CN103933356A - Preoperative intervention medicine composition for neurosurgery and preparation method of composition - Google Patents
Preoperative intervention medicine composition for neurosurgery and preparation method of composition Download PDFInfo
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Abstract
The invention discloses a preoperative intervention medicine composition for neurosurgery and a preparation method of the composition so as to solve the problem of prevention of shiver after idiopathic general anesthesia. The preparation method of the preoperative intervention medicine composition is characterized by comprising the following steps: (1) respectively distilling sarcandra glabra, changnienia amoena, irkutsk anemone rhizome, poncirus bark, fragrant sarcococca herb and asarum forbesii coarse powder by using steam so as to extract volatile oil, collecting the volatile oil, mixing for later use, and reserving medicine residues for later use; (2) uniformly mixing satyrium root, spina gleditsiae, rhizoma cimicifugae, amblystegium serpens, pangolin and loofah sponge with the medicine residues obtained in the step 1, adding 4 times amount of water, adding water so as to decoct two times, decocting for one hour each time, combining decoction, and standing still, then adding 95% alcohol, the amount of which accounts for 3-4 times of the amount of liquid medicine to the decoction, standing still for 15 minutes, then centrifuging for 20 minutes at the speed of 3000rpm/min, taking centrifugate, concentrating and carrying out spray drying so as to obtain a primary material; and (3) spraying the volatile oil obtained in the step (1) into the primary material obtained in the step (2), uniformly mixing, grinding, sieving by using a 60-mesh sieve, and capsuling. The clinical experiment shows that the preoperative intervention medicine composition for prevention of shiver after idiopathic general anesthesia is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to preoperative intervention pharmaceutical composition of a kind of neurosurgery and preparation method thereof.
Background technology
Neurosurgery, especially relates to the patient of operation of opening cranium, and because anesthesia, wound, high cranium are pressed, endotracheal tube stimulates, the impact of extraneous factor, its post-operative complication is much higher compared with other surgical operations.As the incidence rate of shiver with cold (postanesthesia shivering, PS) after idiopathic general anesthesia, previously bibliographical information, common surgical procedures is 5%～38%, operation of opening cranium is 13%～65%.After so-called idiopathic general anesthesia, shiver with cold, also claim " penthiobarbital sample is tetanic " to belong to complication of anesthesia.Shiver with cold under physiological status be body to hypothermic compensation response, shrink and heat production by the quick rhythmicity of skeletal muscle.Mechanism after Craniocerebral Surgery is relevant with the dysfunction of postoperative brain thermotaxic centre, and simultaneously with the sympathetic nerve function retardance under narcotism, heat again profile adjustment is not normal.
At present, be symptomatic treatment targetedly for the treatment of PS, adopt morphine receptor analeptic Pethidine more, or maincenter respiratory stimulant medicine doxapram.But shiver with cold can occur together when appearance, the organism metabolism rate cardiopulmonary load that significantly rising causes increases; Even myocardial ischemia; Also can damage platelet function, coagulation cascade reaction suppresses simultaneously, and blood loss significantly increases, and transfusion volume increases.Therefore how effectively intervening in the preoperative, reduce the incidence rate of PS, and can not cause other post-operative complication, is the new problem of research of neurosurgery operation of opening cranium.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, and preoperative intervention pharmaceutical composition of neurosurgery that a kind of curative effect is affirmed and side effect is little and preparation method thereof is provided.
The technical scheme that the present invention solves its technical problem is: before a kind of neurosurgery general anesthesia patients, intervene medicine, it is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Radix Satyrii nepalensiss, 6 ~ 12 parts of Herba Changnieniae amoenaes, 3 ~ 10 parts of Spina Gleditsiaes, 6 ~ 12 parts of Rhizoma Cimicifugaes, 3 ~ 10 parts of Squama Maniss, 6 ~ 12 parts, delicate fragrance osmanthus, 6 ~ 12 parts of Herba Sarcandraes, 6 ~ 12 parts of Cortex Ponciri trifoliatae, 6 ~ 12 parts of Rhizoma Anemones Altaicaes, 1 ~ 5 part of Asarum forbesii Maxim, 3 ~ 10 parts of Folium Salicis Babylonicae moss, 10 ~ 25 parts of Retinervus Luffae Fructuss.
Chinese medicine of the present invention can be prepared from by following method:
(1) Herba Sarcandrae, Herba Changnieniae amoenae, Rhizoma Anemones Altaicae, Cortex Ponciri trifoliatae, delicate fragrance osmanthus, Asarum forbesii Maxim coarse powder are extracted to volatile oil with vapor distillation respectively, and collect mixing for standby use after volatile oil, medicinal residues are for subsequent use;
(2) in Radix Satyrii nepalensis, Spina Gleditsiae, Rhizoma Cimicifugae, Folium Salicis Babylonicae moss, Squama Manis, Retinervus Luffae Fructus and step 1, gained medicinal residues mix and add 4 times of water yields, decoct with water 2 times, and each 1 hour, collecting decoction, left standstill; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid, concentrated, spraying is dry, draws just material;
(3) gained volatile oil in step 1 is sprayed into step 2 gained and just in material, mix, pulverize, cross 60 mesh sieves, encapsulated forming.
Wherein said: Radix Satyrii nepalensis is the long tuber apart from the blue Satyrium nepalense D. Don of bird foot of orchid.Nature and flavor are flat; Sweet.Return kidney; Heart channel.Merit can strengthening waist and nourishing kidney.
Herba Changnieniae amoenae, for the orchid family Herba Changnieniae amoenae Changuienia amoena Chien, is used as medicine with herb, root.Merit can heat clearing away, removing heat from blood, removing toxic substances.
Spina Gleditsiae is the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Nature and flavor are pungent, temperature.Return liver, stomach warp.The merit poison holding of can subsiding a swelling, evacuation of pus, parasite killing.
Rhizoma Cimicifugae is ranunculaceae plant C.heracleifolia Cimicifuga heracleifolia Kom., Cimicifuga Dahurica Cimicifuga dahurica (Turcz.) Maxim. or the dry rhizome of Rhizoma Cimicifugae Cimicifuga foetida L..Nature and flavor are pungent, micro-sweet, are slightly cold.Return lung, spleen, stomach, large intestine channel.Merit can be delivered rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.
Squama Manis is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Nature and flavor are salty, are slightly cold.Return liver, stomach warp.The merit stimulating milk secretion of can stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.
Delicate fragrance osmanthus is Buxaceae Sarcococca plant delicate fragrance osmanthus Sarcococca ruscifolia Stapf root.Nature and flavor hardship, flat.Merit can regulating QI to relieve pain, dispelling, collateral-activating.
Herba Sarcandrae is the dry Herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Bitter, pungent, flat.GUIXIN, Liver Channel.Merit can clearing away heat and cooling blood, the speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.
Cortex Ponciri trifoliatae is bark bits or the peel bits of rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirus tuifoliata (L.) Raf..Nature and flavor are pungent; Temperature.Return liver; Kidney channel.Merit can endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.
Rhizoma Anemones Altaicae, for Ranunculaceae thimbleweed anemone altaica Anemone altaica Mey., is used as medicine with root stock.Nature and flavor are pungent, temperature.Merit can causing resuscitation with aromatic drugs, reduces phlegm, and calms the nerves.
Asarum forbesii Maxim is rhizome and root or the herb of aristolochiaceae plant Herba Asari Forbesii Asarum forbesii Maxim..Nature and flavor are pungent; Temperature.Return lung; Liver; Kidney; Urinary bladder channel.Merit can expelling wind and cold; Expectorant diuretic; Promoting blood circulation and stopping pain.
Folium Salicis Babylonicae moss is Amblystegiaceae Folium Salicis Babylonicae moss Amblystegium serpens(Hedw.) plant of B.S.G..Nature and flavor are puckery; Flat.Merit can astringing to arrest bleeding.
Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.Merit can dredging collateral, invigorates blood circulation, and dispels the wind.
Composition principle: shiver with cold after idiopathic general anesthesia (PS) is different from other shiver with colds, not only, without the high heat of secondary, also shows as central body temperature simultaneously and declines.In wind and cold disease, to be cold-evil visitor defend point in flesh table the reason of shiver with cold heating, and can not traffic inside and outside the negative and positive of PS to be anaesthetic cause physiological status, be embodied in Yuanyang and lie prostrate in Shao Yin, yang-energy is hindered, defend gas not with flourish phase-splitting and, the gas defended of battalion can not reach due to flesh table thoroughly.Wind and cold disease is with the cold expelling medicine divergence cold-evil of inducing sweat with except shiver with cold, but if PS uses relieving the exterior syndrome with drugs of pungent in flavor and warm in nature medicine, lunar first YANG deficiency, when hiding counter letting out, or becomes raw his disease.Therefore its prevention, should with inside and outside traffic, resolving mass and removing the obstruction of the collateral, consolidate heat clearing away and go forward side by side.
Compared with prior art, the present invention has following characteristics:
1, prescription uniqueness: get Radix Satyrii nepalensis, Spina Gleditsiae in side for monarch, described Radix Satyrii nepalensis, Spina Gleditsiae coordinate, for PS, the few cloudy Yuanyang of the Radix Satyrii nepalensis temperature dim glow of the setting sun, Spina Gleditsiae follows Liver Channel Xin Wentuo and falls apart; Radix Satyrii nepalensis is different from other training tonic thing, and its negative and positive are gentle, and nature and flavor are flat sweet, and without the anxiety of derivative endogenous fire, but the feature of Radix Satyrii nepalensis is to keep and do not walk, the clinical strengthening waist and nourishing kidney that is used for, but coordinate Spina Gleditsiae to lift yang-energy, the gas of Yuanyang can walk in shaoyin channel network.Radix Satyrii nepalensis, Spina Gleditsiae 1:3 ratio decocting liquid gavage, can improve rat serum prostaglandin E l level, and the amount of being-effect linear relationship trend, and single Radix Satyrii nepalensis and single Spina Gleditsiae decocting liquid are for impact and the relatively not statistically significant of blank group of blood prostaglandin E l level.
2, in side, getting Herba Changnieniae amoenae, Rhizoma Cimicifugae, Squama Manis, delicate fragrance osmanthus, Herba Sarcandrae is minister: Herba Changnieniae amoenae, Herba Sarcandrae have the merit of removing summer-heat, can effectively prevent that yang-energy from too laxing brought intenseness of heat, Rhizoma Cimicifugae, delicate fragrance osmanthus elevate a turnable ladder yang-energy, and auxiliary Spina Gleditsiae is lifted yang-energy; Squama Manis expel wind to dredge collateral, increases walking effect.Wherein, head's nine orifices is apt to away in delicate fragrance osmanthus, and its gas floats gently, uses so be particularly useful for the preoperative intervention of neurosurgery operation of opening cranium.
3, supplementary drug thing is fewer but better, Cortex Ponciri trifoliatae endogenous wind stopping dredging collateral; Rhizoma Anemones Altaicae is had one's ideas straightened out and calms the nerves; The pungent temperature of Asarum forbesii Maxim is wandered away, and has effect of promoting blood circulation and stopping pain, is suitable for Postoperative relief pain; Retinervus Luffae Fructus dredging collateral is invigorated blood circulation.
4, the part in neurosurgery operation of opening cranium is cerebral hemorrhage sufferer, too pungent loose in order to prevent the medicine in prescription, so add by Folium Salicis Babylonicae moss assistant system, Folium Salicis Babylonicae moss is puckery flat, has the effect of convergence, can unsmooth battalion not defend mechanism of qi again.
5, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: 20 parts of Radix Satyrii nepalensiss, 10 parts of Herba Changnieniae amoenaes, 6 parts of Spina Gleditsiaes, 10 parts of Rhizoma Cimicifugaes, 6 parts of Squama Maniss, 10 parts, delicate fragrance osmanthus, 10 parts of Herba Sarcandraes, 10 parts of Cortex Ponciri trifoliatae, 10 parts of Rhizoma Anemones Altaicaes, 2 parts of Asarum forbesii Maxims, 6 parts of Folium Salicis Babylonicae moss, 20 parts of Retinervus Luffae Fructuss.
The preparation method of embodiment 1 is: Radix Satyrii nepalensis, Herba Changnieniae amoenae, Spina Gleditsiae, Rhizoma Cimicifugae, Squama Manis, delicate fragrance osmanthus, Herba Sarcandrae, Cortex Ponciri trifoliatae, Rhizoma Anemones Altaicae, Asarum forbesii Maxim, Folium Salicis Babylonicae moss, Retinervus Luffae Fructus mixing and water adding are decocted, after 30 minutes, get filtrate, medicinal residues add water to continue to decoct after 20 minutes and get filtrate, twice filtrate merges, and is divided into two parts of morning and evenings to take.
Embodiment 2, crude drug weight proportion: 10 parts of Radix Satyrii nepalensiss, 6 parts of Herba Changnieniae amoenaes, 3 parts of Spina Gleditsiaes, 6 parts of Rhizoma Cimicifugaes, 3 parts of Squama Maniss, 6 parts, delicate fragrance osmanthus, 6 parts of Herba Sarcandraes, 6 parts of Cortex Ponciri trifoliatae, 6 parts of Rhizoma Anemones Altaicaes, 1 part of Asarum forbesii Maxim, 3 parts of Folium Salicis Babylonicae moss, 10 parts of Retinervus Luffae Fructuss.
Embodiment 3, crude drug weight proportion: 20 parts of Radix Satyrii nepalensiss, 10 parts of Herba Changnieniae amoenaes, 6 parts of Spina Gleditsiaes, 10 parts of Rhizoma Cimicifugaes, 6 parts of Squama Maniss, 10 parts, delicate fragrance osmanthus, 10 parts of Herba Sarcandraes, 10 parts of Cortex Ponciri trifoliatae, 10 parts of Rhizoma Anemones Altaicaes, 2 parts of Asarum forbesii Maxims, 6 parts of Folium Salicis Babylonicae moss, 20 parts of Retinervus Luffae Fructuss.
Embodiment 4, crude drug weight proportion: 30 parts of Radix Satyrii nepalensiss, 12 parts of Herba Changnieniae amoenaes, 10 parts of Spina Gleditsiaes, 12 parts of Rhizoma Cimicifugaes, 10 parts of Squama Maniss, 12 parts, delicate fragrance osmanthus, 12 parts of Herba Sarcandraes, 12 parts of Cortex Ponciri trifoliatae, 12 parts of Rhizoma Anemones Altaicaes, 5 parts of Asarum forbesii Maxims, 10 parts of Folium Salicis Babylonicae moss, 25 parts of Retinervus Luffae Fructuss.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Herba Sarcandrae, Herba Changnieniae amoenae, Rhizoma Anemones Altaicae, Cortex Ponciri trifoliatae, delicate fragrance osmanthus, Asarum forbesii Maxim coarse powder are extracted to volatile oil with vapor distillation respectively, and collect mixing for standby use after volatile oil, medicinal residues are for subsequent use;
(2) in Radix Satyrii nepalensis, Spina Gleditsiae, Rhizoma Cimicifugae, Folium Salicis Babylonicae moss, Squama Manis, Retinervus Luffae Fructus and step 1, gained medicinal residues mix and add 4 times of water yields, decoct with water 2 times, and each 1 hour, collecting decoction, left standstill; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid, concentrated, spraying is dry, draws just material;
(3) gained volatile oil in step 1 is sprayed into step 2 gained and just in material, mix, pulverize, cross 60 mesh sieves, encapsulated forming.
Can set every capsules is 0.5g.
Effective combination of said medicine, coordinates mutually, and traffic is inside and outside, resolving mass and removing the obstruction of the collateral, consolidate heat clearing away, effectively reach the object of prevention PS, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: Patients after Receiving Craniocerebral Operation under the 99 routine neurosurgery general anesthesias that accept for medical treatment year February in February, 2013～2014, and in preoperative 3 days, do not use the medicine of the treatment shiver with colds such as ondansetron, tramadol, clonidine.Operation reason comprises: tumor 26 examples on curtain, and PFT 11 examples, tumor of ventricle 3 examples, cerebrovascular 6 examples, pituitary tumor 19 examples, craniopharyngioma 2 examples, epilepsy surgery 3 examples, other are performed the operation as 29 examples such as hydrocephalus, skull repairing.Age between 7～71 years old, 44.5 ± 10.3 years old mean age, wherein: 14 years old 17 example of age <, 60 years old 11 example of age >; Male patient's 47 examples, female patient 52 examples.
1.1.2 grouping: patient is divided into matched group 32 examples, decoction group 34 examples and Capsules group 33 examples at random.Before three groups of patient treatments, on sex, age, the state of an illness, anesthesia method, compare, difference not statistically significant (P>0.05), has comparability.
1.2 method.
1.2.1 interference method: the conventional preoperative and postoperative administration of matched group, is incubated by skin.Decoction group and Capsules group, on the basis of matched group, from preoperative three days, respectively with gained decoction in the embodiment of the present invention 1, with gained capsule oral in the embodiment of the present invention 3,2 times/d, add up to three days.
1.2.2 statistical analysis: SPSS 13.0 carries out statistical analysis.Enumeration data χ
2inspection.
2 results.
2.1 three groups of PS incidence rates in postoperative 5 hours are respectively: matched group 28.13%(9/32), decoction group 8.82%(3/34), Capsules group 9.09%(3/33).Decoction group and Capsules group shiver with cold incidence rate are starkly lower than matched group (χ
2=4.12, P<0.05; χ
2=3.91, P<0.05).
The comparison of 2.2 3 groups of other recovery rooms of patient (PACU) complication: see the following form,
| ? | Number of cases | Cardiovascular related complication | Digestive complication | Spirit complication | Respiratory complication | The delay of reviving |
| Matched group | 32 | 10 | 4 | 7 | 1 | 1 |
| Decoction group | 34 | 9 | 5 | 7 | 1 | 1 |
| Capsules group | 33 | 11 | 4 | 6 | 0 | 1 |
Matched group, decoction group, Capsules group difference not statistically significant aspect cardiovascular related complication, Digestive complication, spirit complication, respiratory complication, the delay of reviving.
2.3 adverse reaction rate comparisons: obvious medicine related reactions does not appear in decoction group, Capsules group.
3. conclusion.
This result of study shows, take decoction group of the present invention and Capsules group PS incidence rate is starkly lower than matched group, and can not cause other PACU complication, pharmaceutical composition prepared by the inventive method is described, and untoward reaction is light, the higher advantage of safety having aspect the postoperative PS of prevention neurosurgery.
Claims (1)
1. preoperative intervention pharmaceutical composition of neurosurgery and preparation method thereof, is characterized in that, crude drug comprises Radix Satyrii nepalensis, Herba Changnieniae amoenae, Spina Gleditsiae, Rhizoma Cimicifugae, Squama Manis, delicate fragrance osmanthus, Herba Sarcandrae, Cortex Ponciri trifoliatae, Rhizoma Anemones Altaicae, Asarum forbesii Maxim, Folium Salicis Babylonicae moss, Retinervus Luffae Fructus; Formed by following steps:
(1) Herba Sarcandrae, Herba Changnieniae amoenae, Rhizoma Anemones Altaicae, Cortex Ponciri trifoliatae, delicate fragrance osmanthus, Asarum forbesii Maxim coarse powder are extracted to volatile oil with vapor distillation respectively, and collect mixing for standby use after volatile oil, medicinal residues are for subsequent use;
(2) in Radix Satyrii nepalensis, Spina Gleditsiae, Rhizoma Cimicifugae, Folium Salicis Babylonicae moss, Squama Manis, Retinervus Luffae Fructus and step 1, gained medicinal residues mix and add 4 times of water yields, decoct with water 2 times, and each 1 hour, collecting decoction, left standstill; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid, concentrated, spraying is dry, draws just material;
(3) gained volatile oil in step 1 is sprayed into step 2 gained and just in material, mix, pulverize, cross 60 mesh sieves, encapsulated forming.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105687591A (en) * | 2016-02-29 | 2016-06-22 | 王芳 | Pharmaceutical composition for neurosurgical preoperative intervention |
| CN105943906A (en) * | 2016-05-31 | 2016-09-21 | 张学印 | Preparation method of medicament for use before ophthalmologic operation |
| CN107260969A (en) * | 2017-06-15 | 2017-10-20 | 李光宏 | The preoperative intervention pharmaceutical composition of neurosurgery |
-
2014
- 2014-04-28 CN CN201410171226.8A patent/CN103933356B/en not_active Expired - Fee Related
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| 刘福昌: "《天然药物化学》", 28 February 2013, 华中科技大学出版社 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105687591A (en) * | 2016-02-29 | 2016-06-22 | 王芳 | Pharmaceutical composition for neurosurgical preoperative intervention |
| CN105943906A (en) * | 2016-05-31 | 2016-09-21 | 张学印 | Preparation method of medicament for use before ophthalmologic operation |
| CN107260969A (en) * | 2017-06-15 | 2017-10-20 | 李光宏 | The preoperative intervention pharmaceutical composition of neurosurgery |
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