CN103705896A - External use medicine composition for treating alopecia and application thereof - Google Patents
External use medicine composition for treating alopecia and application thereof Download PDFInfo
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- CN103705896A CN103705896A CN201410000799.4A CN201410000799A CN103705896A CN 103705896 A CN103705896 A CN 103705896A CN 201410000799 A CN201410000799 A CN 201410000799A CN 103705896 A CN103705896 A CN 103705896A
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- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 201000004384 Alopecia Diseases 0.000 title claims abstract description 22
- 231100000360 alopecia Toxicity 0.000 title claims abstract description 18
- 239000003814 drug Substances 0.000 title claims abstract description 17
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 13
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 230000003779 hair growth Effects 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 229940040145 liniment Drugs 0.000 claims description 3
- 239000000865 liniment Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 4
- 235000008706 Ilex latifolia Nutrition 0.000 abstract description 2
- 244000078118 Ilex latifolia Species 0.000 abstract description 2
- 244000273928 Zingiber officinale Species 0.000 abstract description 2
- 235000006886 Zingiber officinale Nutrition 0.000 abstract description 2
- 235000008397 ginger Nutrition 0.000 abstract description 2
- 244000018716 Impatiens biflora Species 0.000 abstract 1
- 235000015912 Impatiens biflora Nutrition 0.000 abstract 1
- 235000005155 Tanacetum balsamita Nutrition 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 210000003813 thumb Anatomy 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 21
- 239000012567 medical material Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 238000004321 preservation Methods 0.000 description 8
- 229940079593 drug Drugs 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 230000004936 stimulating effect Effects 0.000 description 3
- 208000001840 Dandruff Diseases 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- 201000002996 androgenic alopecia Diseases 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 206010049865 Achromotrichia acquired Diseases 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 241000576755 Sclerotia Species 0.000 description 1
- 206010068168 androgenetic alopecia Diseases 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 241001233957 eudicotyledons Species 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 208000037922 refractory disease Diseases 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000001841 zingiber officinale Substances 0.000 description 1
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- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to an external use medicine composition for treating alopecia and application thereof. The external use medicine composition is prepared from the following traditional Chinese herbs in parts by weight: 10-20 parts of folium mori, 22-30 parts of garden balsam stem, 32-48 parts of Ilex latifolia thumb, 10-20 parts of radix paeoniae alba, 10-20 parts of ramulus mori, 32-48 parts of dandelion, 32-48 parts of poria, and 6-10 parts of dried ginger. The external use medicine composition can promote the hair root to absorb nutrient and stimulate the hair to grow, and has remarkable effect on curing alopecia.
Description
Technical field
The invention belongs to Chinese medicine technical field, be specifically related to a kind of externally-applied medicinal composition and application thereof of hair growth.
Background technology
Seborrheic alopecia (Seborrheic alopecia, SA) have another name called androgenetic alopecia (Androgenicalopecia, AGA), often show as the gradual alopecia that hair is greasy, consider more, have obvious scratchiness, E Nie district and top to be worth doing, then form great number.It is between twenty and fifty that seborrheic alopecia is apt to occur in the male in 20-30 year, also claims male pattern alopecia (premature alopecia).Seborrheic alopecia is the clinical commonly encountered diseases of department of dermatologry, frequently-occurring disease, is also one of refractory disease.Because primary disease hinders appearance, affect attractive in appearancely, often to patient, bring very large stress and psychological burden, therefore the treatment of seborrheic alopecia is seemed to particularly important.
Summary of the invention
The object of the present invention is to provide a kind of externally-applied medicinal composition and application of hair growth.This externally-applied medicinal composition, as secret prescription handed down in the family from generation to generation, can promote root of hair alimentation, stimulating hair growth, is a kind of specific drug of hair growth.
The object of the present invention is achieved like this:
An externally-applied medicinal composition for hair growth, it is prepared from by the traditional Chinese medicinal material raw materials that comprises following weight portion: Folium Mori 10-20 part, Herba speranskiae tuberculatae 22-30 part, Cortex Ilicis Rotundae 32-48 part, Radix Paeoniae Alba 10-20 part, Ramulus Mori 10-20 part, Herba Taraxaci 32-48 part, Poria 32-48 part, Rhizoma Zingiberis 6-10 part.
Preferably, the externally-applied medicinal composition of hair growth as above, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Folium Mori 13-17 part, Herba speranskiae tuberculatae 25-27 part, Cortex Ilicis Rotundae 38-42 part, Radix Paeoniae Alba 13-17 part, Ramulus Mori 13-17 part, Herba Taraxaci 38-42 part, Poria 38-42 part, Rhizoma Zingiberis 7-9 part.
In a most preferred embodiment of the present invention, the externally-applied medicinal composition of hair growth as above is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 15 parts, Folium Mori, 26 parts of Herba speranskiae tuberculataes, 40 parts of Cortex Ilicis Rotundaes, 15 parts of the Radix Paeoniae Albas, 15 parts of Ramulus Moris, 40 parts of Herba Taraxacis, 40 parts, Poria, 8 parts of Rhizoma Zingiberiss.
Further preferably, the externally-applied medicinal composition of hair growth of the present invention is liniment.
By experimental study, find, externally-applied medicinal composition of the present invention can promote root of hair alimentation, stimulating hair growth, for the symptom effect highly significant that improves hair loss patient.Therefore, second object of the present invention is to provide a kind of pharmaceutical applications, i.e. the application of above-mentioned externally-applied medicinal composition in preparing the external used medicine of hair growth; Especially, the above-mentioned externally-applied medicinal composition application in the external used medicine of preparation treatment seborrheic alopecia.
The preparation method of the externally-applied medicinal composition the present invention relates to comprises the steps: to get Folium Mori, Herba speranskiae tuberculatae, Cortex Ilicis Rotundae, the Radix Paeoniae Alba, Ramulus Mori, Herba Taraxaci, Poria and the Rhizoma Zingiberis of recipe quantity, cleans roguing, dries, and pulverizes; Again above-mentioned graininess medical material is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water that medical material 8-10 doubly measures, decoct 2h, get decocting liquid, filter, add up for the second time the water that medical material 6-8 doubly measures, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.15g/mL; Concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 ℃ of deepfreeze 24h to every milliliter, and cold preservation liquid is filtered, and obtains medicinal liquid.
It is quite effective in cure that externally-applied medicinal composition of the present invention is put affected part treatment seborrheic alopecia outward on the skin, its have action time short, curative effect obviously, the life-time service advantage such as have no side effect, after this medicine external, can reach oily, antipruritic, the anti-dandruff object of control simultaneously, the scalp of can releiving to a certain extent, promote scalp blood circulation, make hair recover gloss, its mechanism of action may be with to inspire root alimentation, stimulating hair growth etc. relevant.
The specific embodiment
The traditional Chinese medicinal material raw materials source that the present invention adopts is as follows: Folium Mori are selected the dried leaves of Moraceae Moraceae plant Mulberry Morus alba L..Herba speranskiae tuberculatae is selected from the dry young stem and leaf of leguminous plant Herba Viciae Amoenae.Cortex Ilicis Rotundae: the dry blade of selecting Cortex Ilicis Rotundae Ilex latifolia Thunb..The Radix Paeoniae Alba is selected the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).Ramulus Mori is selected the dry twig of moraceae plants Mulberry Morus alba L..Herba Taraxaci is selected the herb of dry Herba Taraxaci.Poria is selected the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Rhizoma Zingiberis is selected the dry rhizome of zingiber Zingiber officinale Rosc..
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment 1
Get 15 parts, Folium Mori, 26 parts of Herba speranskiae tuberculataes, 40 parts of Cortex Ilicis Rotundaes, 15 parts of the Radix Paeoniae Albas, 15 parts of Ramulus Moris, 40 parts of Herba Taraxacis, 40 parts, Poria, 8 parts of Rhizoma Zingiberiss, clean roguing, dry, pulverize; Again above-mentioned graininess medical material is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 10 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 8 times of amounts of medical material, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.15g/mL; Concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 ℃ of deepfreeze 24h to every milliliter, and cold preservation liquid is filtered, and obtains medicinal liquid.
Embodiment 2
Get 10 parts of 20 parts, Folium Mori, 22 parts of Herba speranskiae tuberculataes, 38 parts of Cortex Ilicis Rotundaes, 17 parts of the Radix Paeoniae Albas, 10 parts of Ramulus Moris, 48 parts of Herba Taraxacis, 40 parts, Poria and Rhizoma Zingiberiss, clean roguing, dry, pulverize; Again above-mentioned graininess medical material is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 8 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 8 times of amounts of medical material, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.15g/mL; Concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 ℃ of deepfreeze 24h to every milliliter, and cold preservation liquid is filtered, and obtains medicinal liquid.
Embodiment 3
Get 12 parts, Folium Mori, 30 parts of Herba speranskiae tuberculataes, 48 parts of Cortex Ilicis Rotundaes, 13 parts of the Radix Paeoniae Albas, 18 parts of Ramulus Moris, 32 parts of Herba Taraxacis, 45 parts, Poria, 6 parts of Rhizoma Zingiberiss, clean roguing, dry, pulverize; Again above-mentioned graininess medical material is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 8 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 6 times of amounts of medical material, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.15g/mL; Concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 5g crude drug amount, sets to 0-5 ℃ of deepfreeze 24h to every milliliter, and cold preservation liquid is filtered, and obtains medicinal liquid.
The effectiveness study of embodiment 4 Chinese medicines to seborrheic alopecia patient
43 routine seborrheic alopecia patients, male 35 examples, female's 8 examples; Minimum 24 years old of age of onset, maximum 46 years old; The elder of the course of disease reaches 17 years, and the shortest person half a year, average course of disease is 3.6 years.Patient is except the symptom of alopecia, and skin lesion place hair is often greasy shinny, has a large amount of dandruff, is the broken little pityrosporum shape of canescence, conscious pruritus.After treatment starts, all patients wipe Traditional Chinese medicine liniment (medicinal liquid of preparing by the prescription of the embodiment of the present invention 1 and technique) outward, and while embrocating, conscious skin has heating sense, and every day 3-5 time, 1-5 minute, 1 month is a course for the treatment of at every turn, 5 courses for the treatment of of continuous use.After treatment finishes, by following evaluation criteria, carry out curative effect statistical analysis:
Recovery from illness: hair stops coming off, newly all grows, and its distribution density, thickness, color and luster Yu Jianfa district are identical, and it is normal that sebum secretion recovers;
Effective: hair stops coming off, new regeneration reaches more than 70%, and its density, thickness and color and luster all approach Jian Fa district, and sebum secretion obviously reduces;
Effective: hair stops coming off, new regeneration reaches more than 30%, comprises that fine hair on birds or animals hair and poliosis grow;
Invalid: new regeneration less than 30% or still continue alopecia person.
Clinical efficacy is by above standard determination, and result is 43 routine seborrheic alopecia patients, 7 examples of fully recovering, and accounts for 16.3%; Effective 16 examples, account for 37.2%; Effective 14 examples, account for 32.6%; Invalid 6 examples, account for 13.9%; Total effective rate is 86.1%.
Claims (6)
1. an externally-applied medicinal composition for hair growth, is characterized in that described externally-applied medicinal composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Folium Mori 10-20 part, Herba speranskiae tuberculatae 22-30 part, Cortex Ilicis Rotundae 32-48 part, Radix Paeoniae Alba 10-20 part, Ramulus Mori 10-20 part, Herba Taraxaci 32-48 part, Poria 32-48 part, Rhizoma Zingiberis 6-10 part.
2. the externally-applied medicinal composition of hair growth according to claim 1, is characterized in that described externally-applied medicinal composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Folium Mori 13-17 part, Herba speranskiae tuberculatae 25-27 part, Cortex Ilicis Rotundae 38-42 part, Radix Paeoniae Alba 13-17 part, Ramulus Mori 13-17 part, Herba Taraxaci 38-42 part, Poria 38-42 part, Rhizoma Zingiberis 7-9 part.
3. the externally-applied medicinal composition of hair growth according to claim 2, is characterized in that described externally-applied medicinal composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 15 parts, Folium Mori, 26 parts of Herba speranskiae tuberculataes, 40 parts of Cortex Ilicis Rotundaes, 15 parts of the Radix Paeoniae Albas, 15 parts of Ramulus Moris, 40 parts of Herba Taraxacis, 40 parts, Poria, 8 parts of Rhizoma Zingiberiss.
4. according to the externally-applied medicinal composition of hair growth described in claim 1-3 any one, it is characterized in that: described externally-applied medicinal composition is liniment.
5. the application of the compositions described in claim 1-3 any one in preparing the external used medicine of hair growth.
6. the application of the compositions described in claim 1-3 any one in the external used medicine of preparation treatment seborrheic alopecia.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410000799.4A CN103705896B (en) | 2014-01-02 | 2014-01-02 | A kind of externally-applied medicinal composition of hair growth and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410000799.4A CN103705896B (en) | 2014-01-02 | 2014-01-02 | A kind of externally-applied medicinal composition of hair growth and application thereof |
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| CN103705896B CN103705896B (en) | 2016-03-30 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249146A (en) * | 2008-04-17 | 2008-08-27 | 房宁 | Hair-growing and hair care Chinese medicinal composition |
| CN103212040A (en) * | 2013-03-22 | 2013-07-24 | 孙胜波 | Chinese medicinal composition for treatment of seborrheic alopecia |
| CN103386111A (en) * | 2013-08-05 | 2013-11-13 | 谢明臣 | Special prescription for seborrhoeic alopecia |
-
2014
- 2014-01-02 CN CN201410000799.4A patent/CN103705896B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249146A (en) * | 2008-04-17 | 2008-08-27 | 房宁 | Hair-growing and hair care Chinese medicinal composition |
| CN103212040A (en) * | 2013-03-22 | 2013-07-24 | 孙胜波 | Chinese medicinal composition for treatment of seborrheic alopecia |
| CN103386111A (en) * | 2013-08-05 | 2013-11-13 | 谢明臣 | Special prescription for seborrhoeic alopecia |
Non-Patent Citations (3)
| Title |
|---|
| 童知秋: "《中华养生文化大百科》", 30 June 2010, article "透骨草汤", pages: 870 * |
| 陈企望等: "《临床常用中药手册》", 31 October 1994, article "苦丁茶", pages: 51 * |
| 陈暖: "《很老很老的老偏方大全集》", 31 August 2012, article "桑叶，自然力量破除脱发"魔咒"", pages: 35-36 * |
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