CN103655708B - The syndromic veterinary drug composition of a kind for the treatment of livestock and birds respiratory disease that contains honeysuckle - Google Patents
The syndromic veterinary drug composition of a kind for the treatment of livestock and birds respiratory disease that contains honeysuckle Download PDFInfo
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Abstract
The invention provides one and treat the syndromic veterinary drug composition of livestock and birds respiratory disease, it is the preparation being prepared from by the bulk drug of following weight proportion: 20～40 parts of Echinaceas, 20～40 parts of honeysuckles, 6～20 parts of cubebs. The present invention also provides preparation method and the purposes of veterinary drug composition. Pharmaceutical composition of the present invention can effectively be treated the fowl such as pig pneumonia, chicken viral flu poultry prdc disease, and cure rate is high, and drug activity is obviously better than marketed drugs, for clinical application provides new selection.
Description
Technical field
The present invention relates to one and treat the syndromic veterinary drug composition of livestock and birds respiratory disease.
Background technology
Livestock and birds respiratory disease syndrome is a current class principal disease that affects China's aquaculture development. WithThe respiratory symptoms such as cough, adnormal respiration are main. Cause of disease is very complicated, can by one or more bacteriums,Virus, parasite, Chlamydia and environmental factor etc. cause. Concerning pig, this disease claims again " multiple-factorPorcine respiratory disease ", " pig plyability pneumonia ", " porcine respiratory MOI ". Mainly by mycoplasma pneumoniae(MH), porcine reproductive and respiratory syndrome (PRSV), Actinobacillus pleuropneumoniae (APP),The primary diseases such as swine influenza virus (SIV), PRCV (PRLV), Pseudorabies virus (PRV)Former, pasteurella multocida (PM), Streptococcus suis (SS), pig secondary haemophilus (HP), bronchus sepsisBordetella bacilli (BB), mycoplasma hyorhinis (MHR), toxoplasm, eperythrozoon, CSFV and roundwormPessimal stimulation etc. Secondary cases or the concurrency cause of disease and environment, weather conditions influences each other and causes. RightChicken, this disease is called again multiple-factor respiratory diseases, and directly the cause of disease is infectiousness factor, wherein mainly containsFrustrate blood and mycoplasma, Escherichia coli, haemophilus paragallinarum, IBV, laryngotracheitisPoison, NDV, avian influenza virus, avian pneumovirus etc. Indirectly the cause of disease comprise environmental factor (temperature,The air quality of hen house and humidity), stress reaction (vaccine inoculation, turn group, stocking density, lack of water etc.),Nutrition (as malnutritive, VAD) etc.; In addition, some can cause immunosuppressant diseaseComprise that Marek's disease, gumboro disease, the infection of the anaemia factor, reovirus infection, fowl are whiteIn the mycotoxin that blood disease, reticuloendotheliosis disease and Mycotoxins in Feed too high levels causePoison can reduce the immunity of chicken, promotes the generation of breathing problem. Large-scale pig farm porcine respiratory diseaseThe sick syndromic incidence of disease is 30%～60%, and the death rate reaches 5%～30%; Chicken house infective bronchitisOr the infectious laryngotracheitis death rate reaches 50%～70%; Visible its harm is big.
Clinically, livestock and birds respiratory disease syndrome is all generally coefficient by multiple paathogenic factorResult. And the most communicable diseases that cause prdc have the advantages that to be difficult to elimination, existingThere are chemicals and the biologic product all can not be fine by its control; Although and existing part herbal medicine product energySolve preferably this difficult problem, but also have the defects such as product uses inconvenience or suitable result for the treatment of is not remarkable.Therefore, be badly in need of research and development a kind of easy to use, the control livestock and birds respiratory disease syndrome that curative effect is more definiteVeterinary drug product.
Summary of the invention
The object of the present invention is to provide one to treat the syndromic veterinary drug combination of livestock and birds respiratory diseaseThing. Another object of the present invention is to provide preparation method and the purposes of veterinary drug composition.
The invention provides one and treat the syndromic veterinary drug composition of livestock and birds respiratory disease, it isThe preparation being prepared from by the bulk drug of following weight proportion:
20～40 parts of Echinaceas, 20～40 parts of honeysuckles, 6～20 parts of cubebs.
Further, it is the preparation being prepared from by the bulk drug of following weight proportion:
20～25 parts of Echinaceas, 30～40 parts of honeysuckles, 20 parts of cubebs.
Ingredients compatibility of the present invention is precise and appropriate, and drug action is clear and definite, has good result for the treatment of.
Wherein, described preparation is through gastrointestinal absorption preparation.
Further, described preparation is wettable powder, and it is to be prepared by the supplementary material of following weight proportionForm:
20～40 parts of Echinaceas, 20～40 parts of honeysuckles, 6～20 parts of cubebs, lauryl sodium sulfate0.1～1.2 part, 0.1～2.3 part of Aspartame, 0.8～41.5 part of sodium carboxymethylcellulose.
Preferably, described wettable powder is to be prepared from by the supplementary material of following weight proportion:
20～25 parts of Echinaceas, 30～40 parts of honeysuckles, 20 parts of cubebs, lauryl sodium sulfate 0.4～0.7Part, 0.7～1.3 part of Aspartame, 18.9～23 parts of sodium carboxymethylcelluloses.
Wettable powder of the present invention also can be described as the clear wettable powder of Zijin.
Wettable powder of the present invention, has significantly improved the dispersiveness of medicine in water, makes it even for a long timeBe distributed in water, facilitate clinical in drinking-water administration; Improve greatly the palatability of product, for pigDeng the faunichron having a sharp sense of taste, there is luring function.
The present invention also provides the preparation method of above-mentioned wettable powder, and it comprises following operating procedure:
(1) take supplementary material by proportioning;
(2) get Echinacea, honeysuckle, cubeb, pulverize, gained medicinal powder is for subsequent use; Or get Echinacea,Honeysuckle, cubeb, add water or organic solvent extracts, and extract is for subsequent use;
(3) get medicinal powder prepared by step (2) or/and extract adds lauryl sodium sulfate and mixes, powderBroken, add Aspartame and sodium carboxymethylcellulose, mix, obtain wettable powder.
Further, in step (2), (3), the granularity due to pulverizing is at 625～6250 orders.
The present invention also provides the preparation method of above-mentioned wettable powder, and it comprises following operating procedure:
(1) take supplementary material by proportioning;
(2) get Echinacea, honeysuckle, cubeb and lauryl sodium sulfate, pulverize, gained powder addsEnter Aspartame and sodium carboxymethylcellulose, mix, obtain wettable powder.
Further, the granularity due to pulverizing is at 625～6250 orders.
The present invention also provides the medicine of above-mentioned veterinary drug composition at preparation fowl poultry prdcPurposes in thing.
Wherein, described medicine is the medicine for the treatment of pig pneumonia, chicken viral flu.
Pharmaceutical composition of the present invention can effectively be treated the fowl such as pig pneumonia, chicken viral flu poultry respiratory tract diseaseSick syndrome disease, and cure rate is high, and drug activity is obviously better than marketed drugs, for clinical application providesNew selection.
Detailed description of the invention
The preparation of embodiment 1 wettable powder of the present invention
Get Echinacea 39kg, honeysuckle 20kg, cubeb 6kg, lauryl sodium sulfate 1.2kg, mixedMerge and be crushed to 625 order～6250 orders, add Aspartame 1.8kg, add sodium carboxymethylcellulose 32kg,Mix, obtain wettable powder of the present invention (also can be described as the clear wettable powder of Zijin).
The preparation of embodiment 2 wettable powders of the present invention
Get Echinacea 20kg, honeysuckle 40kg, cubeb 10kg, lauryl sodium sulfate 0.8kg, mixedMerge and be crushed to 625 order～6250 orders, add Aspartame 0.2kg, add sodium carboxymethylcellulose 29kg,Mix, obtain wettable powder of the present invention (also can be described as the clear wettable powder of Zijin).
The preparation of embodiment 3 wettable powders of the present invention
Get Echinacea 40kg, honeysuckle 30kg, cubeb 20kg, lauryl sodium sulfate 1.0kg, mixedMerge and be crushed to 625 order～6250 orders, add Aspartame 0.2kg, add sodium carboxymethylcellulose 8.8kg,Mix, obtain wettable powder of the present invention (also can be described as the clear wettable powder of Zijin).
The formula screening of embodiment 4 wettable powders of the present invention
(1) preparation of different formulations product
Get Echinacea, honeysuckle, cubeb, lauryl sodium sulfate, mix and be crushed to 625 orders～6250 orders, add Aspartame and sodium carboxymethylcellulose, mix, and prepare wettable powder of the present invention.
The preferred version of table 1 wettable powder agent prescription of the present invention
(2) quality evaluation of different formulations product
Decentralization is evaluated: get by the each 1g of wettable powder of the present invention of the each formula preparation of table 1, drop into 1000mlIn water, observe or stir and observe its deployment conditions. Disperse slower and inhomogeneous being chosen as " poor "; DisperseSlowly, have caking or particle in dispersion process, agitation as appropriate can be uniformly dispersed, and is chosen as " qualified "; DisperseHurry up, gentle agitation can be uniformly dispersed, and is chosen as " good "; Disperse soon, need not stir and can be uniformly dispersed,Be chosen as " excellent ". The results are shown in Table 3.
Settling volume is than evaluating: by " People's Republic of China's veterinary drug allusion quotation (version in 2010) " annex " inTaking solution, supensoid agent for oral administration, emulsion for oral administration " settling volume is than inspection technique requirement, to respectively joining by table 1The wettable powder of the present invention of side's preparation carries out settling volume than measuring, and sample thief 0.25g puts 50ml tool plugIn graduated cylinder, add water to 50ml, fill in closely, firmly jolting 1min, writes down suspended matter and starts height H0, quietPut and within 3 hours, write down the final height H of suspended matter, be calculated as follows: settling volume ratio=H/H0, sedimentation bodyLong-pending ratio should be not less than 0.90. The results are shown in Table 3.
Palatability quality evaluation: will press table 1 wettable powder of the present invention that respectively prepared by formula respectively by 1.25%Concentration convert drinking water, drink for healthy swinery, observe and record swinery and drink situation, choose palatabilityGrade, evaluation criterion is shown in 2. The results are shown in Table 3.
Table 2 wettable powder Palatability evaluation of the present invention standard
| Opinion rating | Evaluation criterion |
| Excellent | When the drinking-water of dosing is provided, swinery is induced by smell, initiatively fights for and drinks. |
| Good | When the drinking-water of dosing is provided, swinery is drunk by daily drinking habit. |
| Poor | When the drinking-water of dosing is provided, swinery refusal is drunk or the amount of drinking decline relatively usually. |
Table 3 wettable powder quality evaluation result of the present invention
Known according to table 3: formula 2～formula 7 is all qualified, wherein, formula 2～5 suspendible effects moreWell, again filling a prescription 4, palatability and the decentralization optimum of formula 5, therefore, the present invention is finally preferredThe prescription of formula 4,5.
Illustrate beneficial effect of the present invention by test example below.
The clinical tests of the oral wettable powder of test example 1 to pig pneumonia
Material: (every 1 gram is equivalent to crude drug in whole 1g to powder for clearing lung-heat, Xi Monong bio tech ltd, ShanghaiProduce operative norm: two of " People's Republic of China's veterinary drug allusion quotation " versions in 2010); The clear wettable of ZijinPowder (i.e. table 1 fill a prescription the wettable powder of the present invention of 5 preparations).
Case: (clinical main manifestations is pig pneumonia case 47 examples of Chengdu suburbs and counties under the jurisdiction of a large city first pig farm natural occurrence: send outHeat, food is few, cough, diminished breath sound; Nasal cavity stream mucus, expiratory air has corrupt smell).
Method: select the clinical onset growing and fattening pigs that body weight is substantially suitable, identical raising condition in same pig houseBe divided at random down control group, test group and negative control group; Control group is pressed 2% concentration spice with powder for clearing lung-heat,Feeding for sick pig, be used in conjunction 7 days; Test group is converted drinking water with wettable powder of the present invention by 1.25% concentration,Drink for sick pig, be used in conjunction 7 days; Negative control group is raised by daily feeding manner, not administration. Curative effect is sentencedDetermine method: medication is after 7 days, and it is normal that spiritual appetite is recovered, and is judged to recovery from illness; After medication 7 days, spirit foodWish takes a turn for the better, and is judged to effectively; After medication 7 days, symptom is not improved, and it is invalid to be judged to.
Experimental result: in table 4.
The clinical tests result of table 4 wettable powder of the present invention to pig pneumonia
Can find out the result for the treatment of of oral wettable powder of the present invention to pig pneumonia from above result of the testAll be better than powder for clearing lung-heat; The convenience that wettable powder of the present invention uses is better than powder for clearing lung-heat, greatly reduces administrationWorking strength. Also find in test, due to the mode administration of taking drinking-water to add, the present invention is wettableProperty pulvis does not in use affect the feed intake of disease pig.
The clinical tests of test example 2 wettable powders to broiler chicken virus flu
Material: (every 1 gram is equivalent to crude drug in whole 1g to Yinqiao San, Xi Monong bio tech ltd, ShanghaiProduce operative norm: two of " People's Republic of China's veterinary drug allusion quotation " versions in 2010); The clear wettable of ZijinPowder (i.e. table 1 fill a prescription the wettable powder of the present invention of 5 preparations).
Case: broiler chicken virus flu case 323 examples of Leshan chicken house natural occurrence (sick chicken is snored,Expiratory dyspnea, indivedual one-sided faces of chicken are swollen, shed tears. Jumpbogroup material feeding is normal, and spirit is without significant change; DissectThe chicken of snore severity does not have obvious symptom yet).
Method: select the clinical onset broiler chicken of 20 ages in days, divide at random under identical raising condition in same hen houseBecome control group, test group and negative control group; Control group is by the 2g/ plumage dosage spice commercially available Yinqiao San of feeding,Every day 2 times, be used in conjunction 3 days; After being watered with wettable powder of the present invention, test group supplies drink by 2g/ plumage dosage,Every day 2 times, be used in conjunction 3 days; Negative control group is raised by daily feeding manner, not administration. Efficacy determinationMethod: medication, after 3 days, is observed disease chicken spirit appetite situation and makes statistics, and calculate cure rate, aobviousEfficiency, efficient and inefficiency, curative effect determinate standard is as shown in table 5.
Table 5 curative effect determinate standard
| Result for the treatment of | Judge index |
| Recovery from illness | After 3 days, it is normal that spiritual appetite is recovered, clinical symptom disappearance. |
| Effective | After 3 days, spiritual appetite takes a turn for the better, clinical symptom disappearance or alleviate. |
| Invalid | After 3 days, symptom is not improved. |
Experimental result: in table 6.
The clinical tests result of table 6 wettable powder of the present invention to broiler chicken virus flu
Can find out the treatment of wettable powder of the present invention to broiler chicken virus flu from above result of the testEffect is all better than commercially available Yinqiao San; Relatively commercially available Yinqiao San spice administering mode, wettable of the present inventionPulvis is offerd medicine by drinking-water, saves spice process, greatly reduces dispensing labour intensity.
In sum, pharmaceutical composition of the present invention can effectively be treated the fowl such as pig pneumonia, chicken viral fluPoultry prdc disease, and cure rate is high, and drug activity is obviously better than marketed drugs, for facingBed medication provides new selection.
Claims (9)
1. the syndromic veterinary drug composition for the treatment of livestock and birds respiratory disease, is characterized in that: itThe preparation being prepared from by the bulk drug of following weight proportion:
20～25 parts of Echinaceas, 30～40 parts of honeysuckles, 20 parts of cubebs.
2. veterinary drug composition according to claim 1, is characterized in that: described preparation is warpGastrointestinal absorption preparation.
3. the syndromic veterinary drug composition for the treatment of livestock and birds respiratory disease, is characterized in that: instituteThe veterinary drug composition of stating is wettable powder, and it is to be prepared from by the supplementary material of following weight proportion:
20～40 parts of Echinaceas, 20～40 parts of honeysuckles, 6～20 parts of cubebs, lauryl sodium sulfate0.1～1.2 part, 0.1～2.3 part of Aspartame, 0.8～41.5 part of sodium carboxymethylcellulose.
4. veterinary drug composition according to claim 3, is characterized in that: described wettable powderAgent is to be prepared from by the supplementary material of following weight proportion:
20～25 parts of Echinaceas, 30～40 parts of honeysuckles, 20 parts of cubebs, lauryl sodium sulfate 0.4～0.7Part, 0.7～1.3 part of Aspartame, 18.9～23 parts of sodium carboxymethylcelluloses.
5. the preparation method of wettable powder described in claim 3 or 4, is characterized in that: it comprise asLower operating procedure:
(1) take supplementary material by proportioning;
(2) get Echinacea, honeysuckle, cubeb, pulverize, gained medicinal powder is for subsequent use; Or get Echinacea,Honeysuckle, cubeb, add water or organic solvent extracts, and extract is for subsequent use;
(3) get medicinal powder prepared by step (2) or/and extract adds lauryl sodium sulfate and mixes, powderBroken, add Aspartame and sodium carboxymethylcellulose, mix, obtain wettable powder.
6. preparation method according to claim 5, is characterized in that: in step (2), (3),Granularity due to pulverizing is at 625～6250 orders.
7. the preparation method of wettable powder described in claim 3 or 4, is characterized in that: it comprise asLower operating procedure:
(1) take supplementary material by proportioning;
(2) get Echinacea, honeysuckle, cubeb and lauryl sodium sulfate, pulverize, gained powder addsEnter Aspartame and sodium carboxymethylcellulose, mix, obtain wettable powder.
8. described in claim 1～5 any one, veterinary drug composition is raiseeed breathing problem preparation fowlPurposes in syndromic medicine.
9. purposes according to claim 8, is characterized in that: described medicine be treatment pig pneumonia,The medicine of chicken viral flu.
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| CN1736417A (en) * | 2005-07-22 | 2006-02-22 | 江苏省药物研究所 | Composition for treating upper respiratory tract infection and application |
| CN101036695A (en) * | 2007-04-06 | 2007-09-19 | 西北农林科技大学 | Oil-in-water type nanometer emulsion elecampane oil and litsea citrata oil and the method for preparing the same |
| CN101596183A (en) * | 2009-06-04 | 2009-12-09 | 青岛康地恩药业有限公司 | A kind of Echinacea oral liquid and preparation method thereof |
| CN103169762A (en) * | 2012-11-28 | 2013-06-26 | 北京伟嘉人生物技术有限公司 | Drug for enhancing immunity of animals |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1736417A (en) * | 2005-07-22 | 2006-02-22 | 江苏省药物研究所 | Composition for treating upper respiratory tract infection and application |
| CN101036695A (en) * | 2007-04-06 | 2007-09-19 | 西北农林科技大学 | Oil-in-water type nanometer emulsion elecampane oil and litsea citrata oil and the method for preparing the same |
| CN101596183A (en) * | 2009-06-04 | 2009-12-09 | 青岛康地恩药业有限公司 | A kind of Echinacea oral liquid and preparation method thereof |
| CN103169762A (en) * | 2012-11-28 | 2013-06-26 | 北京伟嘉人生物技术有限公司 | Drug for enhancing immunity of animals |
Non-Patent Citations (1)
| Title |
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| 复方紫锥菊体外抗肉鸡新城疫病毒的试验;刘晓琳等;《中国兽医杂志》;20081122;第44卷(第11期);20-22 * |
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Address after: 611130 Wenjiang City, Chengdu Province, Chengdu cross strait science and Technology Industrial Park Road, No. 259 Jin Fu Road, No. Patentee after: Chengdu Qiankun animal pharmaceutical Limited by Share Ltd Address before: 611130 Wenjiang, Chengdu, Chengdu cross strait science and Technology Industrial Development Zone, Jin Fu Road, Sichuan Patentee before: Chengdu Qiankun Animal Pharmaceutical Co.,Ltd. |
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Effective date of registration: 20210305 Address after: 610000 Jinfu Road, Cross-Strait Science and Technology Industrial Development Park, Wenjiang District, Chengdu City, Sichuan Province Patentee after: CHENGDU QIANKUN VETERINARY PHARMACEUTICAL Co.,Ltd. Patentee after: SICHUAN QIANKUN BIOTECHNOLOGY Co.,Ltd. Address before: 611130 no.259 Jinfu Road, Chengdu cross strait science and Technology Industrial Development Park, Wenjiang District, Chengdu City, Sichuan Province Patentee before: CHENGDU QIANKUN VETERINARY PHARMACEUTICAL Co.,Ltd. |