CN103648529A - 用于给处于潜在不良反应的风险的患者施用CD19xCD3双特异性抗体的给药方案 - Google Patents

用于给处于潜在不良反应的风险的患者施用CD19xCD3双特异性抗体的给药方案 Download PDF

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CN103648529A
CN103648529A CN201280020887.XA CN201280020887A CN103648529A CN 103648529 A CN103648529 A CN 103648529A CN 201280020887 A CN201280020887 A CN 201280020887A CN 103648529 A CN103648529 A CN 103648529A
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period
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bispecific antibody
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D·那高森
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Amgen Research Munich GmbH
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Amgen Research Munich GmbH
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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CN201280020887.XA 2011-04-28 2012-04-30 用于给处于潜在不良反应的风险的患者施用CD19xCD3双特异性抗体的给药方案 Pending CN103648529A (zh)

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CN201710597419.3A CN107303387A (zh) 2011-04-28 2012-04-30 用于给处于潜在不良反应的风险的患者施用CD19xCD3双特异性抗体的给药方案

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US201161479961P 2011-04-28 2011-04-28
US61/479,961 2011-04-28
PCT/EP2012/001857 WO2012146394A1 (en) 2011-04-28 2012-04-30 Dosage regimen for administering a cd19xcd3 bispecific antibody to patients at risk for potential adverse effects

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CN201710597419.3A Pending CN107303387A (zh) 2011-04-28 2012-04-30 用于给处于潜在不良反应的风险的患者施用CD19xCD3双特异性抗体的给药方案

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US (2) US10191034B2 (https=)
EP (2) EP3753572A1 (https=)
JP (2) JP6276175B2 (https=)
KR (2) KR102345943B1 (https=)
CN (2) CN103648529A (https=)
AU (2) AU2012247762B2 (https=)
CA (1) CA2832360C (https=)
ES (1) ES2806142T3 (https=)
MX (1) MX354371B (https=)
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ANDREAS VIARDOT ET AL: "Treatment of Patients with Non-Hodgkin Lymphoma (NHL) with CD19_CD3 Bispecific Antibody Blinatumomab (MT103)_ Double-Step Dose increase to continuous infusion of 60 ug/m2/d is tolerable and highly effective &#10", 《BLOOD(ASH ANNAL MEETING ABSTRACTS)》, vol. 116, 31 December 2010 (2010-12-31), pages 2880 *

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MX2013012448A (es) 2014-02-27
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KR20200104415A (ko) 2020-09-03
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US20190293635A1 (en) 2019-09-26
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US11579142B2 (en) 2023-02-14
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JP6539709B2 (ja) 2019-07-03
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US20140199307A1 (en) 2014-07-17
AU2017218919A1 (en) 2017-09-07
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CA2832360A1 (en) 2012-11-01
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