CN108272879A - The Chinese medicine preparation of hypertension is treated by taking joint external application mode orally - Google Patents

The Chinese medicine preparation of hypertension is treated by taking joint external application mode orally Download PDF

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CN108272879A
CN108272879A CN201810210641.8A CN201810210641A CN108272879A CN 108272879 A CN108272879 A CN 108272879A CN 201810210641 A CN201810210641 A CN 201810210641A CN 108272879 A CN108272879 A CN 108272879A
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chinese medicine
extraction
radix
external application
application mode
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豆坤
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
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Abstract

The invention discloses a kind of Chinese medicine preparations for treating hypertension by taking joint external application mode orally, it is related to technical field of traditional Chinese medicine preparation, it is made of external medicine composition and oral traditional Chinese medicine composition, the present invention strengthens the therapeutic effect to hypertension by being used in combination for the external medicine composition and oral traditional Chinese medicine composition, shorten the course for the treatment of, recurrence rate is reduced while improving cure rate, avoids the problem that, cure rate long using the course for the treatment of existing for conventional hypertension therapeutic Chinese medicine preparation or independent innerwear Chinese medicine preparation be low and high recurrence rate.

Description

The Chinese medicine preparation of hypertension is treated by taking joint external application mode orally
Technical field：
The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of to treat hypertension by joint external application mode for oral administration Chinese medicine preparation.
Background technology：
Hypertension, refer to systemic arterial blood pressure (systolic pressure and/or diastolic pressure) increase for main feature (systolic pressure >= 140 millimetress of mercury, the millimetres of mercury of diastolic pressure >=90), it can be with the function of the organs such as the heart, brain, kidney or the clinic of organic lesion Syndrome.Hypertension is most common chronic disease and the most important risk factor of cardiovascular and cerebrovascular diseases.Since part hypertension is suffered from Person has no apparent clinical symptoms, therefore hypertension is otherwise known as " the invisible killer " of human health.
Currently, the treatment of hypertension mostly uses western medicine therapy, western medicine therapy blood pressure lowering is rapider, but the blood pressure that is once discontinued It can be restored to original level again, it is palliative.And the country has deeper research using Chinese medicine hypertension, but it is right The treatment of hypertension still is apparent not enough, and is characterized in that：, drug dose unclear to hypertension incidence mechanism is not allowed, Chinese herbal medicine is matched 5 is not in place, therapeutic effect is unstable, unobvious, cannot effect a radical cure, and blindly uses clearing heat and detoxicating, calming the liver method, makes Obtaining old complaint cannot eradicate early.
Invention content：
Technical problem to be solved by the present invention lies in provide that a kind of short treating period, cure rate are high and recurrence rate is low by interior Take the Chinese medicine preparation that joint external application mode treats hypertension.
The technical problems to be solved by the invention are realized using technical solution below：
The Chinese medicine preparation that hypertension is treated by taking joint external application mode orally, by external medicine composition and traditional Chinese medicine for oral administration group Object composition is closed, the external medicine composition is made of the Chinese medicine of following weight：Radix Angelicae Sinensis 1kg, Herba Ephedrae 2.5kg, rhizoma atractylodis 1.5kg, Caulis Spatholobi 1kg, Rhizoma Chuanxiong 1kg, radix cyathulae 1kg, Radix Notoginseng 1kg, Moschus 0.05kg, Rhizoma Et Radix Notopterygii 1kg, peach kernel 1kg；
The oral traditional Chinese medicine composition is made of the Chinese medicine of following weight：Rhizoma Atractylodis Macrocephalae 20g, Poria cocos 20g, Radix Codonopsis 20g, Radix Glycyrrhizae 20g, coptis 20g, Radix Rehmanniae 30g, Radix Salviae Miltiorrhizae 30g, Cortex Phellodendri 20g, peach kernel 20g, Chinese herbaceous peony 20g, rhizoma cyperi 20g, Rhizoma Gastrodiae 20g, Radix Curcumae 20g, Radix Glehniae 30g, adenophora tetraphylla 30g, radix bupleuri 20g.
The external application mode of the external medicine composition takes hip bath method.
The hip bath temperature of the hip bath method must not exceed 43 DEG C.
Each hip bath time of the hip bath method must not exceed 2h.
The extracting method of the external medicine composition is：By Radix Angelicae Sinensis, Herba Ephedrae, rhizoma atractylodis, Caulis Spatholobi, Rhizoma Chuanxiong, radix cyathulae, Radix Notoginseng, Rhizoma Et Radix Notopterygii, peach kernel are soaked overnight, are then heated to reflux state heat preservation extraction, are filtered while hot after the completion of primary extraction, Filtrate is collected, into gained filter residue plus water, and is again heated to reflux state heat preservation extraction, mistake while hot after the completion of second extraction Filter, merging filtrate are added Moschus when filtrate naturally cools to 40 DEG C or less, are sufficiently mixed to get external application Chinese medicine extracting solution.
It is described interior to be with the extracting method of Chinese medicine composition：Above-mentioned Chinese medicine is soaked overnight, reflux is then heated to State heat preservation is extracted, and is filtered while hot after the completion of primary extraction, is collected filtrate, water is added into gained filter residue, and be again heated to back Stream mode heat preservation extraction, second extraction filter while hot after the completion, and merging filtrate uses Chinese medicine extract to get interior.
The extracting method of the external medicine composition is：By Radix Angelicae Sinensis, Herba Ephedrae, rhizoma atractylodis, Caulis Spatholobi, Rhizoma Chuanxiong, radix cyathulae, Radix Notoginseng, Rhizoma Et Radix Notopterygii, peach kernel are soaked overnight, and extraction aid is added, and stirring and dissolving is complete, are then heated to reflux state heat preservation and are carried It takes, is filtered while hot after the completion of primary extraction, collect filtrate, water is added into gained filter residue, and be again heated to reflux state heat preservation Extraction, second extraction filter while hot after the completion, and Moschus is added, fully in merging filtrate when filtrate naturally cools to 40 DEG C or less Mixing is to get external application Chinese medicine extracting solution.
The extraction aid dosage is the 1-5% of Chinese medicine gross dry weight used in external medicine composition.
It is described interior to be with the extracting method of Chinese medicine composition：Above-mentioned Chinese medicine is soaked overnight, extraction aid is added, stirs It is complete to mix dissolving, is then heated to reflux state heat preservation extraction, is filtered while hot after the completion of primary extraction, filtrate is collected, to gained In filter residue plus water, and be again heated to reflux state heat preservation extraction, filtered while hot after the completion of second extraction, merging filtrate to get Inside use Chinese medicine extract.
The extraction aid dosage is the 1-5% of the interior Chinese medicine gross dry weight used in Chinese medicine composition.
The extraction aid is made of poloxamer and myristic acid through esterification, and preparation method is：First respectively at 20- Absolute ethyl alcohol is added to be made into saturated solution PLURONICS F87, myristic acid at 25 DEG C, then by the saturation ethyl alcohol of PLURONICS F87 Solution is heated to 45-50 DEG C of insulated and stirred 5-10min, and dilute sulfuric acid is added dropwise and adjusts pH value to 4-5, continues to be heated to reflux state Then insulated and stirred starts the saturation ethanol solution that myristic acid is added dropwise, real-time monitoring system pH value during entire dropwise addition, and Adding dilute sulfuric acid in time makes pH stable in 4-5, continues reflux heat preservation after the saturation ethanol solution of myristic acid is added dropwise Stirring, esterification terminate after through be concentrated under reduced pressure recycle ethyl alcohol, condensate residue plus a small amount of water dissolution, acquired solution is naturally cold But it is sent into freeze drier to after room temperature, micro mist is made to get extraction aid through micronizer in dry obtained solid.
The PLURONICS F87, myristic acid mass ratio be 10-20:1.
The pharmacological property of Chinese herbal medicine of the present invention：
Radix Angelicae Sinensis：Sweet in flavor, pungent, warm-natured, Return liver, the heart, the spleen channel, effect enriches blood, invigorates blood circulation, menstruction regulating and pain relieving, moisturize laxation.
Herba Ephedrae：Mildly bitter flavor, pungent, warm-natured, effect sweating cold dispelling is freeinged lung and relieving asthma, inducing diuresis for removing edema.
Rhizoma atractylodis：Acrid flavour, hardship, warm-natured, returns spleen, stomach, Liver Channel, effect is drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.
Caulis Spatholobi：Taste micro-sweet, warm-natured, Return liver, the heart, kidney channel, effect filling liver kidney, benefiting male body essence and invigorating sex functions, antidiarrheal.
Rhizoma Chuanxiong：Acrid flavour, warm-natured, Return liver, gallbladder channel, effect promote breath and open depression dispel pathogenic wind and remove dampness, promoting blood circulation and stopping pain.
Radix cyathulae：Sweet in flavor, slight bitter, it is mild-natured, return liver and kidney channel, effect dispelling stasis of blood and stimulating the menstrual flow, easing joint movement, inducing diuresis for treating strangurtia.
Radix Notoginseng：Sweet in flavor, slight bitter, warm-natured, Return liver, stomach, cure mainly spitting of blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, have blood in stool, uterine bleeding, traumatic hemorrhage, Chest and abdomen shouting pain, tumbling and swelling.
Moschus：Acrid flavour, warm-natured, the thoughts of returning home, liver, the spleen channel, cure mainly pyreticosis coma, apoplexy coma due to blocking of the respiratory system, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, Blood stasis, dysmenorrhoea, accumulation, trusted subordinate sudden and violent pain, arthralgia pain due to rheumatism, traumatic injury, ulcer malignant sore, larynx numbness, aphtha, noma, worm snake sting Wound, difficult labour, stillborn foetus, placenta retension.
Rhizoma Et Radix Notopterygii：Acrid flavour, hardship, it is warm-natured, return bladder, kidney channel, effect to dissipate exterior cold, wind-damp dispelling, sharp joint, analgesic.
Peach kernel：Bitter, sweet, mild-natured, the thoughts of returning home, liver, large intestine channel, effect promoting blood circulation relax bowel, are relieving cough and asthma.
Rhizoma Atractylodis Macrocephalae：Bitter, sweet, warm-natured, returns spleen, stomach, effect strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, tocolysis.
Poria cocos：It is sweet in flavor, light, mild-natured, the thoughts of returning home, lung, spleen, kidney channel, effect clearing damp and promoting diuresis, invigorating the spleen, calming heart.
Radix Codonopsis：It is sweet in flavor, mild-natured, effect tonifying middle-Jiao and Qi, clearing heat and detoxicating, expelling phlegm and arresting coughing.
Radix Glycyrrhizae：Sweet in flavor, mild-natured, the thoughts of returning home, spleen, lung, stomach, effect purging intense heat and detonicating, toast partial temperature, can dissipate table at relieving spasm to stop pain Cold, tonifying middle-Jiao and Qi.
The coptis：Bitter, cold in nature, effect heat-clearing and damp-drying drug, purging intense heat and detonicating.
Radix Rehmanniae：Sweet in flavor, cold in nature, the thoughts of returning home, sweet, kidney channel, effect clearing heat and cooling blood, are promoted the production of body fluid at yin-nourishing.
Radix Salviae Miltiorrhizae：Bitter, cold nature, converge to heart and liver channels, effect promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle.
Cortex Phellodendri：Bitter, it is cold in nature, return kidney, bladder warp, effect heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.
Chinese herbaceous peony：Bitter, cold nature, Return liver, the spleen channel cure mainly irregular menstruation, uterine bleeding, abnormal sweating, abdominal pain, pain over the hypochondriac region, four Limb contraction pain, dizziness of having a headache.
Rhizoma cyperi：Acrid flavour, slight bitter, mild-natured, Return liver, spleen, tri-jiao channel, effect soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.
Rhizoma Gastrodiae：Sweet in flavor, it is not smoothgoing to cure mainly dizziness pupil, head wind headache, extremity numbness, hemiplegia, language for mild-natured, return liver warp Puckery, infantile epilepsy and convulsions.
Radix Curcumae：Acrid flavour, hardship, cold in nature, Return liver, the heart, lung channel, effect promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, the cool blood that clears away heart-fire, cholagogic move back It is yellow.
Radix Glehniae：Sweet in flavor, slight bitter, cold nature, return lung, the spleen channel, effect nourishiing yin to clear away the lung-heat, expelling phlegm and arresting coughing.
Adenophora tetraphylla：Sweet in flavor, cold nature attaches to the lung and stomach meridians, effect nourishiing yin to clear away the lung-heat, reinforcing stomach reg fluid, resolving sputum, QI invigorating.
Radix bupleuri：Acrid flavour, hardship, cold nature, Return liver, courage, lung channel in effect and inducing diaphoresis, soothing liver-qi stagnation, yang invigorating, are brought down a fever Preventing malaria.
The effect of external medicine composition of the present invention：Sweating, blood flow quickening, toxin expelling, promoting menstruation, promoting blood circulation, expand blood vessel, stagnation resolvation, Wind-dispelling, dehumidifying etc..
The effect of oral traditional Chinese medicine composition of the present invention：Clearing heat and detoxicating, promoting blood circulation and removing blood stasis, dispersing stagnated hepatoqi, cardiac stimulant kidney tonifying, invigorating the spleen profit Lung, cool blood, Pingyin sun, traditional Chinese medicine for oral administration is in order to which strengthening vital QI to eliminate pathogenic factors, old life of dispelling are new, and patient avoids pungent fertilizer during medication.
Taboo：Pregnant woman, old man, children and weakness, menstrual period, bleeding crowd.
The beneficial effects of the invention are as follows：
(1) present invention provides a kind of external application Chinese medicine for treating hypertension simultaneously by stringent monarch compatibility relationship Composition and oral traditional Chinese medicine composition；
(2) present invention is strengthened by being used in combination for the external medicine composition and oral traditional Chinese medicine composition to high blood The therapeutic effect of pressure shortens the course for the treatment of, recurrence rate is reduced while improving cure rate, avoids using conventional hypertension therapeutic Chinese medicine The problem of course for the treatment of existing for preparation or independent innerwear Chinese medicine preparation is long, cure rate is low and high recurrence rate；
(3) present invention accelerates the leaching velocity of Chinese herbal medicine effective component by the use of extraction aid, improves simultaneously The extraction yield of effective component imitates the concentration of ingredient, and the presence of the extraction aid to increase external application and liquid Chinese medicine for oral administration The safety in utilization of external application and liquid for oral administration is not interfered with.
Specific implementation mode：
In order to make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, tie below Specific embodiment is closed, the present invention is further explained.
Embodiment 1
The extraction of external medicine composition：By Radix Angelicae Sinensis 1kg, Herba Ephedrae 2.5kg, rhizoma atractylodis 1.5kg, Caulis Spatholobi 1kg, Rhizoma Chuanxiong 1kg, radix cyathulae 1kg, Radix Notoginseng 1kg, Moschus 0.05kg, Rhizoma Et Radix Notopterygii 1kg, peach kernel 1kg add the water of 25 times of Chinese medicine gross dry weights to impregnate Night is then heated to reflux state heat preservation extraction 5h, is filtered while hot after the completion of primary extraction, filtrate is collected, into gained filter residue Add the water of 10 times of Chinese medicine gross dry weights, and be again heated to reflux state heat preservation extraction 3h, is filtered while hot after the completion of second extraction, Moschus 0.05kg is added in merging filtrate when filtrate naturally cools to 40 DEG C or less, is sufficiently mixed and is extracted to get external application Chinese medicine Liquid.
The interior extraction with Chinese medicine composition：By Rhizoma Atractylodis Macrocephalae 20g, Poria cocos 20g, Radix Codonopsis 20g, Radix Glycyrrhizae 20g, coptis 20g, Radix Rehmanniae 30g, Radix Salviae Miltiorrhizae 30g, Cortex Phellodendri 20g, peach kernel 20g, Chinese herbaceous peony 20g, rhizoma cyperi 20g, Rhizoma Gastrodiae 20g, Radix Curcumae 20g, Radix Glehniae 30g, adenophora tetraphylla 30g, radix bupleuri 20g add the water soaked overnight of 5 times of medicinal material gross dry weights, are then heated to reflux state heat preservation extraction 3h, primary extraction It filters while hot after the completion, collects filtrate, the water of 3 times of Chinese medicine gross dry weights is added into gained filter residue, and be again heated to reflux shape State heat preservation extraction 1h, second extraction filter while hot after the completion, and merging filtrate uses Chinese medicine extract to get interior.
Embodiment 2
The extraction of external medicine composition：By Radix Angelicae Sinensis 1kg, Herba Ephedrae 2.5kg, rhizoma atractylodis 1.5kg, Caulis Spatholobi 1kg, Rhizoma Chuanxiong 1kg, radix cyathulae 1kg, Radix Notoginseng 1kg, Moschus 0.05kg, Rhizoma Et Radix Notopterygii 1kg, peach kernel 1kg add the water of 25 times of Chinese medicine gross dry weights to impregnate Night adds the extraction aid of 2% times of Chinese medicine gross dry weight, and stirring and dissolving is complete, is then heated to reflux state heat preservation extraction 5h, It is filtered while hot after the completion of primary extraction, collects filtrate, the water of 10 times of Chinese medicine gross dry weights is added into gained filter residue, and heated again Extraction 3h is kept the temperature to reflux state, is filtered while hot after the completion of second extraction, merging filtrate waits for that filtrate naturally cools to 40 DEG C or less When be added Moschus 0.05kg, be sufficiently mixed to get external application Chinese medicine extracting solution.
The interior extraction with Chinese medicine composition：By Rhizoma Atractylodis Macrocephalae 20g, Poria cocos 20g, Radix Codonopsis 20g, Radix Glycyrrhizae 20g, coptis 20g, Radix Rehmanniae 30g, Radix Salviae Miltiorrhizae 30g, Cortex Phellodendri 20g, peach kernel 20g, Chinese herbaceous peony 20g, rhizoma cyperi 20g, Rhizoma Gastrodiae 20g, Radix Curcumae 20g, Radix Glehniae 30g, adenophora tetraphylla 30g, radix bupleuri 20g add the water soaked overnight of 5 times of medicinal material gross dry weights, add the extraction aid of 2% times of Chinese medicine gross dry weight, and stirring is molten Solution is complete, is then heated to reflux state heat preservation extraction 3h, is filtered while hot after the completion of primary extraction, collect filtrate, filtered to gained In slag plus the water of 3 times of Chinese medicine gross dry weights, and it is again heated to reflux state heat preservation extraction 1h, mistake while hot after the completion of second extraction Filter, merging filtrate use Chinese medicine extract to get interior.
The preparation of extraction aid：First respectively at adding absolute ethyl alcohol to match 12g PLURONICS F87s, 1g myristic acids at 20-25 DEG C It is heated to 45-50 DEG C of insulated and stirred 5-10min at saturated solution, then by the saturation ethanol solution of PLURONICS F87, and is added dropwise dilute Sulphur acid for adjusting pH value continues to be heated to reflux state insulated and stirred to 4-5, and the saturation ethyl alcohol for then starting to be added dropwise myristic acid is molten Liquid, it is entire that monitoring system pH value in real time is added dropwise in the process, and adding dilute sulfuric acid in time makes pH stable in 4-5, waits for myristic acid Saturation ethanol solution be added dropwise after continue flow back insulated and stirred, esterification terminate after through be concentrated under reduced pressure recycle ethyl alcohol, will Condensate residue adds a small amount of water dissolution, is sent into freeze drier after acquired solution cooled to room temperature, dry obtained solid Micro mist is made to get extraction aid through micronizer.
Embodiment 3
The extraction of external medicine composition：By Radix Angelicae Sinensis 1kg, Herba Ephedrae 2.5kg, rhizoma atractylodis 1.5kg, Caulis Spatholobi 1kg, Rhizoma Chuanxiong 1kg, radix cyathulae 1kg, Radix Notoginseng 1kg, Moschus 0.05kg, Rhizoma Et Radix Notopterygii 1kg, peach kernel 1kg add the water of 25 times of Chinese medicine gross dry weights to impregnate Night adds the extraction aid of 3% times of Chinese medicine gross dry weight, and stirring and dissolving is complete, is then heated to reflux state heat preservation extraction 5h, It is filtered while hot after the completion of primary extraction, collects filtrate, the water of 10 times of Chinese medicine gross dry weights is added into gained filter residue, and heated again Extraction 3h is kept the temperature to reflux state, is filtered while hot after the completion of second extraction, merging filtrate waits for that filtrate naturally cools to 40 DEG C or less When be added Moschus 0.05kg, be sufficiently mixed to get external application Chinese medicine extracting solution.
The interior extraction with Chinese medicine composition：By Rhizoma Atractylodis Macrocephalae 20g, Poria cocos 20g, Radix Codonopsis 20g, Radix Glycyrrhizae 20g, coptis 20g, Radix Rehmanniae 30g, Radix Salviae Miltiorrhizae 30g, Cortex Phellodendri 20g, peach kernel 20g, Chinese herbaceous peony 20g, rhizoma cyperi 20g, Rhizoma Gastrodiae 20g, Radix Curcumae 20g, Radix Glehniae 30g, adenophora tetraphylla 30g, radix bupleuri 20g add the water soaked overnight of 5 times of medicinal material gross dry weights, add the extraction aid of 3% times of Chinese medicine gross dry weight, and stirring is molten Solution is complete, is then heated to reflux state heat preservation extraction 3h, is filtered while hot after the completion of primary extraction, collect filtrate, filtered to gained In slag plus the water of 3 times of Chinese medicine gross dry weights, and it is again heated to reflux state heat preservation extraction 1h, mistake while hot after the completion of second extraction Filter, merging filtrate use Chinese medicine extract to get interior.
The preparation of extraction aid：First respectively at adding absolute ethyl alcohol to match 12g PLURONICS F87s, 1g myristic acids at 20-25 DEG C It is heated to 45-50 DEG C of insulated and stirred 5-10min at saturated solution, then by the saturation ethanol solution of PLURONICS F87, and is added dropwise dilute Sulphur acid for adjusting pH value continues to be heated to reflux state insulated and stirred to 4-5, and the saturation ethyl alcohol for then starting to be added dropwise myristic acid is molten Liquid, it is entire that monitoring system pH value in real time is added dropwise in the process, and adding dilute sulfuric acid in time makes pH stable in 4-5, waits for myristic acid Saturation ethanol solution be added dropwise after continue flow back insulated and stirred, esterification terminate after through be concentrated under reduced pressure recycle ethyl alcohol, will Condensate residue adds a small amount of water dissolution, is sent into freeze drier after acquired solution cooled to room temperature, dry obtained solid Micro mist is made to get extraction aid through micronizer.
Reference examples 1
The interior extraction with Chinese medicine composition：By Rhizoma Atractylodis Macrocephalae 20g, Poria cocos 20g, Radix Codonopsis 20g, Radix Glycyrrhizae 20g, coptis 20g, Radix Rehmanniae 30g, Radix Salviae Miltiorrhizae 30g, Cortex Phellodendri 20g, peach kernel 20g, Chinese herbaceous peony 20g, rhizoma cyperi 20g, Rhizoma Gastrodiae 20g, Radix Curcumae 20g, Radix Glehniae 30g, adenophora tetraphylla 30g, radix bupleuri 20g add the water soaked overnight of 5 times of medicinal material gross dry weights, add the extraction aid of 3% times of Chinese medicine gross dry weight, and stirring is molten Solution is complete, is then heated to reflux state heat preservation extraction 3h, is filtered while hot after the completion of primary extraction, collect filtrate, filtered to gained In slag plus the water of 3 times of Chinese medicine gross dry weights, and it is again heated to reflux state heat preservation extraction 1h, mistake while hot after the completion of second extraction Filter, merging filtrate use Chinese medicine extract to get interior.
The preparation of extraction aid：First respectively at adding absolute ethyl alcohol to match 12g PLURONICS F87s, 1g myristic acids at 20-25 DEG C It is heated to 45-50 DEG C of insulated and stirred 5-10min at saturated solution, then by the saturation ethanol solution of PLURONICS F87, and is added dropwise dilute Sulphur acid for adjusting pH value continues to be heated to reflux state insulated and stirred to 4-5, and the saturation ethyl alcohol for then starting to be added dropwise myristic acid is molten Liquid, it is entire that monitoring system pH value in real time is added dropwise in the process, and adding dilute sulfuric acid in time makes pH stable in 4-5, waits for myristic acid Saturation ethanol solution be added dropwise after continue flow back insulated and stirred, esterification terminate after through be concentrated under reduced pressure recycle ethyl alcohol, will Condensate residue adds a small amount of water dissolution, is sent into freeze drier after acquired solution cooled to room temperature, dry obtained solid Micro mist is made to get extraction aid through micronizer.
Reference examples 2
The extraction of external medicine composition：By Radix Angelicae Sinensis 1kg, Herba Ephedrae 2.5kg, rhizoma atractylodis 1.5kg, Caulis Spatholobi 1kg, Rhizoma Chuanxiong 1kg, radix cyathulae 1kg, Radix Notoginseng 1kg, Moschus 0.05kg, Rhizoma Et Radix Notopterygii 1kg, peach kernel 1kg add the water of 25 times of Chinese medicine gross dry weights to impregnate Night adds the extraction aid of 3% times of Chinese medicine gross dry weight, and stirring and dissolving is complete, is then heated to reflux state heat preservation extraction 5h, It is filtered while hot after the completion of primary extraction, collects filtrate, the water of 10 times of Chinese medicine gross dry weights is added into gained filter residue, and heated again Extraction 3h is kept the temperature to reflux state, is filtered while hot after the completion of second extraction, merging filtrate waits for that filtrate naturally cools to 40 DEG C or less When be added Moschus 0.05kg, be sufficiently mixed to get external application Chinese medicine extracting solution.
The preparation of extraction aid：First respectively at adding absolute ethyl alcohol to match 12g PLURONICS F87s, 1g myristic acids at 20-25 DEG C It is heated to 45-50 DEG C of insulated and stirred 5-10min at saturated solution, then by the saturation ethanol solution of PLURONICS F87, and is added dropwise dilute Sulphur acid for adjusting pH value continues to be heated to reflux state insulated and stirred to 4-5, and the saturation ethyl alcohol for then starting to be added dropwise myristic acid is molten Liquid, it is entire that monitoring system pH value in real time is added dropwise in the process, and adding dilute sulfuric acid in time makes pH stable in 4-5, waits for myristic acid Saturation ethanol solution be added dropwise after continue flow back insulated and stirred, esterification terminate after through be concentrated under reduced pressure recycle ethyl alcohol, will Condensate residue adds a small amount of water dissolution, is sent into freeze drier after acquired solution cooled to room temperature, dry obtained solid Micro mist is made to get extraction aid through micronizer.
Reference examples 3
The extraction of external medicine composition：By Radix Angelicae Sinensis 1kg, Herba Ephedrae 2.5kg, rhizoma atractylodis 1.5kg, Caulis Spatholobi 1kg, Rhizoma Chuanxiong 1kg, radix cyathulae 1kg, Radix Notoginseng 1kg, Moschus 0.05kg, Rhizoma Et Radix Notopterygii 1kg, peach kernel 1kg add the water of 25 times of Chinese medicine gross dry weights to impregnate Night adds the extraction aid PLURONICS F87 of 3% times of Chinese medicine gross dry weight, and stirring and dissolving is complete, is then heated to reflux state Heat preservation extraction 5h, filters after the completion of primary extraction, collects filtrate while hot, into gained filter residue plus 10 times of Chinese medicine gross dry weights Water, and it is again heated to reflux state heat preservation extraction 3h, it is filtered while hot after the completion of second extraction, merging filtrate waits for filtrate nature Moschus 0.05kg is added when being cooled to 40 DEG C or less, is sufficiently mixed to get external application Chinese medicine extracting solution.
The interior extraction with Chinese medicine composition：By Rhizoma Atractylodis Macrocephalae 20g, Poria cocos 20g, Radix Codonopsis 20g, Radix Glycyrrhizae 20g, coptis 20g, Radix Rehmanniae 30g, Radix Salviae Miltiorrhizae 30g, Cortex Phellodendri 20g, peach kernel 20g, Chinese herbaceous peony 20g, rhizoma cyperi 20g, Rhizoma Gastrodiae 20g, Radix Curcumae 20g, Radix Glehniae 30g, adenophora tetraphylla 30g, radix bupleuri 20g add the water soaked overnight of 5 times of medicinal material gross dry weights, and the extraction aid pool Lip river for adding 3% times of Chinese medicine gross dry weight is husky Nurse 188, stirring and dissolving is complete, is then heated to reflux state heat preservation extraction 3h, is filtered while hot after the completion of primary extraction, collect filter Liquid, the water of 3 times of Chinese medicine gross dry weights is added into gained filter residue, and is again heated to reflux state heat preservation extraction 1h, second extraction It filters while hot after the completion, merging filtrate uses Chinese medicine extract to get interior.
Embodiment 4
Be utilized respectively embodiment 1, embodiment 2, embodiment 3, reference examples 1, reference examples 2, reference examples 3 prepare in carried with Chinese medicine Take liquid and external application Chinese medicine extracting solution.
The hip bath at 38-40 DEG C of external application Chinese medicine extracting solution, each hip bath time 2h, it is desirable that patient only exposes head, sits within one day Bath 1 time, 10 days are 1 course for the treatment of.When hip bath such as there is dizziness, headache, dry, symptoms of emesis in patient, and appropriate rest can be alleviated.
Interior respectively to be taken before meals 1 time sooner or later daily with Chinese medicine extract is oral, each taking 50mL, 10 days are 1 course for the treatment of.
Choose 600 hypertensive patients, men and women is fifty-fifty, and stochastic averagina is divided into 6 groups, be utilized respectively embodiment 1, embodiment 2, Embodiment 3, reference examples 1, reference examples 2, reference examples 3 it is made it is interior treated with Chinese medicine extract and external application Chinese medicine extracting solution, 3 Curative effect is recorded after the course for the treatment of, as shown in table 1.
Therapeutic effect of 1 Chinese medicine preparation of the present invention of table to hypertension
As shown in Table 1, cure rate can be increased to 50% or more by treating hypertension using joint external application mode for oral administration, and The addition of extraction aid can further increase cure rate and total effective rate, and (increase of extraction aid dosage can also improve cure rate and always have Efficiency cannot be effectively improved cure rate and total effective rate using equivalent PLURONICS F87 as extraction aid, that is, illustrate poloxamer 188 itself do not have significantly help the effect of proposing)；And the cure rate of traditional Chinese medicine for oral administration mode is individually used to be less than 40%, individually use The cure rate of external application Chinese medicine mode is 0.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its Equivalent thereof.

Claims (10)

1. treating the Chinese medicine preparation of hypertension by taking joint external application mode orally, it is characterised in that：By external medicine composition and Oral traditional Chinese medicine composition forms, and the external medicine composition is made of the Chinese medicine of following weight：Radix Angelicae Sinensis 1kg, Herba Ephedrae 2.5kg, rhizoma atractylodis 1.5kg, Caulis Spatholobi 1kg, Rhizoma Chuanxiong 1kg, radix cyathulae 1kg, Radix Notoginseng 1kg, Moschus 0.05kg, Rhizoma Et Radix Notopterygii 1kg, peach kernel 1kg；
The oral traditional Chinese medicine composition is made of the Chinese medicine of following weight：Rhizoma Atractylodis Macrocephalae 20g, Poria cocos 20g, Radix Codonopsis 20g, Radix Glycyrrhizae 20g, Huang Even 20g, Radix Rehmanniae 30g, Radix Salviae Miltiorrhizae 30g, Cortex Phellodendri 20g, peach kernel 20g, Chinese herbaceous peony 20g, rhizoma cyperi 20g, Rhizoma Gastrodiae 20g, Radix Curcumae 20g, Radix Glehniae 30g, adenophora tetraphylla 30g, radix bupleuri 20g.
2. the Chinese medicine preparation according to claim 1 for treating hypertension by taking joint external application mode orally, it is characterised in that： The external application mode of the external medicine composition takes hip bath method.
3. the Chinese medicine preparation according to claim 1 for treating hypertension by taking joint external application mode orally, it is characterised in that： The hip bath temperature of the hip bath method must not exceed 43 DEG C, and each hip bath time must not exceed 2h.
4. the Chinese medicine preparation according to claim 1 for treating hypertension by taking joint external application mode orally, it is characterised in that： The extracting method of the external medicine composition is：By Radix Angelicae Sinensis, Herba Ephedrae, rhizoma atractylodis, Caulis Spatholobi, Rhizoma Chuanxiong, radix cyathulae, Radix Notoginseng, Qiang Living, peach kernel is soaked overnight, is then heated to reflux state heat preservation extraction, is filtered while hot after the completion of primary extraction, collect filter Liquid adds water into gained filter residue, and is again heated to reflux state heat preservation extraction, filters, merges while hot after the completion of second extraction Moschus is added when filtrate naturally cools to 40 DEG C or less in filtrate, is sufficiently mixed to get external application Chinese medicine extracting solution.
5. the Chinese medicine preparation according to claim 1 for treating hypertension by taking joint external application mode orally, it is characterised in that： It is described interior to be with the extracting method of Chinese medicine composition：Above-mentioned Chinese medicine is soaked overnight, reflux state heat preservation is then heated to It extracts, is filtered while hot after the completion of primary extraction, collect filtrate, water is added into gained filter residue, and be again heated to reflux state guarantor Temperature extraction, second extraction filter while hot after the completion, and merging filtrate uses Chinese medicine extract to get interior.
6. the Chinese medicine preparation according to claim 1 for treating hypertension by taking joint external application mode orally, it is characterised in that： The extracting method of the external medicine composition is：By Radix Angelicae Sinensis, Herba Ephedrae, rhizoma atractylodis, Caulis Spatholobi, Rhizoma Chuanxiong, radix cyathulae, Radix Notoginseng, Qiang Living, peach kernel is soaked overnight, and extraction aid is added, and stirring and dissolving is complete, is then heated to reflux state heat preservation extraction, once It is filtered while hot after the completion of extraction, collects filtrate, water is added into gained filter residue, and be again heated to reflux state heat preservation extraction, two It is filtered while hot after the completion of secondary extraction, merging filtrate is added Moschus when filtrate naturally cools to 40 DEG C or less, is sufficiently mixed, i.e., Obtain external application Chinese medicine extracting solution.
7. the Chinese medicine preparation according to claim 1 for treating hypertension by taking joint external application mode orally, it is characterised in that： It is described interior to be with the extracting method of Chinese medicine composition：Above-mentioned Chinese medicine is soaked overnight, adds extraction aid, stirring and dissolving is complete Entirely, it is then heated to reflux state heat preservation to extract, is filtered while hot after the completion of primary extraction, collect filtrate, added into gained filter residue Water, and it is again heated to reflux state heat preservation extraction, it is filtered while hot after the completion of second extraction, merging filtrate uses Chinese medicine to get interior Extracting solution.
8. the Chinese medicine preparation for treating hypertension by taking joint external application mode orally described according to claim 6 or 7, feature exist In：The extraction aid dosage is the 1-5% of external medicine composition or the interior Chinese medicine gross dry weight used in Chinese medicine composition.
9. the Chinese medicine preparation for treating hypertension by taking joint external application mode orally described according to claim 6 or 7, feature exist In：The extraction aid is made of poloxamer and myristic acid through esterification, and preparation method is：First respectively at 20-25 DEG C It is lower to add absolute ethyl alcohol to be made into saturated solution PLURONICS F87, myristic acid, then by the saturation ethanol solution of PLURONICS F87 It is heated to 45-50 DEG C of insulated and stirred 5-10min, and dilute sulfuric acid is added dropwise and adjusts pH value to 4-5, continues to be heated to reflux state heat preservation Then stirring starts the saturation ethanol solution that myristic acid is added dropwise, entire that monitoring system pH value in real time is added dropwise in the process, and in time Adding dilute sulfuric acid makes pH stable in 4-5, continues the insulated and stirred that flows back after the saturation ethanol solution of myristic acid is added dropwise, Esterification terminate after through be concentrated under reduced pressure recycle ethyl alcohol, condensate residue plus a small amount of water dissolution, acquired solution are naturally cooled to It is sent into freeze drier after room temperature, micro mist is made to get extraction aid through micronizer in dry obtained solid.
10. the Chinese medicine preparation according to claim 9 for treating hypertension by taking joint external application mode orally, feature exist In：The PLURONICS F87, myristic acid mass ratio be 10-20:1.
CN201810210641.8A 2018-03-14 2018-03-14 The Chinese medicine preparation of hypertension is treated by taking joint external application mode orally Pending CN108272879A (en)

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Application publication date: 20180713