CN102973872A - Hepatitis B treatment drug - Google Patents

Abstract

The present invention relates to a hepatitis B treatment drug. In the Chinese medicine theory, basic pathogenesis of hepatitis B is asthenia of healthy energy. The drug is mainly provided for solving various pathological changes caused by dampness-heat epidemic spoiling diseases accumulation, fluctuant internal blood tier, qi activity blocking and blood tier suppressing, has functions of liver soothing, heat clearing, spleen invigorating, dampness eliminating, blood circulation activating, blood stasis dissipating, detoxication and bleeding stopping, and has characteristics of no toxic-side effect and recurrence resistance. According to the hepatitis B treatment drug, the traditional Chinese medicine and modern Chinese medicine combined prescription is adopted, and is the most advanced hepatitis B treatment Chinese herbal in our country, wherein a success rate for turning positive of HBSAg, HBeAg and HBcAg into positive of HBsAg, HBeAb and HBcAb is more than 95%, positive of HBsAg, HBeAb and HBcAb can be completely turned into negative, the liver function can be restored to a normal state, and a difficult problem that hepatitis B treatment by the Chinese medicine is difficult is solved; and the hepatitis B treatment drug has characteristics of low cost, short treatment course, high efficacy, and easy taking, can be provided for treating various diseases caused by liver and stomach, and is applicable for hepatitis, viral hepatitis, gastritis, liver cirrhosis, cancers and other diseases.

Description

A kind of medicine for the treatment of hepatitis B treating

Technical field

The present invention relates to a kind of medicine for the treatment of hepatitis B treating, especially Chinese medicine.

Technical background

Long-pending for " damp and hot " in the Chinese medicine, " hypochondriac pain ", " stagnation of liver-QI ", “ wei ", the symptoms such as " acute hepatitis ", " cholestatic hepatitis " in " deficient " and the pharmacy of western medicine, " hepatitis gravis ", " chronic persistent hepatitis and chronic active hepatitis ", the medicines such as existing " bifendate drop pill ", " compound recipe proheparinum tablet ".But these medicine ubiquity weak curative effects are the defective such as recurrence easily, and what have also exists side effect to some extent.

Summary of the invention

The purpose of this invention is to provide a kind of good effect, the little medicine that can make hepatitis B treating of side effect.

It is this that to make the medicine of hepatitis B treating be to be made according to parts by weight by following component:

Rhizoma Polygoni Cuspidati 20 ± 5, Radix Isatidis 10 ± 2,

Radix Salviae Miltiorrhizae 10 ± 3, Gypsum Fibrosum 15 ± 3,

The Rhizoma Anemarrhenae 10 ± 2, Cortex Moutan 10 ± 2,

Radix Scutellariae 10 ± 2, Rhizoma Coptidis 8 ± 2,

Poria 12 ± 3, Fructus Gardeniae 10 ± 4,

Cortex Phellodendri 10 ± 3, Radix Et Rhizoma Rhei 8 ± 2,

Fructus Aurantii 10 ± 2, Rhizoma Atractylodis 12 ± 3,

The processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 10 ± 2, Flos Lonicerae 15 ± 2,

Fructus Forsythiae 10 ± 3, Rhizoma Alismatis 10 ± 3,

Caulis Akebiae 10 ± 2, Cortex Magnoliae Officinalis 10 ± 2,

Herba Pogostemonis 10 ± 2, Fructus Amomi Rotundus 10 ± 2,

Semen Coicis 15 ± 3, Fructus Setariae Germinatus (parched) 10 ± 2,

Fructus Hordei Germinatus (parched) 10 ± 2, Radix Gentianae 15 ± 5,

The Radix Paeoniae Alba 10 ± 2, Radix Bupleuri 10 ± 3,

Fructus Aurantii Immaturus 10 ± 2, Herba Violae 15 ± 5,

Rhizoma Smilacis Glabrae 10 ± 2, Oletum Trogopterori 10 ± 2,

Fructus Trichosanthis 10 ± 2, Pollen Typhae 10 ± 2 (decocting a drug wrapped),

Radix Arnebiae (Radix Lithospermi) 10 ± 3, Herba Hedyotidis Diffusae 15 ± 5,

Radix Glycyrrhizae 10 ± 1, Caulis Bambusae In Taenia 10 ± 2.

In order further to heighten the effect of a treatment, can also in said components, increase into Chinese herbal medicine:

Herba Taraxaci 10 ± 2, Rhizoma Imperatae 10 ± 3,

Flos Chrysanthemi Indici 10 ± 3, Caulis et folium pavettae hongkongensis 15 ± 5,

Herba Senecionis Scandentis 15 ± 5, Herba Patriniae 15 ± 5,

Herba Houttuyniae 15 ± 5, Herba Artemisiae Scopariae 15 ± 5,

The medicine of this treatment hepatitis B treating, the optimum weight umber of each component is:

Rhizoma Polygoni Cuspidati 20, Radix Isatidis 10,

Radix Salviae Miltiorrhizae 10, Gypsum Fibrosum 15,

The Rhizoma Anemarrhenae 10, Cortex Moutan 10,

Radix Scutellariae 10, Rhizoma Coptidis 8,

Poria 12, Fructus Gardeniae 10,

Cortex Phellodendri 10, Radix Et Rhizoma Rhei 10,

Fructus Aurantii 10, Rhizoma Atractylodis 12,

The processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 10, Flos Lonicerae 15,

Fructus Forsythiae 10, Rhizoma Alismatis 10,

Caulis Akebiae 10, Cortex Magnoliae Officinalis 10,

Herba Pogostemonis 10, Fructus Amomi Rotundus 10,

Semen Coicis 15, Fructus Setariae Germinatus (parched) 10,

Fructus Hordei Germinatus (parched) 10, Radix Gentianae 15,

The Radix Paeoniae Alba 10, Radix Bupleuri 10,

Fructus Aurantii Immaturus 10, Herba Violae 15,

The stem or leaf of cattail (decocting a drug wrapped) 10, Radix Arnebiae (Radix Lithospermi) 10,

Herba Hedyotidis Diffusae 15, Radix Glycyrrhizae 8,

Caulis Bambusae In Taenia 10, Herba Taraxaci 10,

Rhizoma Imperatae 10, Flos Chrysanthemi Indici 10,

Caulis et folium pavettae hongkongensis 15, Herba Senecionis Scandentis 15,

Herba Patriniae 15, Herba Houttuyniae 15,

Herba Artemisiae Scopariae 15.

The manufacture method of the medicine of this treatment hepatitis B treating is:

Select authentic medicinal herbs to be used as medicine by above-mentioned ratio of weight and number, medicine is concocted with different materials and maneuver by the property of medicine, to strengthen its drug effect.And by traditional Chinese medical science monarch Compatibility Law, carry out mixing behind the compatibility according to the dosage of above-mentioned requirements.Adopt oven dry, make packing.

Require simultaneously patient to endure and once drink medicine once, drink every day six times.The full whole medicine of the every less important water bubble of medicine is boiled into about four liang, can take.

The traditional Chinese medical science is thought: viral hepatitis belongs to traditional Chinese medical science jaundice " damp and hot, hypochondriac pain, stagnation of liver-QI, wei Deficient " etc. the disease scope, mainly be to be subjected to the heresy of damp-heat virus and to cause.Damp and hot the binding up one's hair of the lighter is acute hepatitis, and then volt in the epidemic disease caused by damp-heat pathogen poison, blood system is not understood, with the passing of time cause the imbalance of the internal organs such as liver,spleen,kidney, negative and positive, QI and blood or deficient and form chronic hepatitis, severe one epidemic disease poison reversible transmission pericardium is hoodwinked key clearly or is joined the army and hinder network or deficiency of vital energy blood prostration negative and positive from the critical emergency case of exhausted formation hepatitis gravis.

Gypsum Fibrosum, the Rhizoma Anemarrhenae, Caulis Bambusae In Taenia, Fructus Gardeniae, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Gentianae, Cortex Moutan, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Herba Violae, Herba Houttuyniae, Rhizoma Smilacis Glabrae, Herba Patriniae, Herba Hedyotidis Diffusae, Radix Arnebiae (Radix Lithospermi), Flos Chrysanthemi Indici, be monarch drug, its bitter in the mouth is cold in nature, energy clearing away heat-fire removing heat from blood, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Herba Pogostemonis, Fructus Amomi Rotundus, Poria, Rhizoma Alismatis, Herba Artemisiae Scopariae, Caulis Akebiae, Semen Coicis are ministerial drug, its acrid in the mouth, bitterness temperature, with drying damp and strengthening spleen, promoting diuresis to eliminate damp pathogen, circulation of qi promoting.Radix Bupleuri, Fructus Aurantii Immaturus, Fructus Aurantii, the Radix Paeoniae Alba, Radix Glycyrrhizae, Pollen Typhae, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, Oletum Trogopterori, Rhizoma Imperatae, be adjuvant drug, its acrid in the mouth, hardship, with depressed liver-energy dispersing and QI regulating, clearing away heat and purging.Cooling blood for hemostasis, the effect of activating blood circulation and dissipating phlegm.Radix Isatidis, Fructus Setariae Germinatus (parched), Fructus Hordei Germinatus, Fructus Trichosanthis, Caulis et folium pavettae hongkongensis, Herba Senecionis Scandentis, for making medicine, with promoting digestion and removing stagnation, invigorating the spleen and regulating the stomach, detoxifcation, promoting the circulation of QI, eliminating stagnation.Particularly wherein Flos Lonicerae, Radix Gentianae, Herba Senecionis Scandentis, Caulis et folium pavettae hongkongensis, Flos Chrysanthemi Indici, Herba Houttuyniae, viral hepatitis is had special curative effect.

In order to show a kind of effect for the treatment of the medicine of hepatitis B treating of the present invention, special " new drug (Chinese medicine) guideline of clinical investigations " with reference to the formulation of Ministry of Public Health bureau of drug administration formulated the clinical research scheme, select representational 240 routine case observations, the treatment situation is as follows:

The case choice criteria

(1) tcm diagnosis standard:

1, impact feed:

Liver dampness-heat in the spleen: rush down when half congealed during stool, stomachache, lack of appetite, weak, the tenesmus of yellowish complexion.(liver power checking, total bilirubin glutamate pyruvate transaminase glutamic oxaloacetic transaminase, GOT is higher) humidity hysteresis is in stomach: diarrhoea.

The weight classification

Classification	Symptom (time) performance
		Gently (+)	Stomach discomfort, does not affect life at every day just rare 2-3 time
In (++)	Stomachache, diarrhoea 4-6 busy impact life every day
		Heavy (+++)	The stomachache tenderness, tenesmus, weak, influential to living

2, dizzy:

Excessive rising of liver-YANG: dizzy, bother or be angry and dizzy every day, being irritable and getting angry easily.

Stagnation of turbid phlegm in middle-JIAO: dizzy and see heaviness of the head as being covered, uncomfortable in chestly feel sick lack of appetite, soft pulse sliding (liver power checking: total bilirubin, albumin are very high)

The weight classification

3, weak

Deficiency of yang of liver and kidney: borborygmus, diarrhoea, the waist lower limb is weak, shortness of breath and fatigue.

Taste are deficient: the stomach poor appetite, and the loose stool, myasthenia of limbs, white and thin fur, (Hepatitis B virus checks surperficial antigen measuring result to thready and weak pulse: the positive)

The weight classification

Classification	The disease performance
		Gently (+)	Slightly tired, the power of not enduring hardships can be adhered to daily life and work
In (++)	The asthenia weight is supported daily life and work reluctantly
		Heavy (+++)	Myasthenia of limbs, diarrhoea can not be adhered to daily life and work

Two, test case standard

1, includes the case standard in: the Hepatitis B virus liver function

(1) hospital diagnosis meets: the diagnosis of " surface antigen is positive "

(2) Excluded cases standard:

Get rid of the liver organic disease such as liver cirrhosis hepatocarcinoma

Clinical data

According to above-mentioned case choice criteria: this group is divided into two groups to 240 examples from the case of Sichuan province, wherein experimental group 160 routine matched group 80 examples

4, sex (seeing the following form)

180 routine gender analysis tables:

	Add up to	The man	The woman	Male: female
					Experimental group	160	120	40	3∶1
Matched group	80	60	20	3∶1

Two groups of Sex distribution no significant differences.

5, age distribution (seeing the following form)

180 routine Analysis of age tables:

	Add up to	10-20 year	20-50 year	50-60 year
					Experimental group	160	50	100	10
Matched group	80	30	40	10

13 years old 60 years old maximum age of experimental group minimal ages

15 years old 53 years old maximum age of matched group minimal ages

40 years old mean age, two groups of age distribution zero differences

6, tcm symptom (seeing the following form)

The tcm symptom analytical table

1, test method:

240 routine patients are divided into two groups at random, test group 160 examples, the medicine for the treatment of hepatitis B treating of the present invention on probation, one pair of medicine was taken three days, took once after 4 hours every day 6 times, and clean water covers powder, fry in shallow oil again after soaking into, fry in shallow oil and once take once, be used in conjunction three months.Matched group 80 examples are used " compound recipe benefit proheparinum tablet " every day 3 times, each 4, are used in conjunction three months.

More than two groups all cut out other drug:

(1) effect index: the main situations such as " the liver spleen do not conform to, excessive rising of liver-YANG, the decline of the change of deficiency of yang of liver and kidney symptom and the decline of liver function and Hepatitis B virus " of observing.

(2) safety indexes:

A, Hepatitis B virus B, liver function C, untoward reaction

2, test changes evaluation criteria:

(1) produce effects: degrees of symptoms reduces (++) or disappearance person after the test

(2) effective: degrees of symptoms minimizing person after the test

(3) invalid: the unchanged person of degrees of symptoms after the test

(4) increase the weight of: degrees of symptoms before adds severe one after the test

3, Hepatitis B virus efficacy analysis table:

4, Hepatitis B virus optimum curative effect decline analytical table:

Project	Time	s/c.0
			HBsAg	4 months	5.00
HBeAg	4 months	17.30

5, the hepatitis B liver function optimum curative effect analytical table that descends in 4 months:

Project	The result	Unit
			Total bilirubin	6	Umol/L
Bilirubin direct	4	Umol/L
			Glutamate pyruvate transaminase	100	U/L

[0114]

Glutamic oxaloacetic transaminase, GOT

76

U/L

More than table can be found out, the medicine for the treatment of hepatitis B treating of the present invention is turned out cloudy effective percentage for absolutely to the symptom of hepatitis B, obviously is better than matched group

6, toxic and side effects and untoward reaction:

Select the 100 routine patients chemical examination before and after test in the test group to detect, Hepatitis B virus, liver function detect does not all find the aggravation phenomenon.Stomachache arranged in the time of in the clinical trial, have loose bowels, the soft symptom such as unable of dizzy, foot belongs to normal range.

Specific embodiment

Embodiment 1

Select the roguing of genuine high-quality Chinese crude drug according to the parts by weight of lower routine each component.

Rhizoma Polygoni Cuspidati 20, Radix Isatidis 10,

Radix Salviae Miltiorrhizae 10, Gypsum Fibrosum 15,

The Rhizoma Anemarrhenae 10, Cortex Moutan 10,

Radix Scutellariae 10, Rhizoma Coptidis 8,

Poria 12, Fructus Gardeniae 10,

Cortex Phellodendri 10, Radix Et Rhizoma Rhei 10,

Fructus Aurantii 10, Rhizoma Atractylodis 12,

The processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 10, Flos Lonicerae 15,

Fructus Forsythiae 10, Rhizoma Alismatis 10,

Caulis Akebiae 10, Cortex Magnoliae Officinalis 10,

Herba Pogostemonis 10, Fructus Amomi Rotundus 10,

Semen Coicis 15, Fructus Setariae Germinatus (parched) 10,

Fructus Hordei Germinatus (parched) 10, Radix Gentianae 15,

The Radix Paeoniae Alba 10, Radix Bupleuri 10,

Fructus Aurantii Immaturus 10, Herba Violae 15,

The stem or leaf of cattail (decocting a drug wrapped) 10, Radix Arnebiae (Radix Lithospermi) 10,

Herba Hedyotidis Diffusae 15, Radix Glycyrrhizae 8,

Caulis Bambusae In Taenia 10, Herba Taraxaci 10,

Rhizoma Imperatae 10, Flos Chrysanthemi Indici 10,

Caulis et folium pavettae hongkongensis 15, Herba Senecionis Scandentis 15,

Herba Patriniae 15, Herba Houttuyniae 15,

Herba Artemisiae Scopariae 15.

Carry out mixing behind the compatibility according to above-mentioned dosage, after all Chinese medicine mixes, put into pot and add an amount of water, water must all flood all medicines, fries in shallow oil into about 4 liang and takes, and takes every day six times.

Embodiment 2

Rhizoma Polygoni Cuspidati 22, Radix Isatidis 12,

Radix Salviae Miltiorrhizae 12, Gypsum Fibrosum 17,

The Rhizoma Anemarrhenae 12, Cortex Moutan 10,

Radix Scutellariae 10, Rhizoma Coptidis 8,

Poria 12, Fructus Gardeniae 10,

Cortex Phellodendri 10, Radix Et Rhizoma Rhei 10,

Fructus Aurantii 10, Rhizoma Atractylodis 12,

The processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 10, Flos Lonicerae 15,

Fructus Forsythiae 10, Rhizoma Alismatis 10,

Caulis Akebiae 10, Cortex Magnoliae Officinalis 10,

Herba Pogostemonis 10, Fructus Amomi Rotundus 12,

Semen Coicis 17, Fructus Setariae Germinatus (parched) 10,

Fructus Hordei Germinatus (parched) 10, Radix Gentianae 17,

The Radix Paeoniae Alba 10, Radix Bupleuri 10,

Fructus Aurantii Immaturus 10, Herba Violae 17,

The stem or leaf of cattail (decocting a drug wrapped) 10, Radix Arnebiae (Radix Lithospermi) 10,

Herba Hedyotidis Diffusae 13, Radix Glycyrrhizae 8,

Caulis Bambusae In Taenia 10, Herba Taraxaci 10,

Rhizoma Imperatae 10, Flos Chrysanthemi Indici 10,

Caulis et folium pavettae hongkongensis 15, Herba Senecionis Scandentis 13,

Herba Patriniae 17, Herba Houttuyniae 12,

Herba Artemisiae Scopariae 12.

Claims (4)

1. medicine for the treatment of hepatitis B treating is characterized in that being made by the following parts by weight that form:

Rhizoma Polygoni Cuspidati 20 ± 5, Radix Isatidis 10 ± 2,

Radix Salviae Miltiorrhizae 10 ± 3, Gypsum Fibrosum 15 ± 3,

The Rhizoma Anemarrhenae 10 ± 2, Cortex Moutan 10 ± 2,

Radix Scutellariae 10 ± 2, Rhizoma Coptidis 8 ± 2,

Poria 12 ± 3, Fructus Gardeniae 10 ± 4,

Cortex Phellodendri 10 ± 3, Radix Et Rhizoma Rhei 8 ± 2,

Fructus Aurantii 10 ± 2, Rhizoma Atractylodis 12 ± 3,

The processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 10 ± 2, Flos Lonicerae 15 ± 2,

Fructus Forsythiae 10 ± 3, Rhizoma Alismatis 10 ± 3,

Caulis Akebiae 10 ± 2, Cortex Magnoliae Officinalis 10 ± 2,

Herba Pogostemonis 10 ± 2, Fructus Amomi Rotundus 10 ± 2,

Semen Coicis 15 ± 3, Fructus Setariae Germinatus (parched) 10 ± 2,

Fructus Hordei Germinatus (parched) 10 ± 2, Radix Gentianae 15 ± 5,

The Radix Paeoniae Alba 10 ± 2, Radix Bupleuri 10 ± 3,

Fructus Aurantii Immaturus 10 ± 2, Herba Violae 15 ± 5,

Rhizoma Smilacis Glabrae 10 ± 2, Oletum Trogopterori 10 ± 2,

Fructus Trichosanthis 10 ± 2, Pollen Typhae 10 ± 2 (decocting a drug wrapped),

Radix Arnebiae (Radix Lithospermi) 10 ± 3, Herba Hedyotidis Diffusae 15 ± 5,

Radix Glycyrrhizae 10 ± 1, Caulis Bambusae In Taenia 10 ± 2.

2. a kind of medicine for the treatment of hepatitis B treating according to claim 1 is characterized in that also comprising following component:

Herba Taraxaci 10 ± 2, Rhizoma Imperatae 10 ± 3,

Flos Chrysanthemi Indici 10 ± 3, Caulis et folium pavettae hongkongensis 15 ± 5,

Herba Senecionis Scandentis 15 ± 5, Herba Patriniae 15 ± 5,

Herba Houttuyniae 15 ± 5, Herba Artemisiae Scopariae 15 ± 5,

3. a kind of medicine for the treatment of hepatitis B treating according to claim 1 is characterized in that the optimum weight umber of each component is:

Rhizoma Polygoni Cuspidati 20, Radix Isatidis 10,

Radix Salviae Miltiorrhizae 10, Gypsum Fibrosum 15,

The Rhizoma Anemarrhenae 10, Cortex Moutan 10,

Radix Scutellariae 10, Rhizoma Coptidis 8,

Poria 12, Fructus Gardeniae 10,

Cortex Phellodendri 10, Radix Et Rhizoma Rhei 10,

Fructus Aurantii 10, Rhizoma Atractylodis 12,

The processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 10, Flos Lonicerae 15,

Fructus Forsythiae 10, Rhizoma Alismatis 10,

Caulis Akebiae 10, Cortex Magnoliae Officinalis 10,

Herba Pogostemonis 10, Fructus Amomi Rotundus 10,

Semen Coicis 15, Fructus Setariae Germinatus (parched) 10,

Fructus Hordei Germinatus (parched) 10, Radix Gentianae 15,

The Radix Paeoniae Alba 10, Radix Bupleuri 10,

Fructus Aurantii Immaturus 10, Herba Violae 15,

The stem or leaf of cattail (decocting a drug wrapped) 10, Radix Arnebiae (Radix Lithospermi) 10,

Herba Hedyotidis Diffusae 15, Radix Glycyrrhizae 8,

Caulis Bambusae In Taenia 10,

4. a kind of medicine for the treatment of hepatitis B treating according to claim 2 is characterized in that:

The optimum weight of each component is

Rhizoma Polygoni Cuspidati 20, Radix Isatidis 10,

Radix Salviae Miltiorrhizae 10, Gypsum Fibrosum 15,

The Rhizoma Anemarrhenae 10, Cortex Moutan 10,

Radix Scutellariae 10, Rhizoma Coptidis 8,

Poria 12, Fructus Gardeniae 10,

Cortex Phellodendri 10, Radix Et Rhizoma Rhei 10,

Fructus Aurantii 10, Rhizoma Atractylodis 12,

The processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 10, Flos Lonicerae 15,

Fructus Forsythiae 10, Rhizoma Alismatis 10,

Caulis Akebiae 10, Cortex Magnoliae Officinalis 10,

Herba Pogostemonis 10, Fructus Amomi Rotundus 10,

Semen Coicis 15, Fructus Setariae Germinatus (parched) 10,

Fructus Hordei Germinatus (parched) 10, Radix Gentianae 15,

The Radix Paeoniae Alba 10, Radix Bupleuri 10,

Fructus Aurantii Immaturus 10, Herba Violae 15,

The stem or leaf of cattail (decocting a drug wrapped) 10, Radix Arnebiae (Radix Lithospermi) 10,

Herba Hedyotidis Diffusae 15, Radix Glycyrrhizae 8,

Caulis Bambusae In Taenia 10, Herba Taraxaci 10,

Rhizoma Imperatae 10, Flos Chrysanthemi Indici 10,

Caulis et folium pavettae hongkongensis 15, Herba Senecionis Scandentis 15,

Herba Patriniae 15, Herba Houttuyniae 15,

Herba Artemisiae Scopariae 15.