CN103656020A - Traditional Chinese medicine composition for treating encephalitozoon intestinalis of freshwater fish and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating encephalitozoon intestinalis of freshwater fish and preparation method thereof Download PDFInfo
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- CN103656020A CN103656020A CN201210355228.3A CN201210355228A CN103656020A CN 103656020 A CN103656020 A CN 103656020A CN 201210355228 A CN201210355228 A CN 201210355228A CN 103656020 A CN103656020 A CN 103656020A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention relates to a traditional Chinese medicine composition for treating encephalitozoon intestinalis of freshwater fish. The traditional Chinese medicine composition comprises the following components in parts by weight: 15 to 25 parts of betel nut, 7 to 12 parts of pumpkin seed, 3 to 5 parts of peking euphorbia root, 4 to 8 parts of sargent gloryvine, 4 to 8 parts of fructus chaenomelis lagenariae, and 5 to 10 parts of szechwan chinaberry fruit. The traditional Chinese medicine composition is used for exterminating encephalitozoon intestinalis of freshwater fish based on the penetrability of special components as well as the paralysis and etermination promoting effect of the Chinese herbal medicines. The preparation method comprises the following steps: naturally drying the natural Chinese herbal medicines; crushing the natural Chinese herbal medicines until the granularity is more than 65 meshes. The traditional Chinese medicine composition can be uniformly mixed with a fish feed for use, and is convenient to use and free from toxic and side effects.
Description
Technical field:
The invention belongs to Aquatic product field of veterinary, especially a kind of sporozoan Chinese medicine composition of freshwater fish intestinal and preparation method thereof for the treatment of.
Background technology:
Along with the development of China's fresh water fishery technology, cultivation density is increasing, and fish diseases incidence probability and hazardness also improve constantly, and parasitic disease has also accounted for certain proportion, has developed in recent years one of serious aquatic animal disease of harm.The treatment of freshwater fish sporidiosis is a great problem of aquatic products industry for many years, and sporozoon, due to the strong protectiveness of sporangiocyst of himself, causes many medicines by sporangiocyst, not consumed before reaching polypide, thereby can not kill capsule Endospore worm.
Summary of the invention:
The object of the present invention is to provide a kind of sporozoan Chinese medicine composition of freshwater fish intestinal for the treatment of, this Chinese medicine composition is effectively abolished sporangiocyst, kills capsule Endospore worm, and drug residue can not occur, and easy to use, cost is lower.
Another object of the present invention is to provide a kind of preparation method for the treatment of the sporozoan Chinese medicine composition of freshwater fish intestinal.
The present invention is achieved through the following technical solutions:
Treat the sporozoan Chinese medicine composition of freshwater fish intestinal, its Chinese medicine composition component and ratio of weight and number thereof are respectively:
Semen Arecae 15-25 part;
Semen Cucurbitae 7-12 part;
Radix Euphorbiae Pekinensis 3-5 part;
Caulis Sargentodoxae 4-8 part;
Fructus Chaenomelis 4-8 part;
Fructus Toosendan 5-10 part.
And the component of this Chinese medicine composition and optimum ratio of weight and number thereof are:
20 parts of Semen Arecaes;
10 parts of Semen Cucurbitaes;
4 parts of Radix Euphorbiae Pekinensiss;
6 parts of Caulis Sargentodoxaes;
6 parts of Fructus Chaenomeliss;
7 parts of Fructus Toosendans.
Treat a preparation method for the sporozoan Chinese medicine composition of freshwater fish intestinal, its step is as follows:
(1) take respectively by weight ratio Semen Arecae, Semen Cucurbitae, Radix Euphorbiae Pekinensis, Caulis Sargentodoxae, Fructus Chaenomelis, Fructus Toosendan and pulverize, and respectively all by 65 mesh sieves;
(2) Semen Arecae after sieving, Semen Cucurbitae, Radix Euphorbiae Pekinensis, Caulis Sargentodoxae, Fructus Chaenomelis, Fructus Toosendan are put into abundant mix homogeneously in three-dimensional hybrid tank, the sporozoan Chinese medicine composition finished product of the freshwater fish intestinal that obtains medical treatment.
Advantage of the present invention and beneficial effect are:
1, to adopt Semen Arecae, Radix Euphorbiae Pekinensis be main prescription element in the present invention, this prescription has very strong paralysis effect for polypide, Semen Arecae itself can raise the level of adhesion molecule-1 (ICAM-1) between fibroblast (FB) express cell, there is the effect of obvious fibrosis, effectively blocking-up sporangiocyst forms, thereby the growth of blocking-up polypide, finally reaches anthelminthic effect.
2, Chinese prescription of the present invention adopts natural Chinese medicines composition, rely on self alkaloid and plant insect-repelling method, can not produce biology drug resistance, and can avoid completely because of the infringement of chemical drugs toxicity to the generation of fish body, be the safe and reliable Aquatic product parasite killing medicine of a class.
3, Chinese prescription compatibility science of the present invention, medicine collection is bought convenient, manufactures simply, can effectively save production cost, and is convenient to large-scale production.
The specific embodiment
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
In component involved in the present invention, Semen Arecae, Semen Cucurbitae, Radix Euphorbiae Pekinensis, Caulis Sargentodoxae, Fructus Chaenomelis, Fructus Toosendan all can be bought and obtain on market.
Embodiment 1
Treat the sporozoan Chinese medicine composition of freshwater fish intestinal, component and the weight thereof of its Chinese medicine composition are respectively: Semen Arecae 15g; Semen Cucurbitae 7g; Radix Euphorbiae Pekinensis 3g; Caulis Sargentodoxae 4g; Fructus Chaenomelis 4g; Fructus Toosendan 5g.
Treat a preparation method for the sporozoan Chinese medicine composition of freshwater fish intestinal, the step of preparation method is as follows:
(1) take respectively by weight ratio Semen Arecae, Semen Cucurbitae, Radix Euphorbiae Pekinensis, Caulis Sargentodoxae, Fructus Chaenomelis, Fructus Toosendan and pulverize, and respectively all by 65 mesh sieves;
(2) Semen Arecae after sieving, Semen Cucurbitae, Radix Euphorbiae Pekinensis, Caulis Sargentodoxae, Fructus Chaenomelis, Fructus Toosendan are put into abundant mix homogeneously in three-dimensional hybrid tank, the sporozoan Chinese medicine composition finished product of the freshwater fish intestinal that obtains medical treatment.
Embodiment 2
Treat the sporozoan Chinese medicine composition of freshwater fish intestinal, component and the weight thereof of its Chinese medicine composition are respectively: Semen Arecae 20g; Semen Cucurbitae 10g; Radix Euphorbiae Pekinensis 4g; Caulis Sargentodoxae 6g; Fructus Chaenomelis 6g; Fructus Toosendan 7g.
The step of its preparation method is with embodiment 1.
Embodiment 3
Treat the sporozoan Chinese medicine composition of freshwater fish intestinal, component and the weight thereof of its Chinese medicine composition are respectively: Semen Arecae 25g; Semen Cucurbitae 12g; Radix Euphorbiae Pekinensis 5g; Caulis Sargentodoxae 8g; Fructus Chaenomelis 8g; Fructus Toosendan 10g.
The step of its preparation method is with embodiment 1.
A kind of sporozoan Chinese medicine composition of freshwater fish intestinal for the treatment of is in the application in preparation treatment freshwater fish intestinal sporozoon medicine.
The using method of the sporozoan Chinese medicine composition of this treatment freshwater fish intestinal, by 1% interpolation and fish meal evenly mix throw something and feed can reach treatment disease effect.
Below by specific experiment, verify advance of the present invention:
1 materials and methods
1.1 material
1.1.1 treating the sporozoan Chinese medicine composition of freshwater fish intestinal is prepared by our company.
1.1.2 test fish: specification is the ill Cyprinus carpio of 200-350g.
1.1.3 feedstuff: honest carp feed.
1.2 method
1.2.1 EXPERIMENTAL DESIGN
The sick fish of test is put into ready pond and support 10 temporarily, remove dead fish, leave altogether ill Cyprinus carpio 60 tails, body weight is 200g～350g.Test fish is assigned to and supports temporarily in No. 1,2, cement pit in (2m * 3m * 1.5m) after sterilization.Wherein No. 1 pond is matched group, is for No. 2 test group.Feedstuff interpolation and medicine adding proportion are in Table 1.
Table 1 contrast and test group feedstuff adding proportion
| Group | 1 | 2 |
| Feedstuff master divide | Basestocks | Basestocks |
| Chinese medicine adding proportion | 0％ | 1％ |
| Daily ration of feeding | 5％ | 5％ |
Support after 2 days temporarily, get abdominal part swelling, the red and swollen fish body of anus 5 tails, dissect intestinal, determine that encapsulation quantity 1# and 2# pond approach.
Throw something and feed after 7 days, the dead fish body in pond quantity during record cultivation, the sick fish body of dissecting, gets intestinal, observes sporangiocyst quantity and sporozoon quantity.
1.2.2 full capsule detects and microscopy
Get ill Cyprinus carpio, with normal saline, dispel epidermal mucus, dissect, dispel fish body intestinal, count intestinal spherule quantity accurately, mucus in scraping intestinal, smear, with normal saline dilution, cover plate, by microscopic examination sporozoon quantity.
2 results and analysis
2.1 fish kills amounts
Divide pond to support latter 9 days temporarily, No. 1 dead Cyprinus carpio 4 tails in pond, No. 2 pond 1 tails.
2.2 full capsule and sporozoon quantity
The full capsule of table 2 and sporozoon quantity
2.3 interpretation of result
As can be seen from the above experimental data, the 2# of the present invention pond of throwing something and feeding, in breeding process, only occur that 1 tail is dead, and 1# pond is due to dead 4 tails of sporozoon, and throw something and feed 7 days afterwards the meansigma methods of full capsule quantity to when sporozoon meansigma methods contrast, can obviously find out that 2# has obvious decline than 1#.The present invention is for abolishing full capsule for proof, and killing sporozoon has good effect.
3 practice tests
On May 13rd, 2012, Zhong Tianqinliao factory presses containing 350 tons, feedstuff of the present invention, and for Cyprinus carpio, Carassius auratus, the sporozoan morbidity of grass carp intestinal endoparasitism pond, pond area reaches 2350 mu, and cure rate reaches 93.7%.
Claims (3)
1. treat the sporozoan Chinese medicine composition of freshwater fish intestinal, it is characterized in that: this Chinese medicine composition component and ratio of weight and number thereof are respectively:
Semen Arecae 15-25 part;
Semen Cucurbitae 7-12 part;
Radix Euphorbiae Pekinensis 3-5 part;
Caulis Sargentodoxae 4-8 part;
Fructus Chaenomelis 4-8 part;
Fructus Toosendan 5-10 part.
2. the sporozoan Chinese medicine composition for the treatment of freshwater fish intestinal according to claim 1, is characterized in that: the component of this Chinese medicine composition and optimum ratio of weight and number thereof are:
20 parts of Semen Arecaes;
10 parts of Semen Cucurbitaes;
4 parts of Radix Euphorbiae Pekinensiss;
6 parts of Caulis Sargentodoxaes;
6 parts of Fructus Chaenomeliss;
7 parts of Fructus Toosendans.
3. a preparation method for the sporozoan Chinese medicine composition for the treatment of as claimed in claim 1 freshwater fish intestinal, is characterized in that: the step of this preparation method is as follows:
(1) take respectively by weight ratio Semen Arecae, Semen Cucurbitae, Radix Euphorbiae Pekinensis, Caulis Sargentodoxae, Fructus Chaenomelis, Fructus Toosendan and pulverize, and respectively all by 65 mesh sieves;
(2) Semen Arecae after sieving, Semen Cucurbitae, Radix Euphorbiae Pekinensis, Caulis Sargentodoxae, Fructus Chaenomelis, Fructus Toosendan are put into abundant mix homogeneously in three-dimensional hybrid tank, the sporozoan Chinese medicine composition finished product of the freshwater fish intestinal that obtains medical treatment.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210355228.3A CN103656020A (en) | 2012-09-24 | 2012-09-24 | Traditional Chinese medicine composition for treating encephalitozoon intestinalis of freshwater fish and preparation method thereof |
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| CN201210355228.3A CN103656020A (en) | 2012-09-24 | 2012-09-24 | Traditional Chinese medicine composition for treating encephalitozoon intestinalis of freshwater fish and preparation method thereof |
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| CN103656020A true CN103656020A (en) | 2014-03-26 |
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| CN201210355228.3A Pending CN103656020A (en) | 2012-09-24 | 2012-09-24 | Traditional Chinese medicine composition for treating encephalitozoon intestinalis of freshwater fish and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940307A (en) * | 2015-06-05 | 2015-09-30 | 浙江大学 | Traditional Chinese medicine composition for preventing and treating honeybee microsporidiosis and use thereof |
| CN107582919A (en) * | 2017-10-23 | 2018-01-16 | 天津瑞贝特科技发展有限公司 | Treat Chinese medicine composition of shrimp enteron aisle sporidiosis and preparation method thereof |
| CN108261489A (en) * | 2016-12-30 | 2018-07-10 | 天津瑞贝特科技发展有限公司 | Treat Chinese medicine composition of crucian Myxosporean and preparation method thereof |
| DE202023100017U1 (en) | 2023-01-03 | 2023-02-17 | Ravi Dhondiraj Barde | Novel drug for the prevention and treatment of bacterial mixed infections in freshwater fish |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102327414A (en) * | 2011-07-12 | 2012-01-25 | 天津生机集团股份有限公司 | Traditional Chinese medicinal injection for treating diphyllobothriasis of dog and preparation method thereof |
| CN102670902A (en) * | 2012-05-18 | 2012-09-19 | 刘天岐 | Ascarid-expelling pill comprising Fructus Toosendan |
-
2012
- 2012-09-24 CN CN201210355228.3A patent/CN103656020A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327414A (en) * | 2011-07-12 | 2012-01-25 | 天津生机集团股份有限公司 | Traditional Chinese medicinal injection for treating diphyllobothriasis of dog and preparation method thereof |
| CN102670902A (en) * | 2012-05-18 | 2012-09-19 | 刘天岐 | Ascarid-expelling pill comprising Fructus Toosendan |
Non-Patent Citations (1)
| Title |
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| 王益平: "中药提要", 《现代中医药》, no. 01, 25 January 2002 (2002-01-25), pages 45 - 49 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940307A (en) * | 2015-06-05 | 2015-09-30 | 浙江大学 | Traditional Chinese medicine composition for preventing and treating honeybee microsporidiosis and use thereof |
| CN104940307B (en) * | 2015-06-05 | 2018-04-17 | 浙江大学 | A kind of Chinese medicine composition and purposes for preventing Nosema apis parasitosis |
| CN108261489A (en) * | 2016-12-30 | 2018-07-10 | 天津瑞贝特科技发展有限公司 | Treat Chinese medicine composition of crucian Myxosporean and preparation method thereof |
| CN107582919A (en) * | 2017-10-23 | 2018-01-16 | 天津瑞贝特科技发展有限公司 | Treat Chinese medicine composition of shrimp enteron aisle sporidiosis and preparation method thereof |
| DE202023100017U1 (en) | 2023-01-03 | 2023-02-17 | Ravi Dhondiraj Barde | Novel drug for the prevention and treatment of bacterial mixed infections in freshwater fish |
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Application publication date: 20140326 |