CN103656286A - Composition for alleviating discomfort after drinking and reducing alcoholic liver injury and application - Google Patents
Composition for alleviating discomfort after drinking and reducing alcoholic liver injury and application Download PDFInfo
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Abstract
The invention relates to a composition for alleviating discomfort after drinking and reducing alcoholic liver injury, and also especially relates to application of the composition to foodstuff, health-care foodstuff and medicines. The disclosed composition for alleviating discomfort after drinking and reducing alcoholic liver injury is composed of 20-80 parts of imperata rhizome, 20-100 parts of radix puerariae, 20-100 parts of mulberry, 10-50 parts of dark plum, 1-20 parts of tea, 30-150 parts of corn oligopeptide, 200-400 parts of fructose-glucose syrup, 20-80 parts of honey, 20-80 parts of xylooligosaccharide, 1-20 parts of gamma-aminobutyric acid and 1-20 parts of taurine. According to the composition provided by the invention, on the basis of analysis on same-kind products and correlated technologies, new resource foodstuff and traditional Chinese medicine materials are subjected to scientific compatibility and give play to cooperative synergic effect, and the composition is capable of alleviating the symptom of discomfort after drinking as well as protecting liver.
Description
Technical field
The present invention relates to a kind of can the compositions of alleviation of alcohol to mankind's hepatic injury, also relate to especially the application of this compositions in Food and hygienical food or medicine.
Background technology
Responsible drinking can promote blood circulation of human body, relieving fatigue; But human body is taken in after ethanol overrun, can cause the symptoms such as lethargy, hepatic injury, gastrorrhagia, central nervous system's paralysis, and human body is caused to huge harm.Ethanol has addiction, one of the most serious social economy and public health problem within the scope of alcohol abuse and the alcohol dependence Xing Shi world today.Report in western countries, alcoholic liver disease has become the sixth-largest cause of death.Liver is unique organ of alcohol metabolism, and the ethanol that human body is taken in has more than 95% through liver metabolism, and therefore heavy drinking will cause a series of changes of liver for a long time.Along with the increase of alcohol to oil ratio, alcoholic liver disease presents rising.Alcoholic liver disease pathogenesis is quite complicated, relates to hereditary individual difference, also with various cytokines, and the direct and indirect action of ethanol and metabolite thereof, nutritional disorder, autoimmune, endotoxin, the many factors such as adhesion factor are relevant.
The traditional Chinese medical science thinks that wine is damp and hot thing, so the general side's of relieving the effect of alcohol clearing away heat-damp and promoting diuresis medical materials that use, similar products on the market utilize this dialectical rule more more, by modern pharmacological research, is interpreted as accelerating metabolism in vivo of ethanol, strengthens the aspects such as ethanol tolerance.The focus of new resource food exploitation in recent years is all tending towards having the relatively high material of certain therapeutic efficiency and safety as new resource food raw material, such raw material effect clear and definite not and because of other factors such as its safety all to every day intake have certain limitation, so some kind amount is well below onset actuating quantity.Mostly chemical drugs antialcoholic drug is the compositions such as analeptic, vitamin and aminoacid, can play fast relieve the effect of alcohol, sobering-up functions, but most chemical drugs relieving mechanism is only to promote ethanol to decompose, and plays temporary mitigation, is difficult to play liver protection effect.
Summary of the invention
Object of the present invention is intended to overcome the defect of prior art, provides a kind of and can alleviate the compositions that uncomfortable after drinking symptom can play the effect of hepatoprotective simultaneously.
Another object of the present invention is to provide the application of this compositions.
Alleviation of the present invention after drinking compositions uncomfortable and reduction alcoholic liver injury is comprised of Rhizoma Imperatae 20-80 part, Radix Puerariae 20-100 part, Fructus Mori 20-100 part, Fructus Mume 10-50 part, tea 1-20 part, maize oligopeptide 30-150 part, high fructose syrup 200-400 part, Mel 20-80 part, oligomeric xylose 20-80 part, γ-aminobutyric acid 1-20 part, taurine 1-20 part.
Present composition formula can be optimized for Rhizoma Imperatae 35-50 part, Radix Puerariae 60-90 part, Fructus Mori 35-50 part, Fructus Mume 10-30 part, tea 1-10 part, maize oligopeptide 50-120 part, high fructose syrup 280-320 part, Mel 30-60 part, oligomeric xylose 20-30 part, γ-aminobutyric acid 1-6 part, taurine 1-6 part composition.
Further formula can form for Rhizoma Imperatae 35-40 part, Radix Puerariae 70-85 part, Fructus Mori 35-45 part, Fructus Mume 12-18 part, tea 1-5 part, maize oligopeptide 50-120 part, high fructose syrup 280-320 part, Mel 40-55 part, oligomeric xylose 23-28 part, γ-aminobutyric acid 2-5 part, taurine 2-4 part.
It is one or more in black tea, green tea, oolong tea, Folium camelliae assamicae that above-mentioned tea can be selected from.
The present invention relates to the application of described compositions in preparing food.
The present invention relates to the application of described compositions in preparing health food.
The present invention relates to the application of described compositions in preparing medicine.
The present composition is made extracting solution or extractum after can as required the medical material part (Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume and tea) in compositions being extracted, is more directly mixed with liquid beverage or oral liquid after adding in proportion other batching.Can also be according to the processing request of food or health food or medicine, add food ingredient or additive, pharmaceutical aids etc. and make food or health food or the medicine that can alleviate malaise symptoms after drinking and reduce alcoholic liver injury.
Compositions integration of edible and medicinal herbs of the present invention is partly selected Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, tea, wherein Rhizoma Imperatae clearing away heat-damp and promoting diuresis can be separated excessive thirst, Radix Puerariae alcoholic intoxication and joins the effect that Fructus Mori, Fructus Mume increase are promoted the production of body fluid and moisturize, and the polyphenols being in harmonious proportion simultaneously wherein with tea can play the effect of antioxidation free radical resisting.Collocation new resource food maize oligopeptide can activate alcohol dehydrogenase activity, suppresses alcoholism; Oligomeric xylose helps the intestines and stomach coordinating function; γ-aminobutyric acid can help to activate liver function, regulates immunologic function; The strong liver function of gallbladder promoting of taurine, antipyretic and anti-inflammatory.Glucose in Mel and high fructose syrup can promote the function of detoxification of liver, improves the content of hepatic glycogen in hepatocyte, maintains the normal function of liver.This compositions eats for a long time or can not bring untoward reaction and side effect for tea-drinking.
The present composition will play the effect of Synergistic on to the analysis foundation of like product and correlation technique after new resource food and Chinese medicine material science compatible combination, can alleviate the effect that uncomfortable after drinking symptom can play hepatoprotective simultaneously.The present composition takes full advantage of the new resource food monomer component feature that metabolic pathway is clear and definite in vivo, effect sensing is clear and definite; Combine the comprehensive effect of traditional Chinese medical herbal treatment symptom and conditioning internal organs simultaneously, by compatibility, make the functional effect of prescription element reach maximum and discharge.
Compositions of the present invention, formula screening Main Basis completes by two experiments: 1, after compositions administration, detect the concentration of alcohol in serum; 2, the performances such as mobility of mice after observation feeding ethanol.
Specific experiment method:
Take normal saline as blank, commercially available certain hangover-alleviating health-care food (oral liquid) and commercially available certain to protect the liver oral liquid prepared by the positive contrast of granule (making 20% aqueous solution), the present embodiment 5 prescriptions of take be for sample.Control sample and treat that test sample all makes every ml and test containing the solution of medical material/raw material 0.5g.Experiment adopts kunming mice, and male and female half and half, fill with wine again after 30 minutes through administration, and each group is all used ethanol content 53%(volume ratio) Chinese liquor by 0.15ml/10g body weight, gavage.
1, after compositions administration, detect the concentration of alcohol in blood.Conclusion judgment basis: ethanol was completely absorbed after entering the intestines and stomach substantially in 30-90 minute, by blood, be delivered to oxidized decomposition in liver, just decompose and more can reduce the impact of ethanol on each internal organs and nervus centralis sooner, alleviate the malaise symptoms such as giddy, vomiting.The lower illustration of ethanol in blood concentration is more obvious, and under this experiment condition, measurement result is in Table 1.
Table 1 experiment mice ethanol in blood content detection result (μ l/ml)
| Group | Fill with 60min after drinking | Fill with 90min after drinking | Fill with 120min after drinking | Fill with 150min after drinking |
| Matched group | 1.83±0.12 | 1.70±0.15 | 1.66±0.10 | 1.37±0.12 |
| Certain hangover-alleviating health-care food group | 1.68±0.11 | 1.62±0.13 | 1.33±0.16 | 1.07±0.15 |
| Certain protects the liver groups of grains | 1.54±0.08 | 1.41±0.10 | 1.12±0.12 | 0.96±0.10 |
| Present composition group | 1.45±0.15 | 1.29±0.09 | 0.89±0.10 | 0.61±0.13 |
2, the performances such as mobility of mice after observation feeding ethanol.Conclusion judgment basis: ethanol reaches after finite concentration and can impact central nervous system in blood, infers that by the feed ability of seeking connections with, the active performance of lethargy time of ethanol mice of judgement said composition evaluates the impact of the malaise symptoms of drinking.Oral liquid prepared by this prescription of result can obviously extend the time of seeking connections with, the minimizing mice drunk sleep time of experiment mice, and under this experiment condition, measurement result is in Table 2.
Table 2 experiment mice is sought connections with time and drunk sleep time observed result
| Group | Drunk sleep time (min) | Seek connections with the time (s) |
| Matched group | 224.80±13.35 | 231.32±40.59 |
| Certain hangover-alleviating health-care food group | 178.91±16.84 | 469.55±42.75 |
| Certain protects the liver groups of grains | 201.75±12.32 | 386.29±37.25 |
| Present composition group | 126.55±10.62 | 587.53±38.68 |
After liver damage often with symptoms such as hepatalgia, hepatosplenomegaly, intercostal loins pain, clinical diagnosis often relies on the indexs such as liver function in conjunction with symptom and medical imaging judgement liver function situation or degree of injury, design accordingly clinical prerun experiment, the beverage concentrate (every 50ml) of the embodiment of the present invention 1 preparation of take carries out as experimental subject.Experiment 1: experimenter, by taking 3 every day, takes 1 month continuously, impression after taking after a week record and drinking, take headache and dizziness, gastrointestinal upset, dry pharynx vomiting etc. after drinking malaise symptoms alleviate or disappear as symptom improvement standard.In 50 experimenters, there are as a result headache after 39 sensation heavy drinkings, dizzy, tired sense of discomfort of vomitting obviously to improve; 32 subject perception drink after excessive thirst symptom obviously improve; After 18 subject perception heavy drinkings, the sense of discomfort of the intestines and stomach is obviously improved.Experiment 2: select to have the dietary habit of drinking and clinical liver function indexes ALT(alanine aminotransferase)/AST(Radix Asparagi door propylhomoserin aminotransferase) there is person higher or in rising trend for study subject, during tested, stop drinking, by taking 3 every day, take continuously after 3 months and observe liver function indexes.Evaluation methodology: it is that symptom is improved standard that liver function indexes ALT/AST reduces by 5 u/L.To diet and take the satisfactory experimenters (effective sample) such as number of times consumption and carry out Statistical Comparison, result shows that the present composition has certain regulating action to liver function indexes.Under this experiment condition, measurement result is in Table 3.
The clinical prerun experimental result of table 3
| Index | Effective sample number | Meansigma methods before examination | Meansigma methods after examination | Symptom is improved number | Effective percentage |
| ALT(u/L) | 15 | ?55.2 | ?37.8 | 5 | 33.3% |
| AST(u/L) | 15 | ?42.6 | ?31.3 | 7 | 46.7% |
The specific embodiment
Below in conjunction with embodiment, the present invention is described further, but be not limited to embodiment.
Embodiment 1:
Alleviation described in the present embodiment after drinking composite formula uncomfortable and reduction alcoholic liver injury is: 20 parts of Rhizoma Imperataes, 20 parts of Radix Puerariaes, 20 parts, Fructus Mori, 10 parts of Fructus Mumes, 1 part of black tea, 30 parts of maize oligopeptides, 200 parts of high fructose syrups, 20 parts of Mel, 20 parts of oligomeric xyloses, 1 part of γ-aminobutyric acid, 1 part of composition of taurine.
Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, black tea are cleaned, adding 15 times of water boils extracts 2 times, each 30min, merge extractive liquid,, it is that 1.15(50 degree is surveyed that 70-80 degree is evaporated to density) clear paste, clear paste filters through 200 orders, adds respectively other component after adding the purified water dispersing and dissolving about 5 times of extractum amounts, 80 degree, be stirred to dissolve fully, then after adding 35 times of purified water to stir to filter, subpackage, sterilizing are made and are had alleviation uncomfortable concentrated liquid beverage after drinking.
Alleviation described in the present embodiment after drinking compositions uncomfortable and reduction alcoholic liver injury can have the alleviation food of uncomfortable effect after drinking for making.
Embodiment 2:
Alleviation described in the present embodiment after drinking composite formula uncomfortable and reduction alcoholic liver injury is: 80 parts of Rhizoma Imperataes, 100 parts of Radix Puerariaes, 100 parts, Fructus Mori, 50 parts of Fructus Mumes, 20 parts of green tea, 150 parts of maize oligopeptides, 400 parts of high fructose syrups, 80 parts of Mel, 80 parts of oligomeric xyloses, 20 parts of γ-aminobutyric acid, 20 parts of compositions of taurine.
Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, green tea are cleaned, adding 10 times of water boils extracts 2 times, each 30min, merge extractive liquid,, it is that 1.10(50 degree is surveyed that 70-80 degree is evaporated to density) clear paste, clear paste filters through 200 orders, adds respectively other component after adding 20 times of 80 purified water dispersing and dissolving about degree, be stirred to dissolve full and uniformly, after filtering, subpackage, sterilizing are made and are had the oral liquid that reduces alcoholic liver injury.
Alleviation described in the present embodiment after drinking compositions uncomfortable and reduction alcoholic liver injury can have the medicine that reduces alcoholic liver injury effect for making.
Embodiment 3:
Alleviation described in the present embodiment after drinking composite formula uncomfortable and reduction alcoholic liver injury is: 35 parts of Rhizoma Imperataes, 60 parts of Radix Puerariaes, 35 parts, Fructus Mori, 10 parts of Fructus Mumes, 1 part of oolong tea, 50 parts of maize oligopeptides, 280 parts of high fructose syrups, 30 parts of Mel, 20 parts of oligomeric xyloses, 1 part of γ-aminobutyric acid, 1 part of composition of taurine.
Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, oolong tea are cleaned; adding 8 times of water boils extracts 3 times; each 30min; merge extractive liquid; be concentrated into density and be 1.3 thick paste standby, get the purified water of 30 times of thick paste amounts and disperse to add maize oligopeptide, oligomeric xylose, γ-aminobutyric acid, taurine, Mel, high fructose syrup to mix after extractum, then add the purified water of the 100 times centrifuge that stirred; get in supernatant subpackage pop can or vial and carry out sterilizing, make liquid beverage.
Alleviation described in the present embodiment after drinking compositions uncomfortable and that reduce alcoholic liver injury can have the health food of alleviating malaise symptoms after drinking and reducing alcoholic liver injury effect for making.
Embodiment 4:
Alleviation described in the present embodiment after drinking composite formula uncomfortable and reduction alcoholic liver injury is: 50 parts of Rhizoma Imperataes, 90 parts of Radix Puerariaes, 50 parts, Fructus Mori, 30 parts of Fructus Mumes, 10 parts of Folium camelliae assamicaes, 120 parts of maize oligopeptides, 320 parts of high fructose syrups, 60 parts of Mel, 30 parts of oligomeric xyloses, 6 parts of γ-aminobutyric acid, 6 parts of compositions of taurine.
Rhizoma Imperatae, Radix Puerariae, Fructus Mori, Fructus Mume, Folium camelliae assamicae are cleaned, add 100 times of 80 degree distilled water warm macerating to extract 3 times for 1.5 hours, extracting solution filters after merging, getting other components adds respectively to stir in filtrate and makes to dissolve fully, after centrifuge separation after 1um microfilter, filtrate subpackage PET bottle and get final product after ultrahigh-temperature instant sterilizing.
Alleviation described in the present embodiment after drinking uncomfortable and reduce the compositions of alcoholic liver injury can be for making the food that can alleviate malaise symptoms after drinking and reduce alcoholic liver injury.
Embodiment 5:
Alleviation described in the present embodiment after drinking composite formula uncomfortable and reduction alcoholic liver injury is: 39 parts of Rhizoma Imperataes, 78 parts of Radix Puerariaes, 39 parts, Fructus Mori, 15.6 parts of Fructus Mumes, 2.4 parts of tea, 120 parts of maize oligopeptides, 300 parts of high fructose syrups, 50 parts of Mel, 25 parts of oligomeric xyloses, 5 parts of γ-aminobutyric acid, 3 parts of compositions of taurine.
Medical material and tea partly add 12 times, water, 10 times and extract twice; boil 30min at every turn; after extracting liquid filtering, be concentrated into the clear paste that density is 1.10-1.15; get dissolved in purified water maize oligopeptide, oligomeric xylose, γ-aminobutyric acid, taurine, Mel, the high fructose syrup of 30 times of amounts of extractum; stirring makes mix homogeneously; subpackage after filtering, sterilizing makes that to have alleviation uncomfortable and reduce the concentrated liquid beverage of alcoholic liver injury effect after drinking.
Alleviation described in the present embodiment after drinking uncomfortable and reduce the compositions of alcoholic liver injury can be for making the health food that can alleviate malaise symptoms after drinking and reduce alcoholic liver injury.
Claims (7)
1. alleviation is uncomfortable and reduce the compositions of alcoholic liver injury after drinking, it is characterized in that being comprised of Rhizoma Imperatae 20-80 part, Radix Puerariae 20-100 part, Fructus Mori 20-100 part, Fructus Mume 10-50 part, tea 1-20 part, maize oligopeptide 30-150 part, high fructose syrup 200-400 part, Mel 20-80 part, oligomeric xylose 20-80 part, γ-aminobutyric acid 1-20 part, taurine 1-20 part.
2. alleviation as claimed in claim 1 is uncomfortable and reduce the compositions of alcoholic liver injury after drinking, it is characterized in that being comprised of Rhizoma Imperatae 35-50 part, Radix Puerariae 60-90 part, Fructus Mori 35-50 part, Fructus Mume 10-30 part, tea 1-10 part, maize oligopeptide 50-120 part, high fructose syrup 280-320 part, Mel 30-60 part, oligomeric xylose 20-30 part, γ-aminobutyric acid 1-6 part, taurine 1-6 part.
3. alleviation as claimed in claim 1 is uncomfortable and reduce the compositions of alcoholic liver injury after drinking, it is characterized in that being comprised of Rhizoma Imperatae 35-40 part, Radix Puerariae 70-85 part, Fructus Mori 35-45 part, Fructus Mume 12-18 part, tea 1-5 part, maize oligopeptide 50-120 part, high fructose syrup 280-320 part, Mel 40-55 part, oligomeric xylose 23-28 part, γ-aminobutyric acid 2-5 part, taurine 2-4 part.
4. alleviation as claimed in claim 1 is uncomfortable and reduce the compositions of alcoholic liver injury after drinking, it is characterized in that being comprised of 3 parts of 39 parts of Rhizoma Imperataes, 78 parts of Radix Puerariaes, 39 parts, Fructus Mori, 15.6 parts of Fructus Mumes, 2.4 parts of tea, 120 parts of maize oligopeptides, 300 parts of high fructose syrups, 50 parts of Mel, 25 parts of oligomeric xyloses, 5 parts of γ-aminobutyric acid, taurine.
5. the uncomfortable and compositions that the reduces alcoholic liver injury application in preparing food after drinking of the alleviation as described in claim 1-4.
6. the uncomfortable and compositions that the reduces alcoholic liver injury application in preparing health food after drinking of the alleviation as described in claim 1-4.
7. the uncomfortable and compositions that the reduces alcoholic liver injury application in preparing medicine after drinking of the alleviation as described in claim 1-4.
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Cited By (11)
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| CN105561006A (en) * | 2015-02-10 | 2016-05-11 | 魏嵋 | Food, health care food or medicine composition with alcohol effect dispelling function and preparation method and application thereof |
| CN106359702A (en) * | 2016-08-26 | 2017-02-01 | 青岛汇棠健康科技有限公司 | Health-caring solid tea for relieving effects of alcohol and preparation method of same |
| CN106858244A (en) * | 2017-02-17 | 2017-06-20 | 陕西必康制药集团控股有限公司 | Maize oligopeptide sobering-up beverage and preparation method thereof |
| CN107149068A (en) * | 2017-05-10 | 2017-09-12 | 重庆市春旭农业发展有限公司 | A kind of honey sobering-up beverage and preparation method thereof |
| CN107348299A (en) * | 2017-07-31 | 2017-11-17 | 湖州金诺康健康科技有限公司 | A kind of solid beverage with liver-protecting and alcoholism-relieving effect |
| CN108771218A (en) * | 2018-05-24 | 2018-11-09 | 河北华维兰达食品科技有限公司 | A kind of alcohol-decomposing beverage formula |
| CN109453267A (en) * | 2018-12-19 | 2019-03-12 | 泓博元生命科技（深圳）有限公司 | Sobering-up composition and the preparation method and application thereof |
| CN109602756A (en) * | 2018-12-19 | 2019-04-12 | 泓博元生命科技（深圳）有限公司 | A kind of sobering-up composition and the preparation method and application thereof |
| CN109924377A (en) * | 2018-12-07 | 2019-06-25 | 西北农林科技大学 | A kind of liver-protection health-care beverage of Quick sobering and preparation method thereof |
| CN111685245A (en) * | 2020-06-27 | 2020-09-22 | 北京醒舒饮料销售有限公司 | Soft drink capable of effectively relieving body discomfort after drinking and preparation method thereof |
| CN115918850A (en) * | 2022-12-02 | 2023-04-07 | 河北农业大学 | Preparation method and application of germinated quinoa wheat flour rich in gamma-aminobutyric acid |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105561006A (en) * | 2015-02-10 | 2016-05-11 | 魏嵋 | Food, health care food or medicine composition with alcohol effect dispelling function and preparation method and application thereof |
| CN105561006B (en) * | 2015-02-10 | 2018-09-28 | 魏嵋 | One kind having treatment alcoholic liver disease function medicament composition and its preparation method and application |
| CN106359702A (en) * | 2016-08-26 | 2017-02-01 | 青岛汇棠健康科技有限公司 | Health-caring solid tea for relieving effects of alcohol and preparation method of same |
| CN106858244A (en) * | 2017-02-17 | 2017-06-20 | 陕西必康制药集团控股有限公司 | Maize oligopeptide sobering-up beverage and preparation method thereof |
| CN107149068A (en) * | 2017-05-10 | 2017-09-12 | 重庆市春旭农业发展有限公司 | A kind of honey sobering-up beverage and preparation method thereof |
| CN107348299A (en) * | 2017-07-31 | 2017-11-17 | 湖州金诺康健康科技有限公司 | A kind of solid beverage with liver-protecting and alcoholism-relieving effect |
| CN108771218A (en) * | 2018-05-24 | 2018-11-09 | 河北华维兰达食品科技有限公司 | A kind of alcohol-decomposing beverage formula |
| CN109924377A (en) * | 2018-12-07 | 2019-06-25 | 西北农林科技大学 | A kind of liver-protection health-care beverage of Quick sobering and preparation method thereof |
| CN109453267A (en) * | 2018-12-19 | 2019-03-12 | 泓博元生命科技（深圳）有限公司 | Sobering-up composition and the preparation method and application thereof |
| CN109602756A (en) * | 2018-12-19 | 2019-04-12 | 泓博元生命科技（深圳）有限公司 | A kind of sobering-up composition and the preparation method and application thereof |
| CN111685245A (en) * | 2020-06-27 | 2020-09-22 | 北京醒舒饮料销售有限公司 | Soft drink capable of effectively relieving body discomfort after drinking and preparation method thereof |
| CN115918850A (en) * | 2022-12-02 | 2023-04-07 | 河北农业大学 | Preparation method and application of germinated quinoa wheat flour rich in gamma-aminobutyric acid |
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