CN103690953A - Animal bite or scratch emergency treatment liquid as well as composition and preparation method thereof - Google Patents
Animal bite or scratch emergency treatment liquid as well as composition and preparation method thereof Download PDFInfo
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- CN103690953A CN103690953A CN201310721538.7A CN201310721538A CN103690953A CN 103690953 A CN103690953 A CN 103690953A CN 201310721538 A CN201310721538 A CN 201310721538A CN 103690953 A CN103690953 A CN 103690953A
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Abstract
The invention discloses an animal bite or scratch emergency treatment liquid as well as a composition and a preparation method thereof. The composition comprises the following components by weight: 2.0%-4.0% of a marine organism bactericide, 12.0%-18.0% of alkyl glycoside, 3.0%-5.0% of cocamidopropyl betaine, 0.5%-1.0% of sodium carbonate and the balance of pure water. The invention further provides a method for preparing the animal bite or scratch emergency treatment liquid from the composition. The method comprises the following steps: 1, adding sodium carbonate, alkyl glycoside and cocamidopropyl betaine into the pure water of 50-60 DEG C according to the weight ratio, and stirring to obtain a mixed solution A; 2, stirring and cooling to 30-35 DEG C, adding the marine organism bactericide into the mixed solution A according to the weight ratio, and uniformly stirring at the temperature to obtain the animal bite or scratch emergency treatment liquid; 3, sub-packaging. The animal bite or scratch emergency treatment liquid contains the marine organism bactericide and has cleaning and sterilizing effects.
Description
Technical field
The present invention relates to disposable sanitary articles, relate in particular to a kind of animal bites scratch emergency processing liquid, composition and method of making the same.
Background technology
According to official statistics, China's rabies morbidity is in recent years gone up rapidly, and within 2007, rabies death is up to 3300 examples.Annual rabies case surpasses 90% and is caused by dog.According to estimates, China supports dog sum and has reached 7,500 ten thousand～200,000,000, but the immunity rate of dog is very low, the dog immunity rate less than 10% of rabies hotspot, Southern Rural Area.Estimating has tens of millions of people every year in rabies exposure.Once by rabies virus infection, cannot cure.
After the animal bite of dog class, should accomplish the wound use of thoroughly cleaning, vaccination, immune serum in time, just can stop rabic infection.In the very first time, cleaning a wound is in time the crucial first step, processes proper meeting 70% bacterial virus is lost activity.
The rabies virus of Canis familiaris L. or cat the to external world resistance of environmental condition is not strong, gets final product deactivation, but can maintain vigour respectively and reach several weeks and several years below 4 ℃ and 0 ℃ at 56 ℃, 30 minutes or 100 ℃, 2 minutes under condition.Therefore with fatsolvent or weak detergent, repeatedly irrigate as early as possible, can play flushing action, also can decompose glycoprotein and the lipoprotein of rabies virus, make virus lose appeal, and easily by eluting.The conventional suds of people carry out emergent management at present.But it is too high that the concentration of suds is difficult for, while blending voluntarily, tend to wound to cause secondary pollution.
Summary of the invention
Provide hereinafter about brief overview of the present invention, to the basic comprehension about some aspect of the present invention is provided.Should be appreciated that this general introduction is not about exhaustive general introduction of the present invention.It is not that intention is determined key of the present invention or pith, and nor is it intended to limit the scope of the present invention.Its object is only that the form of simplifying provides some concept, usings this as the preorder in greater detail of discussing after a while.
The object of the embodiment of the present invention is the defect for above-mentioned prior art, and a kind of animal bites clean and sterilization double effects emergency processing liquid of scratching that has is provided.
The present invention is also provided for the scratch compositions of emergency processing liquid of animal bites.
Another technical scheme of the present invention, the preparation method that provides animal bites to scratch emergency processing liquid.
To achieve these goals, the technical scheme that the present invention takes is:
For the scratch compositions of emergency processing liquid of animal bites, comprise the component of following percentage by weight:
The present invention also provides a kind of and uses above-mentioned compositions to prepare the scratch method of emergency processing liquid of animal bites, comprises the following steps:
Step 1: to the soda, alkyl polyglucoside and the cocamido propyl betaine that add proportional quantity in the pure water of 50-60 ℃, stir, obtain mixed liquor A;
Step 2: stir while being cooled to 30-35 ℃, add the marine organisms bacteria remover of proportional quantity, and stir under this temperature conditions in mixed liquor A, mix homogeneously obtains the animal bites emergency processing liquid of scratching;
Step 3: subpackage.
The present invention provides a kind of animal bites preparing according to above-mentioned method emergency processing liquid of scratching again.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention contains marine organisms sterilization component, has clean and sterilization double effects, and during use, to skin nonirritant and corrosivity, patient keenly feels gently.Glycoprotein and the lipoprotein that can effectively decompose rabies virus, make virus lose appeal and easily by eluting, can carry out sterilization processing to wound simultaneously, easy to use.
The specific embodiment
For making object, technical scheme and the advantage of the embodiment of the present invention clearer, below the technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is the present invention's part embodiment, rather than whole embodiment.Element and the feature described in one embodiment of the invention can combine with element and feature shown in one or more embodiment.It should be noted that for purposes of clarity, in explanation, omitted expression and the description of unrelated to the invention, parts known to persons of ordinary skill in the art and processing.Embodiment based in the present invention, those of ordinary skills, not paying the every other embodiment obtaining under creative work prerequisite, belong to the scope of protection of the invention.
The invention provides a kind ofly for the scratch compositions of emergency processing liquid of animal bites, comprise the component of following percentage by weight:
A kind of marine organisms degerming composition animal bites emergency processing liquid of scratching that contains of the present invention, owing to containing marine organisms bacteria remover composition, therefore has double effects clean and sterilization.
In order to obtain better antiinflammatory and bactericidal action, preferred, described marine organisms bacteria remover comprises the component of following percentage by weight:
It is the cecropin described in CN101104637B that described cecropin can adopt notification number, can certainly adopt other cecropin.
The preferred technical scheme of the present invention: for the scratch compositions of emergency processing liquid of animal bites, comprise the component of following percentage by weight:
Described marine organisms bacteria remover comprises the component of following percentage by weight:
Provided by the inventionly a kind ofly use above-mentioned compositions to prepare the scratch method of emergency processing liquid of animal bites, comprise the following steps:
Step 1: to the soda, alkyl polyglucoside and the cocamido propyl betaine that add proportional quantity in the pure water of 50-60 ℃, stir, obtain mixed liquor A;
Step 2: stir while being cooled to 30-35 ℃, add the marine organisms bacteria remover of proportional quantity, and stir under this temperature conditions in mixed liquor A, mix homogeneously obtains the animal bites emergency processing liquid of scratching;
Step 3: subpackage.
A kind of marine organisms degerming composition animal bites emergency processing liquid and preparation method thereof of scratching that contains of the present invention, because order by merging and the mixing condition of each material are reasonable, a kind of marine organisms degerming composition animal bites each component mix homogeneously of emergency processing liquid of scratching, the good stability of containing that makes to make by preparation method of the present invention.
In order to obtain better mixed effect, the mixing time in described step 1 is 30-40 minute; Mixing speed is 70-85 rev/min.
In order to obtain better mixed effect, the mixing time in described step 2 is 20-30 minute; Mixing speed is 50-60 rev/min.
Preferably, the preparation method of described marine organisms bacteria remover:
Step S10: to the carboxymethyl chitosan and the Sargassum polysaccharides that add proportional quantity in the water of 30～35 ℃, be uniformly mixed 10～20 minutes the first mixed liquor;
Step S20: the cecropin toward adding proportional quantity in the first mixed liquor, stir 3～7 minutes, obtain the second mixed liquor;
Step S30: the N-acetylmuramide lycanohydrlase toward adding proportional quantity in the second mixed liquor, stir 3～7 minutes, obtain marine organisms bacteria remover.
Below by specific embodiment, the present invention is further illustrated:
Embodiment 1
It is a kind of for the scratch compositions of emergency processing liquid of animal bites that the present embodiment provides, and percent meter proportioning is as follows by weight:
Marine organisms bacteria remover in the present embodiment by weight percent meter proportioning is: carboxymethyl chitosan 1.5%; Sargassum polysaccharides 3.0%; Cecropin 7.0%; N-acetylmuramide lycanohydrlase 2.5%; Water 86.0%.
Preparation method:
First prepare marine organisms bacteria remover:
Step S10: to the carboxymethyl chitosan and the Sargassum polysaccharides that add proportional quantity in the water of 32 ℃, be uniformly mixed 15 minutes the first mixed liquor;
Step S20: the cecropin toward adding proportional quantity in the first mixed liquor, stir 5 minutes, obtain the second mixed liquor;
Step S30: the N-acetylmuramide lycanohydrlase toward adding proportional quantity in the second mixed liquor, stir 6 minutes, obtain marine organisms bacteria remover.
The scratch preparation method of emergency processing liquid of animal bites:
Step 1: soda, alkyl polyglucoside and cocamido propyl betaine to adding proportional quantity in the pure water of 55 ℃, with 70 revs/min, stir 35 minutes, obtain mixed liquor A;
Step 2: stir while being cooled to 33 ℃, add the marine organisms bacteria remover of proportional quantity, and at 33 ℃, with 55 revs/min, stir 25 minutes in mixed liquor A, mix homogeneously obtains the animal bites emergency processing liquid of scratching;
Step 3: subpackage.
Using method of the present invention: after being bitten, repeatedly irrigate 3-5 time by product stock solution of the present invention in time.
Wang, man, 6 years old, by dog bite, have hemorrhagely, adopt the treatment fluid very first time of the embodiment of the present invention 1 to rinse 4 times, after recovery from illness without other untoward reaction.
The scratch effect of emergency processing liquid of the present embodiment animal bites is identical with embodiment 1.
The marine organisms bacteria remover of the present embodiment specifies disinfection experiment chamber, disease prevention and control center, Qingdao, sterile products identification experiment chamber to detect through Shandong Province Department of Public Health: the average kill ratio >99.9% of described bacteria remover effect 2min to staphylococcus aureus, escherichia coli, Candida albicans; Effect 5min average kill ratio is 100%; Working concentration is low, bactericidal effect good.
The marine organisms bacteria remover of the present embodiment is cured anti-sterilization professional technique Spot detection through Qingdao: according to the < < of Ministry of Health of the People's Republic of China disinfection technology standard > > toxic grade scale, judge that tested material marine organisms plain bacteria remover alive is actual innocuous substance to chmice acute toxicity; To skin nonirritant; To laboratory animal eyes nonirritant; To laboratory animal vaginal mucosa irritation for extremely slight.Laboratory animal is had no to skin allergic reaction; To PCEMNR without causing micronucleus effect; To mice without causing sperm deformity effect, to male sex-cell hereditary-less toxicity; To laboratory animal, be weak cumulative toxicity, cumulative coefficient K>5.Without teratogenesis, carcinogenic, mutagenic action.
After testing, acid-base value is pH7.89 to the marine organisms bacteria remover of the present embodiment; Colourless, tasteless, noresidue, pollution-free; To the equal ﹤ 0.01mm/a of the corrosion rate of four kinds of sheet metal rustless steels, carbon steel, copper, aluminum, no corrosion.
Embodiment 2
The present embodiment a kind of for the scratch compositions of emergency processing liquid of animal bites, percent meter proportioning is as follows by weight:
Marine growth bacteria remover in the present embodiment by weight percent meter proportioning is: carboxymethyl chitosan 1.0%; Sargassum polysaccharides 2.0%; Cecropin 6.0%; N-acetylmuramide lycanohydrlase 1.5%; Water 89.5%.
Preparation method:
First prepare marine organisms bacteria remover:
Step S10: to the carboxymethyl chitosan and the Sargassum polysaccharides that add proportional quantity in the water of 30 ℃, be uniformly mixed 20 minutes the first mixed liquor;
Step S20: the cecropin toward adding proportional quantity in the first mixed liquor, stir 7 minutes, obtain the second mixed liquor;
Step S30: the N-acetylmuramide lycanohydrlase toward adding proportional quantity in the second mixed liquor, stir 3 minutes, obtain marine organisms bacteria remover.
The scratch preparation method of emergency processing liquid of animal bites:
Step 1: soda, alkyl polyglucoside and cocamido propyl betaine to adding proportional quantity in the pure water of 50 ℃, with 80 revs/min, stir 30 minutes, stir, obtain mixed liquor A;
Step 2: stir while being cooled to 30 ℃, add the marine organisms bacteria remover of proportional quantity, and at 30 ℃, with 50 revs/min, stir 30 minutes in mixed liquor A, mix homogeneously obtains the animal bites emergency processing liquid of scratching;
Step 3: subpackage.
The scratch effect of emergency processing liquid of the present embodiment animal bites is identical with embodiment 1.
Embodiment 3
The present embodiment a kind of contained the marine organisms degerming composition animal bites emergency processing liquid of scratching, and percent meter proportioning is as follows by weight:
Marine growth bacteria remover in the present embodiment by weight percent meter proportioning is: carboxymethyl chitosan 2.0%; Sargassum polysaccharides 4.0%; Cecropin 8.0%; N-acetylmuramide lycanohydrlase 3.5%; Water 82.5%.
Preparation method:
First prepare marine organisms bacteria remover:
Step S10: to the carboxymethyl chitosan and the Sargassum polysaccharides that add proportional quantity in the water of 35 ℃, be uniformly mixed 10 minutes the first mixed liquor;
Step S20: the cecropin toward adding proportional quantity in the first mixed liquor, stir 3 minutes, obtain the second mixed liquor;
Step S30: the N-acetylmuramide lycanohydrlase toward adding proportional quantity in the second mixed liquor, stir 7 minutes, obtain marine organisms bacteria remover.
The scratch preparation method of emergency processing liquid of animal bites:
Step 1: soda, alkyl polyglucoside and cocamido propyl betaine to adding proportional quantity in the pure water of 60 ℃, with 85 revs/min, stir 40 minutes, obtain mixed liquor A;
Step 2: stir while being cooled to 35 ℃, add the marine organisms bacteria remover of proportional quantity, and at 35 ℃, with 60 revs/min, stir 20 minutes in mixed liquor A, mix homogeneously obtains the animal bites emergency processing liquid of scratching;
Step 3: subpackage.
The scratch effect of emergency processing liquid of the present embodiment animal bites is identical with embodiment 1.
Properties of product detect:
Brood body is quantitatively killed detection:
One, equipment
1, test strain: escherichia coli, staphylococcus aureus, Candida albicans.
2, nertralizer: 2% tween+1% lecithin+0.3% soap base+0.1% glycine → PBS (phosphate buffer, pH7.2).Above percent is quality percentage composition.
3, culture medium: nutrient agar, standby after pressuresteam sterilization.
Two, method
1, detect foundation: 2002 editions < < disinfectant technical specification > > of Ministry of Public Health.
2, the animal bites of bactericidal assay: the embodiment 1 emergency processing liquid of scratching.
Table 1
Conclusion: embodiment 1 to contain the marine organisms degerming composition animal bites emergency processing liquid concentration of scratching be that 1:1 refers to use the scratch stock solution of emergency processing liquid of animal bites to process, the effect of escherichia coli, staphylococcus aureus, Candida albicans 2 minutes, 5 minutes, 10 minutes killed to the equal ﹥ 5 of logarithm value.
Irritation test is as follows:
Material and animal
1, tested material shape: liquid; Tested material is processed: stock solution.
2, experimental animal: 3 of one-level New Zealand white rabbit, weight range: 2.5-27kg, female 2, male 1.
3, experimental animal feeding environment: room temperature 20-21 ℃, relative humidity 59-62%RH, single cage is raised.
Test method: experimental animal was observed after 1 day, tested first 24 hours, cuts experimental animal back spinal column diamond wool, left and right each the about 3 * 3cm of unhairing scope
2.Get tested material 0.5ml and be directly coated on skin, then use two layers of gauze (2.5cm * 2.5cm) and one deck cellophane to cover, then fixed with non-stimulated adhesive plaster and binder, opposite side in contrast.Seal 4 hours, remove tested material, and clean and remove residual tested material with warm water.Remove observing for 1,24,48 hour after tested material and smear position dermoreaction, and scoring.
Result of the test:
Observation has no experimental animal obvious abnormal response.Skin irritation result of the test is in Table 2.
Table 2
In the various embodiments described above of the present invention, the sequence number of embodiment is only convenient to describe, and does not represent the quality of embodiment.Description to each embodiment all emphasizes particularly on different fields, and there is no the part of detailed description in certain embodiment, can be referring to the associated description of other embodiment.
In the embodiment such as apparatus and method of the present invention, obviously, each parts or each step reconfigure after can decomposing, combine and/or decomposing.These decomposition and/or reconfigure and should be considered as equivalents of the present invention.Simultaneously, in the above in the description of the specific embodiment of the invention, the feature of describing and/or illustrating for a kind of embodiment can be used in same or similar mode in one or more other embodiment, combined with the feature in other embodiment, or substitute the feature in other embodiment.
Should emphasize, term " comprises/comprises " existence that refers to feature, key element, step or assembly while using herein, but does not get rid of the existence of one or more further feature, key element, step or assembly or add.
Finally it should be noted that: although described above the present invention and advantage thereof in detail, be to be understood that in the situation that do not exceed the spirit and scope of the present invention that limited by appended claim and can carry out various changes, alternative and conversion.And scope of the present invention is not limited only to the specific embodiment of the described process of description, equipment, means, method and step.One of ordinary skilled in the art will readily appreciate that from disclosure of the present invention, can use carry out with the essentially identical function of corresponding embodiment described herein or obtain process, equipment, means, method or step result essentially identical with it, that existing and will be developed future according to the present invention.Therefore, appended claim is intended to comprise such process, equipment, means, method or step in their scope.
Claims (8)
1. for the scratch compositions of emergency processing liquid of animal bites, it is characterized in that, comprise the component of following percentage by weight:
2. according to claim 1ly for the scratch compositions of emergency processing liquid of animal bites, it is characterized in that, described marine organisms bacteria remover comprises the component of following percentage by weight:
3. according to claim 2ly for the scratch compositions of emergency processing liquid of animal bites, it is characterized in that, comprise the component of following percentage by weight:
Described marine organisms bacteria remover comprises the component of following percentage by weight:
4. right to use requires compositions described in 1-3 any one to prepare the scratch method of emergency processing liquid of animal bites, it is characterized in that, comprises the following steps:
Step 1: to the soda, alkyl polyglucoside and the cocamido propyl betaine that add proportional quantity in the pure water of 50-60 ℃, stir, obtain mixed liquor A;
Step 2: stir while being cooled to 30-35 ℃, add the marine organisms bacteria remover of proportional quantity, and stir under this temperature conditions in mixed liquor A, mix homogeneously obtains the animal bites emergency processing liquid of scratching;
Step 3: subpackage.
5. method according to claim 4, is characterized in that, the mixing time in described step 1 is 30-40 minute; Mixing speed is 70-85 rev/min.
6. method according to claim 4, is characterized in that, the mixing time in described step 2 is 20-30 minute; Mixing speed is 50-60 rev/min.
7. method according to claim 4, is characterized in that,
The preparation method of described marine organisms bacteria remover:
Step S10: to the carboxymethyl chitosan and the Sargassum polysaccharides that add proportional quantity in the water of 30～35 ℃, be uniformly mixed 10～20 minutes the first mixed liquor;
Step S20: the cecropin toward adding proportional quantity in the first mixed liquor, stir 3～7 minutes, obtain the second mixed liquor;
Step S30: the N-acetylmuramide lycanohydrlase toward adding proportional quantity in the second mixed liquor, stir 3～7 minutes, obtain marine organisms bacteria remover.
8. the animal bites emergency processing liquid of scratching, is characterized in that, according to the method described in claim 4-7 any one, prepares.
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| US20080255014A1 (en) * | 2004-12-16 | 2008-10-16 | Georgia-Pacific Consumer Products Lp | Antimicrobial foam hand soap |
| CN101182430A (en) * | 2007-10-19 | 2008-05-21 | 平风智 | Health-care multipurpose washing liquor and method for making same |
| CN103040675A (en) * | 2012-12-07 | 2013-04-17 | 青岛海芬海洋生物科技有限公司 | Bacteria-removing marine organism male cleaning liquid |
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Effective date of registration: 20200826 Address after: 225700, Wang Di Economic Development Zone, Taizhou, Jiangsu, Xinghua Patentee after: DINGNENG TECHNOLOGY Co.,Ltd. Address before: 266071 Shandong Province, Qingdao city Laoshan District Songling Road No. 58 No. 33 Building 1 unit 101 Patentee before: QINGDAO HIFUN MARINE BIOLOGICAL TECHNOLOGY Co.,Ltd. |
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