CN103739434B - The extracting method of a kind of lycopene and the application in cosmetics thereof - Google Patents
The extracting method of a kind of lycopene and the application in cosmetics thereof Download PDFInfo
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- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 title claims abstract description 40
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 title claims abstract description 39
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 title claims abstract description 39
- 235000012661 lycopene Nutrition 0.000 title claims abstract description 39
- 229960004999 lycopene Drugs 0.000 title claims abstract description 39
- 239000001751 lycopene Substances 0.000 title claims abstract description 39
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 title claims abstract description 39
- 238000000034 method Methods 0.000 title claims abstract description 14
- 239000002537 cosmetic Substances 0.000 title abstract description 18
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 28
- 238000003756 stirring Methods 0.000 claims abstract description 25
- 239000000284 extract Substances 0.000 claims abstract description 20
- 239000000047 product Substances 0.000 claims abstract description 16
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims abstract description 12
- 240000003768 Solanum lycopersicum Species 0.000 claims abstract description 12
- 239000006228 supernatant Substances 0.000 claims abstract description 12
- 239000000706 filtrate Substances 0.000 claims abstract description 8
- 239000002244 precipitate Substances 0.000 claims abstract description 6
- 238000001291 vacuum drying Methods 0.000 claims abstract description 6
- 238000000605 extraction Methods 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 6
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- 239000007788 liquid Substances 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 2
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- 238000002360 preparation method Methods 0.000 abstract description 2
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- 229920002498 Beta-glucan Polymers 0.000 description 2
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 description 2
- 235000011572 Pyrus ussuriensis Nutrition 0.000 description 2
- 244000173166 Pyrus ussuriensis Species 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 229940081733 cetearyl alcohol Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229940075529 glyceryl stearate Drugs 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
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- KRPAJLYSLFNDOA-UHFFFAOYSA-N mephenesin carbamate Chemical compound CC1=CC=CC=C1OCC(O)COC(N)=O KRPAJLYSLFNDOA-UHFFFAOYSA-N 0.000 description 2
- 229950006838 mephenesin carbamate Drugs 0.000 description 2
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
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- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 229940100460 peg-100 stearate Drugs 0.000 description 2
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- 239000000419 plant extract Substances 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 239000004302 potassium sorbate Substances 0.000 description 2
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
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Abstract
The present invention relates to cosmetic field, disclose the extracting method of a kind of lycopene and the application in cosmetics thereof.Comprise the steps of in the acetone that fresh tomato corium farinosum is added containing fan's repeatedly extract by (1), under constant temperature, filter after stirring with agitator after high speed pretreatment.(2) repeat aforesaid operations 2-3 time, collect lixiviating solution.(3) lixiviate filtrate is filtered with centrifuge, discard precipitate, collect supernatant, standby.(4) centrifugal gained supernatant is put in concentrator, carry out concentration is evaporated under reduced pressure, obtain concentrated solution.(5) the Powdered finished product of lycopene will namely be obtained after concentrated solution vacuum drying.Lycopene is applied to cosmetics, and consumption is the 0.5-0.8% of final products weight.Lycopene preparation method is simple, and purity is high, stable performance, and prepared cosmetics have the senile-resistant efficacy of excellence.
Description
Technical field
The present invention relates to plant extract field and cosmetic field, be specifically related to the extracting method of a kind of lycopene and the application in cosmetics thereof.
Background technology
Along with the quickening of people's rhythm of life, various skin problems also occur therewith.Air-conditioning, computer radiate, sunlight irradiation etc., make skin skin ageing problems such as drying, long speckle, the colour of skin are dim occur.Along with economic, cultural quick growth, people increasingly trend towards natural skin care product.Anti-aging cosmetics in the market is a feast for the eyes, but these products contain harmful chemical composition mostly.Find natural, do not stimulate skin care item to be the dream that in cosmetics circle, skilled worker is common.How natural plant extracts is effectively applied in cosmetics, be skilled worker's problem demanding prompt solution in boundary.
Lycopene is primarily present in the mature fruit of plant of Solanaceae Fructus Lycopersici esculenti, is the most powerful antioxidant being found in current nature.Effect of its scavenging free radicals outclass other carotenoid and vitamin E, and its singlet-oxygen quenching speed constant is 100 times of vitamin E.It can also effectively preventing because of aging, the various diseases that immunity degradation causes.
Extraction to lycopene, is extract from tomato pulp at present mostly.Peel of Fructus Lycopersici esculenti is then taken as waste disposal or is used as animal feeding-stuff.Waste very.In fact containing very abundant lycopene in peel of Fructus Lycopersici esculenti, having document to record, the content of lycopene in fresh tomato skin is all higher much than the content of lycopene in tomato sauce and fresh tomato sarcocarp.(referring specifically to: Zhang Xiaomin, Hu Ruilan, Cuculus polioephalus, permitted gold and jade, Feng Zuoshan.The research of Extracting of Lycopene in peel of Fructus Lycopersici esculenti, Food Additives Used in China, 2005, (No.5): 30-35).Very big economic worth is had after processed extraction.
How lycopene is better applied in cosmetics, play better senile-resistant efficacy by suitable proportioning, remain the problem needing to solve now.
Summary of the invention
It is desirable to provide a kind of equipment is simple, operate lycopene extraction method easily controllable, that production cost is low, extraction ratio is high.
Second purpose of the present invention is in that the application providing above-mentioned lycopene in cosmetics.
The present invention is achieved through the following technical solutions:
A kind of lycopene extraction method, it is characterised in that the method includes the steps of:
1) take fresh tomato skin, clean up, dry, pulverize into powder；
2) Fructus Lycopersici esculenti corium farinosum is added in the acetone containing fan's repeatedly extract, under constant temperature, filter after stirring with agitator after high speed pretreatment；
3) filtering residue after step 2 being filtered, by step 2 method, lixiviate 2-3 time, collects lixiviate filtrate；
4) lixiviate filtrate is used centrifuge remove impurity, discard precipitate, collect supernatant, standby；
5) centrifugal gained supernatant is put in concentrator, carry out concentration is evaporated under reduced pressure, obtain concentrated solution；
6) the Powdered finished product of lycopene will namely be obtained after concentrated solution vacuum drying.
In step (1), described pulverizing adopts this area conventional means to carry out, and preferred powder of the present invention is broken to 30-40 order.
In step (2), the change weight ratio of extract and acetone of described fan is preferably 1:(60-90).
In step (2), the solid-liquid ratio of the described acetone containing fan's repeatedly extract and Fructus Lycopersici esculenti corium farinosum is preferably controlled in 1:(7-9).The temperature of described constant temperature is preferably 35-45 DEG C, and described high speed pretreatment preferably carries out in homogenizer.
The concrete operations of the high speed pretreatment described in step (2) are: 3000-5000r/min processes 3-6min.The concrete operations of described agitator stirring are: 700-1000r/min stirs 60-80min.
In step (4), described centrifugal rotating speed is 3000-4000r/min,.Described centrifugation time is 30-40min.
Obtained lycopene is applied to prepare cosmetics, particularly as follows: mix homogeneously under 50-55 DEG C of condition with base material of cosmetics, is added in an amount of the 0.5-0.8% of final products weight.
The present invention has the beneficial effects that:
1, the inventive method is with fresh tomato skin for raw material, and compared with extracting raw material with other, gained content of lycopene wants high a lot；
2, the present invention is by broken for fresh tomato corium farinosum so that it is is more easy to and is uniformly distributed in digestion agent.Stir with agitator, can more abundant, more rapid be dissolved in digestion agent, shorten extraction time；
3, fan's repeatedly extract is dissolved in acetone by the present invention especially, together as digestion agent lixiviate.Herba Rosmarini Officinalis extract has very strong antioxidant activity, additionally it is possible to reduce the loss of lycopene in extraction process, improves lycopene stability, increases extraction efficiency, and in the product, product is oxidized fewer for particular application；
4, the present invention is by the great many of experiments of inventor and experience preferred extraction time, temperature, solid-liquid ratio, obtains the preparation condition optimized, substantially increases extraction efficiency.The lycopene purity extracted is high, and stable performance, is unlikely to deteriorate；
5, whole extraction process device is simple, it is easy to manipulation, cost is low.It it is the production technology of resource-conserving；
6, the lycopene of the present invention adds in cosmetic formulations, and the cosmetics prepared can desalinate microgroove, and compact skin, promotes the metabolism of cell, promotes the colour of skin, has the anti-senescence function of excellence.
Accompanying drawing explanation
Accompanying drawing is Extracting of Lycopene
Specific embodiment
Embodiment 1
1, take fresh tomato skin, clean up, dry, pulverize into powder；
2,1 part of fan repeatedly extract is joined in 80 parts of acetone, dissolve standby；
3, taking 100 parts of Fructus Lycopersici esculenti corium farinosum and join in 850 parts of acetone containing fan's repeatedly extract, at 45 DEG C, with 4000r/min high speed pretreatment 4 minutes, then stirring was filtered after 80 minutes under 800r/min；
4, the filtering residue after step 3 being filtered, by step 3 method, lixiviate 3 times, collects lixiviate filtrate；
5, lixiviating solution is placed in centrifuge, with under 3500r/min centrifugal 40 minutes, discards precipitate, collect supernatant, standby；
6, centrifugal gained supernatant is put in concentrator, carry out concentration is evaporated under reduced pressure, obtain concentrated solution；
7, the Powdered finished product of lycopene will namely be obtained after concentrated solution vacuum drying.
Embodiment 2
1. take fresh tomato skin, clean up, dry, pulverize into powder；
2. 1 part of fan repeatedly extract is joined in 65 parts of acetone, dissolve standby；
3. taking 100 parts of Fructus Lycopersici esculenti corium farinosum and join in 700 parts of acetone containing fan's repeatedly extract, at 30 DEG C, with 3000r/min high speed pretreatment 3 minutes, then stirring was filtered after 65 minutes under 900r/min；
4. the filtering residue after step 3 being filtered, by step 3 method, lixiviate 3 times, collects lixiviate filtrate；
5. lixiviating solution is placed in centrifuge, with under 3000r/min centrifugal 30 minutes, discards precipitate, collect supernatant, standby；
6. centrifugal gained supernatant is put in concentrator, carry out concentration is evaporated under reduced pressure, obtain concentrated solution；
7. will namely obtain the Powdered finished product of lycopene after concentrated solution vacuum drying.
Embodiment 3
1. take fresh tomato skin, clean up, dry, pulverize into powder；
2. 1 part of fan repeatedly extract is joined in 70 parts of acetone, dissolve standby；
3. taking 100 parts of Fructus Lycopersici esculenti corium farinosum and join in 900 parts of acetone containing fan's repeatedly extract, at 35 DEG C, with 4500r/min high speed pretreatment 5 minutes, then stirring was filtered after 70 minutes under 700r/min；
4. the filtering residue after step 3 being filtered, by step 3 method, lixiviate 2 times, collects lixiviate filtrate；
5. lixiviating solution is placed in centrifuge, with under 4000r/min centrifugal 35 minutes, discards precipitate, collect supernatant, standby；
6. centrifugal gained supernatant is put in concentrator, carry out concentration is evaporated under reduced pressure, obtain concentrated solution
7. will namely obtain the Powdered finished product of lycopene after concentrated solution vacuum drying.
Embodiment 4
It is used for preparing essence lotion by the lycopene of embodiment 1 gained, particularly as follows:
Cetearyl Fructus Canarii albi grease/Olivem 1000 3%
Butyrospermum parkii (BUTYROSPERMUMPARKII) fruit oil 4%
Hydrogenated coco 2%
Caprylic/capric triglyceride 5%
Hydrogenated jojoba oil 2%
Hyaluronate sodium 0.002%
Xanthan gum 0.1%
1,3-PD 3%
Glycerol 4%
Lycopene 0.7%
Flos Moutan root extract 0.2%
Deionized water 76%
Potassium sorbate 0.2%
Citric acid is appropriate
Phenoxyethanol/Sensiva SC50 0.3%
1, cetearyl Fructus Canarii albi grease/Olivem 1000, Butyrospermum parkii (BUTYROSPERMUMPARKII) fruit oil, hydrogenated coco, hydrogenated jojoba oil being put into oil phase pot together, stirring is warming up to 80-85 DEG C, standby as oil phase；
2, hyaluronate sodium, xanthan gum 1,3-PD, glycerol is scattered, put into aqueous phase pot together with deionized water, stirring is warming up to 80-85 DEG C, opens homogenizing 5 minutes, standby as aqueous phase；
3, by oil phase material body suction aqueous phase, homogenizing 10 minutes, it is incubated 80 DEG C and stirs 30 minutes；
4, being added by lycopene in part caprylic/capric triglyceride, stirring is warming up to 50-55 DEG C, treats that lycopene is completely dissolved, standby；
5, after temperature is down to 55 DEG C, the lycopene dissolved is put into together with remaining caprylic/capric triglyceride in aqueous phase pot material body, stir；
6, adding appropriate citric acid adjusts pH value to 6.0-6.5；
7, after temperature is down to 45 DEG C, add Flos Moutan root extract, stir；
8, potassium sorbate, phenoxyethanol/Sensiva SC50, discharging after stirring 30 minutes are added.
Embodiment 5
It is used for preparing facial cream by the lycopene of embodiment 2 gained, particularly as follows:
Methyl sesquistearate 1.3%
PEG-20 methyl sesquistearate 1.7%
Glyceryl stearate/PEG-100 stearate 1.5%
Cetearyl alcohol 2.8%
Butyrospermum parkii (BUTYROSPERMUMPARKII) fruit oil 2%
Polydimethylsiloxane 2%
Ring five polydimethylsiloxane/cyclohexasiloxane 3%
Squalane 3%
Caprylic/capric triglyceride 4%
Tocopherol (vitamin E) 1%
Methyl hydroxybenzoate 0.15%
Propyl hydroxybenzoate 0.1%
Hyaluronate sodium 0.02%
Allantoin 0.2%
Xanthan gum 0.1%
Glycerol 6%
Pyrusussuriensis (sugar) alcohol 6%
Trehalose 1%
Deionized water 69.28%
Lycopene 0.5%
Nicotiamide 1%
Polyacrylamide/C13-14 isoparaffin/laureth-70.6%
Beta glucan 2%
Methylisothiazolinone, iodine propilolic alcohol butyl mephenesin Carbamate 0.15%
Butanediol/water/Flos Moutan root extract 0.1%
1, methyl sesquistearate, PEG-20 methyl sesquistearate, glyceryl stearate/PEG-100 stearate, cetearyl alcohol, Butyrospermum parkii (BUTYROSPERMUMPARKII) fruit oil, polydimethylsiloxane, ring five polydimethylsiloxane/cyclohexasiloxane, squalane, tocopherol (vitamin E), methyl hydroxybenzoate, propyl hydroxybenzoate are put in oil phase pot together, stirring is warming up to 80-85 DEG C, standby；
2, by scattered to hyaluronate sodium, allantoin, xanthan gum glycerol and Pyrusussuriensis (sugar) alcohol, putting in aqueous phase pot together with deionized water, stirring is warming up to 80-85 DEG C, standby；
3, putting in aqueous phase pot by oil phase pot material body, after 10 minutes constant temperature stirring 30 minutes to open homogenizing；
4, the stirring of lycopene part caprylic/capric triglyceride is warming up to 50-55 DEG C of dissolving；
5, trehalose and nicotiamide portions of de-ionized water are dissolved；
6, after aqueous phase pot material body is cooled to 70 DEG C, adding polyacrylamide/C13-14 isoparaffin/laureth-7, homogenizing continues cooling after stirring 10 minutes；
7, after temperature is down to 55 DEG C, add the lycopene and remaining caprylic/capric triglyceride and the trehalose dissolved and nicotiamide that have dissolved, stir；
8, after temperature is down to 45 DEG C, add beta glucan, Methylisothiazolinone, iodine propilolic alcohol butyl mephenesin Carbamate, butanediol/water/Flos Moutan root extract, stir 30 minutes.
Result of use
100 volunteer's trial edition products have been collected for the present embodiment 4,5.Wherein women 60 people, male 40 people.Max age 30 years old, minimal ages 15 years old, 22 years old mean age.
100 volunteer's embodiment 4 products on probation are after 28 days, and feedback opinion is as follows:
100 volunteer's embodiment 5 products on probation are after 28 days, and feedback opinion is as follows:
The effect that has clear improvement in the majority with women.
It can be seen that microgroove is reduced by this product, skin compacts is flexible, improve the colour of skin and all have improvement in various degree from the suggestion of trier's feedback.It can thus be seen that the cosmetics containing lycopene have good senile-resistant efficacy.
The above, it it is only presently preferred embodiments of the present invention, not the present invention is done any pro forma restriction, therefore all contents without departing from technical solution of the present invention, the technical spirit of the foundation present invention, to any simple modification made for any of the above embodiments, equivalent variations and modification, all still falls within the scope of technical solution of the present invention.
Claims (1)
1. a lycopene extraction method, it is characterised in that the method includes the steps of:
1), take fresh tomato skin, clean up, dry, pulverize into powder；
2), by Fructus Lycopersici esculenti corium farinosum add in the acetone containing fan's repeatedly extract, under constant temperature, filter after stirring with agitator after high speed pretreatment；
3), by step 2) filter after filtering residue by step 2) method, lixiviate 2-3 time, collection lixiviate filtrate；
4), lixiviate filtrate is used centrifuge remove impurity, discard precipitate, collect supernatant, standby；
5), centrifugal gained supernatant is put in concentrator, carry out concentration is evaporated under reduced pressure, obtain concentrated solution；
6), the Powdered finished product of lycopene will namely be obtained after concentrated solution vacuum drying；Step 2) described in the concrete operations of high speed pretreatment be: 3000-5000r/min processes 3-6min；The concrete operations of described agitator stirring are: 700-1000r/min stirs 60-80min；Described Fructus Lycopersici esculenti corium farinosum is 30-40 order；
Step 2) in, the change weight ratio of extract and acetone of described fan is 1:(60-90)；Step 2) in, the feed liquid of the described acetone containing fan's repeatedly extract and Fructus Lycopersici esculenti corium farinosum controls at 1:(7-9)；The temperature of described constant temperature is 35-45 DEG C；Described high speed pretreatment carries out in homogenizer；Step 4) in, described centrifugal rotating speed is 3000-4000r/min；Described centrifugation time is 30-40min.
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