CN103648488A - 药物组合物和在治疗咳嗽病况中的用途 - Google Patents

药物组合物和在治疗咳嗽病况中的用途 Download PDF

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Publication number
CN103648488A
CN103648488A CN201280033545.1A CN201280033545A CN103648488A CN 103648488 A CN103648488 A CN 103648488A CN 201280033545 A CN201280033545 A CN 201280033545A CN 103648488 A CN103648488 A CN 103648488A
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CN
China
Prior art keywords
day
composition
cough
coughing
methylxanthine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280033545.1A
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English (en)
Chinese (zh)
Inventor
约翰·布鲁
罗宾·马克·班尼斯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reyes Leather Co ltd Ethiopia Lancome
Infirst Healthcare Ltd
Original Assignee
Biocopea Ltd
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Filing date
Publication date
Application filed by Biocopea Ltd filed Critical Biocopea Ltd
Publication of CN103648488A publication Critical patent/CN103648488A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/02—Ammonia; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201280033545.1A 2011-07-05 2012-04-13 药物组合物和在治疗咳嗽病况中的用途 Pending CN103648488A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1111485.7A GB201111485D0 (en) 2011-07-05 2011-07-05 Drug composition and its use in therapy
GB1111485.7 2011-07-05
PCT/GB2012/050816 WO2013004999A1 (en) 2011-07-05 2012-04-13 Drug combinations and uses in treating a coughing condition

Publications (1)

Publication Number Publication Date
CN103648488A true CN103648488A (zh) 2014-03-19

Family

ID=44512137

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280033545.1A Pending CN103648488A (zh) 2011-07-05 2012-04-13 药物组合物和在治疗咳嗽病况中的用途

Country Status (12)

Country Link
EP (2) EP3251665A1 (enExample)
JP (2) JP2014518252A (enExample)
KR (1) KR101676454B1 (enExample)
CN (1) CN103648488A (enExample)
AU (2) AU2012280019B2 (enExample)
BR (1) BR112014000159A2 (enExample)
CA (1) CA2840793A1 (enExample)
GB (1) GB201111485D0 (enExample)
MX (1) MX2014000129A (enExample)
RU (2) RU2016101054A (enExample)
WO (1) WO2013004999A1 (enExample)
ZA (1) ZA201400010B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104436176A (zh) * 2014-11-17 2015-03-25 华东理工大学 一种基于上呼吸道感染及肺炎用的新型生物抗菌喷雾剂
CN107249621A (zh) * 2014-09-08 2017-10-13 哥谭生物制药股份有限公司 用于治疗肺结节病的粘液溶解剂
CN109793823A (zh) * 2017-11-17 2019-05-24 中国科学院大连化学物理研究所 一种外用止咳平喘软膏剂及其制备方法

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201111485D0 (en) * 2011-07-05 2011-08-17 Biocopea Ltd Drug composition and its use in therapy
US10016437B2 (en) 2009-06-16 2018-07-10 Infirst Healthcare Limited Drug combinations and uses in treating a coughing condition
US9314465B2 (en) 2009-06-16 2016-04-19 Infirst Healthcare Limited Drug combinations and uses in treating a coughing condition
GB201014391D0 (en) * 2010-08-27 2010-10-13 Biocopea Ltd Drug composition and its use in therapy
US9308211B2 (en) 2009-06-16 2016-04-12 Infirst Healthcare Limited Drug combinations and uses in treating a coughing condition
GB0910375D0 (en) 2009-06-16 2009-07-29 Biocopea Ltd Drug composition and its use in therapy
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
CN105473133A (zh) 2013-04-30 2016-04-06 欧缇托匹克公司 干粉制剂及使用方法
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
CA3076353A1 (en) 2017-09-22 2019-03-28 Otitopic Inc. Dry powder compositions with magnesium stearate
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
CN118512451A (zh) * 2018-07-23 2024-08-20 特雷维治疗股份有限公司 慢性咳嗽、呼吸急促和呼吸困难的治疗
KR20220008824A (ko) 2019-04-17 2022-01-21 컴퍼스 패쓰파인더 리미티드 실로시빈으로 불안 장애, 두통 장애 및 섭식 장애를 치료하는 방법
WO2021076961A1 (en) * 2019-10-16 2021-04-22 University Of South Florida Compositions and methods of treatment for inhibiting capillary tube regression
WO2021138578A1 (en) * 2019-12-31 2021-07-08 The Trustees Of Indiana University Repurposing fda-approved drugs as a novel cancer therapeutic avenue through inhibition of prmt5
IL294601A (en) 2020-01-10 2022-09-01 Trevi Therapeutics Inc Methods of administration of nalbuphine
US11628165B1 (en) * 2020-03-25 2023-04-18 Helen Feng Method of boosting immune system against viral infection
WO2025263978A1 (ko) * 2024-06-18 2025-12-26 가톨릭대학교 산학협력단 낭성콩팥병 개선 또는 치료용 조성물 및 이의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058236A1 (en) * 2002-12-20 2004-07-15 Pediamed Pharmaceuticals, Inc. Compositions and methods for treating upper respiratory congestion
WO2011058373A2 (en) * 2009-11-13 2011-05-19 Biocopea Limited Drug combination with theobromine and its use in therapy
WO2012025761A1 (en) * 2010-08-27 2012-03-01 Biocopea Limited Theobromine in combination with an expectorant or a mucolytic for use in therapy

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4756911A (en) 1986-04-16 1988-07-12 E. R. Squibb & Sons, Inc. Controlled release formulation
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US20020009478A1 (en) * 1998-08-24 2002-01-24 Douglas Joseph Dobrozsi Oral liquid mucoadhesive compositions
JP2002363072A (ja) * 2001-04-03 2002-12-18 Taisho Pharmaceut Co Ltd 鎮咳用組成物
JP2003081821A (ja) * 2001-09-12 2003-03-19 Taisho Pharmaceut Co Ltd 医薬組成物
JP4377564B2 (ja) * 2002-05-02 2009-12-02 ロート製薬株式会社 内服用組成物
US20050152967A1 (en) * 2003-03-28 2005-07-14 Pfab, Lp Dynamic variable release
EP1706095B1 (en) 2004-01-20 2008-12-24 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
JP4195895B2 (ja) * 2006-04-04 2008-12-17 小林製薬株式会社 吐出装置を備えた容器に収容される経口投与用液体医薬製剤
US20080003280A1 (en) * 2006-06-26 2008-01-03 Levine Brian M Combination cough treatment compounds and method of treating common coughs
US8420077B2 (en) 2009-04-20 2013-04-16 Allergan, Inc. Silk fibroin hydrogels and uses thereof
GB0919893D0 (en) * 2009-11-13 2009-12-30 Biocopea Ltd Drug composition and its use in therapy
GB0921805D0 (en) * 2009-12-14 2010-01-27 Biocopea Ltd Drug composition and its use in therapy
GB201111485D0 (en) * 2011-07-05 2011-08-17 Biocopea Ltd Drug composition and its use in therapy
GB0921803D0 (en) * 2009-12-14 2010-01-27 Biocopea Ltd Drug composition and its use in therapy
UA47594U (uk) * 2009-09-17 2010-02-10 Игорь Викторович Трутаев Комбінований засіб для лікування та профілактики захворювань дихальних шляхів
JP5815226B2 (ja) * 2009-11-30 2015-11-17 興和株式会社 ロキソプロフェンを含有する医薬組成物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058236A1 (en) * 2002-12-20 2004-07-15 Pediamed Pharmaceuticals, Inc. Compositions and methods for treating upper respiratory congestion
WO2011058373A2 (en) * 2009-11-13 2011-05-19 Biocopea Limited Drug combination with theobromine and its use in therapy
WO2012025761A1 (en) * 2010-08-27 2012-03-01 Biocopea Limited Theobromine in combination with an expectorant or a mucolytic for use in therapy

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107249621A (zh) * 2014-09-08 2017-10-13 哥谭生物制药股份有限公司 用于治疗肺结节病的粘液溶解剂
CN104436176A (zh) * 2014-11-17 2015-03-25 华东理工大学 一种基于上呼吸道感染及肺炎用的新型生物抗菌喷雾剂
CN109793823A (zh) * 2017-11-17 2019-05-24 中国科学院大连化学物理研究所 一种外用止咳平喘软膏剂及其制备方法

Also Published As

Publication number Publication date
WO2013004999A1 (en) 2013-01-10
EP2729136A1 (en) 2014-05-14
MX2014000129A (es) 2014-05-28
EP3251665A1 (en) 2017-12-06
GB201111485D0 (en) 2011-08-17
RU2016101054A3 (enExample) 2018-11-19
JP2018048189A (ja) 2018-03-29
KR101676454B1 (ko) 2016-11-15
RU2014103787A (ru) 2015-08-20
KR20140037947A (ko) 2014-03-27
AU2012280019B2 (en) 2016-10-27
JP2014518252A (ja) 2014-07-28
CA2840793A1 (en) 2013-01-10
AU2016256741A1 (en) 2016-12-01
AU2012280019A1 (en) 2014-01-23
BR112014000159A2 (pt) 2020-10-27
RU2016101054A (ru) 2018-11-19
ZA201400010B (en) 2015-04-29

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PB01 Publication
PB01 Publication
C10 Entry into substantive examination
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ASS Succession or assignment of patent right

Owner name: RUISI PIKOU PIYA CO., LTD.

Free format text: FORMER OWNER: BIOCOPEA LTD.

Effective date: 20141210

Owner name: THE FIRST MEDICAL HEALTH CARE CO., LTD.

Free format text: FORMER OWNER: RUISI PIKOU PIYA CO., LTD.

Effective date: 20141210

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

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Address after: London, England

Applicant after: InFirst Healthcare Ltd.

Address before: Dublin, Ireland

Applicant before: Reyes Leather Co.,Ltd. Ethiopia Lancome

Effective date of registration: 20141210

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Applicant after: Reyes Leather Co.,Ltd. Ethiopia Lancome

Address before: London, England

Applicant before: BIOCOPEA Ltd.

RJ01 Rejection of invention patent application after publication

Application publication date: 20140319

RJ01 Rejection of invention patent application after publication