CN103705896B - A kind of externally-applied medicinal composition of hair growth and application thereof - Google Patents
A kind of externally-applied medicinal composition of hair growth and application thereof Download PDFInfo
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- CN103705896B CN103705896B CN201410000799.4A CN201410000799A CN103705896B CN 103705896 B CN103705896 B CN 103705896B CN 201410000799 A CN201410000799 A CN 201410000799A CN 103705896 B CN103705896 B CN 103705896B
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- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 230000003779 hair growth Effects 0.000 title claims abstract description 18
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 12
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 26
- 239000012567 medical material Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 13
- 238000004321 preservation Methods 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 229940040145 liniment Drugs 0.000 claims description 3
- 239000000865 liniment Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 4
- 230000004936 stimulating effect Effects 0.000 abstract description 4
- 235000015097 nutrients Nutrition 0.000 abstract description 3
- 201000004384 Alopecia Diseases 0.000 description 15
- 231100000360 alopecia Toxicity 0.000 description 11
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 208000001840 Dandruff Diseases 0.000 description 2
- 241000218231 Moraceae Species 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- 235000008708 Morus alba Nutrition 0.000 description 2
- 201000002996 androgenic alopecia Diseases 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 206010049865 Achromotrichia acquired Diseases 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000008706 Ilex latifolia Nutrition 0.000 description 1
- 244000078118 Ilex latifolia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 241000576755 Sclerotia Species 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 206010068168 androgenetic alopecia Diseases 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 241001233957 eudicotyledons Species 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000003752 improving hair Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 208000037922 refractory disease Diseases 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of externally-applied medicinal composition and application thereof of hair growth, this externally-applied medicinal composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Folium Mori 10-20 part, Herba speranskiae tuberculatae 22-30 part, Cortex Ilicis Rotundae 32-48 part, Radix Paeoniae Alba 10-20 part, Ramulus Mori 10-20 part, Herba Taraxaci 32-48 part, Poria 32-48 part, Rhizoma Zingiberis 6-10 part.Externally-applied medicinal composition of the present invention can promote that hair root nutrients absorbs, stimulating hair growth, the curative effect highly significant of hair growth.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of externally-applied medicinal composition and application thereof of hair growth.
Background technology
Seborrheic alopecia (Seborrheicalopecia, SA) androgenetic alopecia (Androgenicalopecia is had another name called, AGA), often show as the gradual alopecia that hair is greasy, consider more, have obvious scratchiness, E Nie district and top to be worth doing, then form great number.Seborrheic alopecia be apt to occur in 20-30 year male between twenty and fifty, also known as male pattern alopecia (prematurealopecia).Seborrheic alopecia is clinical commonly encountered diseases, the frequently-occurring disease of department of dermatologry, is also one of refractory disease.Because primary disease hinders appearance, affect attractive in appearance, often bring very large stress and psychological burden to patient, therefore the treatment of seborrheic alopecia is seemed particularly important.
Summary of the invention
The object of the present invention is to provide a kind of externally-applied medicinal composition and application of hair growth.This externally-applied medicinal composition is as secret prescription handed down in the family from generation to generation, and can promote that hair root nutrients absorbs, stimulating hair growth, be a kind of specific drug of hair growth.
The object of the present invention is achieved like this:
An externally-applied medicinal composition for hair growth, it is prepared from by the traditional Chinese medicinal material raw materials comprising following weight portion: Folium Mori 10-20 part, Herba speranskiae tuberculatae 22-30 part, Cortex Ilicis Rotundae 32-48 part, Radix Paeoniae Alba 10-20 part, Ramulus Mori 10-20 part, Herba Taraxaci 32-48 part, Poria 32-48 part, Rhizoma Zingiberis 6-10 part.
Preferably, the externally-applied medicinal composition of hair growth as above, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Folium Mori 13-17 part, Herba speranskiae tuberculatae 25-27 part, Cortex Ilicis Rotundae 38-42 part, Radix Paeoniae Alba 13-17 part, Ramulus Mori 13-17 part, Herba Taraxaci 38-42 part, Poria 38-42 part, Rhizoma Zingiberis 7-9 part.
In a most preferred embodiment of the present invention, the externally-applied medicinal composition of hair growth as above is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 15 parts, Folium Mori, Herba speranskiae tuberculatae 26 parts, Cortex Ilicis Rotundae 40 parts, the Radix Paeoniae Alba 15 parts, Ramulus Mori 15 parts, Herba Taraxaci 40 parts, 40 parts, Poria, Rhizoma Zingiberis 8 parts.
Further preferably, the externally-applied medicinal composition of hair growth of the present invention is liniment.
Found by experimental study, externally-applied medicinal composition of the present invention can promote that hair root nutrients absorbs, stimulating hair growth, for the symptom effect highly significant improving hair loss patient.Therefore, second object of the present invention is to provide a kind of pharmaceutical applications, i.e. the application of above-mentioned externally-applied medicinal composition in the external used medicine preparing hair growth; Especially, the application of above-mentioned externally-applied medicinal composition in the external used medicine of preparation treatment seborrheic alopecia.
The preparation method of the externally-applied medicinal composition that the present invention relates to comprises the steps: to get the Folium Mori of recipe quantity, Herba speranskiae tuberculatae, Cortex Ilicis Rotundae, the Radix Paeoniae Alba, Ramulus Mori, Herba Taraxaci, Poria and Rhizoma Zingiberis, cleans roguing, dries, pulverize; Again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, the water of first time totalling medical material 8-10 times amount, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 6-8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL; Concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
Affected part treatment seborrheic alopecia is put on the skin quite effective in cure outside externally-applied medicinal composition of the present invention, its have action time short, curative effect obviously, life-time service the advantage such as to have no side effect, the object that control is oily, antipruritic, anti-dandruff can be reached after this medicine external simultaneously, can to releive to a certain extent scalp, promote scalp blood circulation, make hair recover gloss, its mechanism of action may be relevant with inspiring root alimentation, stimulating hair growth etc.
Detailed description of the invention
The traditional Chinese medicinal material raw materials source that the present invention adopts is as follows: Folium Mori select the dried leaves of Moraceae Moraceae plant Mulberry MorusalbaL..Herba speranskiae tuberculatae is selected from the dry young stem and leaf of leguminous plant Herba Viciae Amoenae.Cortex Ilicis Rotundae: the dry blade selecting Cortex Ilicis Rotundae IlexlatifoliaThunb..The Radix Paeoniae Alba selects the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).Ramulus Mori selects the dry twig of moraceae plants Mulberry MorusalbaL..Herba Taraxaci selects the herb of dry Herba Taraxaci.On Polyporaceae Poria Poriacocos(Schw. selected by Poria) dry sclerotia of Wolf.Rhizoma Zingiberis selects the dry rhizome of zingiber ZingiberofficinaleRosc..
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Get 15 parts, Folium Mori, Herba speranskiae tuberculatae 26 parts, Cortex Ilicis Rotundae 40 parts, the Radix Paeoniae Alba 15 parts, Ramulus Mori 15 parts, Herba Taraxaci 40 parts, 40 parts, Poria, Rhizoma Zingiberis 8 parts, clean roguing, dry, pulverize; Again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 10 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL; Concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
Embodiment 2
Get 20 parts, Folium Mori, Herba speranskiae tuberculatae 22 parts, Cortex Ilicis Rotundae 38 parts, the Radix Paeoniae Alba 17 parts, Ramulus Mori 10 parts, Herba Taraxaci 48 parts, 40 parts, Poria and Rhizoma Zingiberis 10 parts, clean roguing, dry, pulverize; Again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 8 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL; Concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
Embodiment 3
Get 12 parts, Folium Mori, Herba speranskiae tuberculatae 30 parts, Cortex Ilicis Rotundae 48 parts, the Radix Paeoniae Alba 13 parts, Ramulus Mori 18 parts, Herba Taraxaci 32 parts, 45 parts, Poria, Rhizoma Zingiberis 6 parts, clean roguing, dry, pulverize; Again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 8 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 6 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL; Concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
Embodiment 4 Chinese medicine is to the effectiveness study of seborrheic alopecia patient
43 routine seborrheic alopecia patients, man 35 example, female 8 example; Minimum 24 years old of age of onset, maximum 46 years old; The most elder of the course of disease reaches 17 years, the shortest person half a year, and average course of disease is 3.6 years.Patient is except the symptom of alopecia, and skin lesion place hair is often greasy shinny, has a large amount of dandruff, the broken little pityrosporum shape in canescence, conscious pruritus.After treatment starts, all patients wipe Traditional Chinese medicine liniment (medicinal liquid prepared by prescription and the technique of the embodiment of the present invention 1) outward, and when embrocating, conscious skin has heating sense, and every day 3-5 time, each 1-5 minute 1 month is a course for the treatment of, 5 courses for the treatment of of continuous use.After treatment terminates, carry out curative effect statistical analysis by following evaluation criteria:
Recovery from illness: hair stops coming off, new sending out all grows, and its distribution density, thickness, color and luster are identical with Jian Fa district, and sebum secretion recovers normal;
Effective: hair stops coming off, a new regeneration reaches more than 70%, and its density, thickness and color and luster are all close to Jian Fa district, and sebum secretion obviously reduces;
Effective: hair stops coming off, new send out regeneration and reach more than 30%, comprise fine hair on birds or animals hair and poliosis grows;
Invalid: new sending out regenerates less than 30% or still continue de-originator.
Clinical efficacy is by above standard determination, and result is that 43 routine seborrheic alopecia patients fully recover 7 examples, accounts for 16.3%; Effective 16 examples, account for 37.2%; Effective 14 examples, account for 32.6%; Invalid 6 examples, account for 13.9%; Total effective rate is 86.1%.
Claims (2)
1. an externally-applied medicinal composition for hair growth, is characterized in that described externally-applied medicinal composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 15 parts, Folium Mori, Herba speranskiae tuberculatae 26 parts, Cortex Ilicis Rotundae 40 parts, the Radix Paeoniae Alba 15 parts, Ramulus Mori 15 parts, Herba Taraxaci 40 parts, 40 parts, Poria, Rhizoma Zingiberis 8 parts; Described externally-applied medicinal composition is obtained by following preparation method: get the Folium Mori of recipe quantity, Herba speranskiae tuberculatae, Cortex Ilicis Rotundae, the Radix Paeoniae Alba, Ramulus Mori, Herba Taraxaci, Poria and Rhizoma Zingiberis, cleans roguing, dries, and pulverizes; Again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put in multi-function extractor and decoct with water secondary, first time adds up the water of medical material 8-10 times amount, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 6-8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15g/mL; Concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, obtains medicinal liquid.
2. the externally-applied medicinal composition of hair growth according to claim 1, is characterized in that: described externally-applied medicinal composition is liniment.
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| CN103705896B true CN103705896B (en) | 2016-03-30 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249146A (en) * | 2008-04-17 | 2008-08-27 | 房宁 | Hair-growing and hair care Chinese medicinal composition |
| CN103212040A (en) * | 2013-03-22 | 2013-07-24 | 孙胜波 | Chinese medicinal composition for treatment of seborrheic alopecia |
| CN103386111A (en) * | 2013-08-05 | 2013-11-13 | 谢明臣 | Special prescription for seborrhoeic alopecia |
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- 2014-01-02 CN CN201410000799.4A patent/CN103705896B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249146A (en) * | 2008-04-17 | 2008-08-27 | 房宁 | Hair-growing and hair care Chinese medicinal composition |
| CN103212040A (en) * | 2013-03-22 | 2013-07-24 | 孙胜波 | Chinese medicinal composition for treatment of seborrheic alopecia |
| CN103386111A (en) * | 2013-08-05 | 2013-11-13 | 谢明臣 | Special prescription for seborrhoeic alopecia |
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