CN103736022B - A kind of pharmaceutical composition for the treatment of hepatitis and liver cirrhosis - Google Patents

Abstract

The invention discloses a kind of pharmaceutical composition for the treatment of hepatitis and liver cirrhosis.Described pharmaceutical composition is made with the raw material of following weight parts: fruit 18-21 part of washing one's hands, Radix Bupleuri 18-21 part, Radix Salviae Miltiorrhizae 18-21 part, Rhizoma Sparganii 18-21 part, Rhizoma Curcumae 18-21 part, Squama Manis 18-21 part, Herba Artemisiae Scopariae 18-21 part, Spina Gleditsiae 15-18 part, Radix Ginseng 15-18 part, Radix Aconiti Lateralis Preparata 15-18 part, Radix Angelicae Sinensis 15-18 part, Carapax Et Plastrum Testudinis 15-18 part, Carapax Trionycis 15-18 part, Herba Taraxaci 15-18 part, Indigo Naturalis 15-18 part, Radix Notoginseng 15-18 part, Semen Vaccariae 15-18 part is active component, overcome the deficiency of existing treatment hepatitis and liver cirrhosis medicine, one is provided to treat the good pharmaceutical composition of hepatitis regulating liver-QI hardening effect.

Description

A kind of pharmaceutical composition for the treatment of hepatitis and liver cirrhosis

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of hepatitis and liver cirrhosis.

Background technology

Hepatitis and viral hepatitis (viralhepatitis) are a kind of infectious disease based on hepatic lesions caused by multiple hepatitis virus.According to etiological diagnosis, hepatitis virus has 5 kinds at least, namely first, second, third, fourth, hepatitis E virus, cause respectively first, second, third, fourth, hepatitis E, i.e. hepatitis A (hepatitisA), hepatitis B (hepatitisB), hepatitis C (hepatitisC), hepatitis D (hepatitisD) and hepatitis E (hepatitisE).Wherein A type and hepatitis E main manifestations are acute hepatitis; B-mode, the third type can be the performance of acute hepatitis or chronic hepatitis, and has the possibility developing into liver cirrhosis and hepatocarcinoma.Clinically with loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, weak for main manifestations.Some patients can have jaundice heating and hepatomegaly with liver function injury.Some patient can chronicity, and even develop into liver cirrhosis, minority can develop into hepatocarcinoma.

Liver cirrhosis (livercirrhosis) is a kind of common chronic hepatopathy.The diffusivity hepatic injury that long-term or repeated action is formed by one or more causes of disease, liver is Progressive symmetric erythrokeratodermia, diffusivity, fibrous lesions.Be embodied in hepatocyte diffusivity degeneration necrosis, then there is proliferation of fibrous tissue and the regeneration of liver cell nodules shape, these three kinds change repeatedly staggered carrying out, and result lobules of liver structure and blood circulation path are reconstructed gradually, liver are out of shape, hardening and cause liver cirrhosis.In China, great majority are posthepatitic cirrhosis, and small part is alcoholic cirrhosis and Cirrhosis In Schistosomiasis.Histopathology there are hepatic necrosis, the regeneration of remaining liver cell nodules, connective tissue proliferation and fiber widely every formation, cause lobules of liver structural deterioration and pseudolobuli formation, liver is out of shape gradually, hardening and develop into liver cirrhosis.In early days because liver compensation more by force can non-evident sympton, stage with liver function injury and portal hypertension for main manifestations, and have multisystem to get involved, often there is the complication such as upper gastrointestinal hemorrhage, hepatic encephalopathy, secondary infection, hypersplenism, ascites, canceration late period.Liver cirrhosis is that many reasons causes liver injury, the early stage non-evident sympton of this disease, and a series of portal hypertension in various degree and hepatic insufficiency appear in stage, until occur the complication such as upper gastrointestinal hemorrhage, hepatic encephalopathy and cause death.Lack the effective medicine of generally recognized as safe clinically at present.

At present, for liver disease, more existing Chinese medicines, as China Patent Publication No. CN1287858A discloses a kind of Chinese medicine composition for the treatment of hepatopathy and preparation method thereof, treat hepatopathy by the combination of people's Fructus Jujubae, Semen Fagopyri Esculenti and other Chinese medicines.China Patent Publication No. CN1294980C discloses a kind of Chinese medicine for the treatment of hepatopathy, by the incompatible treatment hepatopathy of Radix Bupleuri, Flos Genkwa and other Chinese drug-treated group.China Patent Publication No. CN101606984A discloses a kind of Chinese medicine for the treatment of hepatopathy, by the incompatible treatment hepatopathy of Radix Angelicae Sinensis, CHUANSHAO and other Chinese drug-treated group.But it is not obvious that prior art exists curative effect, the deficiencies such as the time is long, treatment hepatitis and liver cirrhosis need the little Chinese medicine composition of a kind of effective, instant effect, side effect badly.

Summary of the invention

The technical problem to be solved in the present invention is the deficiency overcoming existing treatment hepatitis and liver cirrhosis medicine, provides a kind of pharmaceutical composition treatment hepatitis and liver cirrhosis being had to better effects.

In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summary, is made up of the raw material of following weight parts:

To wash one's hands fruit 18-21 part, Radix Bupleuri 18-21 part, Radix Salviae Miltiorrhizae 18-21 part, Rhizoma Sparganii 18-21 part, Rhizoma Curcumae 18-21 part, Squama Manis 18-21 part, Herba Artemisiae Scopariae 18-21 part, Spina Gleditsiae 15-18 part, Radix Ginseng 15-18 part, Radix Aconiti Lateralis Preparata 15-18 part, Radix Angelicae Sinensis 15-18 part, Carapax Et Plastrum Testudinis 15-18 part, Carapax Trionycis 15-18 part, Herba Taraxaci 15-18 part, Indigo Naturalis 15-18 part, Radix Notoginseng 15-18 part, Semen Vaccariae 15-18 part.

Preferably, it is made up by weight of following raw materials according:

Wash one's hands fruit, Radix Bupleuri, Radix Salviae Miltiorrhizae, Rhizoma Sparganii, Rhizoma Curcumae, Squama Manis, Herba Artemisiae Scopariae, Spina Gleditsiae, Radix Ginseng, Radix Aconiti Lateralis Preparata, Radix Angelicae Sinensis, Carapax Et Plastrum Testudinis, Carapax Trionycis, Herba Taraxaci, Indigo Naturalis, Radix Notoginseng, Semen Vaccariae, above each raw material number is equal.

The dosage form of pharmaceutical composition of the present invention can be the medically acceptable dosage form such as capsule, granule, pill, tablet, decoction, and their preparation method, supplementary product consumption are undertaken by existing common process.

The present invention also comprises the application of aforementioned pharmaceutical compositions in the medicine preparing treatment hepatitis and liver cirrhosis.

In pharmaceutical composition prescription of the present invention:

Wash one's hands really, another name tassel (" the low thing of multipotency "), wood suffers from son, fertile pearl, oil droplet, the Fructus Sapindi Mukouossi (" detailed outline "), and son drawn by wood, son (" Chinese tree taxonomy ") suffered from by oil, circle soap, Arillus Longan soap (" modern Practical Chinese medicinal "), bitter Fructus Gardeniae (" Guangxi Chinese veterinarian's medicine is planted ").Source: for sapindaceous plant is without the seed of suffering from tree.Harvesting ripe fruit, removing sarcocarp, gets seed and dries.Without suffering from tree (supplement to the Herbal), have another name called: Huan's (the Classic of Mountains and Rivers), pick up smoke tree wood (Cui leopard " noting at all times ") Rou Lou, smoke tree wood (" bun literary composition "), Lou of keeping silent (" Bencao Shiyi), pick up smoke tree ghost wood (" China notes at all times "), Lu's ghost wood (" detailed outline "), yellow order tree (" Taiwan Prefecture Administration will "), order wave tree.The root (Radix Sapindi Mukorossi) of this plant, bast (Cortex Sapindi mukorossi), browse (Folium Sapindi Mukorossi), sarcocarp (Cortex Sapindi Mukorossi), kernel (Semen Sapindi mukorossi) also hyoscine.Character: dry seed is spherical in shape, path length 14 millimeters.Appearance black is smooth.Hilum is linear, around with white fluff.Seed coat sclerotin, hard.Without endosperm, cotyledons thick, yellow, embryo is sturdy slightly bending.Chemical analysis: containing sapindoside (sapindussaponin), fatty oil, protein.Nature and flavor: bitter are flat, poisonous.1. " herbal classic is met former ": bitter, flat, nontoxic.2. " Nanning City's medicine will ": pained, slightly poisonous.Function cures mainly: heat clearing away, eliminates the phlegm, removing food stagnancy, parasite killing.Control sore throat to swell and ache, cough with asthma, dyspepsia, leucorrhea, infantile malnutrition, skin ulcer numbness, toxic swelling.For diphtheria disease, seminal vesicle is sick, stranguria with turbid discharge frequent micturition.Heat clearing away, eliminates the phlegm, removing food stagnancy, parasite killing.Sore throat swells and ache, cough with asthma, dyspepsia, leucorrhea, infantile malnutrition, skin ulcer tinea, toxic swelling.1. " the SHENGCAO property of medicine is standby to be wanted ": hemostasis; Simmer food parasite killing, go greasy; Boil plaster to dispel the wind, subside a swelling, draw out pus by applying a plaster to the affected part.2. " Guangxi Chinese medicinal herbal ": ashing is ground into powder and blown larynx and control celostomia.3. " will planted by Tianmu Mountains of Zhejiang Province medicine ": control various larynx disease, cold, fever, pertussis, nebulousurine, leucorrhea, infantile malnutrition.

Radix Bupleuri, smokes another name, Asia puecon Hu, mountain dish, eats grass, faggot.Medicinal part: be the root of samphire Radix Bupleuri, Radix Bupeuri Scorzonerfolii. etc.Composition: Radix Bupleuri root is containing volatile oil, bupleurumol, oleic acid, linolenic acid, Palmic acid, stearic acid, carnaubic acid, glucose and Saponin etc.Markets Drug is had, saikoside unit F, E, G, longispinogenin in Saponin.Separately have report, separate saikoside in root and seed, this is the general name of multiple glycoside.In addition, hitodesterol, Δ 7-stigmastenol, Δ 22-stigmastenol, stigmasterol, adonite, Radix Angelicae Dahuricae element is contained in root.Stem, leaf are containing globulariacitrin.Fruit oil-containing 11.2%, wherein has petroselinic acid, petroselidic acid and sub-sleeve acid.Radix Bupeuri Scorzonerfolii. root is containing Saponin, fatty oil, volatile oil, bupleurumol.Stem, leaf are containing globulariacitrin.Golden yellow Radix Bupleuri is containing globulariacitrin, ribitol, 29 ketone, cerotin, α-spinach Lay sterol, flavonols, Saponin, alkaloid, ascorbic acid, carotene etc.Blooming, fruiting period, Quercetin, Isoquercitrin, globulariacitrin, isorhamnetin and isorhamnetin-3-rutinoside can be obtained from flower, leaf, stem.Bigleaf thorowax root root is containing saikoside, hitodesterol, sucrose and polyacetylene compound.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.1. " herbal classic ": " stagnation of QI in main trusted subordinate's the intestines and stomach, diet gathers, and cold and heat pathogen, pushes away Chen Zhixin." 2. " not Lu ": ", except dysphoria with smothery sensation under the typhoid fever heart, all expectorant accumulation of heats be real, evil inverse in the heart, five hide between faint breath, large intestine stops amassing, watery distension, and arthralgia chiefly caused by damp pathogen contracture.Also can do to bathe soup." 3. " property of medicine opinion ": " Zhi Relao arthralgia with restlessness, steam, shoulder and back ache, declares smooth vim and vigour, tired weakness and emaciation; The main therapeutic method to keep the adverse QI flowing downwards helps digestion, and time main, in disease, exterior-heat is not understood, and singly boils clothes."

Radix Salviae Miltiorrhizae, has another name called Radix Salviae Miltiorrhizae, Radix Salviae Miltiorrhizae, Arisaema balansae Engl. etc., is dicotyledon Labiatae, dry root and rhizome.Effect: Radix Salviae Miltiorrhizae has GUIXIN, Liver Channel.Can stasis-dispelling and pain-killing, promoting blood flow to regulate menstruation, lowering blood-fat and reducing weight, clear away heart-fire relieving restlessness.

Rhizoma Sparganii is the tuber of Sparganiaceae plant rhizoma scirpi or little rhizoma scirpi, spire rhizoma scirpi.Composition: little rhizoma scirpi is containing volatile oil 0.05%.Function cures mainly: removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving.Zhi lumps in the chest and abdomen, coagulation of QI-blood, trusted subordinate's pain, the lower swollen pain of the side of body, amenorrhea, postnatal blood stasis is suffered from abdominal pain, and traumatic injury, skin ulcer swells hard.

Rhizoma Curcumae, another name Curcuma wenyujin, Rhizoma Curcumae, radix zedoariae, Rhizoma Trillii Tschonoskii, smelly dung Rhizoma Zingiberis Recens.For the dry rhizome of zingiberaceous plant Rhizoma Curcumae CurcumaphaeocaulisVal., Guangxi zedoary CurcumaKwangsiensisS.G.LeeetC.F.Liang or RADIX CURCUMAE CurcumawenyujinY.H.ChenetC.Ling.The latter practises title " Curcuma wenyujin ".Nature and flavor: pungent, bitter, temperature.Gui Jing: return liver, spleen channel.Function cures mainly: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.

Squama Manis, another name big gun Squama Manis, stir-baked SQUAMA MANITIS etc.Use after generally being concocted by the scute of Manitis (Squama Manis).Concocting method has burning, shortcake is processed, processed with vinegar, urine of baby boys are processed, fry, parching with earth, stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE.Its salty in the mouth, cold nature, returns Liver Channel, stomach warp.Can blood circulation promoting and dispersing pathogen accumulation, stimulating milk secretion of stimulating the menstrual flow, the routed heavily fortified point of eliminating carbuncle.Main blood stasis amenorrhea, lump in the abdomen, rheumatic arthralgia, agalactia, carbuncle, scrofula etc.

Herba Artemisiae Scopariae, another name capillary wormwood, Herba Artemisiae Scopariae, Herba Artemisiae Sieversianae, floss Artemisia, monkey hair are the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. ArtemisiascopariaWaldst.etKit. or Herba Artemisiae Scopariae ArtemisiacapillarisThunb..Gather during the high 6 ~ 10cm of seedling in spring or autumn, alabastrum grew up to time tap, removing impurity and old stem, dry.The habit of gathering spring claims " capillary wormwood ", the title " Herba Artemisiae Scopariae " tapped autumn.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis.

Spina Gleditsiae, also known as Spina Gleditsiae, SPINA GLEDITSIAE, is the Spina jujubae of pulse family deciduous tree plant Gleditsia officinalis.This product nature and flavor are pungent, temperature, the special detumescence and apocenosis of merit, and tcm clinical practice is used for swollen ulcer drug all good therapeutic effect, generally shows as the non-Cheng Zheke of pus and disappears, and formed pus person can make it speed and burst.Modern anticancer pharmacological research shows, Spina Gleditsiae has anticancer tumor-suppression activity.

Radix Ginseng, herbaceos perennial, has strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the effect of Fructus Alpiniae Oxyphyllae of calming the nerves., lack of appetite, asthenia, dizziness and headache, sexual impotence, frequent micturition deficient for impairment caused by overstrain, to quench one's thirst.Radix Ginseng meridian distribution of property and flavor: property is flat, sweet in the mouth, micro-hardship, tepor.Return spleen, lung meridian, heart channel.

Radix Aconiti Lateralis Preparata is the other raw tuber (daughter root) of ranunculaceae plant Aconitum carmichjaelii Debx. (cultivation product).Function cures mainly: recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispelling cold and removing dampness.Control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted inverse, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema children's intermittent infantile convulsion, anemofrigid-damp arthralgia, the contracture of Wei lame, sexual impotence, and cold womb is cloudy, the disease of the leakage of cellulitis skin ulcer and all chronic diseaseses.(1) recuperating depleted YANG and rescuing the patient from collapse: have stronger recuperating depleted YANG effect.For the collapse of fear of cold, cold extremities, faint pulse being about to disappear, Chang Peiwu Radix Ginseng, or Rhizoma Zingiberis, Radix Glycyrrhizae).(2) tonification yang-energy: Radix Aconiti Lateralis Preparata is hot, its property is walked and does not keep, and can pass through 12 warps, therefore the card of all YANG QI deficiency all available it, especially can tonification kidney yang.Kidney-replenishing often joins Cortex Cinnamomi.(3) cold-dispelling pain-relieving: the large heat of this product, cold relieving power is strong, therefore can control inward invasion of pathogenic cold stomach abdomen pain, have loose bowels, and the arthralgia pain of Cold-dampness.

Radix Angelicae Sinensis, calls dry returning, horse hair Radix Angelicae Sinensis, and the Qin where, and horse hair is returned, and cloud is returned, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis.Medicinal part: be the root of umbelliferae angelica.Composition: containing neutral oil compositions such as nopinene, australene, camphenes in Radix Angelicae Sinensis.Containing acid-soluble oil composition, organic acid such as p-methylbenzyl alcohol, 5-methoxyl group-2,3-xylenols; Saccharide; Vitamin; Aminoacid etc.Function cures mainly: benefiting blood and regulating blood circulation, and menstruction regulating and pain relieving moisturizes laxation.For blood deficiency, shallow complexion, dizzy cardiopalmus; Blood deficiency, or have the stagnant menoxenia of the stasis of blood, amenorrhea, dysmenorrhea concurrently; The pain such as deficient cold type stomachache, angina pectoris, rheumatic arthralgia, traumatic injury card; Dryness of the intestine constipation; Chronic cough is panted.

Carapax Et Plastrum Testudinis, source: these product are Testudinidae animal Testudinis Chinemysreevesii(Gray) carapace and sternite.The whole year all can catch, and is many, kills, strip carapace and sternite, remove residual meat after seizure, be called " blood plate " with autumn, season in winter two.Or scald dead with boiling water, strip carapace and sternite, remove residual meat, the person of drying, be called " scalding plate ".Character: this product carapace and sternite are connected by methano, and carapace is slightly longer than sternite, is often separated with sternite.Carapace is oblong arcuation, long 7.5-22cm, wide 6-18cm; Outer surface sepia or pitchy, 3, ridge rib; 1 piece, neck shield, beloid; 5 pieces, vertebra shield, the 1st vertebra shield is grown up in wide or closely equal, and 2-4 vertebra shield is wider than length; Rib shield lateral symmetry, each 4 pieces, 11 pieces, the every side of edge shield, 2 pieces, buttocks shield.Sternite is en plaque, nearly rectangular ellipse, long 6.4-21cm, wide 5.5-17cm; Outer surface is fallow to brownish black, scultellum 12 pieces, and the radial texture of every block normal tool puce, stitches all long in abdomen shield, breast shield and stock shield, larynx shield, anus shield take second place, and stitch the shortest in upper arm shield; Inner surface yellow-white to canescence, the slightly bloodstain had or residual meat, visible hone lamella 9 pieces after Ex-all, indentation rabbet; Front end blunt circle or truncate, rear end tool triangle is incised, the remaining methano bent obliquely upward in wing in both sides.Matter is hard.Feeble QI raw meat, taste is micro-salty.Meridian distribution of property and flavor: salty, sweet, is slightly cold.Return liver, kidney, heart channel.Function cures mainly: nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood, and for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.

Carapax Trionycis, this product is the carapace of Trionychidae animal Trionyx sinensis Wiegmann TrionyxsinensisWiegmann.The whole year all can catch, and is many, kills after seizure with autumn, season in winter two, puts in boiling water and scalds when can peel off to the sclerderm on carapace, takes out, strips carapace, remove residual meat, dry.Character: this product ovalize or oval, the back side is swelled, long 10-15cm, wide 9-14cm.Outer surface pitchy or blackish green, slightly gloss, tool fine mesh wrinkle and lark or canescence speckle, there is a vertical rib centre, and respectively there is symmetrical horizontal dimpled grain 8 both sides, after crust comes off, visible zigzag interlocking seam.Inner surface off-white color, the bossed vertebrae in middle part, neck is inwardly curling, and respectively there is 8, rib both sides, stretch out edge.Matter is hard.Feeble QI raw meat, lightly seasoned.Nature and flavor with return through: salty, be slightly cold.Return liver, kidney channel.Function with cure mainly: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, bring down a fever except steam.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea, chronic malaria malaria with splenomegaly.

Herba Taraxaci, belongs to Compositae herbaceos perennial.Head inflorescence, the bobbles that on seed, adularescent pappus is formed, new life is bred in the new place that racks after the flowers are in blossom.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value simultaneously.Nature,taste and action: sweet, micro-hardship, cold.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Gui Jing: enter spleen, stomach, kidney three warp.Cure mainly: upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, cholecystitis, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.

Indigo Naturalis is the dry pigment in dicotyledon medicine acanthaceous vegetable acanthaceous indigo, dicotyledon medicine leguminous plant Folium et Caulis Indigoferae Tinctoriae, dicotyledon medicine cruciferae isatis, careless Folium Isatidis or polygonaceae plant polygonum tinctorium ait. leaf.Nature and flavor are salty-cold.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, purging liver-fire, arresting convulsion.Cure mainly: epidemic febrile disease intenseness of heat, macule, haematemesis, spitting of blood, pharyngalgia aphtha, pediatric epilepsy scared, skin ulcer are swollen, erysipelas, snake bite and insect sting.

Radix Notoginseng, have another name called Radix Notoginseng, Radix Notoginseng, Herba Senecionis Chrysanthemoidis, blood mountain grass, June drench, Sedum spectabile Boreau, the famous pharmacy man Li Shizhen (1518-1593 A.D.) of the Ming Dynasty is called " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ".Radix Notoginseng is a jewel in Chinese crude drug, records in Qing Dynasty's pharmaceutical texts supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying the first, Radix Notoginseng enriches blood the first, taste with and merit also etc., therefore claiming Panax pseudoginseng, is the most precious person in Chinese medicine." Radix Notoginseng belongs to Araliaceae herbaceos perennial.Nature and flavor: sweet in the mouth; Micro-hardship; Warm in nature.Gui Jing: return Liver Channel; Stomach warp.Function: hemostasis; Loose blood; Analgesic therapy, dissipating blood stasis stops blooding, and desilting bolt stops blooding, blood pressure lowering, reducing swelling and alleviating pain.

Semen Vaccariae, calls milk rice, Wang Buliu, Mai Lanzi, cuts gold, SEMEN VACCARIAE.Medicinal part: be the seed of pinkwort Vaccaria segetalis.Composition: seed is containing triterpenoid saponin, and what be called vacsedoside (vac-segoside) has A, B, C, D4 kind, all for by the derivative polysaccharid glucoside of gypsogenin (gypsogenin).The structure of vacsedoside B and C is determined, the sugar moieties of glycoside A has D-Glucose aldehydic acid (D-glucuronicacid), D-galactose (D-galactose), L-arabinose (L-arabinose), D-xylose (D-xylose), D-fucose (D-fucose), L-rhamnose (L-rhamnose), the sugar moieties of glycoside D has D-Glucose aldehydic acid, D-galactose, D-xylose, D-fucose, L-rhamnose and D-Glucose (D-glucose).The hydrolysis of four kinds of Saponins all same vaccaroside (vaccraoside), be namely gypsogenin-3-β-D-Glucose aldehydic acid glycoside (gypsogenin-3-β-D-giucuronoside.Again containing flavonoid glycoside: Semen Vaccariae flavonoid glycoside (vaccarin), isosaponaretin (isosaponarin).Also containing phytin. (phytin), phospholipid (phospholipid), stigmasterol (stigmasterol) etc.[function cures mainly] promoting the circulation of blood is stimulated the menstrual flow, and expedites the emergence of stimulating milk secretion, detumescence sore.Control women's amenorrhea, galactostasis, difficult labour, stranguria with blood, carbuncle, incised wound is hemorrhage.To stimulate the menstrual flow stimulating milk secretion: for amenorrhea and agalactia.It is many and obstructed that Semen Vaccariae controls milk; As the deficiency syndrome of hypogalactia, then need the medicine of adapted benefiting vital QI and blood.Promoting blood circulation and detumescence: for blood stasis lump and sore and toxic.1. " herbal classic ": " main incised wound is stopped blooding by pain, gone out thorn, except migratory arthralgia endogenous cold." 2. " not Lu ": " only vexed epistaxis."

The pure Chinese medicine composition of pharmaceutical composition of the present invention, wherein:

Wash one's hands really, get its desilting removing toxic substances, toxin expelling suppurates, removing food stagnancy effect.

Radix Bupleuri, get that it is soothing the liver, heat clearing away removing toxic substances, stagnation of liver-QI gas, the effect of cold expelling yang invigorating.

Radix Salviae Miltiorrhizae, gets its removing heat from blood, promoting blood circulation to remove obstruction in the collateral is had one's ideas straightened out, treating the liver induration.

Rhizoma Sparganii, gets its removing blood stasis circulation of qi promoting, removing food stagnancyization is stagnant, the effect for the treatment of the liver splenomegaly.

Rhizoma Curcumae, gets its promoting the circulation of blood removing blood stasis, the effect for the treatment of the liver splenomegaly.

Squama Manis, gets its promoting blood circulation to remove obstruction in the collateral, toxin expelling of subsiding a swelling, changes hard soft or hard, promoting muscle growth functions.

Herba Artemisiae Scopariae, gets its clearing away heat-damp and promoting diuresis, promoting the function of the gallbladder to alleviate jaundice, heat clearing away toxic action.

Spina Gleditsiae, gets its mass dissipating and swelling eliminating, anticancer, detumescence toxin expelling effect.

Radix Ginseng, gets its strongly invigorating primordial QI, the deficiency of vital energy takes off, heart failure, body of wall antivirus action.

Radix Aconiti Lateralis Preparata, gets it and rescues inverse returning to life from the nether world, the effect of yang invigorating solid.

Radix Angelicae Sinensis, gets that it is enriched blood, the effect of invigorating blood circulation.

Carapax Et Plastrum Testudinis, get its kind cloudy YANG hyperactivity suppressing, hard masses softening and resolving, hepatosplenomegaly, soothing the liver through effect.

Carapax Trionycis, gets its dissipating blood stasis dredging collateral, hard masses softening and resolving effect.

Herba Taraxaci, gets its heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, the jaundice that disappears effect.

Indigo Naturalis, gets its removing heat from blood, removes swollen toxin expelling, antitumaous effect.

Radix Notoginseng, gets its promoting blood circulation and hemostasis, swelling eliminating and pain stopping, removing heat from blood disinfective action.

Semen Vaccariae, gets its dredging collateral dampness removing, Huoxue San " toxic action.

This pharmaceutical composition be inventor in long-term practice to the result that TCM Recipe art is developed meticulously in conjunction with modern crafts, have fabulous effect to hepatitis and liver cirrhosis.

Detailed description of the invention

With specific embodiment, the invention will be further described below, but the present invention is not limited to these embodiments.

Embodiment 1

Wash one's hands fruit 180g, Radix Bupleuri 210g, Radix Salviae Miltiorrhizae 180g, Rhizoma Sparganii 210g, Rhizoma Curcumae 180g, Squama Manis 210g, Herba Artemisiae Scopariae 180g, Spina Gleditsiae 180g, Radix Ginseng 150g, Radix Aconiti Lateralis Preparata 180g, Radix Angelicae Sinensis 150g, Carapax Et Plastrum Testudinis 180g, Carapax Trionycis 150g, Herba Taraxaci 180g, Indigo Naturalis 150g, Radix Notoginseng 180g, Semen Vaccariae 150g.

Above each raw material is taken by proportional quantity, decoct with water twice, first time adds 7 times of water gagings, decocts 1.5 hours, second time adds 8 times of water gagings, decoct 1.5 hours, collecting decoction, filter, filtrate be concentrated into when relative density is 1.30(70 DEG C survey) extractum, add the magnesium stearate adjuvant of conventional amount used, technique makes tablet routinely, specification 0.5g/ sheet.

Embodiment 2

Wash one's hands fruit 210g, Radix Bupleuri 180g, Radix Salviae Miltiorrhizae 210g, Rhizoma Sparganii 180g, Rhizoma Curcumae 210g, Squama Manis 180g, Herba Artemisiae Scopariae 210g, Spina Gleditsiae 150g, Radix Ginseng 180g, Radix Aconiti Lateralis Preparata 150g, Radix Angelicae Sinensis 180g, Carapax Et Plastrum Testudinis 150g, Carapax Trionycis 180g, Herba Taraxaci 150g, Indigo Naturalis 180g, Radix Notoginseng 150g, Semen Vaccariae 180g.

Above each raw material is taken by proportional quantity, decoct with water twice, first time adds 7 times of water gagings, decocts 1.5 hours, and second time adds 8 times of water gagings, decoct 1.5 hours, collecting decoction, filter, filtrate be concentrated into when relative density is 1.30(70 DEG C survey) extractum, add appropriate cane sugar powder, technique makes granule routinely.

Embodiment 3

Wash one's hands fruit 180g, Radix Bupleuri 180g, Radix Salviae Miltiorrhizae 180g, Rhizoma Sparganii 180g, Rhizoma Curcumae 180g, Squama Manis 180g, Herba Artemisiae Scopariae 180g, Spina Gleditsiae 180g, Radix Ginseng 180g, Radix Aconiti Lateralis Preparata 180g, Radix Angelicae Sinensis 180g, Carapax Et Plastrum Testudinis 180g, Carapax Trionycis 180g, Herba Taraxaci 180g, Indigo Naturalis 180g, Radix Notoginseng 180g, Semen Vaccariae 180g.

Take above each raw material, decoct with water twice, first time adds 8 times of water gagings, decocts 2 hours, and second time adds 6 times of water gagings, decocts 1.5 hours, collecting decoction, filters, obtains decoction.

Embodiment 4

Wash one's hands fruit 180g, Radix Bupleuri 180g, Radix Salviae Miltiorrhizae 180g, Rhizoma Sparganii 180g, Rhizoma Curcumae 180g, Squama Manis 180g, Herba Artemisiae Scopariae 180g, Spina Gleditsiae 180g, Radix Ginseng 180g, Radix Aconiti Lateralis Preparata 180g, Radix Angelicae Sinensis 180g, Carapax Et Plastrum Testudinis 180g, Carapax Trionycis 180g, Herba Taraxaci 180g, Indigo Naturalis 180g, Radix Notoginseng 180g, Semen Vaccariae 180g.

Take above each raw material by proportional quantity, decoct with water twice, first time adds 7 times of water gagings, decoct 1.5 hours, second time adds 8 times of water gagings, decocts 1.5 hours, collecting decoction, filter, filtrate be concentrated into when relative density is 1.30(70 DEG C survey) extractum, add the dextrin adjuvant of conventional amount used, technique routinely, make capsule, 0.5g/ grain.

Experimental example: pharmaceutical composition of the present invention is to the clinical efficacy of hepatitis

Experiment material: pharmaceutical composition prepared by the embodiment of the present invention 4.

Experiment place: the Guangxi Qinzhou hospital of traditional Chinese hospital.

1, case and method

2007-2013, connect and control Patients with Viral Hepatitis 156 example, male 82 example, women 74 example, age is in 18-69 year, higher than normal 2-10 doubly, higher than normal 2-10 doubly, Bil is higher than 2-6 times of normal value for AST for ALT, but nonjoinder liver cirrhosis, without other severe complications, age of sucking and non-pregnancy get rid of the liver function injury patient that medicine and other reasons cause, and before entering group, March had not taken and protected the liver and antiviral drugs.156 examples are viral is divided into treatment group and matched group at random, treatment group 80 example, wherein male 50 example, women 30 example, 38 years old mean age, hepatitis A, hepatitis C 12 example, hepatitis B 68 example, acute hepatitis 30 example, chronic hepatitis 50 example, use " ZANGYINCHEN capsule ", 2, oral, one day three times; Matched group 76 example, wherein male 42 example, women 34 example, 32 years old mean age, hepatitis A, hepatitis C 10 example, hepatitis B 66 example, acute hepatitis 26 example, chronic hepatitis 50 example, uses compound liver-benepitino remedy, three, oral, one day three times.Two groups of cases have comparability.Primary Care is vitamin and flesh former times sheet.

Observation index treatment before, treatment after two weeks, January, February patient's liver function, renal function, routine blood test, coagulation function, treat terminate the above-mentioned indices of rear whole check.

Usage and dosage: the embodiment of the present invention 4, capsule, every day 3 times, each 2, oral; 30d is 1 course for the treatment of, is used in conjunction 2 courses for the treatment of.

2, efficacy determination

Be as the criterion according to clinical symptom disappearance, be divided into recovery from illness, effective, invalid.

Recovery from illness: Clinical symptom and sign disappears, recover normal, Serum ALT, AST, Bil all recover normal.

Effective: the basic or major part of Clinical symptom and sign disappears, and Serum ALT, AST, Bi1 have one to recover normal.

Invalid: Clinical symptom and sign is without improvement, and Index for examination has no improvement.

3, curative effect is summed up

Table 1: the improvement of symptom and sign before and after two groups of treatments

Table 2: the improvement of ALT, AST, Bil before and after two groups of treatments

The all cases of therapeutic outcome are taken medicine no headache dizziness, heating, erythra, alopecia, and joint aches is hemorrhage, degradation untoward reaction under appetite.

Experimental example: pharmaceutical composition of the present invention is to the clinical efficacy of liver cirrhosis

Experiment material: pharmaceutical composition prepared by the embodiment of the present invention 4.

Experiment place: the Guangxi Qinzhou hospital of traditional Chinese hospital.

1, case and method

2009-2013, connect control patient 120 example, male 64 example, women 56 example, the age 41-82 year.Course of disease 0.5-2.5.Test group 90 example, matched group 30 example is divided into by complete randomly assigne.Two groups of patient age, sex, cardinal symptom, courses of disease etc., relatively all without significant difference, have comparability.

1.1 usage and dosages:

Experimental group: the embodiment of the present invention 4, capsule, every day 3 times, each 2, oral; 30d is 1 course for the treatment of.

Matched group: take " Oxymatrine Capsule ", takes according to its description usage and dosage, within 30 days, is a course for the treatment of.

1.2 observation items:

Observe inquiry: weak, loss of appetite, abdominal distention, suffer from diarrhoea, the symptomatic condition such as to become thin;

Image check: hepatomegaly, splenomegaly, ascites degree;

Chemical examination: bilirubin, ALT, AST, GGT, routine blood test.

2, efficacy determination

Be as the criterion according to clinical symptom disappearance, be divided into recovery from illness, effective, invalid.

Recovery from illness: Clinical symptom and sign disappears, recover normal, experimental check is normal.

Effective: the basic or major part of Clinical symptom and sign disappears, experimental check improves or normal.

Invalid: Clinical symptom and sign, without improvement, contrasts without obviously changing before experimental check and treatment.

3, curative effect is summed up

	Number of cases	Recovery from illness	Effectively	Invalid	Effective percentage
						Treatment group	90	6	62	24	75.6%
Matched group	30	1	18	11	63.3%

Therapeutic outcome: after terminating the course for the treatment of, compared with matched group, treatment group better effects if, effective percentage reaches 75.6%, and has no side effect.

Claims (3)

1. treat a pharmaceutical composition for hepatitis and liver cirrhosis, it is characterized in that: this pharmaceutical composition be made up of the raw material of following weight parts:

To wash one's hands fruit 18-21 part, Radix Bupleuri 18-21 part, Radix Salviae Miltiorrhizae 18-21 part, Rhizoma Sparganii 18-21 part, Rhizoma Curcumae 18-21 part, Squama Manis 18-21 part, Herba Artemisiae Scopariae 18-21 part, Spina Gleditsiae 15-18 part, Radix Ginseng 15-18 part, Radix Aconiti Lateralis Preparata 15-18 part, Radix Angelicae Sinensis 15-18 part, Carapax Et Plastrum Testudinis 15-18 part, Carapax Trionycis 15-18 part, Herba Taraxaci 15-18 part, Indigo Naturalis 15-18 part, Radix Notoginseng 15-18 part, Semen Vaccariae 15-18 part.

2. the pharmaceutical composition for the treatment of hepatitis according to claim 1 and liver cirrhosis, is characterized in that: this pharmaceutical composition be made up of the raw material of following weight parts:

Wash one's hands fruit, Radix Bupleuri, Radix Salviae Miltiorrhizae, Rhizoma Sparganii, Rhizoma Curcumae, Squama Manis, Herba Artemisiae Scopariae, Spina Gleditsiae, Radix Ginseng, Radix Aconiti Lateralis Preparata, Radix Angelicae Sinensis, Carapax Et Plastrum Testudinis, Carapax Trionycis, Herba Taraxaci, Indigo Naturalis, Radix Notoginseng, Semen Vaccariae, above each raw material number is equal.

3. the application of the pharmaceutical composition according to any one of claim 1 or 2 in the medicine preparing treatment hepatitis and liver cirrhosis.