CN103635788B - 对磁性粒子的团簇的检测 - Google Patents

对磁性粒子的团簇的检测 Download PDF

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Publication number
CN103635788B
CN103635788B CN201280032198.0A CN201280032198A CN103635788B CN 103635788 B CN103635788 B CN 103635788B CN 201280032198 A CN201280032198 A CN 201280032198A CN 103635788 B CN103635788 B CN 103635788B
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cluster
magnetic
sample
magnetic particle
time
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CN201280032198.0A
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Chinese (zh)
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CN103635788A (zh
Inventor
A·兰佐尼
M·W·J·普林斯
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Koninklijke Philips NV
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Koninklijke Philips Electronics NV
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
    • G01N2021/1727—Magnetomodulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers

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  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN201280032198.0A 2011-06-30 2012-06-18 对磁性粒子的团簇的检测 Active CN103635788B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11172070.2 2011-06-30
EP11172070A EP2541230A1 (en) 2011-06-30 2011-06-30 Detection of clusters of magnetic particles
PCT/IB2012/053051 WO2013001400A1 (en) 2011-06-30 2012-06-18 Detection of clusters of magnetic particles

Publications (2)

Publication Number Publication Date
CN103635788A CN103635788A (zh) 2014-03-12
CN103635788B true CN103635788B (zh) 2016-12-14

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CN201280032198.0A Active CN103635788B (zh) 2011-06-30 2012-06-18 对磁性粒子的团簇的检测

Country Status (5)

Country Link
US (1) US10036729B2 (enExample)
EP (2) EP2541230A1 (enExample)
JP (1) JP6270717B2 (enExample)
CN (1) CN103635788B (enExample)
WO (1) WO2013001400A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130051647A (ko) * 2011-11-10 2013-05-21 한국전자통신연구원 자성 입자를 이용한 바이오 물질의 분석 방법
JP6225114B2 (ja) * 2011-11-14 2017-11-01 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． クラスタ検出に関する装置
JP7225656B2 (ja) * 2018-10-10 2023-02-21 凸版印刷株式会社 目的物質検出装置及び目的物質検出方法
TWI776251B (zh) * 2020-10-08 2022-09-01 中原大學 基於目標分子吸附之磁控量測系統
CN113515868B (zh) * 2021-08-04 2024-07-19 常熟理工学院 一种磁流变弹性体的链簇模型构建方法及性能估测方法
CN118818588B (zh) * 2024-07-12 2025-02-28 中国科学院近代物理研究所 高计数率twin-TPC的在线簇团重建方法、装置及设备

Family Cites Families (20)

* Cited by examiner, † Cited by third party
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JPS62118255A (ja) * 1985-11-19 1987-05-29 Toshimitsu Musha 磁界を用いた免疫反応の検出法
CN1032399A (zh) * 1986-05-22 1989-04-12 尤尼利弗公司 免疫测定方法
DE3751865T2 (de) * 1986-09-22 1997-01-16 Nippon Telegraph & Telephone Lasermagnetisches immuntestverfahren und vorrichtung dazu
JP3244509B2 (ja) * 1991-01-16 2002-01-07 株式会社シノテスト 磁性粒子担体を用いた間接凝集反応法
JP4240303B2 (ja) 2002-01-29 2009-03-18 旭化成株式会社 バイオセンサ、磁性分子測定方法、及び、測定対象物測定方法
GB0410976D0 (en) 2004-05-17 2004-06-16 Randox Lab Ltd Magnetic particle detector system
EP1846766B1 (en) * 2005-01-31 2014-01-01 Koninklijke Philips N.V. Rapid and sensitive biosensing
JP2006247535A (ja) * 2005-03-10 2006-09-21 Toyo Univ 回転磁場を利用した反応促進方法
SE0600870L (sv) 2006-04-19 2007-08-21 Imego Ab Detekteringsanordning och förfarande
CN101479617A (zh) 2006-06-28 2009-07-08 皇家飞利浦电子股份有限公司 具有场发生器和传感器元件的磁传感器设备
JP5970153B2 (ja) * 2006-12-19 2016-08-17 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 凝集パラメータの測定
US8190372B2 (en) 2007-02-23 2012-05-29 Koninklijke Philips Electronics N.V. Sensor device for and a method of sensing magnetic particles
US9068977B2 (en) * 2007-03-09 2015-06-30 The Regents Of The University Of Michigan Non-linear rotation rates of remotely driven particles and uses thereof
WO2009007797A1 (en) 2007-07-09 2009-01-15 Koninklijke Philips Electronics N.V. Microelectronic sensor device with magnetic field generator and carrier
US20100277160A1 (en) 2007-12-18 2010-11-04 Koninklijke Philips Electronics N.V. Magnetic sensor device
WO2009083814A2 (en) * 2007-12-20 2009-07-09 Koninklijke Philips Electronics N.V. Microelectronic sensor device for the detection of target particles
US20110014719A1 (en) * 2008-03-17 2011-01-20 Koninklijke Philips Electronics N.V. Cartridge for assays with magnetic particles
EP2326956B1 (en) * 2008-09-05 2019-08-14 Koninklijke Philips N.V. Apparatus and method for detecting supaparamagnetic clusters
WO2010084383A1 (en) * 2009-01-22 2010-07-29 Koninklijke Philips Electronics N. V. Mixed actuation protocol for a magnetic biosensor device
JPWO2011049044A1 (ja) * 2009-10-19 2013-03-14 国立大学法人東京工業大学 磁性微粒子を用いるバイオセンサ

Also Published As

Publication number Publication date
CN103635788A (zh) 2014-03-12
EP2726848A1 (en) 2014-05-07
WO2013001400A1 (en) 2013-01-03
US20140120632A1 (en) 2014-05-01
US10036729B2 (en) 2018-07-31
EP2541230A1 (en) 2013-01-02
JP2014518389A (ja) 2014-07-28
EP2726848B1 (en) 2016-04-13
JP6270717B2 (ja) 2018-01-31

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