CN103732065B - 用于治疗丙型肝炎病毒感染的苯并呋喃化合物 - Google Patents

用于治疗丙型肝炎病毒感染的苯并呋喃化合物 Download PDF

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Publication number
CN103732065B
CN103732065B CN201280040219.3A CN201280040219A CN103732065B CN 103732065 B CN103732065 B CN 103732065B CN 201280040219 A CN201280040219 A CN 201280040219A CN 103732065 B CN103732065 B CN 103732065B
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China
Prior art keywords
cyclopropyl
mmol
fluorophenyl
methylsulfonylamino
benzofuran
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Expired - Fee Related
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CN201280040219.3A
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English (en)
Chinese (zh)
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CN103732065A (zh
Inventor
P.Y.聪
J.F.米勒
A.J.皮特
J.B.肖特维尔
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Glaxo Group Ltd
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Glaxo Group Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201280040219.3A 2011-08-19 2012-08-10 用于治疗丙型肝炎病毒感染的苯并呋喃化合物 Expired - Fee Related CN103732065B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161525440P 2011-08-19 2011-08-19
US61/525440 2011-08-19
US201261650681P 2012-05-23 2012-05-23
US61/650681 2012-05-23
PCT/US2012/050268 WO2013028371A1 (en) 2011-08-19 2012-08-10 Benzofuran compounds for the treatment of hepatitis c virus infections

Publications (2)

Publication Number Publication Date
CN103732065A CN103732065A (zh) 2014-04-16
CN103732065B true CN103732065B (zh) 2016-10-26

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CN201280040219.3A Expired - Fee Related CN103732065B (zh) 2011-08-19 2012-08-10 用于治疗丙型肝炎病毒感染的苯并呋喃化合物

Country Status (38)

Country Link
US (2) US8927593B2 (enExample)
EP (2) EP2744332B1 (enExample)
JP (2) JP6367712B2 (enExample)
KR (1) KR101913800B1 (enExample)
CN (1) CN103732065B (enExample)
AR (1) AR087563A1 (enExample)
AU (1) AU2012299295B2 (enExample)
BR (1) BR112014002845A2 (enExample)
CA (1) CA2844086A1 (enExample)
CL (2) CL2014000393A1 (enExample)
CO (1) CO6862153A2 (enExample)
CR (1) CR20140078A (enExample)
CY (1) CY1118399T1 (enExample)
DK (1) DK2744332T3 (enExample)
DO (1) DOP2014000034A (enExample)
EA (1) EA032841B1 (enExample)
ES (1) ES2611731T3 (enExample)
HR (1) HRP20161743T1 (enExample)
HU (1) HUE030300T2 (enExample)
IL (1) IL230487B (enExample)
IN (1) IN2014CN00572A (enExample)
JO (1) JO3281B1 (enExample)
LT (1) LT2744332T (enExample)
MA (1) MA35443B1 (enExample)
ME (1) ME02588B (enExample)
MX (1) MX354676B (enExample)
PE (1) PE20141201A1 (enExample)
PH (1) PH12014500385A1 (enExample)
PL (1) PL2744332T3 (enExample)
PT (1) PT2744332T (enExample)
RS (1) RS55462B1 (enExample)
SG (1) SG10201606883QA (enExample)
SI (1) SI2744332T1 (enExample)
SM (2) SMT201700028T1 (enExample)
TW (1) TWI538915B (enExample)
UY (1) UY34274A (enExample)
WO (1) WO2013028371A1 (enExample)
ZA (1) ZA201401020B (enExample)

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SG10201606646RA (en) * 2011-08-17 2016-09-29 Glaxosmithkline Llc Therapeutic methods
BR112014002845A2 (pt) 2011-08-19 2017-02-21 Glaxo Group Ltd “composto, sal farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto”
MX2017006140A (es) * 2014-11-10 2017-11-16 Glaxosmithkline Intellectual Property (No 2) Ltd Composiciones de accion prolongada de combinacion y métodos para hepatitis c.
CA2967185A1 (en) * 2014-11-10 2016-05-19 Glaxosmithkline Intellectual Property (No.2) Limited Long acting pharmaceutical compositions for hepatitis c
KR20180006522A (ko) 2016-07-07 2018-01-18 삼성디스플레이 주식회사 액정 조성물 및 이를 포함하는 액정 표시 장치
WO2018026656A1 (en) * 2016-08-01 2018-02-08 University Of Pittsburgh -Of The Commonwealth System Of Higher Education Boryl ethers, carbonates, and cyclic acetals as oxidatively-triggered drug delivery vehicles
ES2898217T3 (es) * 2017-03-02 2022-03-04 Assembly Biosciences Inc Compuestos de sulfamida cíclica y métodos de uso de los mismos
UY38051A (es) * 2018-01-17 2019-08-30 Glaxosmithkline Ip Dev Ltd INHIBIDORES DE LA PI4KIIIß
PH12022550983A1 (en) * 2019-10-25 2023-10-09 Sumitomo Pharma Co Ltd Novel substituted condensed ring compound
CN111026203B (zh) * 2019-12-02 2021-01-26 宁波德晶元科技有限公司 一种适用于真空热水壶的加热控制方法与系统

Citations (4)

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WO2001002424A2 (en) * 1999-07-07 2001-01-11 Du Pont Pharmaceuticals Company Peptide boronic acid inhibitors of hepatitis c virus protease
CN1731993A (zh) * 2002-11-01 2006-02-08 维洛药品公司 苯并呋喃化合物、组合物以及治疗和预防丙型肝炎病毒感染及相关疾病的方法
CN101336236A (zh) * 2005-12-01 2008-12-31 惠氏公司 用于治疗丙型肝炎病毒感染的邻氨基苯甲酸衍生物
CN102015606A (zh) * 2007-06-08 2011-04-13 满康德股份有限公司 IRE-1α抑制剂

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DE60239384D1 (de) 2001-01-25 2011-04-21 Us Of America Represented By The Secretary Dept Of Health And Human Services Formulierungen von borsäure-verbindungen
RS54108B1 (sr) 2006-02-16 2015-12-31 Anacor Pharmaceuticals Inc. Mali molekuli koji sadrže boron kao agensi protiv zapaljenja
JP2009536660A (ja) * 2006-05-02 2009-10-15 アナコール ファーマシューティカルズ，インコーポレイテッド 加水分解耐性ホウ素含有治療剤及びその使用方法
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001002424A2 (en) * 1999-07-07 2001-01-11 Du Pont Pharmaceuticals Company Peptide boronic acid inhibitors of hepatitis c virus protease
CN1731993A (zh) * 2002-11-01 2006-02-08 维洛药品公司 苯并呋喃化合物、组合物以及治疗和预防丙型肝炎病毒感染及相关疾病的方法
CN101336236A (zh) * 2005-12-01 2008-12-31 惠氏公司 用于治疗丙型肝炎病毒感染的邻氨基苯甲酸衍生物
CN102015606A (zh) * 2007-06-08 2011-04-13 满康德股份有限公司 IRE-1α抑制剂

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PH12014500385A1 (en) 2020-06-22
EP2744332A4 (en) 2015-01-14
EP2744332A1 (en) 2014-06-25
US9682999B2 (en) 2017-06-20
DOP2014000034A (es) 2014-06-01
CN103732065A (zh) 2014-04-16
IN2014CN00572A (enExample) 2015-04-03
HRP20161743T1 (hr) 2017-02-24
IL230487A0 (en) 2014-03-31
EA201490213A1 (ru) 2014-07-30
SMT201700028B (it) 2017-03-08
ZA201401020B (en) 2020-11-25
SG10201606883QA (en) 2016-10-28
CL2014000393A1 (es) 2014-08-01
AU2012299295B2 (en) 2016-03-31
ME02588B (me) 2017-06-20
PL2744332T3 (pl) 2017-03-31
SMT201700028T1 (it) 2017-03-08
SI2744332T1 (sl) 2017-01-31
AR087563A1 (es) 2014-04-03
CA2844086A1 (en) 2013-02-28
HUE030300T2 (en) 2017-04-28
UY34274A (es) 2013-04-05
EA032841B1 (ru) 2019-07-31
AU2012299295A1 (en) 2014-02-20
EP3199531A1 (en) 2017-08-02
IL230487B (en) 2019-06-30
US20130237501A1 (en) 2013-09-12
JP2014527529A (ja) 2014-10-16
ES2611731T3 (es) 2017-05-10
CL2017000293A1 (es) 2017-10-06
JP6367712B2 (ja) 2018-08-01
CR20140078A (es) 2014-03-20
KR20140054287A (ko) 2014-05-08
JP2017125010A (ja) 2017-07-20
CO6862153A2 (es) 2014-02-10
MX354676B (es) 2018-03-15
EP2744332B1 (en) 2016-10-26
DK2744332T3 (en) 2017-01-16
RS55462B1 (sr) 2017-04-28
LT2744332T (lt) 2017-01-10
US8927593B2 (en) 2015-01-06
CY1118399T1 (el) 2017-06-28
KR101913800B1 (ko) 2018-11-01
MX2014001989A (es) 2014-02-27
BR112014002845A2 (pt) 2017-02-21
TW201321390A (zh) 2013-06-01
MA35443B1 (fr) 2014-09-01
PE20141201A1 (es) 2014-10-03
PT2744332T (pt) 2017-01-24
TWI538915B (zh) 2016-06-21
WO2013028371A1 (en) 2013-02-28
US20150080343A1 (en) 2015-03-19
JO3281B1 (ar) 2018-09-16

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