CN103638220A - Medicament for treating recurrent aphtha and preparation method of medicament - Google Patents
Medicament for treating recurrent aphtha and preparation method of medicament Download PDFInfo
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- CN103638220A CN103638220A CN201310672990.9A CN201310672990A CN103638220A CN 103638220 A CN103638220 A CN 103638220A CN 201310672990 A CN201310672990 A CN 201310672990A CN 103638220 A CN103638220 A CN 103638220A
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Abstract
The invention discloses a medicament for treating recurrent aphtha and a preparation method of the medicament. The medicament is mainly prepared from medicines such as eggplant, China rose, musk, black sesame, cistanche, jujube, root of pilose asiabell, rhizoma corydalis, persimmon frost and the like according to a certain weight ratio. The medicament disclosed by the invention has the functions of detoxifying and healing sore and dispelling the wind and relieving pain, and is rapid to take an effect, good in curative effect and free of toxic or side effect when used for treating recurrent aphtha.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of recurrent aphtha and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Recurrent aphtha is the highest a kind of disease of sickness rate in the disease of cari oris mucosa, common cold, dyspepsia, psychentonia, the gloomy situation such as discomfort all can accidentally occur, be apt to occur in lip, cheek, lingual margin etc., any position at mucosa all can occur, but attached gingiva, hard palate are rare completely in keratinization.Age is regardless of, and age of onset estimates that women is more between 10～20 years old.All can occur throughout the year, ulcer has self limiting, can be left and right spontaneous recovery in 10 days.The title recurrent aphtha if aphtha often occurs or rises one after another.Its disease damage is ulcer infringement, and ulcer has the features such as periodicity, recurrent and self limiting.Because Western medicine cannot effectively be treated recurrent aphtha, so there is great demand to the Chinese medicine of rapid, effective treatment recurrent aphtha in people, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, has finally found the medicine of effective treatment recurrent aphtha, thereby has completed the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment recurrent aphtha.
Another object of the present invention has just been to provide the preparation method of this Chinese medicine composition.
Medicine of the present invention is to select Fructus Solani melongenae, Flos Rosae Chinensis, Moschus, Semen Sesami Nigrum, Herba Cistanches, Fructus Jujubae, Radix Codonopsis, Rhizoma Corydalis, Mannosum Kaki, Corium elephatis, Herba Menthae, catechu, Folium Musae, Fructus Canarii albi charcoal, Nidus Vespae, Mel medicine to combine preparation, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of recurrent aphtha.Select Fructus Solani melongenae to be because its nature and flavor are sweet, cool, enter spleen, stomach, large intestine channel, have heat clearing away, invigorate blood circulation, pain relieving, the function of detumescence, controls discharging fresh blood stool, pyretic toxicity carbuncle sore, skin ulcer.Select Flos Rosae Chinensis to be because its nature and flavor are sweet, temperature, enters Liver Channel, has promoting blood flow to regulate menstruation, and the function of subduing swelling and detoxicating, controls menoxenia, menalgia, and traumatic injury, blood stasis swells and ache, swollen ulcer drug.Select Moschus to be because its nature and flavor are pungent, temperature, enters the heart, spleen, Liver Channel, has and has one's ideas straightened out, ward off dirty, dredging collateral, the function of dissipating blood stasis, controls apoplexy, syncope due to accumulation of phlegm ， Jing Epilepsy, attacked by pestiferous factors is unhappy, trusted subordinate's sudden pain ， mass in the abdomen hypochondriac lump, traumatic injury, swollen ulcer drug.Select Semen Sesami Nigrum, different name Semen Lini, its nature and flavor are sweet, flat, return liver, kidney, large intestine channel, have invigorating the liver and kidney, benefiting essence-blood, the function that intestine moistening is dry, controls and feels dizzy, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.Select Herba Cistanches to be because the sweet acid of its nature and flavor is salty, temperature, enters kidney, large intestine channel, has the kidney invigorating, and benefit essence, moisturizes, and the function of bowel relieving, controls impotence in male, infertilitas feminis, leukorrhagia, metrorrhagia, chills and pain of the waist and kness, blood depletion constipation.Select Fructus Jujubae to be because its nature and flavor are sweet, temperature, enters spleen, stomach warp, has spleen reinforcing stomach function regulating, and supplementing QI for promoting the production of body fluid adjusts battalion to defend, and separates the function of poison of drug, controls insufficiency of stomach lack of appetite, the weak loose stool of spleen, and qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, and fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Select Rhizoma Corydalis to be because its nature and flavor are arduous, temperature, enters liver, stomach warp, invigorates blood circulation, and dissipating blood stasis, regulates the flow of vital energy, and the function of pain relieving is controlled all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.Select Mannosum Kaki to be because its nature and flavor are sweet cool, few the moon of starting with, Taiyin channels, has clearing heat and moistening dryness, and the function of reducing phlegm, controls cough due to lung-heat, dry pharynx laryngalgia, aphtha of the mouth and tongue, spits blood, and spitting of blood, quenches one's thirst.Select Corium elephatis to be because its nature and flavor are sweet, salty, temperature, enters bladder meridian, has hemostasis, and the function of sore, controls traumatic hemorrhage, and all wounds, ulcer do not close up for a long time.Select Herba Menthae to be because its nature and flavor are pungent, cool, enter lung, Liver Channel, have dispelling wind, heat radiation, wards off dirtyly, and the function of removing toxic substances, controls affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.Select catechu to be because its nature and flavor are bitter, puckery, be slightly cold, return lung meridian, have the function of removing dampness promoting tissue regeneration and ulcer healing, control ulcer being unable to heal, eczema, aphtha, falls and flutters the pain of injury, traumatic hemorrhage.Select Folium Musae to be because its property slightly sweet flavor is cold, enter conscience two warps, have clearing away heat and promoting diuresis, the function of removing toxic substances, controls calentura, heatstroke, and beriberi, carbuncle removing toxic substances, scalds.Select Fructus Canarii albi to be because its property sweet-puckery flavor acid is flat, enter lung, stomach warp, have lung heat clearing, sore-throat relieving, promotes the production of body fluid, and the function of removing toxic substances, controls laryngopharynx swelling and pain, excessive thirst, and cough is spitted blood, bacillary dysentery, epilepsy, separates tetrodotoxin, TTX and alcoholism.Select Nidus Vespae to be because its nature and flavor are sweet, flat, return stomach warp, dispel the wind, counteracting toxic substances, parasite killing, the function of pain relieving, for toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot.Select Mel to be because its nature and flavor are sweet, flat, enter lung, spleen, large intestine channel, there is invigorating middle warmer, moisturize, pain relieving, the function of removing toxic substances, controls xeropulmonary cough, dryness of the intestine constipation, gastralgia, nasal sinusitis, aphtha, the burning hot wound of soup, separates Aconitum Carmichaeli.
The specific embodiment
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight
Fructus Solani melongenae 8-15 gram of Flos Rosae Chinensis 15-25 gram of Moschus 1-3 gram
Semen Sesami Nigrum 5-15 gram of Herba Cistanches 5-10 gram of Fructus Jujubae 5-10 gram
Radix Codonopsis 4-8 gram of Rhizoma Corydalis 5-15 gram of Mannosum Kaki 8-16 gram
Corium elephatis 5-12 gram of Herba Menthae 5-15 gram of catechu 5-15 gram
Folium Musae 15-25 gram of Fructus Canarii albi 10-20 gram of Nidus Vespae 15-22 gram
Mel 35-45 gram
Be preferably
2 grams, 20 grams of Moschus of 10 grams of Flos Rosae Chinensiss of Fructus Solani melongenae
6 grams, 6 grams of Fructus Jujubaes of 8 grams of Herba Cistanches of Semen Sesami Nigrum
10 grams of 10 grams of Mannosum Kakis of 5 grams of Rhizoma Corydalis of Radix Codonopsis
10 grams, 10 grams of catechu of 6 grams of Herba Menthaes of Corium elephatis
20 grams, 15 grams of Nidus Vespae of 20 grams of Fructus Canarii albis of Folium Musae
40 grams of Mel
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Fructus Solani melongenae: the autumn in summer gathers when fruit is ripe, section, dries;
2, Flos Rosae Chinensis: summer, the autumn semi-open flower of gathering, dries, or dries with low baking temperature;
3, Moschus: infiltrate sachet with warm water, remove fur inner membrance impurity after cutting open, the used time is got Moschus core porphyrize;
4, Semen Sesami Nigrum: get crude drug, remove impurity, sieve removes chip;
5, Herba Cistanches: choose clean impurity, clear water soaks, and changes water every day 1-2 times, as is salty Herba Cistanches, and bubble is salinity to the greatest extent, runs through, and longitudinal section, dries;
6, Fructus Jujubae: choose clean impurity, enucleation, dries;
7, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
8, Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
9, Mannosum Kaki: get ripe Fructus Kaki, the crust of pruning, weather exposure, after January, places in seat circle, then through January Fructus kaki Siccus, raw adularescent Refined Mercurous chloride on Fructus kaki Siccus, with under broom brush, is Mannosum Kaki;
10, Corium elephatis: get Corium elephatis and soak approximately 3 days, clean, slightly vexed, shine to eighty per cant dry, then get wet once, consistent to internal and external temperature, be cut into the thin slice of thick approximately 2 millimeters, dry;
11, Herba Menthae: choose clean impurity, remove undesirable root, first leaf is trembled and separately put down, then stem is sprayed to clear water, run through rear cutting, dry, then with leaf and even;
12, catechu: remove impurity, the used time smashs to pieces;
13, Folium Musae: choose decontamination, dry;
14, Fructus Canarii albi charcoal: Fructus Canarii albi is made charcoal and ground into powder;
15, Nidus Vespae: get crude drug, remove impurity, stripping and slicing, sieve removes chip;
16, Mel: get pure Mel, temper with slow fire, filter skimming.
Two, preparation
1, the Fructus Solani melongenae of described quantity, Flos Rosae Chinensis, Moschus, Semen Sesami Nigrum, Herba Cistanches, Fructus Jujubae, Radix Codonopsis, Rhizoma Corydalis, Mannosum Kaki, Corium elephatis, Herba Menthae, catechu, Folium Musae, Fructus Canarii albi charcoal, Nidus Vespae are ground into superfine powder altogether.
2, by ground medicine superfine powder, add the Mel of described weight to mix well, make paste and get final product.
Medicine of the present invention has the function of removing toxic substances sore, wind-expelling pain-stopping, is used for the treatment of recurrent aphtha instant effect, good effect, does not recur.
By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get 15 of West Germany rabbits, male and female dual-purpose, body weight 2.0-2.5kg, is coated in the medicine mixing up the anal of rabbit, drug of topical application every day secondary, the drug of topical application is 5 days continuously, observes administration reaction every day, and result shows that rabbit is movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 100 examples for medical treatment.
2, diagnostic criteria
Responsive or occur needle point sample size or slightly large congested district from the beginning of lesion, form in a short time diameter in 2～4mm left and right, circular or oval, sharply marginated shallow aphtha.Center micro-pits, surface is covered with the faint yellow pseudomembrane of one deck, and ulcer mucosa hyperemia is around blush shape, and it is not hard that lay one's hand at its end.Ulcer number is generally 2～3 left and right.After ulcer, there is more violent burning pain.
3, Therapeutic Method
Select above-mentioned medicament, to patient, be applied to affected part, every 4 hours once, within 5 days, is a course for the treatment of, continuously two courses for the treatment of of the drug of topical application.
4, efficacy assessment standard
Effective: the recovery from illness of recurrent aphtha symptom, recovers normal;
Take a turn for the better: recurrent aphtha symptom alleviates, and the state of an illness progressively takes a turn for the better;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by Drug therapy Patients with RAU 100 examples of the present invention, effective 92 examples of result, obvious effective rate is 92%, 3 examples that take a turn for the better, and improvement rate is 3%, invalid 5 examples, total effective rate is 95%.
Claims (3)
1. a medicine for the treatment of recurrent aphtha, is characterized in that: it is to be made by the crude drug in following weight range:
Fructus Solani melongenae 8-15 gram of Flos Rosae Chinensis 15-25 gram of Moschus 1-3 gram
Semen Sesami Nigrum 5-15 gram of Herba Cistanches 5-10 gram of Fructus Jujubae 5-10 gram
Radix Codonopsis 4-8 gram of Rhizoma Corydalis 5-15 gram of Mannosum Kaki 8-16 gram
Corium elephatis 5-12 gram of Herba Menthae 5-15 gram of catechu 5-15 gram
Folium Musae 15-25 gram of Fructus Canarii albi 10-20 gram of Nidus Vespae 15-22 gram
Mel 35-45 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
2 grams, 20 grams of Moschus of 10 grams of Flos Rosae Chinensiss of Fructus Solani melongenae
6 grams, 6 grams of Fructus Jujubaes of 8 grams of Herba Cistanches of Semen Sesami Nigrum
10 grams of 10 grams of Mannosum Kakis of 5 grams of Rhizoma Corydalis of Radix Codonopsis
10 grams, 10 grams of catechu of 6 grams of Herba Menthaes of Corium elephatis
20 grams, 15 grams of Nidus Vespae of 20 grams of Fructus Canarii albis of Folium Musae
40 grams of Mel.
3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Fructus Solani melongenae: the autumn in summer gathers when fruit is ripe, section, dries;
(2) Flos Rosae Chinensis: summer, the autumn semi-open flower of gathering, dries, or dries with low baking temperature;
(3) Moschus: infiltrate sachet with warm water, remove fur inner membrance impurity after cutting open, the used time is got Moschus core porphyrize;
(4) Semen Sesami Nigrum: get crude drug, remove impurity, sieve removes chip;
(5) Herba Cistanches: choose clean impurity, clear water soaks, and changes water every day 1-2 times, as is salty Herba Cistanches, and bubble is salinity to the greatest extent, runs through, and longitudinal section, dries;
(6) Fructus Jujubae: choose clean impurity, enucleation, dries;
(7) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
(8) Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
(9) Mannosum Kaki: get ripe Fructus Kaki, the crust of pruning, weather exposure, after January, places in seat circle, then through January Fructus kaki Siccus, raw adularescent Refined Mercurous chloride on Fructus kaki Siccus, with under broom brush, is Mannosum Kaki;
(10) Corium elephatis: get Corium elephatis and soak approximately 3 days, clean, slightly vexed, shine to eighty per cant dry, then get wet once, consistent to internal and external temperature, be cut into the thin slice of thick approximately 2 millimeters, dry;
(11) Herba Menthae: choose clean impurity, remove undesirable root, first leaf is trembled and separately put down, then stem is sprayed to clear water, run through rear cutting, dry, then with leaf and even;
(12) catechu: remove impurity, the used time smashs to pieces;
(13) Folium Musae: choose decontamination, dry;
(14) Fructus Canarii albi charcoal: Fructus Canarii albi is made charcoal and ground into powder;
(15) Nidus Vespae: get crude drug, remove impurity, stripping and slicing, sieve removes chip;
(16) Mel: get pure Mel, with slow fire, temper, filtration skimming '
(2) preparation
(1) Fructus Solani melongenae of described quantity, Flos Rosae Chinensis, Moschus, Semen Sesami Nigrum, Herba Cistanches, Fructus Jujubae, Radix Codonopsis, Rhizoma Corydalis, Mannosum Kaki, Corium elephatis, Herba Menthae, catechu, Folium Musae, Fructus Canarii albi charcoal, Nidus Vespae are ground into superfine powder altogether;
(2) by ground medicine superfine powder, add the Mel of described weight to mix well, make paste and get final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031357A (en) * | 2015-08-20 | 2015-11-11 | 王莉 | Medicine for treating oral ulcer and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207912A (en) * | 1997-08-08 | 1999-02-17 | 杨青山 | Oral tonic wine capsule for curing disease pain and health care |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207912A (en) * | 1997-08-08 | 1999-02-17 | 杨青山 | Oral tonic wine capsule for curing disease pain and health care |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031357A (en) * | 2015-08-20 | 2015-11-11 | 王莉 | Medicine for treating oral ulcer and preparation method thereof |
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