CN103735638A - Traditional Chinese medicine compound preparation for treating livestock and poultry respiratory tract disease - Google Patents
Traditional Chinese medicine compound preparation for treating livestock and poultry respiratory tract disease Download PDFInfo
- Publication number
- CN103735638A CN103735638A CN201310507845.5A CN201310507845A CN103735638A CN 103735638 A CN103735638 A CN 103735638A CN 201310507845 A CN201310507845 A CN 201310507845A CN 103735638 A CN103735638 A CN 103735638A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- preparation
- weight
- parts
- chinese medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a traditional Chinese medicine compound preparation for treating livestock and poultry respiratory tract disease. The compound preparation comprises the following raw materials: 80-120 parts by weight of honeysuckle, 80-120 parts by weight of fructus forsythiae, 120-180 parts by weight of scutellaria baicalensis, 80-120 parts by weight of white mulberry root-bark, 80-120 parts by weight of fructus arctii, 80-120 parts by weight of platycodon grandiflorum, 80-120 parts by weight of semen lepidii, and 80-120 parts by weight of moutan bark. The traditional Chinese medicine compound preparation has relatively good curative effect on chicken infectious bronchitis and swine enzootic pneumonia, has no obvious long-term toxicity effect on tested animals, and has quite good security.
Description
Technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind of compound Chinese medicinal preparation for the treatment of livestock and birds respiratory disease.
Background technology
The disease of breathing of pig is to infect a kind of contact causing, chronic common transmittable disease by Mycoplasma hyopneumoniae, and the feature performance that pig obtains is after being ill cough and breathes.It can cause the generation of many respiratory infectious diseases, and very harmful to pig industry distributes very wide, and sickness rate is higher, and fatality rate is lower.Its clinical cardinal symptom, for cough, asthma, is ventral breathing, sick pig just, mid-term appetite normal, but normal growth impaired development, feedstuff declines with interest rate, easily secondary other diseases, sick pig cure after easily recurrence etc. under bad feeding environment.
Infectious bronchitis (infectious bronchitis, IB) is that the one of the chicken that caused by virus is acute, height contagiousness respiratory tract disease.It is characterized in that disease pertussis is coughed, sneeze and tracheal rale.Chickling, also can there is watery nasal discharge, laying hen lay eggs reduce and quality change bad.The enlargement of nephropathy reason change type kidney, has urate deposition.
The chicken at each age of primary disease all can fall ill, but chickling is the most serious.Overheated, severe cold, crowded, improper ventilation, vitamin, anti-material and other malnutritions and vaccination etc. all can promote the generation of primary disease.The source of infection of primary disease is disease chicken and is with malicious chicken, and main mode of transmission is droplet infection.In addition, also can pass through feedstuff, drinking-water etc. through alimentary infection.After sick chicken rehabilitation, can be with poison, primary disease, without seasonality, infects rapidly, malnutrition, and feeding and management is improper, sanitary condition is poor, temperature is uncomfortable, improper ventilation, mycoplasma infection, aerosol immunization are improper and transportation, the stressors such as crowded all can impel primary disease to occur.
The natural infection 36h or longer that hides, artificial challenge is 18～36h.Sick chicken often be can't see forerunner's clinical symptom, occurs suddenly breathing clinical symptom, and involves rapidly full group.Neck, mouth breathing are stretched in the normal performance of following chicken in 4 week age, sneeze, cough, rale, and asthenia universalis, lassitude, poor appetite, feather pine is random, lethargy, wing is sagging.Often be crowded together, so as to warming.Indivedual chicken nasal sinuses swelling, stream stickiness nose juice, tear are many, become thin gradually, the dysplasia of rehabilitation chicken.5～6 week age above chicken, outstanding clinical symptom is rale, asthma and micro-coughing, simultaneously with subtracting the symptoms such as food, depressed or dysentery.There is slight respiratory symptom in Adult Chicken, laying hen egg production declines, and produce soft shell list, abnormal-shape egg, " pigeon egg " or thick shell egg.It is bad that the quality of egg becomes, the thin water sample that is of albumen, and egg yolk and Protein Separation and albumen stick together on egg shell membrane surface etc.
The control of livestock and birds respiratory disease is had to the several aspects of vaccine, chemical medicine and Chinese herb prevention haply.Although vaccine immunity program relates to above disease more, the disease of breathing and chicken pass to prop up and still happen occasionally, and Chinese medicine is with its dispelling wind and heat pathogens, clearing lung, relieving asthma, relieving sore throat and diminishing swelling is the rule for the treatment of, can obviously alleviate or effectively remove the lassitude that livestock and birds respiratory disease causes, loss of appetite, fertility performance decline particularly watery nasal discharge, sneeze, cough, trachea rale, tracheitis, bronchitis is the clinical symptoms such as pneumonia even, plays the therapeutic effect for the treatment of both the principal and secondary aspects of a disease.
Therefore, how obtaining a kind of compound Chinese medicinal preparation that can effectively treat livestock and birds respiratory disease, can be again those skilled in the art's technical problem urgently to be resolved hurrily.
Summary of the invention
The object of this invention is to provide a kind of compound Chinese medicinal preparation for the treatment of livestock and birds respiratory disease, it is characterized in that described compound preparation comprises the crude drug of following weight proportion:
Flos Lonicerae 80-120 weight portion Fructus Forsythiae 80-120 weight portion Radix Scutellariae 120-180 weight portion Cortex Mori 80-120 weight portion Fructus Arctii 80-120 weight portion Radix Platycodonis 80-120 weight portion Semen Lepidii (Semen Descurainiae) 80-120 weight portion Cortex Moutan 80-120 weight portion;
Preferably, described crude drug proportioning is
Flos Lonicerae 90-110 weight portion Fructus Forsythiae 90-110 weight portion Radix Scutellariae 140-160 weight portion Cortex Mori 90-110 weight portion Fructus Arctii 90-110 weight portion Radix Platycodonis 90-110 weight portion Semen Lepidii (Semen Descurainiae) 90-110 weight portion Cortex Moutan 90-110 weight portion.
In a preferred embodiment of the present invention, described compound Chinese medicinal preparation comprises or does not comprise other western medicine composition.
On the other hand, described compound Chinese medicinal preparation comprises or does not comprise other Chinese medicinal components.
The present invention also relates to the preparation method of above-mentioned compound Chinese medicinal preparation on the other hand, and described preparation method comprises the steps:
More than the seven flavor medicine material except Radix Scutellariae adds 8-12 times of water gaging decoction, after boiling, add Radix Scutellariae, decoct 3 times, each 1-3h, merges decoction liquor, filter, hold over night, leaching supernatant, be evaporated to relative density 1.05～1.10 (50 ℃), let cool, and adds ethanol, make containing alcohol amount to 55-65%, place, leaching supernatant, reclaims ethanol extremely without alcohol taste, add appropriate potassium sorbate, add water and regulate concentration, filter, lower high temperature sterilize is heated to seethe with excitement, between the clean area of 100000 ranks, let cool sterile filling, obtain.
The present invention also relates to the compound Chinese medicinal preparation of above-mentioned treatment livestock and birds respiratory disease on the other hand in the purposes of preparing in the compound Chinese medicinal preparation for the treatment of livestock and birds respiratory disease.
In a preferred embodiment of the present invention, described livestock and birds respiratory disease is mycoplasma pneumoniae of swine or infectious bronchitis of chicken.
The present invention is by the proportioning of reasonably combined component and component, realize best therapeutic effect, the down in spirits, the inappetence that mainly for mycoplasma pneumoniae of swine, infectious bronchitis of chicken, cause, fertility performance declines, particularly cough, dyspnea, trachea has rale, tracheitis, bronchitis, even pulmonary congestion, edema, pneumonia is in various degree that main clinical disease has great clinical value.
The specific embodiment
Embodiment 1
Prescription and preparation technology
Flos Lonicerae 100g Fructus Forsythiae 100g Radix Scutellariae 150g Cortex Mori 100g Fructus Arctii 100g Radix Platycodonis 100g Semen Lepidii (Semen Descurainiae) 100g Cortex Moutan 100g is according to < < veterinary drug quality of production management regulation > > requirement, and this product technological process of production is:
Crude drug → selection → wash → cut medicine → oven dry → extraction → filtration → concentrated → precipitate with ethanol → dilute → be up to the standards → subpackage → pack → be up to the standards → warehouse-in
Preparation technology: above seven tastes (except Radix Scutellariae) medical material adds 10 times of water gagings and decocts 3 times, each 2h, wherein Radix Scutellariae boil rear under, merge decoction liquor, filter hold over night, leaching supernatant, be evaporated to relative density 1.05～1.10 (50 ℃), let cool, add ethanol, make, containing alcohol amount to 60%, to place, leaching supernatant, reclaim ethanol to without alcohol taste, add 2 Keshan potassium sorbates, add water and be adjusted to 1000mL, filter, lower high temperature (100 ℃) sterilizing that is heated to seethe with excitement, lets cool sterile filling between the clean area of 100,000 ranks, obtains.
Chicken and pig: treatment 1.5mL/kgbw, 7 days courses for the treatment of, drinking-water administration; Preventive dose reduces by half.
Clinical therapeutic efficacy
For infectious bronchitis
The characteristics of incidence of respiratory tract disease in producing for poultry, Pharmacodynamic test of active extract adopt the Massachusetts41 strain (breathing pattern strain) being provided by China Veterinery Drug Inspection Office to carry out challenge test, evaluate its dispelling wind and heat pathogens, clearing lung, relieving asthma, the effect of relieving sore throat and diminishing swelling.
Table 1 test grouping and processing
The variation (mg/mL) of table 2 to IB chicken tracheal mucosa sIgA content
As seen from table, during off-test, compared with positive controls, it is not remarkable with matched group difference that oral liquid can obviously increase respiratory mucosa sIgA secretion (P < 0.05).
The impact of oral liquid on the sick chicken curative effect of IB
The impact of the curative effect of table 3 oral liquid on the sick chicken of IB
After treatment in 7 days finishes, oral liquid can effectively be alleviated disease chicken clinical symptoms compared with positive controls, improves histopathology damage, significantly adds the secretion of sIgA, and its total effective rate is 86.7%, illustrates that oral liquid has good curative effect to chicken biography.
For the therapeutic effect of mycoplasma pneumoniae of swine
The curative effect of table 3 oral liquid to mycoplasma pneumoniae of swine
Invalid: at duration of test, present chicken biography and prop up and mycoplasma pneumoniae of swine typical clinical symptom, spirit is depressed, drives to walk, and appetite significantly declines, cough, trachea rale
Effective: the mental status takes a turn for the better, and appetite is obviously recovered, motion on a small quantity, accidental stream nose liquid, sneeze
Recovery from illness: after medication treatment, it is normal that sick chicken, the sick pig mental status, appetite, drinking-water, breathing, behavior, feces form etc. are recovered; Cut open inspection and observe each internal organs without obvious pathological change, be judged to healing.
Total effective rate: duration of test, after medication treatment, the percentage rate that effective and healing number accounts for this group experimental animal quantity is total effective rate.
Acute toxicity test data
In order to observe the acute toxic reaction of Oral Liquid On Mice, survey its LD
50and maximum tolerated dose, to evaluate its safety.In this test small mouse 1 day, maximum dosage-feeding is equivalent to crude drug amount 204000mg/kgbw, is 160 times of chicken recommended dose, and any toxic reaction, does not appear in Continuous Observation one week.The Ministry of Agriculture's new veterinary drug general toxicity test specification regulation: per os approach single administration amount is actual nontoxic the above person of 5000mg/kgbw.Result shows, oral liquid has good safety, for reality nontoxic.
2. long term toxicity test data
In order to observe, repeat continuously to give the toxic reaction that Oral Liquid On Mice produces, the clinical symptoms and the order of severity that occur at first, the target organ of toxicity and recovery thereof and development are determined nontoxic amounts of reactants, for drafting chicken safe dose, provide reference.In long term toxicity test, respectively with oral liquid high dose group 51g/kgbw, middle dosage group 25.5g/kgbw and the continuous gavage 28 of low dose group 12.75g/kgbw everyday, after drug withdrawal, continue to observe 2 weeks.The each dosage group of result oral liquid Mouse Weight, behavioral activity, hematological indices, blood biochemical learn index, cut open inspection and pathological study and matched group relatively has no significant difference, and the every observation index of convalescent period mice and matched group relatively have no significant change.As can be seen here, under this experimental condition, oral liquid has no obvious long term toxicity effect to animal subject, shows that this medical instrument has good safety.
The above is the preferred embodiments of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of principle of the present invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (6)
1. treat a compound Chinese medicinal preparation for livestock and birds respiratory disease, it is characterized in that described compound preparation comprises the crude drug of following weight proportion:
Flos Lonicerae 80-120 weight portion Fructus Forsythiae 80-120 weight portion Radix Scutellariae 120-180 weight portion Cortex Mori 80-120 weight portion Fructus Arctii 80-120 weight portion Radix Platycodonis 80-120 weight portion Semen Lepidii (Semen Descurainiae) 80-120 weight portion Cortex Moutan 80-120 weight portion;
Preferably, described crude drug proportioning is
Flos Lonicerae 90-110 weight portion Fructus Forsythiae 90-110 weight portion Radix Scutellariae 140-160 weight portion Cortex Mori 90-110 weight portion Fructus Arctii 90-110 weight portion Radix Platycodonis 90-110 weight portion Semen Lepidii (Semen Descurainiae) 90-110 weight portion Cortex Moutan 90-110 weight portion;
Preferably, described compound Chinese medicinal preparation is selected from tablet, capsule, granule, pill, powder, unguentum, sublimed preparation, powder, solution, injection, suppository, spray, drop.
2. compound preparation according to claim 1, described compound Chinese medicinal preparation comprises or does not comprise other western medicine composition.
3. compound preparation according to claim 1, described compound Chinese medicinal preparation comprises or does not comprise other Chinese medicinal components.
4. the preparation method of the compound preparation described in claim 1-3 any one, described preparation method comprises the steps:
More than the seven flavor medicine material except Radix Scutellariae adds 8-12 times of water gaging decoction, after boiling, add Radix Scutellariae, decoct 3 times, each 1-3h, merge decoction liquor, filter, hold over night, leaching supernatant, be evaporated to relative density 1.05～1.10 (50 ℃), let cool, add ethanol, make containing alcohol amount to 55-65%, place, leaching supernatant, reclaim ethanol extremely without alcohol taste, add appropriate potassium sorbate, add water and regulate concentration, filter, lower high temperature sterilize is heated to seethe with excitement, between the clean area of 100000 ranks, let cool sterile filling, obtain extract, optional, described extract and pharmaceutically acceptable carrier are made to tablet, capsule, granule, pill, powder, unguentum, sublimed preparation, powder, solution, injection, suppository, spray, drop.
5. the purposes of the compound preparation described in claim 1-3 any one in the compound Chinese medicinal preparation of preparation treatment livestock and birds respiratory disease.
6. application according to claim 5, described livestock and birds respiratory disease includes but not limited to the respiratory tract disease that mycoplasma pneumoniae of swine or infectious bronchitis of chicken cause.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310507845.5A CN103735638A (en) | 2013-10-25 | 2013-10-25 | Traditional Chinese medicine compound preparation for treating livestock and poultry respiratory tract disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310507845.5A CN103735638A (en) | 2013-10-25 | 2013-10-25 | Traditional Chinese medicine compound preparation for treating livestock and poultry respiratory tract disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103735638A true CN103735638A (en) | 2014-04-23 |
Family
ID=50492753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310507845.5A Pending CN103735638A (en) | 2013-10-25 | 2013-10-25 | Traditional Chinese medicine compound preparation for treating livestock and poultry respiratory tract disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103735638A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11130689A (en) * | 1997-10-27 | 1999-05-18 | Nisshin Flour Milling Co Ltd | Agent for preventing and treating swine disease |
| CN1456341A (en) * | 2003-06-03 | 2003-11-19 | 南京中医药大学 | Lung clearing oral liquid preparation for treating viral pneumonia in Children and preparing method thereof |
| WO2007046643A1 (en) * | 2005-10-19 | 2007-04-26 | Chang Seon Song | Composition comprising an extract of pine needle for preventing and treating animal disease caused by viruses and the use thereof |
| CN101757414A (en) * | 2008-11-07 | 2010-06-30 | 唐超 | Chinese medicinal pill for clearing pharyngeal heat and detoxicating |
| CN102885962A (en) * | 2012-10-30 | 2013-01-23 | 天津生机集团股份有限公司 | Traditional Chinese medicine composition for treating chicken respiratory infectious bronchitis |
-
2013
- 2013-10-25 CN CN201310507845.5A patent/CN103735638A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11130689A (en) * | 1997-10-27 | 1999-05-18 | Nisshin Flour Milling Co Ltd | Agent for preventing and treating swine disease |
| CN1456341A (en) * | 2003-06-03 | 2003-11-19 | 南京中医药大学 | Lung clearing oral liquid preparation for treating viral pneumonia in Children and preparing method thereof |
| WO2007046643A1 (en) * | 2005-10-19 | 2007-04-26 | Chang Seon Song | Composition comprising an extract of pine needle for preventing and treating animal disease caused by viruses and the use thereof |
| CN101757414A (en) * | 2008-11-07 | 2010-06-30 | 唐超 | Chinese medicinal pill for clearing pharyngeal heat and detoxicating |
| CN102885962A (en) * | 2012-10-30 | 2013-01-23 | 天津生机集团股份有限公司 | Traditional Chinese medicine composition for treating chicken respiratory infectious bronchitis |
Non-Patent Citations (3)
| Title |
|---|
| 凌育燊: "鸡呼吸道疾病的中草药防治（续）", 《畜禽业》, no. 11, 31 December 2002 (2002-12-31), pages 28 - 29 * |
| 张素萍: "《中药制药生产技术》", 28 February 2011, article "水提醇沉与醇提水沉工艺技术", pages: 94 * |
| 王鹏: "呼喘清口服液药理临床研究资料", 《HTTP://WWW.DOCIN.COM/P-506467648.HTML》, 24 October 2012 (2012-10-24) * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105641149B (en) | Jingfang toxicity-removing oral liquid and preparation method thereof | |
| CN106138360A (en) | A kind of Chinese medicine composition and preparation method thereof, application | |
| CN101439090A (en) | Formulation containing honeysuckle flower and scutellaria, and uses thereof | |
| CN101209294A (en) | Chinese medicinal granule for animals with cough and asthma relieving efficacy | |
| CN104436142B (en) | A kind of Chinese medicine composition for treating pig epidemic diarrhea | |
| CN109549973A (en) | It is a kind of with treat and prevent livestock and poultry Chinese medicine composition, and its preparation method and application | |
| CN104288217B (en) | A kind of Chinese medicine composition and purposes | |
| CN101601756A (en) | Chinese medicine composition of treatment chicken colibacillosis and preparation method thereof | |
| CN101015615A (en) | Jingfang antiphlogistic powder for treating chicken respiratory infectious bronchitis and its preparing process | |
| CN106822721A (en) | It is a kind of to treat traditional Chinese medicine compound oral liquid of swine enzootic pneumonia and preparation method thereof | |
| CN105535406A (en) | Traditional Chinese medicine composition for preventing and treating livestock respiratory disease | |
| CN109395039A (en) | Chinese medicine composition and preparation method thereof for treating mycoplasma gallinarum | |
| CN103656145B (en) | Medicine being used for the treatment of pig lung plague and preparation method thereof | |
| CN102028798A (en) | Traditional Chinese medicine composite for treating respiratory disease of livestock and poultry | |
| CN101209293A (en) | Chinese medicinal granule with heat-clearing, detoxication, wind-expelling and cold-expelling efficacy | |
| CN103655999B (en) | Medicine of control bird flu and preparation method thereof | |
| CN103142702A (en) | Chinese herbal medicine injection liquid for treating porcine reproductive and respiratory syndrome and preparation method thereof | |
| CN103735638A (en) | Traditional Chinese medicine compound preparation for treating livestock and poultry respiratory tract disease | |
| CN101972325A (en) | Medicament composition for treating chick coccidiosis and preparation method thereof | |
| CN113813306B (en) | Traditional Chinese medicine composition for preventing and treating infectious rhinitis of chicken | |
| CN108524746A (en) | A kind of Chinese medicine composition of prevention fowl cough | |
| CN107789394A (en) | A kind of composition for being used to treat livestock and poultry diarrhea | |
| CN103041124A (en) | Medicament for treating avian infectious bronchitis and preparation method thereof | |
| CN104353053A (en) | Traditional Chinese medicine composition for treating swine mycoplasmal pneumonia and preparation method thereof | |
| CN107952001A (en) | A kind of Chinese and western medicinal composition that blue otopathy is broken out for child care pig and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140423 |