CN103638220B

CN103638220B - Medicament for treating recurrent aphtha and preparation method of medicament

Info

Publication number: CN103638220B
Application number: CN201310672990.9A
Authority: CN
Inventors: 苏振华
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-12-12
Filing date: 2013-12-12
Publication date: 2015-04-08
Anticipated expiration: 2033-12-12
Also published as: CN103638220A

Abstract

The invention discloses a medicament for treating recurrent aphtha and a preparation method of the medicament. The medicament is mainly prepared from medicines such as eggplant, China rose, musk, black sesame, cistanche, jujube, root of pilose asiabell, rhizoma corydalis, persimmon frost and the like according to a certain weight ratio. The medicament disclosed by the invention has the functions of detoxifying and healing sore and dispelling the wind and relieving pain, and is rapid to take an effect, good in curative effect and free of toxic or side effect when used for treating recurrent aphtha.

Description

A kind of medicine for the treatment of recurrent aphtha and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of recurrent aphtha and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Recurrent aphtha is a kind of disease that in the disease of cari oris mucosa, sickness rate is the highest, common cold, dyspepsia, psychentonia, the gloomy situation such as discomfort all can accidentally occur, be apt to occur in lip, cheek, lingual margin etc., all can occur at any position of mucosa, but attached gingiva, hard palate are then rare completely in keratinization.Age is regardless of, and age of onset was estimated between 10 ~ 20 years old, and women is more.All can occur throughout the year, ulcer has self limiting, can spontaneous recovery in about 10 days.The title recurrent aphtha if aphtha often occurs or rises one after another.Its disease damage is ulcerative lesions, and ulcer has the features such as periodicity, recurrent and self limiting.Because Western medicine effectively cannot treat recurrent aphtha, therefore there is great demand in the Chinese medicine of people to rapid, effective treatment recurrent aphtha, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment recurrent aphtha, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment recurrent aphtha.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Fructus Solani melongenae, Flos Rosae Chinensis, Moschus, Semen Sesami Nigrum, Herba Cistanches, Fructus Jujubae, Radix Codonopsis, Rhizoma Corydalis, Mannosum Kaki, Corium elephatis, Herba Menthae, catechu, Folium Musae, Fructus Canarii albi charcoal, Nidus Vespae, Mel medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of recurrent aphtha.Fructus Solani melongenae is selected to be that enter spleen, stomach, large intestine channel, have heat clearing away, invigorate blood circulation, pain relieving, the function of detumescence, controls discharging fresh blood stool, pyretic toxicity carbuncle sore, skin ulcer because its nature and flavor are sweet, cool.Flos Rosae Chinensis is selected to be that temperature, enter Liver Channel, have promoting blood flow to regulate menstruation, the function of subduing swelling and detoxicating, controls menoxenia, menalgia, traumatic injury, and blood stasis swells and ache, swollen ulcer drug because its nature and flavor are sweet.Select Moschus to be because its nature and flavor are pungent, temperature, enter the heart, spleen, Liver Channel, have and have one's ideas straightened out, ward off dirty, dredging collateral, the function of dissipating blood stasis, controls apoplexy, syncope due to accumulation of phlegm ， Jing Epilepsy, and attacked by pestiferous factors is unhappy, trusted subordinate's sudden pain ， mass in the abdomen hypochondriac lump, traumatic injury, swollen ulcer drug.Select Semen Sesami Nigrum, different name Semen Lini, its nature and flavor are sweet, flat, return liver, kidney, large intestine channel, have invigorating the liver and kidney, benefiting essence-blood, the function that intestine moistening is dry, control and feel dizzy, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.Select Herba Cistanches to be that temperature, enters kidney, large intestine channel, have the kidney invigorating because the sweet acid of its nature and flavor is salty, benefit essence, moisturize, the function of bowel relieving, controls impotence in male, infertilitas feminis, leukorrhagia, metrorrhagia, chills and pain of the waist and kness, blood depletion constipation.Select Fructus Jujubae to be that temperature, enters spleen, stomach warp, have spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid because its nature and flavor are sweet, adjust battalion to defend, separate the function of poison of drug, control insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis.Rhizoma Corydalis is selected to be that temperature, enter liver, stomach warp, invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, the function of pain relieving, controls all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury because its nature and flavor are worked hard.Select Mannosum Kaki to be because its nature and flavor are sweet cool, few the moon of starting with, Taiyin channels, has clearing heat and moistening dryness, and the function of reducing phlegm, controls cough due to lung-heat, and dry pharynx is had sore throat, aphtha of the mouth and tongue, spits blood, and spitting of blood, quenches one's thirst.Select Corium elephatis to be because its nature and flavor are sweet, salty, temperature, enter bladder meridian, have hemostasis, the function of sore, controls traumatic hemorrhage, and all wounds, ulcer do not close up for a long time.Select Herba Menthae to be because its nature and flavor are pungent, cool, enter lung, Liver Channel, have dispelling wind, heat radiation, ward off dirty, the function of removing toxic substances, controls affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.Select catechu to be because its nature and flavor are bitter, puckery, be slightly cold, return lung meridian, have the function of removing dampness promoting tissue regeneration and ulcer healing, control ulcer being unable to heal, eczema, aphtha, fall and flutter the pain of injury, traumatic hemorrhage.Select Folium Musae to be because its property slightly sweet flavor, cold, enter conscience two warp, have clearing away heat and promoting diuresis, the function of removing toxic substances, controls calentura, heatstroke, beriberi, and carbuncle detoxifies, and scalds.Fructus Canarii albi is selected to be that flat, enter lung, stomach warp, have lung heat clearing, sore-throat relieving, promote the production of body fluid, the function of removing toxic substances, controls laryngopharynx swelling and pain, excessive thirst, and cough is spitted blood, bacillary dysentery, epilepsy, separates tetrodotoxin, TTX and alcoholism because its property sweet-puckery flavor acid.Nidus Vespae is selected to be because its nature and flavor are sweet, flat, return stomach warp, dispel the wind, counteracting toxic substances, parasite killing, the function of pain relieving, for toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot.Select Mel to be that flat, enter lung, spleen, large intestine channel, have invigorating middle warmer, moisturize, pain relieving, the function of removing toxic substances, controls xeropulmonary cough, dryness of the intestine constipation, gastralgia, nasal sinusitis, aphtha, the burning hot wound of soup because its nature and flavor are sweet, separate Aconitum Carmichaeli.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight

Fructus Solani melongenae 8-15 gram of Flos Rosae Chinensis 15-25 gram of Moschus 1-3 gram

Semen Sesami Nigrum 5-15 gram of Herba Cistanches 5-10 gram of Fructus Jujubae 5-10 gram

Radix Codonopsis 4-8 gram of Rhizoma Corydalis 5-15 gram of Mannosum Kaki 8-16 gram

Corium elephatis 5-12 gram of Herba Menthae 5-15 gram of catechu 5-15 gram

Folium Musae 15-25 gram of Fructus Canarii albi 10-20 gram of Nidus Vespae 15-22 gram

Mel 35-45 gram

Be preferably

2 grams, Fructus Solani melongenae 10 grams of Flos Rosae Chinensiss 20 grams of Moschus

6 grams, Semen Sesami Nigrum 8 grams of Herba Cistanches 6 grams of Fructus Jujubaes

Radix Codonopsis 5 grams of Rhizoma Corydalis 10 grams of Mannosum Kakis 10 grams

10 grams, Corium elephatis 6 grams of Herba Menthaes 10 grams of catechu

20 grams, Folium Musae 20 grams of Fructus Canarii albis 15 grams of Nidus Vespae

Mel 40 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Fructus Solani melongenae: the autumn in summer gathers when fruit is ripe, section, dries;

2, Flos Rosae Chinensis: summer, autumn gather semi-open flower, dry, or dry with low baking temperature;

3, Moschus: infiltrate sachet with warm water, cut open rear removing fur inner membrance impurity, the used time gets Moschus core porphyrize;

4, Semen Sesami Nigrum: get crude drug, removing impurity, sieve removes chip;

5, Herba Cistanches: pick clean impurity, clear water soaks, and changes water every day 1-2 times, and as being salty Herba Cistanches, bubble is salinity to the greatest extent, runs through, longitudinal section, dries;

6, Fructus Jujubae: pick clean impurity, enucleation, dry;

7, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

8, Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

9, Mannosum Kaki: get ripe Fructus Kaki, crust of pruning, weather exposure, after January, places in seat circle, then through January Fructus kaki Siccus, on Fructus kaki Siccus, raw adularescent Refined Mercurous chloride, with under broom brush, is Mannosum Kaki;

10, Corium elephatis: get Corium elephatis and soak about 3 days, clean, slightly vexed, shine to eighty per cant dry, then get wet once, consistent to internal and external temperature, be cut into the thin slice of thick about 2 millimeters, dry;

11, Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;

12, catechu: removing impurity, the used time smashs to pieces;

13, Folium Musae: pick decontamination, dries;

14, Fructus Canarii albi charcoal: Fructus Canarii albi is made charcoal and grinds into powder;

15, Nidus Vespae: get crude drug, removing impurity, stripping and slicing, sieve removes chip;

16, Mel: get pure Mel, temper with slow fire, filters skimming.

Two, prepare

1, the Fructus Solani melongenae of described quantity, Flos Rosae Chinensis, Moschus, Semen Sesami Nigrum, Herba Cistanches, Fructus Jujubae, Radix Codonopsis, Rhizoma Corydalis, Mannosum Kaki, Corium elephatis, Herba Menthae, catechu, Folium Musae, Fructus Canarii albi charcoal, Nidus Vespae are ground into superfine powder altogether.

2, by ground medicine superfine powder, the Mel adding described weight is mixed well, and makes paste and get final product.

Medicine of the present invention has the function of removing toxic substances sore, wind-expelling pain-stopping, is used for the treatment of recurrent aphtha instant effect, good effect, does not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get West Germany rabbit 15, male and female dual-purpose, body weight 2.0-2.5kg, the medicine mixed up is coated in the anal of rabbit, drug of topical application every day secondary, the continuous drug of topical application 5 days, observe administration reaction every day, result shows that rabbit is movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 100 examples for medical treatment.

2, diagnostic criteria

Responsive or occur needle point sample size or slightly large congested district from the beginning of lesion, namely form diameter in a short time at about 2 ~ 4mm, circular or oval, sharply marginated shallow aphtha.Center micro-pits, surface is covered with the faint yellow pseudomembrane of one deck, and around ulcer, mucosa hyperemia is in blush shape, and it is not hard that its end lays one's hand on.Ulcer number is generally about 2 ~ 3.More violent burning pain is had after ulcer.

3, Therapeutic Method

Select above-mentioned medicament, be applied to affected part to patient, every 4 hours once, within 5 days, is a course for the treatment of, two courses for the treatment of of the continuous drug of topical application.

4, efficacy assessment standard

Effective: recurrent aphtha symptom is fully recovered, recover normal;

Take a turn for the better: recurrent aphtha symptom alleviates, and the state of an illness progressively takes a turn for the better;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

In above-mentioned treatment, by Drug therapy Patients with RAU 100 example of the present invention, effective 92 examples of result, obvious effective rate is 92%, and take a turn for the better 3 examples, and improvement rate is 3%, and invalid 5 examples, total effective rate is 95%.

Claims

1. treat a medicine for recurrent aphtha, it is characterized in that: it is made up of the crude drug in following weight range:

Corium elephatis 5-12 gram of Herba Menthae 5-15 gram of catechu 5-15 gram

Mel 35-45 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

10 grams, Corium elephatis 6 grams of Herba Menthaes 10 grams of catechu

Mel 40 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Fructus Solani melongenae: the autumn in summer gathers when fruit is ripe, section, dries;

(2) Flos Rosae Chinensis: summer, autumn gather semi-open flower, dry, or dry with low baking temperature;

(3) Moschus: infiltrate sachet with warm water, cut open rear removing fur inner membrance impurity, the used time gets Moschus core porphyrize;

(4) Semen Sesami Nigrum: get crude drug, removing impurity, sieve removes chip;

(5) Herba Cistanches: pick clean impurity, clear water soaks, and changes water every day 1-2 times, and as being salty Herba Cistanches, bubble is salinity to the greatest extent, runs through, longitudinal section, dries;

(6) Fructus Jujubae: pick clean impurity, enucleation, dry;

(7) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

(8) Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

(9) Mannosum Kaki: get ripe Fructus Kaki, crust of pruning, weather exposure, after January, places in seat circle, then through January Fructus kaki Siccus, on Fructus kaki Siccus, raw adularescent Refined Mercurous chloride, with under broom brush, is Mannosum Kaki;

(10) Corium elephatis: get Corium elephatis and soak about 3 days, clean, slightly vexed, shine to eighty per cant dry, then get wet once, consistent to internal and external temperature, be cut into the thin slice of thick about 2 millimeters, dry;

(11) Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;

(12) catechu: removing impurity, the used time smashs to pieces;

(13) Folium Musae: pick decontamination, dries;

(14) Fructus Canarii albi charcoal: Fructus Canarii albi is made charcoal and grinds into powder;

(15) Nidus Vespae: get crude drug, removing impurity, stripping and slicing, sieve removes chip;

(16) Mel: get pure Mel, temper with slow fire, filtration skimming '

(2) prepare

(1) Fructus Solani melongenae of described quantity, Flos Rosae Chinensis, Moschus, Semen Sesami Nigrum, Herba Cistanches, Fructus Jujubae, Radix Codonopsis, Rhizoma Corydalis, Mannosum Kaki, Corium elephatis, Herba Menthae, catechu, Folium Musae, Fructus Canarii albi charcoal, Nidus Vespae are ground into superfine powder altogether;

(2) by ground medicine superfine powder, the Mel adding described weight is mixed well, and makes paste and get final product.