CN103623276B - A kind of oral preparation of Chinese traditional medicinal for the treatment of hepatitis B - Google Patents
A kind of oral preparation of Chinese traditional medicinal for the treatment of hepatitis B Download PDFInfo
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- CN103623276B CN103623276B CN201310674063.0A CN201310674063A CN103623276B CN 103623276 B CN103623276 B CN 103623276B CN 201310674063 A CN201310674063 A CN 201310674063A CN 103623276 B CN103623276 B CN 103623276B
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- 208000002672 hepatitis B Diseases 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000003814 drug Substances 0.000 claims abstract description 24
- 229940079593 drug Drugs 0.000 claims abstract description 14
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 239000000706 filtrate Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 208000006454 hepatitis Diseases 0.000 claims description 8
- 231100000283 hepatitis Toxicity 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 14
- 241000700605 Viruses Species 0.000 abstract description 4
- 230000003203 everyday effect Effects 0.000 abstract description 4
- 230000007774 longterm Effects 0.000 abstract description 3
- 231100000614 poison Toxicity 0.000 abstract description 2
- 239000003440 toxic substance Substances 0.000 abstract description 2
- 238000012795 verification Methods 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 description 4
- 206010008909 Chronic Hepatitis Diseases 0.000 description 2
- 241000700721 Hepatitis B virus Species 0.000 description 2
- 206010019799 Hepatitis viral Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000004596 appetite loss Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000019017 loss of appetite Diseases 0.000 description 2
- 235000021266 loss of appetite Nutrition 0.000 description 2
- 201000001862 viral hepatitis Diseases 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000037319 Hepatitis infectious Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- 210000002700 urine Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of oral preparation of Chinese traditional medicinal for the treatment of hepatitis B, it is be made up of the crude drug of following weight portion: 20 ~ 30 parts, Poria, Thallus Laminariae (Thallus Eckloniae) 20 ~ 30 parts, Herba Leonuri 20 ~ 30 parts, Rhizoma Imperatae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Radix Gentianae 10 ~ 20 parts, 5 ~ 15 parts, Folium Mori, Oletum Trogopterori 5 ~ 15 parts, 5 ~ 10 parts, Radix Glycyrrhizae.The effects such as Chinese medicine preparation of the present invention, has heat-clearing and toxic substances removing, soothing liver-QI dampness removing, are adapted to hepatitis B.During treatment, oral, every day twice, each serving dose about 10 grams.Chinese medicine preparation of the present invention, has significant curative effect to hepatitis B, general medication one to two months, can transfer virus to carry by great three positive.Through clinical verification, its effective percentage reaches 94.8%, the advantage such as have instant effect, determined curative effect, effective percentage is high, long-term effect is good.
Description
Technical field
The present invention relates to a kind of oral preparation of Chinese traditional medicinal for the treatment of hepatitis B.
Background technology
Viral hepatitis is the general designation of hepatic diseases, hepatitis medically can be divided into first, second, third, fourth, penta, oneself, heptan seven type.Viral hepatitis causes swelling of liver cell, is to spread one of extensively very harmful infectious disease in the world.Wherein hepatitis B be popular the most extensively, the most serious a kind of infectious hepatitis of harm.Hepatitis B, being called for short hepatitis B, is the liver injury caused by hepatitis B virus, primary disease extend over the entire globe, clinical manifestation is weak, loss of appetite, Nausea and vomiting, detests oil, diarrhoea and abdominal distention, and some cases has heating, jaundice, about has half patient onset to hide.Find in inspection, after hepatitis B virus infection human body, be extensively present in the places such as blood, saliva, vaginal secretions, milk, seminal fluid, mainly through propagation such as blood, property contact, close contacts, so hepatitis B morbidity has familial.But be not that each people infecting virus can become hepatitis B patient, viral load, the factor such as virulence and mode of infection of this and patient infection are closely related, everyone body constitution, immunoreation state, also play an important role in the hepatitis B state of an illness and lapsing to of the course of disease.So result below may be there is after patient infection's hepatitis B virus: do not fall ill and produce protectiveness hepatitis B surface antibody, the asymptomatic carrier of long-term chronic, slight chronic hepatitis, hepatitis gravis.
At present, the treatment method of hepatitis B and medicine a lot, but mostly there is unsatisfactory curative effect, cure after the defects such as easily recurrence, the course for the treatment of be long.
Summary of the invention
For above-mentioned prior art, the invention provides a kind of oral preparation of Chinese traditional medicinal for the treatment of hepatitis B.
The present invention is achieved by the following technical solutions:
A kind of oral preparation of Chinese traditional medicinal for the treatment of hepatitis B, it is be made up of the crude drug of following weight portion: 20 ~ 30 parts, Poria, Thallus Laminariae (Thallus Eckloniae) 20 ~ 30 parts, Herba Leonuri 20 ~ 30 parts, Rhizoma Imperatae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Radix Gentianae 10 ~ 20 parts, 5 ~ 15 parts, Folium Mori, Oletum Trogopterori 5 ~ 15 parts, 5 ~ 10 parts, Radix Glycyrrhizae.
Preferably, be made up of the crude drug of following weight portion: 25 parts, Poria, Thallus Laminariae (Thallus Eckloniae) 25 parts, Herba Leonuri 25 parts, Rhizoma Imperatae 15 parts, Radix Scutellariae 15 parts, Radix Gentianae 15 parts, 10 parts, Folium Mori, Oletum Trogopterori 10 parts, 8 parts, Radix Glycyrrhizae.
The preparation method of the oral preparation of Chinese traditional medicinal of described treatment hepatitis B is: get each crude drug, mixing, add 10 ~ 15 times amount (weight multiple) water, soak 1 hour, then conventional decoction 2 ~ 3 hours, filter to get filtrate, 5 ~ 8 times amount (weight multiple) water is added in filtering residue, conventional decoction 2 ~ 3 hours, filter to get filtrate, merge twice filtrate, being concentrated into relative density is 1.10 ~ 1.20(50 DEG C of survey) concentrated solution, add the ethanol with concentrated solution equal volume amounts, after mixing, reclaim ethanol extremely without ethanol taste, spraying dry, the Chinese medicine preparation of hepatitis must be treated, during embody rule, granule or tablet or electuary can be made, conventional pharmaceutic adjuvant can be added if desired.
The effects such as Chinese medicine preparation of the present invention, has heat-clearing and toxic substances removing, soothing liver-QI dampness removing, are adapted to hepatitis B.During treatment, oral, every day twice, each serving dose about 10 grams, general medication one is to obtaining significant curative effect after two months.
Chinese medicine preparation of the present invention, has significant curative effect to hepatitis B, general medication one to two months, can transfer virus to carry by great three positive.Through clinical verification, its effective percentage reaches 94.8%, the advantage such as have instant effect, determined curative effect, effective percentage is high, long-term effect is good.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1 prepares the oral preparation of Chinese traditional medicinal for the treatment of hepatitis B
Formula is: 25 grams, Poria, Thallus Laminariae (Thallus Eckloniae) 25 grams, Herba Leonuri 25 grams, Rhizoma Imperatae 15 grams, Radix Scutellariae 15 grams, Radix Gentianae 15 grams, 10 grams, Folium Mori, Oletum Trogopterori 10 grams, 8 grams, Radix Glycyrrhizae.
Preparation method is: get each crude drug, and mixing, adds 12 times amount (weight multiple) water, soak 1 hour, then conventional decoction 2.5 hours, filters to get filtrate, in filtering residue, add 6 times amount (weight multiple) water, conventional decoction 2.5 hours, filters to get filtrate, merge twice filtrate, being concentrated into relative density is 1.15(50 DEG C of survey) concentrated solution, add the ethanol with concentrated solution equal volume amounts, after mixing, reclaim ethanol extremely without ethanol taste, spraying dry, must treat the Chinese medicine preparation of hepatitis.
During treatment, oral, every day twice, each serving dose about 10 grams, general medication one is to obtaining significant curative effect after two months.
Embodiment 2 prepares the oral preparation of Chinese traditional medicinal for the treatment of hepatitis B
Formula is: 20 grams, Poria, Thallus Laminariae (Thallus Eckloniae) 30 grams, Herba Leonuri 20 grams, Rhizoma Imperatae 20 grams, Radix Scutellariae 10 grams, Radix Gentianae 20 grams, 5 grams, Folium Mori, Oletum Trogopterori 15 grams, 5 grams, Radix Glycyrrhizae.
Preparation method is: get each crude drug, and mixing, adds 10 times amount (weight multiple) water, soak 1 hour, then conventional decoction 2 hours, filters to get filtrate, in filtering residue, add 8 times amount (weight multiple) water, conventional decoction 3 hours, filters to get filtrate, merge twice filtrate, being concentrated into relative density is 1.10 ~ 1.20(50 DEG C of survey) concentrated solution, add the ethanol with concentrated solution equal volume amounts, after mixing, reclaim ethanol extremely without ethanol taste, spraying dry, adds customary adjuvant and makes granule.
Embodiment 3 prepares the oral preparation of Chinese traditional medicinal for the treatment of hepatitis B
Formula is: 30 grams, Poria, Thallus Laminariae (Thallus Eckloniae) 20 grams, Herba Leonuri 30 grams, Rhizoma Imperatae 10 grams, Radix Scutellariae 20 grams, Radix Gentianae 10 grams, 15 grams, Folium Mori, Oletum Trogopterori 5 grams, 10 grams, Radix Glycyrrhizae.
Preparation method is: get each crude drug, mixing, add 15 times amount (weight multiple) water, soak 1 hour, then conventional decoction 3 hours, filters to get filtrate, adds 5 times amount (weight multiple) water in filtering residue, conventional decoction 2 hours, filter to get filtrate, merge twice filtrate, being concentrated into relative density is 1.10 ~ 1.20(50 DEG C of survey) concentrated solution, add the ethanol with concentrated solution equal volume amounts, after mixing, reclaim ethanol extremely without ethanol taste, spraying dry, the Chinese medicine preparation of hepatitis must be treated, add customary adjuvant and make tablet.
Clinical data:
Patient data: patient 155 example, all suffers from hepatitis B (the hepatitis B great three positive for chronic hepatitis of active stage), wherein, and man 92 example, 46 years old mean age, female 63 example, 47 years old mean age.
Diagnosis basis: liver function ten, hepatitis B six, ultrasound diagnosis, oral account general lassitude, weak, loss of appetite, feels sick and detests oil, yellow complexion, yellow urine.
Therapeutic Method: patient all adopts Chinese medicine preparation of the present invention (prepared by embodiment 1) to treat, oral, every day twice, each serving dose 10 grams, observe the curative effect after two months, in two months periods, healing person continues drug administration with consolidate curative effect.
The standard of curative effect evaluation:
Cure: liver histological checks Non Apparent Abnormality, and great three positive transfers virus to and carries.
Invalid: the state of an illness is without significant change.
Therapeutic outcome: patient 155 example, treated after one month, cured 91 examples, after two months, cured 147 examples, and cure rate is 94.8%, and all the other 9 examples are without significant change, invalid.
Claims (3)
1. treat the oral preparation of Chinese traditional medicinal of hepatitis B for one kind, it is characterized in that: be made up of the crude drug of following weight portion: 20 ~ 30 parts, Poria, Thallus Laminariae (Thallus Eckloniae) 20 ~ 30 parts, Herba Leonuri 20 ~ 30 parts, Rhizoma Imperatae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Radix Gentianae 10 ~ 20 parts, 5 ~ 15 parts, Folium Mori, Oletum Trogopterori 5 ~ 15 parts, 5 ~ 10 parts, Radix Glycyrrhizae.
2. a kind of oral preparation of Chinese traditional medicinal for the treatment of hepatitis B according to claim 1, it is characterized in that: be made up of the crude drug of following weight portion: 25 parts, Poria, Thallus Laminariae (Thallus Eckloniae) 25 parts, Herba Leonuri 25 parts, Rhizoma Imperatae 15 parts, Radix Scutellariae 15 parts, Radix Gentianae 15 parts, 10 parts, Folium Mori, Oletum Trogopterori 10 parts, 8 parts, Radix Glycyrrhizae.
3. a kind of preparation method for the treatment of the oral preparation of Chinese traditional medicinal of hepatitis B described in claim 1 and 2, it is characterized in that: get each crude drug, mixing, add 10 ~ 15 times of water gagings, soak 1 hour, then conventional decoction 2 ~ 3 hours, filter to get filtrate, 5 ~ 8 times of water gagings are added in filtering residue, conventional decoction 2 ~ 3 hours, filter to get filtrate, merge twice filtrate, be concentrated into the concentrated solution that relative density is 1.10 ~ 1.20, add the ethanol with concentrated solution equal volume amounts, after mixing, reclaim ethanol extremely without ethanol taste, spraying dry, the Chinese medicine preparation of hepatitis must be treated, or: add conventional pharmaceutic adjuvant and make granule or tablet or electuary.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310674063.0A CN103623276B (en) | 2013-12-13 | 2013-12-13 | A kind of oral preparation of Chinese traditional medicinal for the treatment of hepatitis B |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310674063.0A CN103623276B (en) | 2013-12-13 | 2013-12-13 | A kind of oral preparation of Chinese traditional medicinal for the treatment of hepatitis B |
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| Publication Number | Publication Date |
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| CN103623276A CN103623276A (en) | 2014-03-12 |
| CN103623276B true CN103623276B (en) | 2015-09-30 |
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| CN201310674063.0A Expired - Fee Related CN103623276B (en) | 2013-12-13 | 2013-12-13 | A kind of oral preparation of Chinese traditional medicinal for the treatment of hepatitis B |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160559A (en) * | 1996-11-30 | 1997-10-01 | 李泽良 | Hepatitis B curing toxin-dissipating pill |
| CN102772595A (en) * | 2012-08-17 | 2012-11-14 | 张守潘 | Traditional Chinese composition for treating chronic hepatitis B |
| CN102895362A (en) * | 2012-10-30 | 2013-01-30 | 张晓彤 | Traditional Chinese medicine preparation for treating hepatitis B |
| CN102973872A (en) * | 2011-09-02 | 2013-03-20 | 范军 | Hepatitis B treatment drug |
-
2013
- 2013-12-13 CN CN201310674063.0A patent/CN103623276B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160559A (en) * | 1996-11-30 | 1997-10-01 | 李泽良 | Hepatitis B curing toxin-dissipating pill |
| CN102973872A (en) * | 2011-09-02 | 2013-03-20 | 范军 | Hepatitis B treatment drug |
| CN102772595A (en) * | 2012-08-17 | 2012-11-14 | 张守潘 | Traditional Chinese composition for treating chronic hepatitis B |
| CN102895362A (en) * | 2012-10-30 | 2013-01-30 | 张晓彤 | Traditional Chinese medicine preparation for treating hepatitis B |
Non-Patent Citations (1)
| Title |
|---|
| 中医药治疗乙肝及乙肝病毒携带者的概况;马永才;《中国营养保健》;20120725(第07期);第2289-2290页 * |
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| CN103623276A (en) | 2014-03-12 |
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