises raw material medicines, wherein the raw material medicines comprise a first raw material medicine with the mass percentage of 90% and a second raw material medicine with the mass percentage of 10%;

the first raw material medicine comprises the following components: 45 g of radix bupleuri, 45 g of paniculate swallowwort root, 45 g of Japanese ardisia herb, 45 g of chrysanthemum, 45 g of isatis root, 45 g of liquorice, 45 g of mulberry leaf, 45 g of angelica, 45 g of red paeony root and 45 g of lithospermum;

the second raw material medicine comprises the following components: 8.33 g of Sichuan pepper, 8.33 g of Erycibe obtusifolia, 8.33 g of frankincense, 8.33 g of myrrh, 8.33 g of figwort and 8.33 g of cassia seed;

the steeping fluid is 40-degree rice wine, and the mass of the rice wine is 5 kg;

the dosage of the ganoderma lucidum powder is 30 g.

The preparation method of the embodiment comprises the following steps:

step 2, putting the raw material medicines into an impregnation liquid, and impregnating for 15 days to obtain a semi-finished product;

step 3, putting the ganoderma lucidum powder into the semi-finished product, uniformly mixing, soaking for 3 days, and filtering out the raw material medicine to obtain eye protection liquid;

and 4, standing the eye protection solution in water for 7 days, and filtering out precipitates to obtain a finished product of eye protection solution. Wherein the water temperature is 25 ℃.

Example 2

An eye-protecting liquid comprises raw material medicines, wherein the raw material medicines comprise a first raw material medicine with the mass percent of 85% and a second raw material medicine with the mass percent of 15%;

the first raw material medicine comprises the following components: 51 g of radix bupleuri, 51 g of paniculate swallowwort root, 51 g of Japanese ardisia herb, 51 g of chrysanthemum, 51 g of isatis root, 51 g of liquorice, 51 g of mulberry leaf, 51 g of angelica, 51 g of red paeony root and 51 g of lithospermum;

the second raw material medicine comprises the following components: 15 g of Sichuan pepper, 15 g of erycibe obtusifolia, 15 g of frankincense, 15 g of myrrh, 15 g of figwort and 15 g of cassia seed;

the steeping fluid is 42-degree rice wine, and the mass of the rice wine is 6 kg;

the dosage of the ganoderma lucidum powder is 37 g.

The preparation method of the embodiment comprises the following steps:

step 2, putting the raw material medicines into an impregnation liquid, and impregnating for 10 days to obtain a semi-finished product;

step 3, putting the ganoderma lucidum powder into the semi-finished product, uniformly mixing, soaking for 4 days, and filtering out the raw material medicine to obtain eye protection liquid;

and 4, standing the eye protection solution in water for 10 days, and filtering out precipitates to obtain a finished product of eye protection solution. Wherein the water temperature is 22 ℃.

Example 3

An eye-protecting liquid comprises raw material medicines, wherein the raw material medicines comprise a first raw material medicine with the mass percent of 95% and a second raw material medicine with the mass percent of 5%;

the first raw material medicine comprises the following components: 57 g of Chinese thorowax root, 57 g of paniculate swallowwort root, 57 g of Japanese ardisia herb, 57 g of chrysanthemum, 57 g of indigowoad root, 57 g of liquorice, 57 g of mulberry leaf, 57 g of Chinese angelica, 57 g of red paeony root and 57 g of sinkiang arnebia root;

the second raw material medicine comprises the following components: 5 g of Sichuan pepper, 5 g of Erycibe obtusifolia, 5 g of frankincense, 5 g of myrrh, 5 g of figwort and 5 g of cassia seed;

the steeping fluid is 45-degree rice wine, and the mass of the rice wine is 6 kg;

the dosage of the ganoderma lucidum powder is 35 g.

The preparation method of the embodiment comprises the following steps:

step 2, putting the raw material medicines into an impregnation liquid, and impregnating for 20 days to obtain a semi-finished product;

step 3, putting the ganoderma lucidum powder into the semi-finished product, uniformly mixing, soaking for 2 days, and filtering out the raw material medicine to obtain eye protection liquid;

and 4, standing the eye protection solution in water for 8 days, and filtering out precipitates to obtain a finished product of eye protection solution. Wherein the water temperature is 20 ℃.

Example 4

the first raw material medicine comprises the following components: 40 g of bupleurum, 45 g of paniculate swallowwort root, 48 g of Japanese ardisia herb, 42 g of chrysanthemum, 46 g of isatis root, 45 g of liquorice, 50 g of mulberry leaf, 44 g of angelica, 47 g of red paeony root and 43 g of lithospermum;

the second raw material medicine comprises the following components: sichuan pepper 8 g, bur clover vine 9 g, frankincense 8.5 g, myrrh 9 g, scrophularia root 7.5 g and cassia seed 8 g;

the dosage of the ganoderma lucidum powder is 30 g.

The preparation method of the embodiment comprises the following steps:

Crowd probation survey

In order to test the actual using effect of the eye protection solution, 400 myopic eye patients meeting the clinical diagnosis standard of eye diseases are selected for crowd trial investigation. Randomized into four groups of 100 people each, with no systematic differences from group to group. The eye protecting liquid of the present invention may be also used in treating presbyopia, astigmatism and glaucoma.

Each group of patients uses the eye protection solution of the invention in the embodiment 1-4, and the eye protection solution is dripped into eyes once a day in the morning, the noon and the evening, 15 days are taken as a treatment course, and the treatment course is one. The clinical treatment results are shown in table 1.

The evaluation criteria are as follows:

and (3) curing: the clinical symptoms of the patient disappear, and the patient does not relapse within 1 year;

the effect is shown: the clinical symptoms of the patient basically disappear, and the patient has relapse within 1 year;

the method has the following advantages: the clinical symptoms of the patients are improved;

and (4) invalidation: the clinical symptoms and signs of the patients are unchanged.

The total clinical effective rate is (cure + significant effect + effective)/total people is 100%.

TABLE 1

Group of	Total number of cases	Cure of disease	Show effect	Is effective	Invalidation	Total effective rate in clinic
							Example 1	100 persons	53	27	16	4	96％
Example 2	100 persons	50	26	17	7	93％
							Example 3	100 persons	51	25	18	6	94％
Example 4	100 persons	49	30	12	9	91％

Comparing the clinical efficacy of four groups in table 1, it can be seen that the total effective rate of example 1 of the present invention is the highest, and comparing it with example 4, it can be shown that the clinical efficacy is better when the quality of each component in the first crude drug is equal and the quality of each component in the second crude drug is equal.

The total effective rate of the clinical curative effects of the four groups is 91 percent at the lowest, so the eye protection solution can effectively relieve asthenopia and improve vision, and is suitable for treating eye diseases such as presbyopia, myopia, astigmatism, glaucoma and the like.

Although the present application has been described with reference to a few embodiments, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the application as defined by the appended claims.

Claims

1. The eye protection solution is characterized by comprising raw material medicines, wherein the raw material medicines comprise 85-95% of a first raw material medicine and 5-15% of a second raw material medicine by mass percentage;

2. The eye-protecting solution of claim 1, wherein the components of the first raw material are equal in mass.

3. The eye-protecting solution of claim 1, wherein the components of the second raw material are equal in mass.

4. The eye-care solution of claim 1, further comprising an immersion fluid;

the mass ratio of the steeping fluid to the bulk drugs is 10: 1.

5. The eye-protecting solution according to claim 4, wherein the steeping solution is rice wine or white spirit.

6. The eye-protecting liquid according to claim 5, wherein the degree of the rice wine or the white spirit is more than 40 degrees.

7. The eye-care solution according to claim 5, further comprising Ganoderma lucidum powder;

8. A method of preparing an eye-care solution according to any one of claims 1 to 7, comprising:

9. The method of claim 8, further comprising, after obtaining the eye-care solution:

10. Use of at least one of eye drops according to any one of claims 1 to 7 and eye drops prepared by the method according to any one of claims 8 to 9 for the treatment of presbyopia, myopia, astigmatism and glaucoma.